Chiral symmetry breaking and surface faceting in chromonic liquid crystal droplets with giant elastic anisotropy.

abstract：:Mutations of inversin cause type II nephronophthisis, an infantile autosomal recessive disease characterized by cystic kidney disease and developmental defects. Inversin regulates Wnt signaling and is required for convergent extension movements during early embryogenesis. We now show that Inversin is essential for Xen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lienkamp S,Ganner A,Boehlke C,Schmidt T,Arnold SJ,Schäfer T,Romaker D,Schuler J,Hoff S,Powelske C,Eifler A,Krönig C,Bullerkotte A,Nitschke R,Kuehn EW,Kim E,Burkhardt H,Brox T,Ronneberger O,Gloy J,Walz G

更新日期：2010-11-23 00:00:00

abstract：:Metabolomic markers associated with incident central adiposity gain were investigated in young adults. In a 9-mo prospective study of university freshmen (n = 264). Blood samples and anthropometry measurements were collected in the first 3 d on campus and at the end of the year. Plasma from individuals was pooled by p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hootman KC,Trezzi JP,Kraemer L,Burwell LS,Dong X,Guertin KA,Jaeger C,Stover PJ,Hiller K,Cassano PA

更新日期：2017-05-23 00:00:00

abstract：:Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo L,Wei G,Zhu J,Liao W,Leonard WJ,Zhao K,Paul W

更新日期：2009-08-11 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, mutations in either of two unlinked genes, RAM1 or RAM2, abolish the farnesyltransferase activity responsible for prenylation of Ras proteins and the a-factor mating pheromone. Here we report that the function of RAM1 and RAM2 genes is required for the membrane localization of Ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He B,Chen P,Chen SY,Vancura KL,Michaelis S,Powers S

更新日期：1991-12-15 00:00:00

abstract：:Although Wingless (Wg)/Wnt signaling has been implicated in heart development of multiple organisms, conflicting results have been reported regarding the role of Wnt/beta-catenin pathway in cardiac myogenesis: Wg/armadillo signaling promotes heart development in Drosophila, whereas activation of Wnt/beta-catenin signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Naito AT,Shiojima I,Akazawa H,Hidaka K,Morisaki T,Kikuchi A,Komuro I

更新日期：2006-12-26 00:00:00

abstract：:Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown mechanism. Sulfiredoxin (Srx) is a novel oxidative stress-induced antioxidant protein whose function in tumorigenesis and cancer progression has not been well studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Q,Jiang H,Xiao Z,Baker A,Young MR,Veenstra TD,Colburn NH

更新日期：2011-04-26 00:00:00

abstract：:Therapeutic mAbs must not only bind to their target but must also be free from "developability issues" such as poor stability or high levels of aggregation. While small-molecule drug discovery benefits from Lipinski's rule of five to guide the selection of molecules with appropriate biophysical properties, there is cu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raybould MIJ,Marks C,Krawczyk K,Taddese B,Nowak J,Lewis AP,Bujotzek A,Shi J,Deane CM

更新日期：2019-03-05 00:00:00

abstract：:Retinal prosthetics offer hope for patients with retinal degenerative diseases. There are 20-25 million people worldwide who are blind or facing blindness due to these diseases, and they have few treatment options. Drug therapies are able to help a small fraction of the population, but for the vast majority, their bes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nirenberg S,Pandarinath C

更新日期：2012-09-11 00:00:00

abstract：:Explosions account for 79% of combat-related injuries, leading to multiorgan hemorrhage and uncontrolled bleeding. Uncontrolled bleeding is the leading cause of death in battlefield traumas as well as in civilian life. We need to stop the bleeding quickly to save lives, but, shockingly, there are no treatments to stop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lashof-Sullivan MM,Shoffstall E,Atkins KT,Keane N,Bir C,VandeVord P,Lavik EB

更新日期：2014-07-15 00:00:00

abstract：:The DNA end-joining protein Ku70 is one of several proteins that inhibit apoptosis by sequestering the proapoptotic factor Bax from the mitochondria. However, the molecular mechanism underlying Ku70-dependent inhibition of Bax is not fully understood. Here, we show that the absence of Ku70 results in the accumulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amsel AD,Rathaus M,Kronman N,Cohen HY

更新日期：2008-04-01 00:00:00

abstract：:Systemic delivery of bioactive molecules in the CNS is hampered by the blood-brain barrier, which has bottlenecked noninvasive physiological study of the brain and the development of CNS drugs. Here we report that irradiation with an ultrashort pulsed laser to the blood vessel wall induces transient leakage of blood p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi M,Ku T,Chong K,Yoon J,Choi C

更新日期：2011-05-31 00:00:00

abstract：:Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells cultivated under steady-state conditions in a chemostat. The use of this sensitive and controlled system led to the detection of a rapid inhibition in the incorporation of (3-H)thymidine into cellular acid-precipitable material 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tovey M,Brouty-Boyé D,Gresser I

更新日期：1975-06-01 00:00:00

abstract：:Guanosine 3':5'-cyclic monophosphate (cGMP) increased 7-fold in rat pineal glands incubated in the presence of l-norepinephrine. This response consisted of two components-one was stereospecific and inhibited by alpha-adrenergic antagonists while the other was not stereospecific and not readily inhibited by antagonists...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Dea RF,Zatz M

更新日期：1976-10-01 00:00:00

abstract：:An implicit assumption of speciation biology is that population differentiation is an important stage of evolutionary diversification, but its significance as a rate-limiting control on phylogenetic speciation dynamics remains largely untested. If population differentiation within a species is related to its speciatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harvey MG,Seeholzer GF,Smith BT,Rabosky DL,Cuervo AM,Brumfield RT

更新日期：2017-06-13 00:00:00

abstract：:Osteoclasts, bone-resorptive multinucleated cells derived from hematopoietic stem cells, are associated with many bone-related diseases, such as osteoporosis. Osteoclast-targeting small-molecule inhibitors are valuable tools for studying osteoclast biology and for developing antiresorptive agents. Here, we have discov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawatani M,Okumura H,Honda K,Kanoh N,Muroi M,Dohmae N,Takami M,Kitagawa M,Futamura Y,Imoto M,Osada H

更新日期：2008-08-19 00:00:00

abstract：:The crystal structure of the dimeric gene V protein of bacteriophage f1 was determined using multiwavelength anomalous diffraction on the selenomethionine-containing wild-type and isoleucine-47-->methionine mutant proteins with x-ray diffraction data phased to 2.5 A resolution. The structure of the wild-type protein h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skinner MM,Zhang H,Leschnitzer DH,Guan Y,Bellamy H,Sweet RM,Gray CW,Konings RN,Wang AH,Terwilliger TC

更新日期：1994-03-15 00:00:00

abstract：:We address the stability of multicharged finite systems driven by Coulomb forces beyond the Rayleigh instability limit. Our exploration of the nuclear dynamics of heavily charged Morse clusters enabled us to vary the range of the pair potential and of the fissibility parameter, which results in distinct fragmentation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Last I,Levy Y,Jortner J

更新日期：2002-07-09 00:00:00

abstract：:Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Y,Lin F,Chipman PR,Bator CM,Baker TS,Shoham M,Kuhn RJ,Medof ME,Rossmann MG

更新日期：2002-08-06 00:00:00

abstract：:Lewis base catalyzed bromo- and iodolactonization reactions have been developed and the effects of catalyst structure on rate and cyclization selectivity have been systematically explored. The effects of substrate structure on halolactonization reactions and the interaction of those effects with the effects of catalys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Denmark SE,Burk MT

更新日期：2010-11-30 00:00:00

abstract：:Local tissue stem cells have been described in airways of the lung but their contribution to normal epithelial maintenance is currently unknown. We therefore developed aggregation chimera mice and a whole-lung imaging method to determine the relative contributions of progenitor (Clara) and bronchiolar stem cells to ep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giangreco A,Arwert EN,Rosewell IR,Snyder J,Watt FM,Stripp BR

更新日期：2009-06-09 00:00:00

abstract：:The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware implementations of CS-based acquisition devices--especially in optics--have only start...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Studer V,Bobin J,Chahid M,Mousavi HS,Candes E,Dahan M

更新日期：2012-06-26 00:00:00

abstract：:Probasin, a rat prostatic protein, is statistically related to members of a protein family that includes serum, cellular, and nuclear proteins. In vivo, probasin appears both in the secretions and in the nucleus of prostatic epithelial cells. Using primer extension and S1 nuclease protection assays we detected only on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spence AM,Sheppard PC,Davie JR,Matuo Y,Nishi N,McKeehan WL,Dodd JG,Matusik RJ

更新日期：1989-10-01 00:00:00

abstract：:One mechanism of silver resistance in microorganisms is accumulation of the metal ions in the cell. Here, we report on the phenomenon of biosynthesis of silver-based single crystals with well-defined compositions and shapes, such as equilateral triangles and hexagons, in Pseudomonas stutzeri AG259. The crystals were u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klaus T,Joerger R,Olsson E,Granqvist CG

更新日期：1999-11-23 00:00:00

abstract：:The magnetic microstructure of a natural, finely exsolved intergrowth of submicron magnetite blocks in an ulvöspinel matrix is characterized by using off-axis electron holography in the transmission electron microscope. Single-domain and vortex states in individual blocks, as well as magnetostatic interaction fields b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrison RJ,Dunin-Borkowski RE,Putnis A

更新日期：2002-12-24 00:00:00

abstract：:Addition of a 0.5 M KCl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mRNAs by Krebs-cell lysates. In the presence of the wash fraction, 1 pmol of rabbit or mouse 10S RNA directs the incorporation of 80 pmol of leucine into rabbit globin. The a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metafora S,Terada M,Dow LW,Marks PA,Bank A

更新日期：1972-05-01 00:00:00

abstract：:Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate of approximately 15% after 5 years. Novel approaches are needed to treat this disease. We show elevated NAD(P)H:quinone oxidoreductase-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bey EA,Bentle MS,Reinicke KE,Dong Y,Yang CR,Girard L,Minna JD,Bornmann WG,Gao J,Boothman DA

更新日期：2007-07-10 00:00:00

abstract：:The underlying causes of late-Holocene climate variability in the tropics are incompletely understood. Here we report a 1,500-year reconstruction of climate history and glaciation in the Venezuelan Andes using lake sediments. Four glacial advances occurred between anno Domini (A.D.) 1250 and 1810, coincident with sola...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polissar PJ,Abbott MB,Wolfe AP,Bezada M,Rull V,Bradley RS

更新日期：2006-06-13 00:00:00

abstract：:The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao SW,Kobayashi K,Johansen FE,Sollid LM,Andersen JT,Milford E,Roopenian DC,Lencer WI,Blumberg RS

更新日期：2008-07-08 00:00:00

abstract：:Vaccination is the most effective medical intervention ever introduced and, together with clean water and sanitation, it has eliminated a large part of the infectious diseases that once killed millions of people. A recent study concluded that since 1924 in the United States alone, vaccines have prevented 40 million ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rappuoli R,Pizza M,Del Giudice G,De Gregorio E

更新日期：2014-08-26 00:00:00

abstract：:Phospholamban (PLN) is an effective inhibitor of the sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA). Here, we examined PLN stability and degradation in primary cultured mouse neonatal cardiomyocytes (CMNCs) and mouse hearts using immunoblotting, molecular imaging, and [(35)S]methionine pulse-chase experiments, tog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng AC,Miyake T,Yokoe S,Zhang L,Rezende LM Jr,Sharma P,MacLennan DH,Liu PP,Gramolini AO

更新日期：2015-06-09 00:00:00