Abstract:
:Rotavirus is the most common cause of diarrhea leading to hospitalization in young children. Rotavirus vaccines are available in Canada but have not been introduced in all provinces. In a controlled trial, 2 study sites (Prince Edward Island and the Capital District Health Authority (District 9, Nova Scotia) introduced universal rotavirus vaccine programs for infants at 2 and 4 months of age beginning 1 December 2010, using public health nurse or general practitioner-delivery models, respectively. A third site (Saint John, NB) served as the non-intervention control setting. Vaccine coverage, rotavirus hospitalizations, intussusception and all-cause diarrhea were monitored. A universal rotavirus vaccine program with >90% coverage was associated with reductions in rotavirus-associated hospitalizations (from a peak of 52.8 hospitalizations/100,000 population to 0 hospitalizations) in infants < 12 months and 1 to < 2 y of age 12 months after program implementation. No apparent reduction occurred in the site with vaccine coverage of < 40%, or in the non-intervention control site. No cases of intussusception were associated with vaccine receipt, and no increase in all-cause diarrhea was observed. A universal infant rotavirus vaccine program with high coverage was associated with reductions in rotavirus and no safety signals; no reduction was observed in settings with low vaccine coverage.
journal_name
Hum Vaccin Immunotherjournal_title
Human vaccines & immunotherapeuticsauthors
Sanford C,Langley JM,Halperin SA,Zelman M,Mvrvpdoi
10.1080/21645515.2015.1012028subject
Has Abstractpub_date
2015-01-01 00:00:00pages
870-4issue
4eissn
2164-5515issn
2164-554Xjournal_volume
11pub_type
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journal_title:Human vaccines & immunotherapeutics
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pub_type: 杂志文章,评审
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章
doi:10.1080/21645515.2017.1319021
更新日期:2017-08-03 00:00:00
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journal_title:Human vaccines & immunotherapeutics
pub_type: 杂志文章
doi:10.4161/21645515.2014.980684
更新日期:2014-01-01 00:00:00
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journal_title:Human vaccines & immunotherapeutics
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doi:10.1080/21645515.2016.1162936
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