Abstract:
:This study aimed to analysis outcome and prognosis of interstitial 125I seed implantation in patients with cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous cell carcinoma (ESCC). We conducted a retrospective review of 19 patients with 32 cervical lymph nodes recurrences after multimodal treatment (lymphadenectomy, radiotherapy, chemotherapy, and various combinations of these treatments) of thoracic ESCC, who underwent (125)I seed implantation in our department from 2003 to 2011. All the patients were followed up until expiration and the median duration of follow up was 7 months (range, 3-44 months). Syndromes significantly improved after implantation. The local control rates after 3, 6, 12, and 24 months were 84.2%, 63.2%, 32.0%, and 26.0%, respectively, with a median of 10 months. The median overall survival time was 7 months (95% CI, 5.6-8.4), and 1- and 2-year survival rates were 31.6% and 10.5%, respectively. Among these patients, there were 11 died of progression of disease (PD) 3-44 months after implantation. One patient presented grade IV skin toxic effect and repaired by free flap transplantation. No fatal complications such as massive bleeding happened. In univariate analysis, N stage, number of recurrent nodes, recurrence interval time, and D90 were prognostic factors of the tumor local control and survival (p = 0.131 vs. 0.029, 0.129 vs. 0.071, 0.042 vs. 0.042, and 0.056 vs. 0.065, respectively). Multivariate analysis demonstrated that N stage, number of recurrent nodes, and recurrence interval time were independent prognostic factors of the tumor local control (p = 0.022, 0.019, and <0.001, respectively), and recurrence interval time was prognostic factor of the survival (p < 0.001). Interstitial (125)I seed implantation is a safe and effective salvage treatment for cervical lymph node recurrence after multimodal treatment. The N stage, number of recurrent nodes and recurrence interval time are factors influencing tumor local control, and the recurrence interval time is independent factor influencing survival after percutaneous (125)I seed implantation in ESCC with cervical lymph node recurrence.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Lin L,Wang J,Jiang Y,Meng N,Tian S,Yang R,Ran W,Liu Cdoi
10.7785/tcrt.2012.500409subject
Has Abstractpub_date
2015-04-01 00:00:00pages
201-7issue
2eissn
1533-0346issn
1533-0338pii
tcrt.2012.500409journal_volume
14pub_type
杂志文章abstract:BACKGROUND:The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer. METHODS:The messenger RNA expression of deoxycytidine kinase was analyzed with the use of the U...
journal_title:Technology in cancer research & treatment
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abstract:OBJECTIVE:The main objective in studying large-scale cancer omics is to identify molecular mechanisms of cancer and discover novel biomedical targets. This work not only discovers the cancer subtypes in genome scale data by using clustering and classification but also measures their accuracy. METHODS:Initially, candid...
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