Association between missense mutations in the BBS2 gene and nonsyndromic retinitis pigmentosa.

abstract：Importance:Congenital stationary night blindness (CSNB) implies a stable condition, with the major symptom being nyctalopia present at birth. Pediatric clinical presentation and the course of different genetic subtypes of CSNB have not, to our knowledge, been well described in the era of molecular genetic diagnosis. O...

journal_title：JAMA ophthalmology

authors： Miraldi Utz V,Pfeifer W,Longmuir SQ,Olson RJ,Wang K,Drack AV

更新日期：2018-04-01 00:00:00

abstract：Importance:Macular edema (ME) is the leading cause of decreased visual acuity (VA) associated with retinal vein occlusion (RVO). Identifying factors associated with better outcomes in RVO eyes treated with anti-vascular endothelial growth factor (VEGF) therapy may provide information useful in counseling patients. Obj...

journal_title：JAMA ophthalmology

authors： Scott IU,VanVeldhuisen PC,Ip MS,Blodi BA,Oden NL,King J,Antoszyk AN,Peters MA,Tolentino M,SCORE2 Investigator Group.

更新日期：2017-06-01 00:00:00

abstract：Importance:This study used optical coherence tomographic angiography to assess for impaired blood flow in myopic eyes with or without open-angle glaucoma. Objective:To compare the peripapillary perfused capillary density (PCD) between eyes with and without glaucoma. Design, Setting, and Participants:In this cross-sec...

journal_title：JAMA ophthalmology

authors： Suwan Y,Fard MA,Geyman LS,Tantraworasin A,Chui TY,Rosen RB,Ritch R

更新日期：2018-05-01 00:00:00

abstract：IMPORTANCE:Progressive geographic atrophy (GA) of the retinal pigment epithelium leads to loss of central vision. To identify GA in age-related macular degeneration and assess treatment, correlation of function observed on microperimetry with structure observed on optical coherence tomographic (OCT) images may be of va...

journal_title：JAMA ophthalmology

authors： Pilotto E,Convento E,Guidolin F,Abalsamo CK,Longhin E,Parrozzani R,Midena E

更新日期：2016-08-01 00:00:00

abstract：IMPORTANCE:Macular telangiectasia type 2 is a bilateral disease with characteristic alterations of the macular capillary network and neural atrophy. Vascular and neurodegenerative hypotheses have been proposed to explain these clinical findings, but many questions regarding the pathogenesis remain. OBSERVATIONS:We rep...

journal_title：JAMA ophthalmology

authors： Gillies MC,Mehta H,Bird AC

更新日期：2015-08-01 00:00:00

abstract：IMPORTANCE:Tuberculosis is an endemic infectious disease in developing countries. Patients receiving treatment for systemic tuberculosis may develop paradoxical growth of tuberculomas in the brain, which can lead to vision loss. OBSERVATIONS:We describe 3 patients who had paradoxical development of tuberculomas in the...

journal_title：JAMA ophthalmology

authors： Joseph M,Mendonca TM,Vasu U,Nithyanandam S,Mathew T

更新日期：2013-11-01 00:00:00

abstract：Importance:Most premature infants will not develop retinopathy of prematurity (ROP) of clinical relevance, yet screening evaluations often continue beyond hospital discharge, even for those infants without ROP. Objectives:To identify the characteristics of infants at low risk for ROP, for whom further postdischarge sc...

journal_title：JAMA ophthalmology

authors： Wade KC,Ying GS,Baumritter A,Gong A,Kemper AR,Quinn GE,e-ROP Cooperative Group.

更新日期：2019-02-01 00:00:00

abstract：Importance:Contemporary data on use of eye care by US adults are critical, as the prevalence of age-related eye disease and vision impairment are projected to increase in the coming decades. Objectives:To provide nationally representative estimates on self-reported use of eye care by adults aged 50 to 80 years, and to...

journal_title：JAMA ophthalmology

authors： Ehrlich JR,Ndukwe T,Solway E,Woodward MA,Singer DC,Newman-Casey PA,Kirch M,Delott LB,Kullgren JT,Stagg BC,Musch DC,Malani PN

更新日期：2019-06-20 00:00:00

abstract：OBJECTIVE:To determine whether treatment of choroidal melanoma influences survival by correlating age at death, cause of death, age at treatment, and survival predictors. DESIGN, SETTING, AND PARTICIPANTS:Prospective cohort study performed at the Liverpool Ocular Oncology Centre, a supraregional, tertiary referral ser...

journal_title：JAMA ophthalmology

authors： Damato BE,Heimann H,Kalirai H,Coupland SE

更新日期：2014-05-01 00:00:00

abstract：IMPORTANCE:Myopia is a significant public health problem, making it important to determine whether a bifocal spectacle treatment involving near prism slows myopia progression in children. OBJECTIVE:To determine whether bifocal and prismatic bifocal spectacles control myopia in children with high rates of myopia progre...

journal_title：JAMA ophthalmology

authors： Cheng D,Woo GC,Drobe B,Schmid KL

更新日期：2014-03-01 00:00:00

abstract：Importance:Coronavirus disease 2019 (COVID-19) has been recognized as a pandemic by the World Health Organization. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can also infect tissues besides the respiratory system, such as the ocular tissues, remains unclear. Objective:To determine whether SAR...

journal_title：JAMA ophthalmology

authors： Yan Y,Diao B,Liu Y,Zhang W,Wang G,Chen X

更新日期：2020-10-08 00:00:00

abstract：Importance:Early detection of choroidal melanoma at a small tumor size is emphasized in the literature. However, there is little published information on the specific risks of plaque-irradiated small choroidal melanoma on visual acuity and metastasis. Objective:To analyze outcomes of plaque radiotherapy for small chor...

journal_title：JAMA ophthalmology

authors： Shields CL,Sioufi K,Srinivasan A,Di Nicola M,Masoomian B,Barna LE,Bekerman VP,Say EAT,Mashayekhi A,Emrich J,Komarnicky L,Shields JA

更新日期：2018-12-01 00:00:00

abstract：IMPORTANCE:The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been inconsistent and mostly limited to evaluation of 2 no...

journal_title：JAMA ophthalmology

authors： Schaumberg DA,Rose L,DeAngelis MM,Semba RD,Hageman GS,Chasman DI

更新日期：2014-01-01 00:00:00

abstract：Importance:Glaucoma-related adverse events constitute serious complications of cataract removal in infancy, yet long-term data on incidence and visual outcome remain lacking. Objective:To identify and characterize incident cases of glaucoma and glaucoma-related adverse events (glaucoma + glaucoma suspect) among childr...

journal_title：JAMA ophthalmology

authors： Freedman SF,Beck AD,Nizam A,Vanderveen DK,Plager DA,Morrison DG,Drews-Botsch CD,Lambert SR,Infant Aphakia Treatment Study Group.

更新日期：2020-12-17 00:00:00

abstract：Importance:Mobility limitations arising from vision impairment (VI) can result in loss of independence and reduced quality of life. However, few data are available on the association between VI and mobility limitations at a population-based level, particularly in Asian populations. Objective:To assess the association ...

journal_title：JAMA ophthalmology

authors： Fenwick EK,Ong PG,Man RE,Cheng CY,Sabanayagam C,Wong TY,Lamoureux EL

更新日期：2016-10-01 00:00:00

abstract：Importance:Some eyes with neovascular age-related macular degeneration (AMD) have persistent exudation despite frequent intravitreal anti-vascular endothelial growth factor (VEGF) injections. Adjuvant therapies that further reduce edema may improve vision outcomes. Objective:To compare the short-term effect of topical...

journal_title：JAMA ophthalmology

authors： Hsu J,Patel SN,Wolfe JD,Shah CP,Chen E,Jenkins TL,Wibbelsman TD,Obeid A,Mikhail M,Garg SJ,Ho AC,Chiang A,Spirn MJ,Vander JF

更新日期：2020-05-01 00:00:00

abstract：Importance:Adding a laser-induced chorioretinal anastomosis (L-CRA) to current treatments for central retinal vein occlusion (CRVO) may improve outcomes and lessen therapy burdens. Objective:To determine the 2-year efficacy of intravitreal ranibizumab with an L-CRA vs ranibizumab alone for patients with macular edema ...

journal_title：JAMA ophthalmology

authors： McAllister IL,Smithies LA,Chen FK,Mackey DA,Sanfilippo PG

更新日期：2018-12-01 00:00:00

abstract：IMPORTANCE:To facilitate comparative clinical outcome research in low vision rehabilitation, we must use patient-centered measurements that reflect clinically meaningful changes in visual ability. OBJECTIVE:To quantify the effects of currently provided low vision rehabilitation (LVR) on patients who present for outpat...

journal_title：JAMA ophthalmology

authors： Goldstein JE,Jackson ML,Fox SM,Deremeik JT,Massof RW,Low Vision Research Network Study Group.

更新日期：2015-07-01 00:00:00

abstract：Importance:Medical and surgical interventions for glaucoma are effective only if they are affordable to patients. Little is known about how affordable glaucoma interventions are in developing and developed countries. Objective:To compare the prices of topical glaucoma medications, laser trabeculoplasty, and trabeculec...

journal_title：JAMA ophthalmology

authors： Zhao PY,Rahmathullah R,Stagg BC,Almobarak F,Edward DP,Robin AL,Stein JD

更新日期：2018-11-01 00:00:00

abstract：Importance:Because studies have suggested that atropine might slow the progression of myopia in children, randomized clinical trials are warranted to understand this potential causal relationship. Objective:To evaluate the efficacy and safety of atropine, 0.01%, eyedrops on slowing myopia progression and axial elongat...

journal_title：JAMA ophthalmology

authors： Wei S,Li SM,An W,Du J,Liang X,Sun Y,Zhang D,Tian J,Wang N

更新日期：2020-10-01 00:00:00

abstract：IMPORTANCE:Superior rectus transposition (SRT) with or without medial rectus recession (MRc) has been introduced as an alternative to MRc alone for treatment of esotropic Duane syndrome; however, the effectiveness of these procedures has not been compared previously. OBJECTIVE:To compare the safety and efficacy of MRc...

journal_title：JAMA ophthalmology

authors： Yang S,MacKinnon S,Dagi LR,Hunter DG

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of selective laser trabeculoplasty (SLT) for the treatment of primary open-angle glaucoma in an African-derived population in the developing world. METHODS:Sixty-one subjects from St. Lucia with medically treated primary open-angle glaucoma underwent a 30-day washout, followed by bil...

journal_title：JAMA ophthalmology

authors： Realini T

更新日期：2013-03-01 00:00:00

abstract：Importance:The Diabetic Retinopathy Clinical Research Network Protocol S randomized clinical trial results suggest that ranibizumab is a reasonable treatment alternative to panretinal photocoagulation (PRP) when managing proliferative diabetic retinopathy (PDR), with or without concomitant baseline diabetic macular ede...

journal_title：JAMA ophthalmology

authors： Hutton DW,Stein JD,Bressler NM,Jampol LM,Browning D,Glassman AR,Diabetic Retinopathy Clinical Research Network.

更新日期：2017-06-01 00:00:00

abstract：IMPORTANCE:Eye and vision disease burden should help guide ophthalmologic research prioritization. The Global Burden of Disease (GBD) Study 2010 compiled data from 1990 to 2010 on 291 diseases and injuries, 1160 disease and injury sequelae, and 67 risk factors in 187 countries. The Cochrane Database of Systematic Revie...

journal_title：JAMA ophthalmology

authors： Boyers LN,Karimkhani C,Hilton J,Richheimer W,Dellavalle RP

更新日期：2015-01-01 00:00:00

abstract：IMPORTANCE:The potential effect of treatments for diabetic macular edema (DME) on driving should be of value to patients and clinicians, such as ophthalmologists and other physicians, who treat patients with diabetes mellitus. OBJECTIVE:To determine the effect of ranibizumab on driving and patient-reported vision func...

journal_title：JAMA ophthalmology

authors： Bressler NM,Varma R,Mitchell P,Suñer IJ,Dolan C,Ward J,Ferreira A,Ehrlich JS,Turpcu A

更新日期：2016-02-01 00:00:00

abstract：Importance:Both primary and secondary forms of childhood glaucoma have many distinct causative mechanisms, and in many cases a cause is not immediately clear. The broad phenotypic spectrum of secondary glaucoma, particularly in individuals with variants in FOXC1 or PITX2 genes associated with Axenfeld-Rieger syndrome, ...

journal_title：JAMA ophthalmology

authors： Siggs OM,Souzeau E,Pasutto F,Dubowsky A,Smith JEH,Taranath D,Pater J,Rait JL,Narita A,Mauri L,Del Longo A,Reis A,Chappell A,Kearns LS,Staffieri SE,Elder JE,Ruddle JB,Hewitt AW,Burdon KP,Mackey DA,Craig JE

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To assess the benefit of increased follow-up and treatment with ranibizumab between months 24 and 36 in the Ranibizumab for Edema of the Macula in Diabetes (READ-2) Study. DESIGN:Prospective, interventional, multicenter follow-up of a randomized clinical trial. METHODS:Patients who agreed to participate bet...

journal_title：JAMA ophthalmology

authors： Do DV,Nguyen QD,Khwaja AA,Channa R,Sepah YJ,Sophie R,Hafiz G,Campochiaro PA,READ-2 Study Group.

更新日期：2013-02-01 00:00:00

abstract：IMPORTANCE:Binocular summation (BiS) is defined as the superiority of visual function for binocular over monocular viewing. Binocular summation decreases with age and large interocular differences in visual acuity. To our knowledge, BiS has not heretofore been well studied as a functional measure of binocularity in str...

journal_title：JAMA ophthalmology

authors： Pineles SL,Velez FG,Isenberg SJ,Fenoglio Z,Birch E,Nusinowitz S,Demer JL

更新日期：2013-11-01 00:00:00

abstract：Importance:Visual impairment and visual disorders often co-occur with other chronic conditions. Understanding patterns of multimorbidity is important for reducing health care use and improving health outcomes. Objective:To identify chronic condition patterns and their association with visual impairment and health care...

journal_title：JAMA ophthalmology

authors： Zheng DD,Christ SL,Lam BL,Feaster DJ,McCollister K,Lee DJ

更新日期：2020-04-01 00:00:00

abstract：Importance:Anti-vascular endothelial growth factor (anti-VEGF) is a breakthrough treatment for wet age-related macular degeneration (wAMD), the most common cause of blindness in western countries. Anti-VEGF treatment prevents vision loss and has been shown to produce vision gains lasting as long as 5 years. Although th...

journal_title：JAMA ophthalmology

authors： Mulligan K,Seabury SA,Dugel PU,Blim JF,Goldman DP,Humayun MS

更新日期：2019-11-14 00:00:00