Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic β-cells.

abstract：:RNA polymerase pausing represents an important mechanism of transcriptional regulation. In this study, we use a single-molecule transcription assay to investigate the effect of template base-pair composition on pausing by RNA polymerase II and the evolutionarily distinct mitochondrial polymerase Rpo41. For both enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamft B,Bintu L,Ishibashi T,Bustamante C

更新日期：2012-06-05 00:00:00

abstract：:Adult rat arterial smooth muscle cells (SMC) in primary culture modulate from contractile to synthetic phenotype. This process includes partial loss of myofilaments and formation of an extensive rough endoplasmic reticulum and a large Golgi complex. It gives the cells the ability to initiate DNA synthesis and actively...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nilsson J,Sjölund M,Palmberg L,Thyberg J,Heldin CH

更新日期：1985-07-01 00:00:00

abstract：:Natural killer (NK) cells are key players in the innate response to viruses, including herpesviruses. In particular, the variety of viral strategies to modulate the recognition of certain herpesviruses witnesses the importance of NK cells in the control of this group of viruses. Still, NK evasion strategies have remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grauwet K,Cantoni C,Parodi M,De Maria A,Devriendt B,Pende D,Moretta L,Vitale M,Favoreel HW

更新日期：2014-11-11 00:00:00

abstract：:When the magnetic susceptibility of frozen aqueous solutions of human oxyhemoglobin was measured in the range between 25 and 250 K, it showed a temperature-dependent behavior typical of a thermal equilibrium between a ground singlet state and an excited triplet state for two electrons per heme, the energy separation b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cerdonio M,Congiu-Castellano A,Mogno F,Pispisa B,Romani GL,Vitale S

更新日期：1977-02-01 00:00:00

abstract：:Replication-competent viruses, such as Vaccinia virus (VACV), are powerful tools for the development of oncolytic viral therapies and elicit superior immune responses when used as vaccine and immunotherapeutic vectors. However, severe complications from uncontrolled viral replication can occur, particularly in immunoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grigg P,Titong A,Jones LA,Yilma TD,Verardi PH

更新日期：2013-09-17 00:00:00

abstract：:It is well known that two regular tetrahedra can be combined with a single regular octahedron to tile (complete fill) three-dimensional Euclidean space . This structure was called the "octet truss" by Buckminster Fuller. It was believed that such a tiling, which is the Delaunay tessellation of the face-centered cubic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway JH,Jiao Y,Torquato S

更新日期：2011-07-05 00:00:00

abstract：:Salmonella enterica serovar Typhi can colonize the gallbladder and persist in an asymptomatic carrier state that is frequently associated with the presence of gallstones. We have shown that salmonellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces in vitro. Here, we test the hypothesi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crawford RW,Rosales-Reyes R,Ramírez-Aguilar Mde L,Chapa-Azuela O,Alpuche-Aranda C,Gunn JS

更新日期：2010-03-02 00:00:00

abstract：:The sessile plants have evolved a large number of receptor-like kinases (RLKs) and receptor-like cytoplasmic kinases (RLCKs) to modulate diverse biological processes, including plant innate immunity. Phosphorylation of the RLK/RLCK complex constitutes an essential step to initiate immune signaling. Two Arabidopsis pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin W,Li B,Lu D,Chen S,Zhu N,He P,Shan L

更新日期：2014-03-04 00:00:00

abstract：:Evidence is given for the existence of an electron transport pathway to oxygen in the thylakoid membranes of chloroplasts (chlororespiration). Plastoquinone is shown to be a redox carrier common to both photosynthetic and chlororespiratory pathways. It is shown that, in dark-adapted chloroplasts, an electrochemical gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennoun P

更新日期：1982-07-01 00:00:00

abstract：:Although the future often seems intangible, we can make it more concrete by imagining prospective events. Here, using functional MRI, we demonstrate a mechanism by which the ventromedial prefrontal cortex supports such episodic simulations, and thereby contributes to affective foresight: This region supports processes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benoit RG,Szpunar KK,Schacter DL

更新日期：2014-11-18 00:00:00

abstract：:Cellular wound healing or the repair of plasma membrane/cell wall damage (plasma membrane damage) occurs frequently in nature. Although various cellular perturbations, such as DNA damage, spindle misalignment, and impaired daughter cell formation, are monitored by cell cycle checkpoint mechanisms in budding yeast, whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kono K,Al-Zain A,Schroeder L,Nakanishi M,Ikui AE

更新日期：2016-06-21 00:00:00

abstract：:Rearrangements between tandem sequence homologies of various lengths are a major source of genomic change and can be deleterious to the organism. These rearrangements can result in either deletion or duplication of genetic material flanked by direct sequence repeats. Molecular genetic analysis of repetitive sequence i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bzymek M,Lovett ST

更新日期：2001-07-17 00:00:00

abstract：:Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G1/S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray-Bablin J,Zalvide J,Fox MP,Knickerbocker CJ,DeCaprio JA,Keyomarsi K

更新日期：1996-12-24 00:00:00

abstract：:Heteroduplex molecules of pneumococcal DNA, prepared by cross-annealing resolved complementary strands, have been used as donors in transformation. A number of pairs of genetic markers are situated exclusively in the trans configuration in these heteroduplexes. Insertion of two markers from trans configuration into op...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roger M

更新日期：1972-02-01 00:00:00

abstract：:Protein ubiquitination plays an important role in ATP-dependent protein turnover, and it also may regulate other cellular events. Covalent attachment of ubiquitin to other proteins is catalyzed by three different enzymes, E1, E2, and E3. We have previously shown that protein ubiquitination can be regulated by phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong SK,Chock PB

更新日期：1994-11-22 00:00:00

abstract：:It has long been recognized that the renal proximal tubular epithelium of the hamster is a bona fide estrogen target tissue. The effect of estrogens on the growth of proximal tubule cell explants and dissociated single cells derived from these explant outgrowths has been studied in culture. Renal tubular cells were gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberley TD,Lauchner LJ,Pugh TD,Gonzalez A,Goldfarb S,Li SA,Li JJ

更新日期：1989-03-01 00:00:00

abstract：:N-type Ca2+ channels mediate Ca2+ influx, which initiates fast exocytosis of neurotransmitters at synapses, and they interact directly with the SNARE proteins syntaxin and SNAP-25 (synaptosome-associated protein of 25 kDa) through a synaptic protein interaction (synprint) site in the intracellular loop connecting doma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng ZH,Yokoyama CT,Catterall WA

更新日期：1997-05-13 00:00:00

abstract：:Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER) chaperone for which only few client proteins and no cofactors are known and whose mode of action is unclear. To decipher the mode of GRP94 action in vivo, we exploited our finding that GRP94 is necessary for the production of insulin-like growth fac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ostrovsky O,Makarewich CA,Snapp EL,Argon Y

更新日期：2009-07-14 00:00:00

abstract：:The underlying structure is taken as a strongly superharmonic cone [unk], defined as a partially ordered abelian semigroup with identity 0 which admits a multiplication by nonnegative scalars and satisfies two fundamental axioms of a potentialtheoretic character. In terms of a fixed nonzero element e there is introduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsove M,Leutwiler H

更新日期：1975-07-01 00:00:00

abstract：:Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the template for both transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox R,Pickar A,Qiu S,Tsao J,Rodenburg C,Dokland T,Elson A,He B,Luo M

更新日期：2014-10-21 00:00:00

abstract：:The six individual catalytic polypeptide chains within the two catalytic trimers of Escherichia coli aspartate transcarbamoylase (ATCase; EC 2.1.3.2) are folded into two discrete structural domains interconnected in part by helix 12, which comprises residues 285-305 and is located near the carboxyl terminus of the cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson CB,Schachman HK

更新日期：1991-01-15 00:00:00

abstract：:Transcription factors (TFs) are the main players in transcriptional regulation in eukaryotes. However, it remains unclear what role TFs played in the origin of all of the different eukaryotic multicellular lineages. In this paper, we explore how the origin of TF repertoires shaped eukaryotic evolution and, in particul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Mendoza A,Sebé-Pedrós A,Šestak MS,Matejcic M,Torruella G,Domazet-Loso T,Ruiz-Trillo I

更新日期：2013-12-10 00:00:00

abstract：:Animals capable of regenerating multiple tissue types, organs, and appendages after injury are common yet sporadic and include some sponge, hydra, planarian, and salamander (i.e., newt and axolotl) species, but notably such regenerative capacity is rare in mammals. The adult MRL mouse strain is a rare exception to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bedelbaeva K,Snyder A,Gourevitch D,Clark L,Zhang XM,Leferovich J,Cheverud JM,Lieberman P,Heber-Katz E

更新日期：2010-03-30 00:00:00

abstract：:Most of the activities of IFN-gamma are the result of STAT1-mediated transcriptional responses. In this study, we show that the BRCA1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of IFN-gamma target genes and mediates growth inhibition by this cytokine. After IFN-gam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Lee SW,Ouchi M,Aaronson SA,Horvath CM

更新日期：2000-05-09 00:00:00

abstract：:Hypertonicity-induced binding of the transcription factor TonEBP/OREBP to its cognate DNA element, ORE/TonE, is associated with increased transcription of several osmotically regulated genes. Previously, it was found that hypertonicity rapidly causes nuclear translocation and phosphorylation of TonEBP/OREBP and, more ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferraris JD,Williams CK,Persaud P,Zhang Z,Chen Y,Burg MB

更新日期：2002-01-22 00:00:00

abstract：:The activation of Janus kinases (JAKs) is crucial for propagation of the proliferative response initiated by many cytokines. The proliferation of various cell lines, particularly those of hematopoietic origin, is also modulated by mediators of oxidative stress such as nitric oxide and thiol redox reagents. Herein we d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duhé RJ,Evans GA,Erwin RA,Kirken RA,Cox GW,Farrar WL

更新日期：1998-01-06 00:00:00

abstract：:Ethionamide (ETA) is an important component of second-line therapy for the treatment of multidrug-resistant tuberculosis. Synthesis of radiolabeled ETA and an examination of drug metabolites formed by whole cells of Mycobacterium tuberculosis (MTb) have allowed us to demonstrate that ETA is activated by S-oxidation be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeBarber AE,Mdluli K,Bosman M,Bekker LG,Barry CE 3rd

更新日期：2000-08-15 00:00:00

abstract：:Two functional human dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) cDNAs were isolated from a cDNA expression library by genetic complementation in Escherichia coli. These cDNAs differed in size but exhibited a common overlapping DNA sequence. Contained within this sequence was a single long open reading frame sufficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McIntosh EM,Ager DD,Gadsden MH,Haynes RH

更新日期：1992-09-01 00:00:00

abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

更新日期：2014-11-25 00:00:00

abstract：:Barth, Larsen, and others showed that complex submanifolds of complex projective space, CP(N), of small codimension strongly resemble CP(N) both homotopically and cohomologically. These results are generalized to yield analogous results for complex subspaces of arbitrary homogeneous complex manifolds. One very special...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommese AJ

更新日期：1977-04-01 00:00:00