Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development.

abstract：Importance:After long-duration spaceflight, morphological changes in the optic nerve head (ONH) and surrounding tissues have been reported. Objective:To develop methods to quantify ONH and surrounding tissue changes using preflight and postflight optical coherence tomographic scans of the ONH region. Design, Setting,...

journal_title：JAMA ophthalmology

authors： Patel N,Pass A,Mason S,Gibson CR,Otto C

更新日期：2018-02-01 00:00:00

abstract：Importance:To prevent blindness, repeated infant eye examinations are performed to detect severe retinopathy of prematurity (ROP), yet only a small fraction of those screened need treatment. Early individual risk stratification would improve screening timing and efficiency and potentially reduce the risk of blindness. ...

journal_title：JAMA ophthalmology

authors： Pivodic A,Hård AL,Löfqvist C,Smith LEH,Wu C,Bründer MC,Lagrèze WA,Stahl A,Holmström G,Albertsson-Wikland K,Johansson H,Nilsson S,Hellström A

更新日期：2019-11-07 00:00:00

abstract：Importance:Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear. Objective:To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma. Design, Setting, and Participants:This case series study was a retrospective medical record...

journal_title：JAMA ophthalmology

authors： Deák GG,Goldstein DA,Zhou M,Fawzi AA,Jampol LM

更新日期：2019-02-01 00:00:00

abstract：IMPORTANCE:Tuberculosis is an endemic infectious disease in developing countries. Patients receiving treatment for systemic tuberculosis may develop paradoxical growth of tuberculomas in the brain, which can lead to vision loss. OBSERVATIONS:We describe 3 patients who had paradoxical development of tuberculomas in the...

journal_title：JAMA ophthalmology

authors： Joseph M,Mendonca TM,Vasu U,Nithyanandam S,Mathew T

更新日期：2013-11-01 00:00:00

abstract：Importance:Visual acuity (VA) outcomes differ considerably among patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) drugs. Identification of pharmacogenetic associations may help clinicians understand the mechanisms underlying this variability a...

journal_title：JAMA ophthalmology

authors： Lorés-Motta L,Riaz M,Grunin M,Corominas J,van Asten F,Pauper M,Leenders M,Richardson AJ,Muether P,Cree AJ,Griffiths HL,Pham C,Belanger MC,Meester-Smoor MA,Ali M,Heid IM,Fritsche LG,Chakravarthy U,Gale R,McKibbin M,

更新日期：2018-08-01 00:00:00

abstract：Importance:Adding a laser-induced chorioretinal anastomosis (L-CRA) to current treatments for central retinal vein occlusion (CRVO) may improve outcomes and lessen therapy burdens. Objective:To determine the 2-year efficacy of intravitreal ranibizumab with an L-CRA vs ranibizumab alone for patients with macular edema ...

journal_title：JAMA ophthalmology

authors： McAllister IL,Smithies LA,Chen FK,Mackey DA,Sanfilippo PG

更新日期：2018-12-01 00:00:00

abstract：Importance:The frequency of anti-vascular endothelial growth factor (VEGF) injections has grown exponentially with the introduction of bevacizumab, ranibizumab, and most recently aflibercept. The cost associated with these medications has garnered significant national attention, warranting a granular analysis of their ...

journal_title：JAMA ophthalmology

authors： Berkowitz ST,Sternberg P Jr,Feng X,Chen Q,Patel S

更新日期：2019-06-20 00:00:00

abstract：Importance:Although almost equal numbers of male and female medical students enter into ophthalmology residency programs, whether they have similar surgical experiences during training is unclear. Objective:To determine differences for cataract surgery and total procedural volume between male and female residents duri...

journal_title：JAMA ophthalmology

authors： Gong D,Winn BJ,Beal CJ,Blomquist PH,Chen RW,Culican SM,Dagi Glass LR,Domeracki GF,Goshe JM,Jones JK,Khouri AS,Legault GL,Martin TJ,Mitchell KT,Naseri A,Oetting TA,Olson JH,Pettey JH,Reinoso MA,Reynolds AL,Siatkows

更新日期：2019-07-18 00:00:00

abstract：Importance:Given the rarity of posterior uveal melanoma in patients younger than 21 years, reporting clinical experience in this area has relevance. Objective:To describe the baseline clinical features, treatment, and clinical course of a group of patients younger than 21 years who have primary posterior uveal melanom...

journal_title：JAMA ophthalmology

authors： Fry MV,Augsburger JJ,Corrêa ZM

更新日期：2019-01-01 00:00:00

abstract：IMPORTANCE:African American individuals are at high risk of diabetes mellitus and diabetic retinopathy but have suboptimal rates of dilated fundus examinations (DFEs). Early intervention is crucial for the prevention of diabetic retinopathy in this high-risk population. OBJECTIVE:To test the efficacy of behavioral act...

journal_title：JAMA ophthalmology

authors： Weiss DM,Casten RJ,Leiby BE,Hark LA,Murchison AP,Johnson D,Stratford S,Henderer J,Rovner BW,Haller JA

更新日期：2015-09-01 00:00:00

abstract：IMPORTANCE:Visualization and interpretation of the optic nerve and retina are essential parts of most physical examinations. OBJECTIVE:To design and validate a smartphone-based retinal adapter enabling image capture and remote grading of the retina. DESIGN, SETTING, AND PARTICIPANTS:This validation study compared the...

journal_title：JAMA ophthalmology

authors： Bastawrous A,Giardini ME,Bolster NM,Peto T,Shah N,Livingstone IA,Weiss HA,Hu S,Rono H,Kuper H,Burton M

更新日期：2016-02-01 00:00:00

abstract：Importance:The Diabetic Retinopathy Clinical Research Network Protocol S randomized clinical trial results suggest that ranibizumab is a reasonable treatment alternative to panretinal photocoagulation (PRP) when managing proliferative diabetic retinopathy (PDR), with or without concomitant baseline diabetic macular ede...

journal_title：JAMA ophthalmology

authors： Hutton DW,Stein JD,Bressler NM,Jampol LM,Browning D,Glassman AR,Diabetic Retinopathy Clinical Research Network.

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:Patching has been a mainstay in treating unilateral congenital cataract. However, its efficacy has not been rigorously assessed. OBJECTIVE:To examine the association between patching and visual acuity in a cohort of children treated for unilateral congenital cataract. DESIGN, SETTING, AND PARTICIPANTS:This...

journal_title：JAMA ophthalmology

authors： Drews-Botsch C,Celano M,Cotsonis G,Hartmann EE,Lambert SR,Infant Aphakia Treatment Study Group.

更新日期：2016-08-01 00:00:00

abstract：Importance:The ocular surface is continuously exposed to the environment. Although studies have focused on associations between outdoor environmental conditions and dry eye, information on associations between the indoor environment and dry eye is lacking. Objective:To determine associations between the indoor environ...

journal_title：JAMA ophthalmology

authors： Huang A,Janecki J,Galor A,Rock S,Menendez D,Hackam AS,Jeng BH,Kumar N

更新日期：2020-08-01 00:00:00

abstract：Importance:Given the estimates of increasing prevalence of myopia, especially in Asia, it is important to determine the current prevalence of myopia among populations of schoolchildren in Japan. Objective:To investigate the current prevalence rate of myopia and the association between environmental factors and myopia ...

journal_title：JAMA ophthalmology

authors： Yotsukura E,Torii H,Inokuchi M,Tokumura M,Uchino M,Nakamura K,Hyodo M,Mori K,Jiang X,Ikeda SI,Kondo S,Negishi K,Kurihara T,Tsubota K

更新日期：2019-08-15 00:00:00

abstract：Importance:The 2-year efficacy and safety of combination therapy of ranibizumab administered together with verteporfin photodynamic therapy (vPDT) compared with ranibizumab monotherapy in participants with polypoidal choroidal vasculopathy (PCV) are unclear. Objective:To compare treatment outcomes of ranibizumab, 0.5 ...

journal_title：JAMA ophthalmology

authors： Lim TH,Lai TYY,Takahashi K,Wong TY,Chen LJ,Ruamviboonsuk P,Tan CS,Lee WK,Cheung CMG,Ngah NF,Patalauskaite R,Margaron P,Koh A,EVEREST II Study Group.

更新日期：2020-09-01 00:00:00

abstract：IMPORTANCE:Few studies have been published on the association of the radiation dose received to the eyes during radiotherapy (RT) for childhood cancer and the risk for later cataract. OBJECTIVE:To investigate the risk for cataract after treatment of nonretinoblastoma solid cancer in childhood. DESIGN, SETTING, AND PA...

journal_title：JAMA ophthalmology

authors： Allodji RS,Diallo I,El-Fayech C,Kahlouche A,Dumas A,Schwartz B,Oberlin O,Benadjaoud MA,Labbé M,Jackson A,Bullet J,Rubino C,Haddy N,De Vathaire F

更新日期：2016-04-01 00:00:00

abstract：Importance:Some eyes with neovascular age-related macular degeneration (AMD) have persistent exudation despite frequent intravitreal anti-vascular endothelial growth factor (VEGF) injections. Adjuvant therapies that further reduce edema may improve vision outcomes. Objective:To compare the short-term effect of topical...

journal_title：JAMA ophthalmology

authors： Hsu J,Patel SN,Wolfe JD,Shah CP,Chen E,Jenkins TL,Wibbelsman TD,Obeid A,Mikhail M,Garg SJ,Ho AC,Chiang A,Spirn MJ,Vander JF

更新日期：2020-05-01 00:00:00

abstract：IMPORTANCE:There is a major lack of randomized controlled clinical trials evaluating the efficacy of prismatic treatments for hemianopia. Evidence for their effectiveness is mostly based on anecdotal case reports and open-label evaluations without a control condition. OBJECTIVE:To evaluate the efficacy of real relativ...

journal_title：JAMA ophthalmology

authors： Bowers AR,Keeney K,Peli E

更新日期：2014-02-01 00:00:00

abstract：Importance:Congenital Zika syndrome (CZS) is known to be associated with severe malformations in newborns. Although microcephaly is the hallmark of this disease, the ocular findings are important given the severe visual impairment that has been observed in these patients. Regardless of the increased number of CZS cases...

journal_title：JAMA ophthalmology

authors： Fernandez MP,Parra Saad E,Ospina Martinez M,Corchuelo S,Mercado Reyes M,Herrera MJ,Parra Saavedra M,Rico A,Fernandez AM,Lee RK,Ventura CV,Berrocal AM,Dubovy SR

更新日期：2017-11-01 00:00:00

abstract：Importance:There are limited published data on the phenotype of retinitis pigmentosa (RP) related to CNGB1 variants. These data are needed both for prognostic counseling of patients and for understanding potential treatment windows. Objective:To describe the detailed clinical and molecular genetic findings in a series...

journal_title：JAMA ophthalmology

authors： Hull S,Attanasio M,Arno G,Carss K,Robson AG,Thompson DA,Plagnol V,Michaelides M,Holder GE,Henderson RH,Raymond FL,Moore AT,Webster AR

更新日期：2017-02-01 00:00:00

abstract：IMPORTANCE:Myopia (nearsightedness) has its onset in childhood and affects about one-third of adults in the United States. Along with its high prevalence, myopia is expensive to correct and is associated with ocular diseases that include glaucoma and retinal detachment. OBJECTIVE:To determine the best set of predictor...

journal_title：JAMA ophthalmology

authors： Zadnik K,Sinnott LT,Cotter SA,Jones-Jordan LA,Kleinstein RN,Manny RE,Twelker JD,Mutti DO,Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group.

更新日期：2015-06-01 00:00:00

abstract：Importance:Mobility limitations arising from vision impairment (VI) can result in loss of independence and reduced quality of life. However, few data are available on the association between VI and mobility limitations at a population-based level, particularly in Asian populations. Objective:To assess the association ...

journal_title：JAMA ophthalmology

authors： Fenwick EK,Ong PG,Man RE,Cheng CY,Sabanayagam C,Wong TY,Lamoureux EL

更新日期：2016-10-01 00:00:00

abstract：Objective:To compare oral voriconazole with placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis. Design, Setting, and Participants:The Mycotic Ulcer Treatment Trial II (MUTT II), a multicenter, double-masked, placebo-controlled, randomized clinical trial, was conducted in India ...

journal_title：JAMA ophthalmology

authors： Prajna NV,Krishnan T,Rajaraman R,Patel S,Srinivasan M,Das M,Ray KJ,O'Brien KS,Oldenburg CE,McLeod SD,Zegans ME,Porco TC,Acharya NR,Lietman TM,Rose-Nussbaumer J,Mycotic Ulcer Treatment Trial II Group.

更新日期：2016-12-01 00:00:00

abstract：IMPORTANCE:We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the treatment of glaucoma. We report the intraocular pressure (IOP)-lowering effects and safety of K-115 based on our results. OBJECTIVE:To study the IOP-...

journal_title：JAMA ophthalmology

authors： Tanihara H,Inoue T,Yamamoto T,Kuwayama Y,Abe H,Araie M,K-115 Clinical Study Group.

更新日期：2013-10-01 00:00:00

abstract：Importance:Although low-income populations have more eye problems, whether they face greater difficulty obtaining eye care appointments is unknown. Objective:To compare rates of obtaining eye care appointments and appointment wait times for those with Medicaid vs those with private insurance. Design, Setting, and Par...

journal_title：JAMA ophthalmology

authors： Lee YH,Chen AX,Varadaraj V,Hong GH,Chen Y,Friedman DS,Stein JD,Kourgialis N,Ehrlich JR

更新日期：2018-06-01 00:00:00

abstract：Importance:Identifying the course of glaucomatous visual field (VF) loss that progresses from normal to perimetric blindness is important for treatment and prognostication. Objective:To model the process of glaucomatous VF decay over the entire perimetric range from normal to perimetric blindness. Design, Setting, an...

journal_title：JAMA ophthalmology

authors： Otarola F,Chen A,Morales E,Yu F,Afifi A,Caprioli J

更新日期：2016-05-01 00:00:00

abstract：IMPORTANCE:This study confirmed the long-term outcomes of the ZB5M phakic intraocular lens (PIOL). OBJECTIVE:To evaluate the potential long-term risk associated with ZB5M PIOL implantation. DESIGN, SETTING, AND PARTICIPANTS:A retrospective, nonrandomized, consecutive cohort study of a total of 208 eyes implanted with...

journal_title：JAMA ophthalmology

authors： Alio JL,Abbouda A,Peña-Garcia P,Huseynli S

更新日期：2013-12-01 00:00:00

abstract：IMPORTANCE:Macular telangiectasia type 2 is a bilateral disease with characteristic alterations of the macular capillary network and neural atrophy. Vascular and neurodegenerative hypotheses have been proposed to explain these clinical findings, but many questions regarding the pathogenesis remain. OBSERVATIONS:We rep...

journal_title：JAMA ophthalmology

authors： Gillies MC,Mehta H,Bird AC

更新日期：2015-08-01 00:00:00

abstract：Importance:Most premature infants will not develop retinopathy of prematurity (ROP) of clinical relevance, yet screening evaluations often continue beyond hospital discharge, even for those infants without ROP. Objectives:To identify the characteristics of infants at low risk for ROP, for whom further postdischarge sc...

journal_title：JAMA ophthalmology

authors： Wade KC,Ying GS,Baumritter A,Gong A,Kemper AR,Quinn GE,e-ROP Cooperative Group.

更新日期：2019-02-01 00:00:00