Abstract:
:Sera from certain patients with systemic lupus erythematosus (SLE) and related rheumatic diseases contain antibodies that selectively deplete extracts of HeLa cells of RNase P activity. Most of the sera that recognize RNase P, an endoribonuclease with an essential RNA subunit, also contain antibodies against another small ribonucleoprotein known as the Th antigen. A species of RNA about 400 nucleotides in length is the only RNA species found in common in all immunoprecipitates prepared with anti-RNase P antibodies. The discovery of antibodies against RNase P defines a major class of antibodies produced by patients with autoimmune disease.
journal_name
Proc Natl Acad Sci U S Aauthors
Gold HA,Craft J,Hardin JA,Bartkiewicz M,Altman Sdoi
10.1073/pnas.85.15.5483subject
Has Abstractpub_date
1988-08-01 00:00:00pages
5483-7issue
15eissn
0027-8424issn
1091-6490journal_volume
85pub_type
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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journal_title:Proceedings of the National Academy of Sciences of the United States of America
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更新日期:2006-01-31 00:00:00