Abstract：
OBJECTIVE:The main objective in studying large-scale cancer omics is to identify molecular mechanisms of cancer and discover novel biomedical targets. This work not only discovers the cancer subtypes in genome scale data by using clustering and classification but also measures their accuracy. METHODS:Initially, candidate cancer subtypes are recognized by max-flow/min-cut graph clustering. Finally, prognosis-enhanced neural network classifier is proposed for classification. We analyzed the heterogeneity and identified the subtypes of glioblastoma multiforme, an aggressive adult brain tumor, from 215 samples with microRNA expression (12 042 genes). The samples were classified into 4 different classes such as mesenchymal, classical, proneural, and neural subtypes owing to mutations and gene expression. The results are measured using the metrics such as silhouette width, biological stability index, clustering accuracy, precision, recall, and f-measure. RESULTS:Max-flow/min-cut clustering produces higher clustering accuracy of 88.93% for 215 samples. The proposed prognosis-enhanced neural network classifier algorithm produces higher accuracy results of 89.2% for 215 samples efficiently. CONCLUSION:From the experimental results, the proposed prognosis-enhanced neural network classifier is seen as an alternative, which is full of promise for cancer subtype prediction in genome scale data.
journal_name
Technol Cancer Res Treatjournal_title
Technology in cancer research & treatmentauthors
Vasudevan P,Murugesan Tdoi
10.1177/1533033818790509subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1533033818790509eissn
1533-0346issn
1533-0338journal_volume
17pub_type
杂志文章abstract：BACKGROUND:There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which is widely prevalent in South China and is the most prevalent metastatic cancer among head and neck cancers. Recently, it has been shown that miR-494 is involved in the progression and prognosis of nasopharynge...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818809993
更新日期：2018-01-01 00:00:00
abstract：:Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die via IRE is the creation of pores in cell membranes, without substantial increase in tissue temperature. To determine the degree t...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrtexpress.2013.600253
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:To investigate the application value of apparent diffusion coefficient value in the pathological type, histologic grade, and presence of lymph node metastases of esophageal carcinoma. MATERIALS AND METHODS:Eighty-six patients with pathologically confirmed esophageal carcinoma were divided into different grou...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819892254
更新日期：2019-01-01 00:00:00
abstract：:A fiber confocal back scattering micro-spectrometer (FCBS) was established, which combined fiber confocal microscopy with light scattering spectroscopy (LSS) for early diagnosis of the cancer cell at cellular level. An adherent monolayer human normal gastric epithelium line GES-1 and a carcinoma cell line NCI-N87 as w...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500222
更新日期：2011-10-01 00:00:00
abstract：:We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034615626011
更新日期：2017-02-01 00:00:00
abstract：:The therapeutic utility of the anthracycline antibiotic doxorubicin is limited due to its cardiotoxicity. Our aim was to investigate the efficacy of fullerenol C(60)(OH)(24) in preventing single, high-dose doxorubicin-induced cardiotoxicity in rats with malignant neoplasm. Experiment was performed on adult female Spra...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700102
更新日期：2008-02-01 00:00:00
abstract：:Planning robotic radiosurgery treatments for multiple (n > 3) metastatic brain lesions is challenging due to the need of satisfying a large number of dose-volume constraints and the requirement of prescribing different dose levels to individual targets. In this study, we developed a sequential two-step optimization te...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500210
更新日期：2011-08-01 00:00:00
abstract：:Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor with generally disappointing results in terms of survival, however, there are occasional long-term survivors probably due to the biologic characteristics of the disease. Standard uptake value (SUV) of [(18)F] Fluorodeoxyglucose (FDG) evaluated by phot...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.7785/tcrt.2012.500245
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Gene expression profiles from early-onset breast cancer and normal tissues were analyzed to explore the genes and prognostic factors associated with breast cancer. METHODS:GSE109169 and GSE89116 were obtained from the database of Gene Expression Omnibus. We firstly screened the differentially expressed gene...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033819893670
更新日期：2020-01-01 00:00:00
abstract：:Numerous beam directions using 3-D conformal techniques can be employed in treating tumors in the posterior fossa, each with characteristic normal tissue exposure along the entrance and exit trajectory. A representative variety of beam configurations were modeled in a modern computer planning system initially with the...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460300200611
更新日期：2003-12-01 00:00:00
abstract：PURPOSE:To investigate the role of intensity-modulated proton therapy (IMPT) for hepatocellular carcinoma (HCC) patients to be treated with stereotactic body radiation therapy (SBRT) in a risk-adapted dose prescription regimen. METHODS:A cohort of 30 patients was retrospectively selected as "at-risk" of dose de-escala...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820980412
更新日期：2020-01-01 00:00:00
abstract：:We previously showed that microRNA-182 (miR-182) might promote cell proliferation and migration in triple-negative breast cancer (TNBC). This study aimed to investigate circular RNAs (circRNAs) that interact with miR-182 and play important roles in TNBC. Thirty patients with TNBC were enrolled. One pair of tumor and a...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820950827
更新日期：2020-01-01 00:00:00
abstract：:Targeted immunotherapy using dendritic cell vaccine has been employed for the treatment of solid tumors. Topical 5-aminolevulinic acid-mediated photodynamic therapy, an established approach for topical cancers, can induce an effective antitumor immune response. We have previously shown that 5-aminolevulinic acid-media...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818785275
更新日期：2018-01-01 00:00:00
abstract：:Drug delivery to solid tumors is one of the most challenging aspects in cancer therapy. Whereas agents seem promising in the test tube, clinical trials often fail due to unfavorable pharmacokinetics, poor delivery, low local concentrations, and limited accumulation in the target cell. A major step forwards in the trea...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460300200303
更新日期：2003-06-01 00:00:00
abstract：:Complement 3a (C3a) and complement 5a (C5a), small cleavage fragments generated by complement activation, has been previously shown to be obviously up-regulated in highly metastatic hepatocellular carcinoma (HCC) cells. However, their functional roles in HCC cells remains unclear. Here, we investigated the biological ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033820970668
更新日期：2020-01-01 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) and Protein kinase B (PKB/Akt) play a crucial role in the formation of many malignant tumors and have been shown to be the important therapeutic targets. In the present study, we examined immunohistochemical expression of phosphorylated Akt (p-Akt) and COX-2 in 45 gastric adenocarcinomas with ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460900800608
更新日期：2009-12-01 00:00:00
abstract：:Stereotactic radiosurgery (SRS) refers to a single radiation treatment delivering a high dose to an intra-cranial target localized in three-dimensions by CT and/or MRI imaging. Traditionally, immobilization of the patient's head has been achieved using a rigid stereotactic head frame as the key step in allowing for ac...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460900800404
更新日期：2009-08-01 00:00:00
abstract：:In cryosurgery it is crucial that the performance of cryoprobes is predictable and constant. In this study we tested the intra- and interneedle variation between 17-gauge cryoprobes in two homogeneous mediums. Also, a multiprobe setup was tested. Cryoprobe performance was defined as the time it takes one cryoprobe to ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460800700406
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:We recently developed a novel, open-source in vivo dosimetry that uses the electronic portal imaging device to detect dose delivery discrepancies. We applied our method on patients with rectal cancer treated on a belly board device. METHODS:In vivo dosimetry was performed on 10 patients with rectal cancer trea...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533034617711519
更新日期：2017-12-01 00:00:00
abstract：:A review of the literature on the current applications of breast magnetic resonance imaging (MRI) indications, their rationale and their place in diagnosis and management of breast cancer was given. Contrast-enhanced breast MRI is developing as a valuable adjunct to mammography and sonography. Its high sensitivity for...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460400300602
更新日期：2004-12-01 00:00:00
abstract：:The therapy of brain tumors has been limited by a lack of effective methods of drug delivery to the brain. Systemic administration is often associated with toxic side effects and ultimately fails to achieve therapeutic concentrations within a tumor. An attractive strategy that has gained importance in brain tumor ther...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460500400409
更新日期：2005-08-01 00:00:00
abstract：PURPOSE:In this study, we aimed to evaluate the prognostic value of fluorodeoxyglucose uptake in the lung parenchyma and the presence of subclinical interstitial lung disease on computed tomography as predictive factors for survival following stereotactic body radiation therapy in patients with stage I non-small cell l...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818794934
更新日期：2018-01-01 00:00:00
abstract：:The study of the effectiveness of cryotherapy as a curative treatment for prostate cancer has often relied on the use of either in vitro cell culture monolayers or animal models. While the data gleaned from these studies have been valuable, each model has inherent limitations. In order to bridge the gap between in vit...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460700600204
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND AND AIMS:To evaluate long-term outcomes and prognostic factors of laparoscopic microwave ablation as a first-line treatment for hepatocellular carcinoma located at the liver surface not feasible for percutaneous ablation. METHODS:51 consecutive patients receiving laparoscopic microwave ablation in our cente...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818824338
更新日期：2019-01-01 00:00:00
abstract：:Although an MRI scanner is a single stand-alone modality, different acquisition techniques may be applied to collect structural and functional information, including vascular or angiogenic properties measured by dynamic contrast enhanced MRI (DCE-MRI) and Choline (Cho) metabolism measured by proton MR spectroscopy ima...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND AND AIM:Methylated SEPT9 is a novel circulating tumor DNA marker for colorectal cancer, while the effects of various colorectal cancer clinicopathological factors on its detection performance have not been fully evaluated. This study aims to investigate the significance of the clinicopathological factors on ...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818791794
更新日期：2018-01-01 00:00:00
abstract：:We have constructed a multimodal contrast agent suitable for near-infrared, NIR, fluorescent imaging as well as magnetic resonance imaging, MRI. This class of agents may be useful for preoperative tumor localization and tumor functional evaluation and for intraoperative delineation of tumor margins. We have covalently...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/153303460600500401
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:The aim of the in vivo dosimetry, during the fractionated radiation therapy, is the verification of the correct dose delivery to patient. Nowadays, in vivo dosimetry procedures for photon beams are based on the use of the electronic portal imaging device and dedicated software to elaborate electronic portal ima...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章
doi：10.1177/1533033818779201
更新日期：2018-01-01 00:00:00
abstract：:The role of salvage cryoablation of the prostate for patients with clinically localized prostate cancer that have failed radiotherapy to the prostate is reviewed with reference to alternatives including salvage radical prostatectomy and brachytherapy. The diagnosis and work-up of local recurrence/persistence of cancer...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,评审
doi：10.1177/153303460500400210
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to investigate the prognostic role of neutrophil to lymphocyte ratio in ovarian cancer. Growing number of articles reported the relationship between neutrophil to lymphocyte ratio and prognosis in ovarian cancer, but the results remains inconclusive. The meta-analysis was conducted to...
journal_title：Technology in cancer research & treatment
pub_type： 杂志文章,meta分析
doi：10.1177/1533033818791500
更新日期：2018-01-01 00:00:00
