The Pathological Features of Colorectal Cancer Determine the Detection Performance on Blood ctDNA.

Abstract:

BACKGROUND AND AIM:Methylated SEPT9 is a novel circulating tumor DNA marker for colorectal cancer, while the effects of various colorectal cancer clinicopathological factors on its detection performance have not been fully evaluated. This study aims to investigate the significance of the clinicopathological factors on methylated SEPT9 performance in a symptomatic endoscopy cohort, with a specific focus on colorectal cancer. METHODS:A total of 1160 participants were recruited in this study, including 300 patients with colorectal cancer, 122 patients with adenoma, 103 patients with hyperplastic polyps, 568 normal participants (no evidence of disease), and 67 patients with other gastrointestinal diseases. Peripheral blood samples of these participants were collected from 3 Chinese hospitals, and the methylated SEPT9 level was measured using the Epi proColon 2.0 assay. RESULTS:Cancer stage, size, and invasion depth were positively correlated with the detection sensitivity, while no difference in sensitivity was identified among cancers at various locations. Infiltrative colorectal cancer exhibited higher sensitivity than ulcerative and protrude colorectal cancer, while no difference in sensitivity was observed among assessed histological types. The colorectal cancer differentiation showed a clear correlation with the cancer stage, and moderate and poorly differentiated colorectal cancer exhibited higher sensitivity than well-differentiated colorectal cancer. Furthermore, colorectal cancer with distal metastasis (M1) showed higher sensitivity than those without any metastasis, while colorectal cancer with lymph node metastasis (N1 and N2) did not show statistical significance compared to those without it. Finally, local vessel or nerve invasion did not affect the sensitivity. CONCLUSION:Factors that reflect the colorectal cancer intrinsic properties, including cancer stage, size, invasion depth, classification, differentiation, and metastasis, exhibited significant effect on the mSEPT9 detection performance.

authors

He N,Song L,Kang Q,Jin P,Cai G,Zhou J,Zhou G,Sheng J,Cai S,Wang J,Han X,Nie Y,Wu K

doi

10.1177/1533033818791794

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1533033818791794

eissn

1533-0346

issn

1533-0338

journal_volume

17

pub_type

杂志文章
  • Cancer Subtype Discovery Using Prognosis-Enhanced Neural Network Classifier in Multigenomic Data.

    abstract:OBJECTIVE:The main objective in studying large-scale cancer omics is to identify molecular mechanisms of cancer and discover novel biomedical targets. This work not only discovers the cancer subtypes in genome scale data by using clustering and classification but also measures their accuracy. METHODS:Initially, candid...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033818790509

    authors: Vasudevan P,Murugesan T

    更新日期:2018-01-01 00:00:00

  • Serum lncRNA TINCR Serve as a Novel Biomarker for Predicting the Prognosis in Triple-Negative Breast Cancer.

    abstract:BACKGROUND:Tissue differentiation-inducing non-protein coding RNA (TINCR) has been shown to play a crucial role in pathogenesis of various types of human cancer including breast cancer (BC). The purpose of this study was to determine the potential prognostic value of serum lncRNA TINCR in BC. METHODS:Quantitative reve...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820965574

    authors: Wang X,Li S,Xiao H,Deng X

    更新日期:2020-01-01 00:00:00

  • Automated Intensity Modulated Radiation Therapy Treatment Planning for Cervical Cancer Based on Convolution Neural Network.

    abstract:PURPOSE:To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer, including a Convolution Neural Network (CNN)-based prediction model and an automated optimization strategy. METHODS:A CNN deep learning model was trained to predict a patient-specify set of IMRT objec...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820957002

    authors: Jihong C,Penggang B,Xiuchun Z,Kaiqiang C,Wenjuan C,Yitao D,Jiewei Q,Kerun Q,Jing Z,Tianming W

    更新日期:2020-01-01 00:00:00

  • Experimental Study on Evaluation of Blood Supply Level and Embolization Ratio of Liver Cancer Based on I-Flow Software.

    abstract:OBJECTIVE:To confirm the feasibility and accuracy of the method for evaluating blood supply and embolization rate of liver cancer based on I-flow software through animal experiments and clinical study. METHODS:Rabbits underwent selective angiography under different perfusion conditions in the same kidney. The blood su...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820970665

    authors: Li Y,Zhou F,Liu F,Wang M,Xing W

    更新日期:2020-01-01 00:00:00

  • Image Guidance-Based Target Volume Margin Expansion in IMRT of Head and Neck Cancer.

    abstract::This study quantifies the setup uncertainties to optimize the planning target volume (PTV) margin based on daily image guidance, its dosimetric impact, and radiobiological implication for intensity-modulated radiation therapy (IMRT) in head and neck cancer. Ten patients were retrospectively chosen who had been treated...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034614561162

    authors: Srivastava SP,Cheng CW,Das IJ

    更新日期:2016-02-01 00:00:00

  • Adenovirus-mediated ING4 Gene Transfer in Osteosarcoma Suppresses Tumor Growth via Induction of Apoptosis and Inhibition of Tumor Angiogenesis.

    abstract::The inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors. ING4 as a novel member of ING family has potential tumor-suppressive effects via multiple pathways. However, the therapeutic effect of adenovirus-mediated ING4 (Ad-ING4) gene transfer in human osteosarcoma is still unknown....

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500424

    authors: Xu M,Xie Y,Sheng W,Miao J,Yang J

    更新日期:2015-10-01 00:00:00

  • The performance of 17-gauge cryoprobes in vitro.

    abstract::In cryosurgery it is crucial that the performance of cryoprobes is predictable and constant. In this study we tested the intra- and interneedle variation between 17-gauge cryoprobes in two homogeneous mediums. Also, a multiprobe setup was tested. Cryoprobe performance was defined as the time it takes one cryoprobe to ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460800700406

    authors: Beemster PW,Lagerveld BW,Witte LP,de la Rosette JJ,Pes MP,Wijkstra H

    更新日期:2008-08-01 00:00:00

  • Long Noncoding RNA LUCAT1 Promotes Multiple Myeloma Cell Growth by Regulating the TGF-β Signaling Pathway.

    abstract:OBJECTIVE:Long noncoding RNAs (lncRNAs) are potential biomarkers for cancers. Nevertheless, the ability of long noncoding RNA lung cancer-associated transcript 1 in patients with multiple myeloma remains unknown. The purpose of this current study was to figure out its function in multiple myeloma. METHODS:Firstly, the...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820945770

    authors: Liu Z,Gao H,Peng Q,Yang Y

    更新日期:2020-01-01 00:00:00

  • Linear Accelerator-Based Radiotherapy Simulation Using On-Board Kilovoltage Cone-Beam Computed Tomography for 3-Dimensional Volumetric Planning and Rapid Treatment in the Palliative Setting.

    abstract:BACKGROUND:Palliation of advanced disease using radiotherapy can create difficult clinical situations where standard computed tomography simulation and immobilization techniques are not feasible. We developed a linear accelerator-based radiotherapy simulation technique using nonstandard patient positioning for head and...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819865623

    authors: Dyer BA,Nair CK,Deardorff CE,Wright CL,Perks JR,Rao SS

    更新日期:2019-01-01 00:00:00

  • Screening of Prognostic Factors in Early-Onset Breast Cancer.

    abstract:BACKGROUND:Gene expression profiles from early-onset breast cancer and normal tissues were analyzed to explore the genes and prognostic factors associated with breast cancer. METHODS:GSE109169 and GSE89116 were obtained from the database of Gene Expression Omnibus. We firstly screened the differentially expressed gene...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819893670

    authors: Yu Z,He Q,Xu G

    更新日期:2020-01-01 00:00:00

  • Commissioning of an integrated platform for time-resolved treatment delivery in scanned ion beam therapy by means of optical motion monitoring.

    abstract::The integrated use of optical technologies for patient monitoring is addressed in the framework of time-resolved treatment delivery for scanned ion beam therapy. A software application has been designed to provide the therapy control system (TCS) with a continuous geometrical feedback by processing the external surrog...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrtexpress.2013.600275

    authors: Fattori G,Saito N,Seregni M,Kaderka R,Pella A,Constantinescu A,Riboldi M,Steidl P,Cerveri P,Bert C,Durante M,Baroni G

    更新日期:2014-12-01 00:00:00

  • Dosimetric Effect of Intrafraction Tumor Motion in Lung Stereotactic Body Radiotherapy Using CyberKnife Static Tracking System.

    abstract:PURPOSE:We investigated the dosimetric effect of intrafraction tumor motion in lung stereotactic body radiotherapy using the CyberKnife static tracking system. METHODS:Four-dimensional computed tomography scans of a dynamic thorax phantom were acquired. Two motion ranges, 3 collimator sizes, and 4 treatment starting p...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819859448

    authors: Chang Y,Liu HY,Liang ZW,Nie X,Yang J,Liu G,Li Q,Yang ZY

    更新日期:2019-01-01 00:00:00

  • Volumetric response evaluation after intensity modulated radiotherapy in patients with supratentorial gliomas.

    abstract::Radiotherapy is frequently indicated to treat cerebral gliomas. Accurate response evaluation after radiotherapy is essential to determine the efficacy of treatment. We retrospectively analyzed the volumetric tumor response after simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) in patients with...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500233

    authors: Cho KH,Choi JH,Kim JY,Lee SH,Yoo H,Shin KH,Kim TH,Moon SH,Lee SH,Park HC

    更新日期:2012-02-01 00:00:00

  • Early Candidate Biomarkers of Non-Small Cell Lung Cancer Are Screened and Identified in Premalignant Lung Lesions.

    abstract::A specific protein profile that accompanies neoplastic transformation in the premalignant airway epithelium could provide an opportunity for early diagnosis of lung cancer. The aim of this study was to screen and identify early candidate biomarkers of non-small cell lung cancer. Thirteen non-small cell lung cancer sam...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615627391

    authors: Nan Y,Du J,Ma L,Jiang H,Jin F,Yang S

    更新日期:2017-02-01 00:00:00

  • Histological and finite element analysis of cell death due to irreversible electroporation.

    abstract::Irreversible electroporation (IRE) has been shown to be an effective method of killing cells locally. In contrast to radiofrequency ablation, the mechanism by which cells are thought to die via IRE is the creation of pores in cell membranes, without substantial increase in tissue temperature. To determine the degree t...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrtexpress.2013.600253

    authors: Long G,Bakos G,Shires PK,Gritter L,Crissman JW,Harris JL,Clymer JW

    更新日期:2014-12-01 00:00:00

  • Breast Tumor Analysis Using Shifted-Excitation Raman Difference Spectroscopy (SERDS).

    abstract::We used a shifted-excitation Raman difference spectroscopy method for the ex vivo classification of resected and formalin-fixed breast tissue samples as normal (healthy) tissue, fibroadenoma, or invasive carcinoma. We analyzed 8 tissue samples containing invasive carcinoma that were surrounded by normal tissue and 3 t...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033818782532

    authors: Gebrekidan MT,Erber R,Hartmann A,Fasching PA,Emons J,Beckmann MW,Braeuer A

    更新日期:2018-01-01 00:00:00

  • Fiber confocal back-scattering micro-spectral analysis for single cell.

    abstract::A fiber confocal back scattering micro-spectrometer (FCBS) was established, which combined fiber confocal microscopy with light scattering spectroscopy (LSS) for early diagnosis of the cancer cell at cellular level. An adherent monolayer human normal gastric epithelium line GES-1 and a carcinoma cell line NCI-N87 as w...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500222

    authors: Wang C,Li Y,Liu G,Ma J,Li Z,Wei X

    更新日期:2011-10-01 00:00:00

  • The Prognostic Landscape of Tumor-Infiltrating Immune Cells and Immune Checkpoints in Glioblastoma.

    abstract::Tumor-infiltrating immune cells are part of a complex microenvironment and associated with improved clinical outcomes in a broad range of tumor types. However, a detailed map for the prognostic landscape of tumor-infiltrating immune cells and immune checkpoint modulators in glioblastoma is still lacking. Here, with th...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033819869949

    authors: Wu S,Yang W,Zhang H,Ren Y,Fang Z,Yuan C,Yao Z

    更新日期:2019-01-01 00:00:00

  • MiR-19-3p Induces Tumor Cell Apoptosis via Targeting FAS in Rectal Cancer Cells.

    abstract::MicroRNAs are reported as a vital important factor in cancer cell initiation and progression processes. MicroRNA-19-3p has drawn the attention of many researchers in recent years because of its wide expression and its key role in serious kinds of tumor cells. However, the detailed mechanism of microRNA-19a-3p in these...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820917978

    authors: Su YF,Zang YF,Wang YH,Ding YL

    更新日期:2020-01-01 00:00:00

  • Circulating Tumor Cells Counting Act as a Potential Prognostic Factor in Cervical Cancer.

    abstract:BACKGROUND:Circulating tumor cells (CTCs) hold huge potential for both clinical applications and basic research into the management of cancer, but the relationship between CTC count and cervical cancer prognosis remains unclear. Therefore, research on this topic is urgently required. OBJECTIVE:This study investigated ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820957005

    authors: Du K,Huang Q,Bu J,Zhou J,Huang Z,Li J

    更新日期:2020-01-01 00:00:00

  • Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis.

    abstract::Hepatocellular carcinoma (HCC) is the most aggressive type of gastrointestinal tumor, with a high rate of mortality. However, identifying biomarkers for the treatment of HCC remains to be developed. We aimed to determine whether cell division cycle 25C (CDC25C) could be used as a novel diagnostic and therapeutic bioma...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820967474

    authors: Xun R,Lu H,Wang X

    更新日期:2020-01-01 00:00:00

  • The Characteristics of Blue Laser Imaging and the Application in Diagnosis of Early Digestive Tract Cancer.

    abstract:BACKGROUND:The blue laser imaging is a kind of new endoscopic system, sending 2 different wavelengths of laser. RESULT:It can observed that the gastrointestinal mucosa shallow capillaries and mucosal surface microstructure are shown in bright and high resolution images, thus being helpful to the diagnosis of early dig...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/1533033819825877

    authors: Bi Y,Min M,Zhang F,Li X

    更新日期:2019-01-01 00:00:00

  • Dosimetric Comparison of Craniospinal Irradiation Using Different Tomotherapy Techniques.

    abstract::The objective of this study is to compare the new and conventional tomotherapy treatment techniques and to evaluate dosimetric differences between them. A dosimetric analysis was performed by comparing planning target volume (PTV) median dose, 95% of PTV dose coverage, Paddick conformity index (CI), homogeneity index ...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034614556932

    authors: Zhang X,Penagaricano J,Han EY,Morrill S,Hardee M,Liang X,Gupta SK,Corry PM,Ratanatharathom V

    更新日期:2015-08-01 00:00:00

  • EZH2 regulates the expression of p16 in the nasopharyngeal cancer cells.

    abstract::The increasing evidence supported the role of Enhancer of Zeste Homolog 2 (EZH2) in the cancer development and progression. However, its precise role in the tumorigenesis of Nasopharyngeal Carcinoma (NPC) remains to be elucidated. EZH2 was depleted by retroviral infection in the NPC cells (HK-1, CNE-2, CNE-1 and C666-...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.7785/tcrt.2012.500315

    authors: Zhong J,Min L,Huang H,Li L,Li D,Li J,Ma Z,Dai L

    更新日期:2013-06-01 00:00:00

  • Positron emission tomography in cancer research and treatment.

    abstract::Positron emission tomography (PET), the imaging of pharmaceuticals labeled with positron-emitting radionuclides, is a rapidly growing modality for the diagnosis and management of cancer. PET yields high-quality images characterizing substrate metabolism, cellular proliferation, receptor density, and other parameters t...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/153303460200100603

    authors: Mandelkern M,Raines J

    更新日期:2002-12-01 00:00:00

  • Laparoscopic Microwave Ablation of Hepatocellular Carcinoma at Liver Surface: Technique Effectiveness and Long-Term Outcomes.

    abstract:BACKGROUND AND AIMS:To evaluate long-term outcomes and prognostic factors of laparoscopic microwave ablation as a first-line treatment for hepatocellular carcinoma located at the liver surface not feasible for percutaneous ablation. METHODS:51 consecutive patients receiving laparoscopic microwave ablation in our cente...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033818824338

    authors: Wang T,Zhang XY,Lu X,Zhai B

    更新日期:2019-01-01 00:00:00

  • Conventional Radiotherapy and Stereotactic Radiosurgery in the Management of Metastatic Spine Disease.

    abstract::Spinal metastases are a common manifestation of malignant tumors that can cause severe pain, spinal cord compression, pathological fractures, and hypercalcemia, and these clinical manifestations will ultimately reduce the health-related quality of life and even shorten life expectancy in patient with cancer. Effective...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533033820945798

    authors: Zhang HR,Li JK,Yang XG,Qiao RQ,Hu YC

    更新日期:2020-01-01 00:00:00

  • MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers.

    abstract::Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresist...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章,评审

    doi:10.1177/1533033818805997

    authors: Ye J,Zou M,Li P,Liu H

    更新日期:2018-01-01 00:00:00

  • Cryosurgery for lung cancer: clinical results and technical aspects.

    abstract::Lung carcinoma is the most frequently diagnosed malignancy in the world, with the incidence increasing through the 20th century. Presentation may be as a tumor mass primarily obstructing the central bronchial lumen, or a mass infiltrating lung tissue. Cryosurgery can be used as a method of palliative treatment for bot...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/153303460400300207

    authors: Maiwand MO,Asimakopoulos G

    更新日期:2004-04-01 00:00:00

  • Fascin Overexpression Promotes Cholangiocarcinoma RBE Cell Proliferation, Migration, and Invasion.

    abstract::Fascin is overexpressed in various tumor tissues and is closely related to tumor metastasis and invasion. However, the role of fascin in cholangiocarcinoma RBE cells has not been clearly reported. This study aimed to establish a cholangiocarcinoma cell line with stable and high expression of fascin to observe the effe...

    journal_title:Technology in cancer research & treatment

    pub_type: 杂志文章

    doi:10.1177/1533034615580696

    authors: Zhao H,Yang F,Zhao W,Zhang C,Liu J

    更新日期:2016-04-01 00:00:00