Nitric oxide and thiol redox regulation of Janus kinase activity.

abstract：:Veratridine or high potassium concentration increased guanosine 3',5'-cyclic monophosphate (cGMP) levels in neuroblastoma cells of clone N1E-115 without affecting levels of adenosine 3',5'-cyclic monophosphate (cAMP). The increases in cGMP appear to be a direct result of the depolarizing action of these agents and not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Study RE,Breakefield XO,Bartfai T,Greengard P

更新日期：1978-12-01 00:00:00

abstract：:The rpoN gene encoding the transcription factor sigma54 in Myxococcus xanthus has been cloned using a heterologous rpoN probe. The sequence of the cross-hybridizing DNA confirmed the existence of an ORF 1518 bp long that encodes a well conserved member of the sigma54 family of sigma factors. Low- as well as high-strin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keseler IM,Kaiser D

更新日期：1997-03-04 00:00:00

abstract：:Xenopus laevis tadpole tails contain fast muscle fibers oriented in chevrons and two pairs of slow muscle "cords" along the length of the tail. When tail resorption is inhibited by a number of different treatments, fast muscle but not the slow cord muscle still is lost, demonstrating that the fast tail muscle is a dir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das B,Schreiber AM,Huang H,Brown DD

更新日期：2002-09-17 00:00:00

abstract：:Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP966, we investigated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malvaez M,McQuown SC,Rogge GA,Astarabadi M,Jacques V,Carreiro S,Rusche JR,Wood MA

更新日期：2013-02-12 00:00:00

abstract：:Therapy-related acute myeloid leukemias (t-AML) with translocations of the MLL gene are associated with the use of topoisomerase II inhibitors. We established the emergence of the malignant clone in a child who developed t-AML with a t(11;19) (q23;p13.3) during treatment for acute lymphoblastic leukemia (ALL). The MLL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blanco JG,Dervieux T,Edick MJ,Mehta PK,Rubnitz JE,Shurtleff S,Raimondi SC,Behm FG,Pui CH,Relling MV

更新日期：2001-08-28 00:00:00

abstract：:The lactose permease (LacY) of Escherichia coli, a paradigm for the major facilitator superfamily, catalyzes the coupled stoichiometric translocation of a galactopyranoside and an H(+) across the cytoplasmic membrane. To catalyze transport, LacY undergoes large conformational changes that allow alternating access of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serdiuk T,Madej MG,Sugihara J,Kawamura S,Mari SA,Kaback HR,Müller DJ

更新日期：2014-04-22 00:00:00

abstract：:The reactions catalyzed by Mo enzymes each find the product differing from the substrate by two electrons and two protons (or some multiple thereof). The coordination chemistry of Mo suggests that there is a distinct relationship between acid-base and redox properties of Mo complexes, and that a coupled electron-proto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stiefel EI

更新日期：1973-04-01 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:Two-dimensional molecular aggregate (2DMA), a thin sheet of strongly interacting dipole molecules self-assembled at close distance on an ordered lattice, is a fascinating fluorescent material. It is distinctively different from the conventional (single or colloidal) dye molecules and quantum dots. In this paper, we ve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Jin D,Xiao J,Nam SH,Liu X,Liu Y,Zhang X,Fang NX

更新日期：2017-09-19 00:00:00

abstract：:Male chickens with the henny feathering trait have a female feathering pattern. In two henny-feathered breeds, the Sebright bantam and the Golden Campine, the synthesis of estrogen is increased as a consequence of increased activity of aromatase, a cytochrome P-450 enzyme that converts androgen to estrogen. The activi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leshin M

更新日期：1985-05-01 00:00:00

abstract：:Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGrath DM,Barbu EM,Driessen WH,Lasco TM,Tarrand JJ,Okhuysen PC,Kontoyiannis DP,Sidman RL,Pasqualini R,Arap W

更新日期：2013-02-26 00:00:00

abstract：:We report a method for introducing mtDNA mutations into the mouse female germ line by means of embryonic stem (ES) cell cybrids. Mitochondria were recovered from the brain of a NZB mouse by fusion of synaptosomes to a mtDNA-deficient (rho degrees ) cell line. These cybrids were enucleated and the cytoplasts were elect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sligh JE,Levy SE,Waymire KG,Allard P,Dillehay DL,Nusinowitz S,Heckenlively JR,MacGregor GR,Wallace DC

更新日期：2000-12-19 00:00:00

abstract：:In over 90% of cervical cancers and cancer-derived cell lines, the p53 tumor suppressor pathway is disrupted by human papillomavirus (HPV). The HPV E6 protein promotes the degradation of p53 and thus inhibits the stabilization and activation of p53 that would normally occur in response to HPV E7 oncogene expression. R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hietanen S,Lain S,Krausz E,Blattner C,Lane DP

更新日期：2000-07-18 00:00:00

abstract：:Changes in climate during the 20th century differ from region to region across the United States. We provide strong evidence that spatial variations in US temperature trends are linked to the hydrologic cycle, and we also present unique information on the seasonal and latitudinal structure of the linkage. We show that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Portmann RW,Solomon S,Hegerl GC

更新日期：2009-05-05 00:00:00

abstract：:A sensitive in vitro crosslinking technique using a photoactive derivative of the chimeric activator LexA-E2F-1 was used to identify yeast proteins that might influence the response of RNA polymerase II to transcriptional activators. We found that a novel yeast protein, Xtc1p, could be covalently crosslinked to the ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emili A,Kobayashi R,Ingles CJ

更新日期：1998-09-15 00:00:00

abstract：:Vibrio cholerae is both an inhabitant of estuarine environments and the etiologic agent of the diarrheal disease cholera. Previous work has demonstrated that V. cholerae forms both an exopolysaccharide-dependent biofilm and a Ca2+-dependent biofilm. In this work, we demonstrate a role for the O-antigen polysaccharide ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kierek K,Watnick PI

更新日期：2003-11-25 00:00:00

abstract：:Pituitary ablation (hypophysectomy) in rats was previously reported to cause a precipitous change in the relative abundance of two alternative splice variants of the "BK"- or "Maxi K"-encoding Slo gene in adrenal chromaffin cells. Inclusion of the optional "STREX" exon (STRess axis-regulated EXon) in a C-terminal spli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai GJ,McCobb DP

更新日期：2002-05-28 00:00:00

abstract：:A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamashiro D,Li CH,Ramasharma K,Sairam MR

更新日期：1984-09-01 00:00:00

abstract：:SapB is a morphogenetic peptide that is important for aerial mycelium formation by the filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial mycelium formation and depends on most of the genes known to be required for the morphogenesis of aerial hyphae. Furthermore, the application ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodani S,Hudson ME,Durrant MC,Buttner MJ,Nodwell JR,Willey JM

更新日期：2004-08-03 00:00:00

abstract：:A family of peptide signaling molecules (AtPeps) and their plasma membrane receptor AtPepR1 are known to act in pathogen-defense signaling cascades in plants. Little is currently known about the molecular mechanisms that link these signaling peptides and their receptor, a leucine-rich repeat receptor-like kinase, to d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qi Z,Verma R,Gehring C,Yamaguchi Y,Zhao Y,Ryan CA,Berkowitz GA

更新日期：2010-12-07 00:00:00

abstract：:Ischemia and reperfusion both contribute to tissue damage after myocardial infarction. Although many drugs have been shown to reduce infarct size when administered before ischemia, few have been shown to be effective when administered at reperfusion. Moreover, although it is generally accepted that a burst of reactive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granville DJ,Tashakkor B,Takeuchi C,Gustafsson AB,Huang C,Sayen MR,Wentworth P Jr,Yeager M,Gottlieb RA

更新日期：2004-02-03 00:00:00

abstract：:A monoclonal antibody has been developed that recognizes a mouse lymphocyte antigen, Ly-23, that is controlled by an H-3 histocompatibility complex-linked gene on the second chromosome. Competitive binding experiments demonstrate that this antigen is distinct from the polymorphic beta 2-microglobulin antigen, which al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasser DL,Ziebur J,Matsumoto K

更新日期：1983-11-01 00:00:00

abstract：:Nucleotide sequences that direct transcription of the human 5-lipoxygenase gene have been examined by ligation to the chloramphenicol acetyltransferase gene and determination of chloramphenicol acetyltransferase activity in transfected HeLa and HL-60 cells. Various lengths of 5'-flanking sequences up to 5.9 kilobase p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshiko S,Rådmark O,Samuelsson B

更新日期：1990-12-01 00:00:00

abstract：:Classical hypotheses regarding the evolutionary origin of paired appendages propose transformation of precursor structures (gill arches and lateral fin folds) into paired fins. During development, gnathostome paired appendages form as outgrowths of body wall somatopleure, a tissue composed of somatic lateral plate mes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tulenko FJ,McCauley DW,Mackenzie EL,Mazan S,Kuratani S,Sugahara F,Kusakabe R,Burke AC

更新日期：2013-07-16 00:00:00

abstract：:Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

更新日期：2010-11-16 00:00:00

abstract：:Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold unfavorable results or even tamper with data in order to achieve desired outcom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adda J,Decker C,Ottaviani M

更新日期：2020-06-16 00:00:00

abstract：:CD4 can physically associate with the CD3-T-cell receptor complex as visualized in cocapping experiments. This association occurs when the T-cell receptor is cross-linked by certain anti-variable region antibodies that appear to induce a conformational change in the receptor such that it associate with CD4. Similar as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojo JM,Saizawa K,Janeway CA Jr

更新日期：1989-05-01 00:00:00

abstract：:Many "workers" in north temperate colonies of the eusocial paper wasp Polistes fuscatus disappear within a few days of eclosion. We provide evidence that these females are pursuing an alternative reproductive strategy, i.e., dispersing to overwinter and become nest foundresses the following spring, instead of helping ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeve HK,Peters JM,Nonacs P,Starks PT

更新日期：1998-11-10 00:00:00

abstract：:A mutation partially suppressing the UV sensitivity caused by recF143 in a uvrA6 background was located at codon 37 of recA where GTG (valine) became ATG (methionine). This mutation, originally named srf-803, was renamed recA803. Little if any suppression of the recF143 defect in UV induction of a lexA regulon promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Madiraju MV,Templin A,Clark AJ

更新日期：1988-09-01 00:00:00

abstract：:Multiple resistance and pH adaptation (Mrp) complexes are sophisticated cation/proton exchangers found in a vast variety of alkaliphilic and/or halophilic microorganisms, and are critical for their survival in highly challenging environments. This family of antiporters is likely to represent the ancestor of cation pum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li B,Zhang K,Nie Y,Wang X,Zhao Y,Zhang XC,Wu XL

更新日期：2020-12-08 00:00:00