Current and potential immune therapies and vaccines in the management of psoriasis.

Abstract:

:Psoriasis is a chronic, immune skin disease associated with significant morbidity. Development of psoriasis is influenced by numerous genes, one allele is HLA-CW*0602. Other genes and single nucleotide polymorphisms affect immunologic pathways and antimicrobial peptide synthesis. Dendritic cells initiate psoriasis by activating T-cells toward a Th1 and Th17 response, with increased cytokines including TNF-α, IL-6, -12, -17, -22, and -23. IL-22 appears to promote keratinocyte dedifferentiation and increased antimicrobial peptide synthesis while TNF-α and IL-17 induce leukocyte localization within the psoriatic plaque. These recent insights identifying key cytokine pathways have led to the development of inhibitors with significant efficacy in the treatment of psoriasis. While a strategy for vaccine modulation of the immune response in psoriasis is in progress, with new technology they may provide a cost-effective long-term treatment that may induce tolerance or targeted self-inhibition for patients with autoimmune disorders, such as psoriasis.

journal_name

Hum Vaccin Immunother

authors

Kaffenberger BH,Lee GL,Tyler K,Chan DV,Jarjour W,Ariza ME,Williams MV,Wong HK

doi

10.4161/hv.27532

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

876-86

issue

4

eissn

2164-5515

issn

2164-554X

pii

27532

journal_volume

10

pub_type

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