当前位置： SCI文献检索 > JOURNAL OF STRUCTURAL BIOLOGY期刊下所有文献 > The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements.

The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements.

Abstract：

:The C1q-tumor necrosis factor 5 (C1QTNF5) protein plays a significant role in retinal pigmented epithelium (RPE) cellular adhesion. The C1QTNF5 gene is co-transcribed with the frizzled-related protein (MFRP) gene. A Ser-to-Arg mutation at site 163 (S163R) in C1QTNF5 is known to cause late-onset retinal macular degeneration (L-ORMD). Here we also found that C1QTNF5 monomers can multimerize into a bouquet-like octadecamer. We found that a novel intermolecular hydrogen-bond network of S163 that glues adjacent globular heads of C1QTNF5 together was weakened or abolished by the R163 pathogenic mutation. These findings could underlie the structural basis of this protein's adhesive function and relate to the pathogenesis of its S163R mutation. Additionally, the fact that C1QTNF5 immobilized to a resin selectively enriched detergent extracted membrane-bound MFRP, further confirmed their interaction, implying functions other than cellular adhesion for C1QTNF5.

journal_name

J Struct Biol

journal_title

Journal of structural biology

authors

Tu X,Palczewski K

doi

10.1016/j.jsb.2014.02.001

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

86-94

issue

1

eissn

1047-8477

issn

1095-8657

pii

S1047-8477(14)00025-2

journal_volume

186

pub_type

杂志文章

相关文献

JOURNAL OF STRUCTURAL BIOLOGY文献大全
  • Dry and survive: morphological changes during anhydrobiosis in a bdelloid rotifer.

    abstract：:Bdelloid rotifers are aquatic microinvertebrates able to cope with the loss of environmental water by entering dormancy, and are thus capable of living in temporary habitats. When water is evaporating, bdelloids contract into "tuns", silence metabolism and lose water from the body, a condition known as anhydrobiosis. ...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2010.04.003

    authors： Marotta R,Leasi F,Uggetti A,Ricci C,Melone G

    更新日期：2010-07-01 00:00:00

  • Discontinuous membrane helices in transport proteins and their correlation with function.

    abstract：:Alpha-helical bundles and beta-barrel proteins represent the two basic types of architecture known for integral membrane proteins. Irregular structural motifs have been revealed with the growing number of structures determined. "Discontinuous" helices are present in membrane proteins that actively transport ions. In t...

    journal_title：Journal of structural biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jsb.2007.01.011

    authors： Screpanti E,Hunte C

    更新日期：2007-08-01 00:00:00

  • The fibrils of Ure2p homologs from Saccharomyces cerevisiae and Saccharoymyces paradoxus have similar cross-β structure in both dried and hydrated forms.

    abstract：:The ability to convert into amyloid fibrils is a common feature of prion proteins. However, not all amyloid-forming proteins act as prions. Here, we compared two homologs of the yeast prion protein Ure2 from Saccharomyces cerevisiae and Saccharomyces paradoxus, ScUre2p and SpUre2p, which have different prion propensit...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2011.03.008

    authors： Wang YQ,Bongiovanni M,Gras SL,Perrett S

    更新日期：2011-06-01 00:00:00

  • In situ detection of specific gene expression during and immediately after transcription at electron microscopic level.

    abstract：:In situ hybridization (ISH) is a widely applied technique used for visualizing specific nucleic acid sequences at chromosomal, cytologic, and histologic levels. It sometimes fails, however, to demonstrate precise cell identity, early stages of gene expression and variants of alternative splicing because of its limited...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2005.09.010

    authors： Kitazawa S,Kitazawa R

    更新日期：2006-01-01 00:00:00

  • Structural basis for pH dependent monomer-dimer transition of 3,4-dihydroxy 2-butanone-4-phosphate synthase domain from Mycobacterium tuberculosis.

    abstract：:3,4-dihydroxy 2-butanone 4-phosphate synthase (DHBPS) and GTP cyclohydrolase-II (GTPCH-II) are the two initial enzymes involved in riboflavin biosynthesis pathway, which has been shown to be essential for the pathogens. In Mycobacterium tuberculosis (Mtb), the ribA2 gene (Rv1415) encodes for the bi-functional enzyme w...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2011.01.013

    authors： Singh M,Kumar P,Karthikeyan S

    更新日期：2011-05-01 00:00:00

  • Higher order assembling of the mycobacterial polar growth factor DivIVA/Wag31.

    abstract：:DivIVA or Wag31, which is an essential pole organizing protein in mycobacteria, can self-assemble at the negatively curved side of the membrane at the growing pole to form a higher order structural scaffold for maintaining cellular morphology and localizing various target proteins for cell-wall biogenesis. The structu...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2019.107429

    authors： Choukate K,Gupta A,Basu B,Virk K,Ganguli M,Chaudhuri B

    更新日期：2020-02-01 00:00:00

  • Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 A resolution.

    abstract：:As a long-term goal we want to use cryoelectron tomography to understand how non-enveloped viruses, such as picornaviruses, enter cells and translocate their genomes across membranes. To this end, we developed new image-processing tools using an in vitro system to model viral interactions with membranes. The complex o...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2007.08.009

    authors： Bostina M,Bubeck D,Schwartz C,Nicastro D,Filman DJ,Hogle JM

    更新日期：2007-11-01 00:00:00

  • Formation of biomineral iron oxides compounds in a Fe hyperaccumulator plant: Imperata cylindrica (L.) P. Beauv.

    abstract：:We report a detailed work of composition and location of naturally formed iron biominerals in plant cells tissues grown in iron rich environments as Imperata cylindrica. This perennial grass grows on the Tinto River banks (Iberian Pyritic Belt) in an extreme acidic ecosystem (pH∼2.3) with high concentration of dissolv...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2015.11.005

    authors： Fuente V,Rufo L,Juárez BH,Menéndez N,García-Hernández M,Salas-Colera E,Espinosa A

    更新日期：2016-01-01 00:00:00

  • 3D morphology of the human hepatic ferritin mineral core: new evidence for a subunit structure revealed by single particle analysis of HAADF-STEM images.

    abstract：:Ferritin, the major iron storage protein, has dual functions; it sequesters redox activity of intracellular iron and facilitates iron turn-over. Here we present high angle annular dark field (HAADF) images from individual hepatic ferritin cores within tissue sections, these images were obtained using spherical aberrat...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2008.12.001

    authors： Pan YH,Sader K,Powell JJ,Bleloch A,Gass M,Trinick J,Warley A,Li A,Brydson R,Brown A

    更新日期：2009-04-01 00:00:00

  • Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR.

    abstract：:Lipocalin-type prostaglandin D synthase (L-PGDS) acts as both a PGD(2) synthase and an extracellular transporter for small lipophilic molecules. From a series of biochemical studies, it has been found that L-PGDS has an ability to bind a variety of lipophilic ligands such as biliverdin, bilirubin and retinoids in vitr...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2009.10.005

    authors： Miyamoto Y,Nishimura S,Inoue K,Shimamoto S,Yoshida T,Fukuhara A,Yamada M,Urade Y,Yagi N,Ohkubo T,Inui T

    更新日期：2010-02-01 00:00:00

  • Identification and crystallization of a protease-resistant core of calnexin that retains biological activity.

    abstract：:Calnexin is a molecular chaperone that facilitates folding of glycoproteins in the endoplasmic reticulum (ER). The cloned lumenal domain of canine calnexin, cnxDeltaTMC, retains its biological activity without the transmembrane and cytosolic region. For the purpose of structure determination we generated a crystalliza...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1006/jsbi.1998.4032

    authors： Hahn M,Borisova S,Schrag JD,Tessier DC,Zapun A,Tom R,Kamen AA,Bergeron JJ,Thomas DY,Cygler M

    更新日期：1998-11-01 00:00:00

  • Crystal structure of the periplasmic sensor domain of histidine kinase VbrK suggests indirect sensing of β-lactam antibiotics.

    abstract：:Bacterial two-component regulatory systems (TCS) play important roles in sensing environmental stimuli and responding to them by regulating gene expression. VbrK/VbrR, a TCS in Vibrio parahaemolyticus, confers resistance to β-lactam antibiotics through activating a β-lactamase gene. Its periplasmic sensor domain was p...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2020.107610

    authors： Goh BC,Chua YK,Qian X,Lin J,Savko M,Dedon PC,Lescar J

    更新日期：2020-11-01 00:00:00

  • Automatic cryo-EM particle selection for membrane proteins in spherical liposomes.

    abstract：:Random spherically constrained (RSC) single particle reconstruction is a method to obtain structures of membrane proteins embedded in lipid vesicles (liposomes). As in all single-particle cryo-EM methods, structure determination is greatly aided by reliable detection of protein "particles" in micrographs. After fittin...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2014.01.004

    authors： Liu Y,Sigworth FJ

    更新日期：2014-03-01 00:00:00

  • Repeatability in protein sequences.

    abstract：:Low complexity regions (LCRs) in protein sequences have special properties that are very different from those of globular proteins. The rules that define secondary structure elements do not apply when the distribution of amino acids becomes biased. While there is a tendency towards structural disorder in LCRs, various...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2019.08.003

    authors： Kamel M,Mier P,Tari A,Andrade-Navarro MA

    更新日期：2019-11-01 00:00:00

  • Windex: a toolset for indexing helices.

    abstract：:We describe here a set of procedures and algorithms that may be used as an aid in determining the indexing rule of a helical specimen. Crystallizing macromolecules into helical arrays has the potential to speed up and simplify the process of three-dimensional reconstruction of the macromolecular structure. The process...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2003.10.008

    authors： Ward A,Moody MF,Sheehan B,Milligan RA,Carragher B

    更新日期：2003-10-01 00:00:00

  • Rapid near-atomic resolution single-particle 3D reconstruction with SIMPLE.

    abstract：:Cryogenic electron microscopy (cryo-EM) and single-particle analysis enables determination of near-atomic resolution structures of biological molecules. However, large computational requirements limit throughput and rapid testing of new image processing tools. We developed PRIME, an algorithm part of the SIMPLE softwa...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2018.08.005

    authors： Reboul CF,Kiesewetter S,Eager M,Belousoff M,Cui T,De Sterck H,Elmlund D,Elmlund H

    更新日期：2018-11-01 00:00:00

  • Vectorization with SIMD extensions speeds up reconstruction in electron tomography.

    abstract：:Electron tomography allows structural studies of cellular structures at molecular detail. Large 3D reconstructions are needed to meet the resolution requirements. The processing time to compute these large volumes may be considerable and so, high performance computing techniques have been used traditionally. This work...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2010.01.008

    authors： Agulleiro JI,Garzón EM,García I,Fernández JJ

    更新日期：2010-06-01 00:00:00

  • Topological mapping of 13 epitopes on a subunit of Androctonus australis hemocyanin.

    abstract：:A topological localization of epitopes on the surface of the Aa6 subunit of Androctonus australis hemocyanin has been carried out. First, immunocomplex strings composed of native hemocyanin and monoclonal antibodies were examined in the electron microscope and submitted to an image processing by correspondence analysi...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/1047-8477(90)90087-s

    authors： Lamy J,Billiald P,Taveau JC,Boisset N,Motta G,Lamy J

    更新日期：1990-03-01 00:00:00

  • Three different approaches for calculating the three-dimensional structure of microtubules decorated with kinesin motor domains.

    abstract：:We have used three different electron microscopy approaches to calculate three-dimensional maps of tubulin assemblies decorated with the motor domain of kinesin. The approaches used were: (1) Tilt series reconstruction of negatively stained tubulin sheets. (2) Back-projection reconstruction of microtubules in ice. (3)...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1006/jsbi.1997.3851

    authors： Sosa H,Hoenger A,Milligan RA

    更新日期：1997-03-01 00:00:00

  • Solution structure of the cyclic-nucleotide binding homology domain of a KCNH channel.

    abstract：:The carboxy-terminal region of the KCNH family of potassium channels contains a cyclic-nucleotide binding homology domain (CNBHD) that is important for channel gating and trafficking. The solution structure of the CNBHD of the KCNH potassium of zebrafish was determined using solution NMR spectroscopy. This domain exis...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2014.03.008

    authors： Li Q,Ng HQ,Yoon HS,Kang C

    更新日期：2014-04-01 00:00:00

  • Structural and functional characterization of two unusual endonuclease III enzymes from Deinococcus radiodurans.

    abstract：:While most bacteria possess a single gene encoding the bifunctional DNA glycosylase Endonuclease III (EndoIII) in their genomes, Deinococcus radiodurans possesses three: DR2438 (DrEndoIII1), DR0289 (DrEndoIII2) and DR0982 (DrEndoIII3). Here we have determined the crystal structures of DrEndoIII1 and an N-terminally tr...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2015.05.009

    authors： Sarre A,Ökvist M,Klar T,Hall DR,Smalås AO,McSweeney S,Timmins J,Moe E

    更新日期：2015-08-01 00:00:00

  • 3D imaging of diatoms with ion-abrasion scanning electron microscopy.

    abstract：:Ion-abrasion scanning electron microscopy (IASEM) takes advantage of focused ion beams to abrade thin sections from the surface of bulk specimens, coupled with SEM to image the surface of each section, enabling 3D reconstructions of subcellular architecture at approximately 30nm resolution. Here, we report the first a...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2009.02.014

    authors： Hildebrand M,Kim S,Shi D,Scott K,Subramaniam S

    更新日期：2009-06-01 00:00:00

  • A two step approach for semi-automated particle selection from low contrast cryo-electron micrographs.

    abstract：:Over recent years advances in cryo-electron microscopy for the study of macromolecular structure have resulted in resolutions in the range 10-15 A becoming routine. With this drive for increased resolution comes the need to collect larger datasets, commonly >10,000 particle images. Manual selection of particles from m...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2003.10.024

    authors： Hall RJ,Patwardhan A

    更新日期：2004-01-01 00:00:00

  • X-ray vs. NMR structure of N-terminal domain of δ-subunit of RNA polymerase.

    abstract：:The crystal structure of the N-terminal domain of the RNA polymerase δ subunit (Nδ) from Bacillus subtilis solved at a resolution of 2.0Å is compared with the NMR structure determined previously. The molecule crystallizes in the space group C222(1) with a dimer in the asymmetric unit. Importantly, the X-ray structure ...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2014.06.001

    authors： Demo G,Papoušková V,Komárek J,Kadeřávek P,Otrusinová O,Srb P,Rabatinová A,Krásný L,Žídek L,Sklenář V,Wimmerová M

    更新日期：2014-08-01 00:00:00

  • Denoising of high-resolution single-particle electron-microscopy density maps by their approximation using three-dimensional Gaussian functions.

    abstract：:Cryo-electron microscopy (cryo-EM) of frozen-hydrated preparations of isolated macromolecular complexes is the method of choice to obtain the structure of complexes that cannot be easily studied by other experimental methods due to their flexibility or large size. An increasing number of macromolecular structures are ...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2016.04.007

    authors： Jonić S,Vargas J,Melero R,Gómez-Blanco J,Carazo JM,Sorzano CO

    更新日期：2016-06-01 00:00:00

  • Interaction of GroEL and GroEL/GroES complexes with a nonnative subtilisin variant: a small-angle neutron scattering study.

    abstract：:Small-angle neutron scattering and contrast variation were used to study the solution structure of GroEL and GroEL/GroES chaperonins complexed with a nonnative variant of the polypeptide substrate, subtilisin (PJ9). The subtilisin was 86% deuterated (dPJ9) so that it contrasted sufficiently with the chaperonin, allowi...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/s1047-8477(03)00002-9

    authors： Krueger S,Gregurick SK,Zondlo J,Eisenstein E

    更新日期：2003-03-01 00:00:00

  • The canine baculum: the structure and mechanical properties of an unusual bone.

    abstract：:The baculum is an extraskeletal bone located in the penis of a few species in several orders of mammals such as carnivores, insectivores, rodents, bats and primates. This study aims to describe the structure, architecture and mechanical properties of the canine baculum. To this end canine bacula from castrated and unc...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2011.06.006

    authors： Sharir A,Israeli D,Milgram J,Currey JD,Monsonego-Ornan E,Shahar R

    更新日期：2011-09-01 00:00:00

  • Crystallization and preliminary X-ray diffraction analysis of UDP-N-acetylglucosamine enolpyruvyltransferase of Enterobacter cloacae.

    abstract：:Single crystals of UDP-N-acetylglucosamine enolpyruvyltransferase of Enterobacter cloacae have been grown by vapor diffusion using phosphate buffer as the precipitant. The crystals belong to the monoclinic space group C2 with a = 86.9 A, b = 155.9 A, c = 83.8 A, beta = 91.6 degrees. Assuming two monomers per asymmetri...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1006/jsbi.1996.0071

    authors： Sack S,Dauter Z,Wanke C,Amrhein N,Mandelkow E,Schönbrunn E

    更新日期：1996-07-01 00:00:00

  • A ridge-based framework for segmentation of 3D electron microscopy datasets.

    abstract：:Three-dimensional (3D) electron microscopy (EM) has become a major player in structural cell biology as it enables the analysis of subcellular architecture at an unprecedented level of detail. Interpretation of the resulting 3D volumes strongly depends on segmentation, which consists in decomposing the volume into the...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2012.10.002

    authors： Martinez-Sanchez A,Garcia I,Fernandez JJ

    更新日期：2013-01-01 00:00:00

  • Crystallization of sparingly soluble stress-related proteins from cyanobacteria by controlled urea solublization.

    abstract：:The phycobilisome photosynthetic antenna complex, found in cyanobacteria and red-algae, interacts with proteins expressed specifically to deal with different forms of physiological stress. Under conditions of nutrient starvation, the NblA protein is required for the process that leads to phycobilisome degradation and ...

    journal_title：Journal of structural biology

    pub_type： 杂志文章

    doi：10.1016/j.jsb.2006.10.021

    authors： Dines M,Sendersky E,Schwarz R,Adir N

    更新日期：2007-04-01 00:00:00