Serum carboxymethyllysine, an advanced glycation end product, and age-related macular degeneration: the Age, Gene/Environment Susceptibility-Reykjavik Study.

abstract：Importance:Congenital stationary night blindness (CSNB) implies a stable condition, with the major symptom being nyctalopia present at birth. Pediatric clinical presentation and the course of different genetic subtypes of CSNB have not, to our knowledge, been well described in the era of molecular genetic diagnosis. O...

journal_title：JAMA ophthalmology

authors： Miraldi Utz V,Pfeifer W,Longmuir SQ,Olson RJ,Wang K,Drack AV

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the association between vitreous fluid levels of inflammatory factors and macular edema in patients with branch retinal vein occlusion (BRVO). METHODS:In 39 patients with BRVO and macular edema and 21 individuals with idiopathic macular hole (MH) serving as controls, vitreous fluid samples were o...

journal_title：JAMA ophthalmology

authors： Noma H,Mimura T,Eguchi S

更新日期：2013-02-01 00:00:00

abstract：IMPORTANCE:Descemet stripping automated endothelial keratoplasty (DSAEK) for isolated endothelial dysfunction has become the preferred surgical option for many corneal surgeons. However, there are limited large-scale reports on DSAEK survival and clinical variables affecting the risk of rejection and failure after fail...

journal_title：JAMA ophthalmology

authors： Mitry D,Bhogal M,Patel AK,Lee BS,Chai SM,Price MO,Price FW Jr,Jun AS,Aldave AJ,Mehta JS,Busin M,Allan BD

更新日期：2014-06-01 00:00:00

abstract：Importance:To our knowledge, a set of well-defined diagnostic criteria is not yet developed for the diagnosis of Vogt-Koyanagi-Harada (VKH) disease. Objective:To develop and evaluate a set of diagnostic criteria for VKH disease using data from Chinese patients. Design, Setting, and Participants:This case-control stud...

journal_title：JAMA ophthalmology

authors： Yang P,Zhong Y,Du L,Chi W,Chen L,Zhang R,Zhang M,Wang H,Lu H,Yang L,Zhuang W,Yang Y,Xing L,Feng L,Jiang Z,Zhang X,Wang Y,Zhong H,Jiang L,Zhao C,Li F,Cao S,Liu X,Chen X,Shi Y,Zhao W,Kijlstra A

更新日期：2018-09-01 00:00:00

abstract：IMPORTANCE:Patients and clinicians need to accurately assess the risks and benefits of pars plana vitrectomy for proliferative diabetic retinopathy, but clinical trial data may not reflect real-world experience. OBJECTIVE:To prospectively audit the complications of vitrectomy for proliferative diabetic retinopathy and...

journal_title：JAMA ophthalmology

authors： Jackson TL,Johnston RL,Donachie PH,Williamson TH,Sparrow JM,Steel DH

更新日期：2016-01-01 00:00:00

abstract：IMPORTANCE:Anti-vascular endothelial growth factor (VEGF) medicines have revolutionized diabetic macular edema (DME) treatment. A recent randomized clinical trial comparing anti-VEGF agents for patients with decreased vision from DME found that at 1 year aflibercept (2.0 mg) achieved better visual outcomes than repacka...

journal_title：JAMA ophthalmology

authors： Ross EL,Hutton DW,Stein JD,Bressler NM,Jampol LM,Glassman AR,Diabetic Retinopathy Clinical Research Network.

更新日期：2016-08-01 00:00:00

abstract：IMPORTANCE:Although trabeculotomy is a glaucoma surgical procedure for modest intraocular pressure (IOP) reduction, some eyes exhibit very low IOP during the early postoperative period. To our knowledge, the reason and its effect have not been investigated. OBJECTIVES:To investigate ciliochoroidal detachment (CCD) imm...

journal_title：JAMA ophthalmology

authors： Akagi T,Nakano E,Nakanishi H,Uji A,Yoshimura N

更新日期：2016-03-01 00:00:00

abstract：Importance:Some eyes with neovascular age-related macular degeneration (AMD) have persistent exudation despite frequent intravitreal anti-vascular endothelial growth factor (VEGF) injections. Adjuvant therapies that further reduce edema may improve vision outcomes. Objective:To compare the short-term effect of topical...

journal_title：JAMA ophthalmology

authors： Hsu J,Patel SN,Wolfe JD,Shah CP,Chen E,Jenkins TL,Wibbelsman TD,Obeid A,Mikhail M,Garg SJ,Ho AC,Chiang A,Spirn MJ,Vander JF

更新日期：2020-05-01 00:00:00

abstract：IMPORTANCE:To facilitate comparative clinical outcome research in low vision rehabilitation, we must use patient-centered measurements that reflect clinically meaningful changes in visual ability. OBJECTIVE:To quantify the effects of currently provided low vision rehabilitation (LVR) on patients who present for outpat...

journal_title：JAMA ophthalmology

authors： Goldstein JE,Jackson ML,Fox SM,Deremeik JT,Massof RW,Low Vision Research Network Study Group.

更新日期：2015-07-01 00:00:00

abstract：Importance:The 2-year efficacy and safety of combination therapy of ranibizumab administered together with verteporfin photodynamic therapy (vPDT) compared with ranibizumab monotherapy in participants with polypoidal choroidal vasculopathy (PCV) are unclear. Objective:To compare treatment outcomes of ranibizumab, 0.5 ...

journal_title：JAMA ophthalmology

authors： Lim TH,Lai TYY,Takahashi K,Wong TY,Chen LJ,Ruamviboonsuk P,Tan CS,Lee WK,Cheung CMG,Ngah NF,Patalauskaite R,Margaron P,Koh A,EVEREST II Study Group.

更新日期：2020-09-01 00:00:00

abstract：IMPORTANCE:The presence of choroidal hyperreflective foci in Stargardt disease is, to our knowledge, a potentially new finding. Evaluation of these foci may aid in better understanding of the disease process. OBJECTIVES:To report the presence of choroidal hyperreflective foci in spectral-domain optical coherence tomog...

journal_title：JAMA ophthalmology

authors： Piri N,Nesmith BL,Schaal S

更新日期：2015-04-01 00:00:00

abstract：IMPORTANCE:African American individuals are at high risk of diabetes mellitus and diabetic retinopathy but have suboptimal rates of dilated fundus examinations (DFEs). Early intervention is crucial for the prevention of diabetic retinopathy in this high-risk population. OBJECTIVE:To test the efficacy of behavioral act...

journal_title：JAMA ophthalmology

authors： Weiss DM,Casten RJ,Leiby BE,Hark LA,Murchison AP,Johnson D,Stratford S,Henderer J,Rovner BW,Haller JA

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of selective laser trabeculoplasty (SLT) for the treatment of primary open-angle glaucoma in an African-derived population in the developing world. METHODS:Sixty-one subjects from St. Lucia with medically treated primary open-angle glaucoma underwent a 30-day washout, followed by bil...

journal_title：JAMA ophthalmology

authors： Realini T

更新日期：2013-03-01 00:00:00

abstract：IMPORTANCE:Eye and vision disease burden should help guide ophthalmologic research prioritization. The Global Burden of Disease (GBD) Study 2010 compiled data from 1990 to 2010 on 291 diseases and injuries, 1160 disease and injury sequelae, and 67 risk factors in 187 countries. The Cochrane Database of Systematic Revie...

journal_title：JAMA ophthalmology

authors： Boyers LN,Karimkhani C,Hilton J,Richheimer W,Dellavalle RP

更新日期：2015-01-01 00:00:00

abstract：Importance:Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina is rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins with anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3P...

journal_title：JAMA ophthalmology

authors： Sala-Vila A,Díaz-López A,Valls-Pedret C,Cofán M,García-Layana A,Lamuela-Raventós RM,Castañer O,Zanon-Moreno V,Martinez-Gonzalez MA,Toledo E,Basora J,Salas-Salvadó J,Corella D,Gómez-Gracia E,Fiol M,Estruch R,Lapetra J,Fi

更新日期：2016-10-01 00:00:00

abstract：IMPORTANCE:Few studies have been published on the association of the radiation dose received to the eyes during radiotherapy (RT) for childhood cancer and the risk for later cataract. OBJECTIVE:To investigate the risk for cataract after treatment of nonretinoblastoma solid cancer in childhood. DESIGN, SETTING, AND PA...

journal_title：JAMA ophthalmology

authors： Allodji RS,Diallo I,El-Fayech C,Kahlouche A,Dumas A,Schwartz B,Oberlin O,Benadjaoud MA,Labbé M,Jackson A,Bullet J,Rubino C,Haddy N,De Vathaire F

更新日期：2016-04-01 00:00:00

abstract：Importance:Visual acuity (VA) outcomes differ considerably among patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) drugs. Identification of pharmacogenetic associations may help clinicians understand the mechanisms underlying this variability a...

journal_title：JAMA ophthalmology

authors： Lorés-Motta L,Riaz M,Grunin M,Corominas J,van Asten F,Pauper M,Leenders M,Richardson AJ,Muether P,Cree AJ,Griffiths HL,Pham C,Belanger MC,Meester-Smoor MA,Ali M,Heid IM,Fritsche LG,Chakravarthy U,Gale R,McKibbin M,

更新日期：2018-08-01 00:00:00

abstract：IMPORTANCE:Binocular summation (BiS) is defined as the superiority of visual function for binocular over monocular viewing. Binocular summation decreases with age and large interocular differences in visual acuity. To our knowledge, BiS has not heretofore been well studied as a functional measure of binocularity in str...

journal_title：JAMA ophthalmology

authors： Pineles SL,Velez FG,Isenberg SJ,Fenoglio Z,Birch E,Nusinowitz S,Demer JL

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Increased lipofuscin accumulation is assumed to be an important factor in the pathogenesis of age-related macular degeneration (AMD), although direct evidence for this hypothesis is missing. OBJECTIVE:To quantitatively investigate lipofuscin-associated fundus autofluorescence (AF) in patients with early and...

journal_title：JAMA ophthalmology

authors： Gliem M,Müller PL,Finger RP,McGuinness MB,Holz FG,Charbel Issa P

更新日期：2016-07-01 00:00:00

abstract：Importance:Preservation of peripheral visual field (VF) is considered an advantage for anti-vascular endothelial growth factor agents compared with panretinal photocoagulation (PRP) for treatment of proliferative diabetic retinopathy. Long-term data on VF are important when considering either treatment approach. Objec...

journal_title：JAMA ophthalmology

authors： Maguire MG,Liu D,Glassman AR,Jampol LM,Johnson CA,Baker CW,Bressler NM,Gardner TW,Pieramici D,Stockdale CR,Sun JK,DRCR Retina Network.

更新日期：2020-03-01 00:00:00

abstract：Importance:Although almost equal numbers of male and female medical students enter into ophthalmology residency programs, whether they have similar surgical experiences during training is unclear. Objective:To determine differences for cataract surgery and total procedural volume between male and female residents duri...

journal_title：JAMA ophthalmology

authors： Gong D,Winn BJ,Beal CJ,Blomquist PH,Chen RW,Culican SM,Dagi Glass LR,Domeracki GF,Goshe JM,Jones JK,Khouri AS,Legault GL,Martin TJ,Mitchell KT,Naseri A,Oetting TA,Olson JH,Pettey JH,Reinoso MA,Reynolds AL,Siatkows

更新日期：2019-07-18 00:00:00

abstract：Importance:The ocular surface is continuously exposed to the environment. Although studies have focused on associations between outdoor environmental conditions and dry eye, information on associations between the indoor environment and dry eye is lacking. Objective:To determine associations between the indoor environ...

journal_title：JAMA ophthalmology

authors： Huang A,Janecki J,Galor A,Rock S,Menendez D,Hackam AS,Jeng BH,Kumar N

更新日期：2020-08-01 00:00:00

abstract：Importance:Vitreoretinal lymphoma is a diagnostic challenge and the pathophysiology is still unclear. Objective:To describe an imaging finding seen on optical coherence tomography (OCT) of patients with vitreoretinal lymphoma. Design, Setting, and Participants:This case series study was a retrospective medical record...

journal_title：JAMA ophthalmology

authors： Deák GG,Goldstein DA,Zhou M,Fawzi AA,Jampol LM

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy of WINROP (https://winrop.com), an algorithm based on serial measurements of neonatal body weight to predict proliferative retinopathy of prematurity (ROP), in a Korean population of preterm infants. METHODS:The records of preterm infants with gestational age less than 32 weeks wh...

journal_title：JAMA ophthalmology

authors： Choi JH,Löfqvist C,Hellström A,Heo H

更新日期：2013-01-01 00:00:00

abstract：Importance:Most premature infants will not develop retinopathy of prematurity (ROP) of clinical relevance, yet screening evaluations often continue beyond hospital discharge, even for those infants without ROP. Objectives:To identify the characteristics of infants at low risk for ROP, for whom further postdischarge sc...

journal_title：JAMA ophthalmology

authors： Wade KC,Ying GS,Baumritter A,Gong A,Kemper AR,Quinn GE,e-ROP Cooperative Group.

更新日期：2019-02-01 00:00:00

abstract：IMPORTANCE:Tuberculosis is an endemic infectious disease in developing countries. Patients receiving treatment for systemic tuberculosis may develop paradoxical growth of tuberculomas in the brain, which can lead to vision loss. OBSERVATIONS:We describe 3 patients who had paradoxical development of tuberculomas in the...

journal_title：JAMA ophthalmology

authors： Joseph M,Mendonca TM,Vasu U,Nithyanandam S,Mathew T

更新日期：2013-11-01 00:00:00

abstract：IMPORTANCE:Myopia (nearsightedness) has its onset in childhood and affects about one-third of adults in the United States. Along with its high prevalence, myopia is expensive to correct and is associated with ocular diseases that include glaucoma and retinal detachment. OBJECTIVE:To determine the best set of predictor...

journal_title：JAMA ophthalmology

authors： Zadnik K,Sinnott LT,Cotter SA,Jones-Jordan LA,Kleinstein RN,Manny RE,Twelker JD,Mutti DO,Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group.

更新日期：2015-06-01 00:00:00

abstract：Importance:Anti-vascular endothelial growth factor (anti-VEGF) is a breakthrough treatment for wet age-related macular degeneration (wAMD), the most common cause of blindness in western countries. Anti-VEGF treatment prevents vision loss and has been shown to produce vision gains lasting as long as 5 years. Although th...

journal_title：JAMA ophthalmology

authors： Mulligan K,Seabury SA,Dugel PU,Blim JF,Goldman DP,Humayun MS

更新日期：2019-11-14 00:00:00

abstract：IMPORTANCE:Swedish Interactive Thresholding Algorithm (SITA) testing strategies for the Humphrey Field Analyzer have become a clinical standard. Measurements from SITA Fast are thought to be more variable than SITA Standard, yet some clinics routinely use SITA Fast because it is quicker. OBJECTIVE:To examine the measu...

journal_title：JAMA ophthalmology

authors： Saunders LJ,Russell RA,Crabb DP

更新日期：2015-01-01 00:00:00

abstract：IMPORTANCE:Acanthamoeba keratitis is a debilitating eye disease that requires effective topical drug therapy. Currently, there is no standard in vitro test to evaluate anti-Acanthamoeba drugs. OBJECTIVE:To develop a practical in vitro complete-kill assay to assess anti-Acanthamoeba drugs. DESIGN AND SETTING:Isolates ...

journal_title：JAMA ophthalmology

authors： Kowalski RP,Abdel Aziz S,Romanowski EG,Shanks RM,Nau AC,Raju LV

更新日期：2013-11-01 00:00:00