Solar modulation of Little Ice Age climate in the tropical Andes.

abstract：:The high concentration of gonadotropin-releasing hormone (GnRH) in milk of several species implies that the mammary gland is either a site of synthesis for this neuropeptide or that it is efficiently concentrated from plasma by this organ. By PCR amplification of mammary gland cDNA, we have demonstrated expression of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palmon A,Ben Aroya N,Tel-Or S,Burstein Y,Fridkin M,Koch Y

更新日期：1994-05-24 00:00:00

abstract：:The underlying structure is taken as a strongly superharmonic cone [unk], defined as a partially ordered abelian semigroup with identity 0 which admits a multiplication by nonnegative scalars and satisfies two fundamental axioms of a potentialtheoretic character. In terms of a fixed nonzero element e there is introduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsove M,Leutwiler H

更新日期：1975-07-01 00:00:00

abstract：:The addition of insulin to a mixture of plasma membrane and mitochondrial fractions from rat adipocytes results in a decrease in the phosphorylation of a mitochondrial protein identified as the alpha subunit of pyruvate dehydrogenase [pyruvate:lipoamide oxidoreductase (decarboxylating and acceptor-acetylating), EC 1.2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seals JR,Jarett L

更新日期：1980-01-01 00:00:00

abstract：:The early detection of pathogens with epidemic potential is of major importance to public health. Most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geoghegan JL,Senior AM,Di Giallonardo F,Holmes EC

更新日期：2016-04-12 00:00:00

abstract：:Major changes in the mRNA population of murine liver occur after administration of bacterial lipopolysaccharide, an agent that causes increases in the concentrations of acute-phase serum proteins. The mRNA for one of these, serum amyloid A, is increased at least 500-fold compared to the normal level. It becomes one of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morrow JF,Stearman RS,Peltzman CG,Potter DA

更新日期：1981-08-01 00:00:00

abstract：:A common challenge in pathogen discovery by deep sequencing approaches is to recognize viral or subviral pathogens in samples of diseased tissue that share no significant homology with a known pathogen. Here we report a homology-independent approach for discovering viroids, a distinct class of free circular RNA subvir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Q,Wang Y,Cao M,Pantaleo V,Burgyan J,Li WX,Ding SW

更新日期：2012-03-06 00:00:00

abstract：:Cleavage of the group-specific antigen (Gag) polyprotein by HIV-1 protease represents the critical first step in the conversion of immature noninfectious viral particles to mature infectious virions. Selective pressure exerted by HIV-1 protease inhibitors, a mainstay of current anti-HIV-1 therapies, results in the acc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh L,Louis JM,Ghirlando R,Clore GM

更新日期：2016-11-01 00:00:00

abstract：:To examine the influence of interferon gamma (IFN-gamma) on tumorigenicity, we established constitutively IFN-gamma-producing cell lines from a malignant mouse neuroblastoma, C1300, by retroviral transfer of a mouse IFN-gamma cDNA. The gene-transferred cells generally showed an enhanced high-level expression of the ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe Y,Kuribayashi K,Miyatake S,Nishihara K,Nakayama E,Taniyama T,Sakata T

更新日期：1989-12-01 00:00:00

abstract：:Mannan-binding protein (MBP), a Ca2+-dependent mammalian lectin specific for mannose and N-acetylglucosamine, is an important serum component associated with innate immunity. MBP activates complement and functions as a direct opsonin on binding to mannooligosaccharide-bearing pathogens. We have found that MBP recogniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma Y,Uemura K,Oka S,Kozutsumi Y,Kawasaki N,Kawasaki T

更新日期：1999-01-19 00:00:00

abstract：:The opposite slopes of "Evolution Canyon" in Israel have served as a natural model system of adaptation to a microclimate contrast. Long-term studies of Drosophila melanogaster populations inhabiting the canyon have exhibited significant interslope divergence in thermal and drought stress resistance, candidate genes, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hübner S,Rashkovetsky E,Kim YB,Oh JH,Michalak K,Weiner D,Korol AB,Nevo E,Michalak P

更新日期：2013-12-24 00:00:00

abstract：:Oocyte endowment dwindles away during prepubertal and adult life until menopause occurs, and apoptosis has been identified as a central mechanism responsible for oocyte elimination. A few recent reports suggest that uncontrolled inflammation may adversely affect ovarian reserve. We tested the possible role of the proi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uri-Belapolsky S,Shaish A,Eliyahu E,Grossman H,Levi M,Chuderland D,Ninio-Many L,Hasky N,Shashar D,Almog T,Kandel-Kfir M,Harats D,Shalgi R,Kamari Y

更新日期：2014-08-26 00:00:00

abstract：:Maternal deletion of the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3-4(m), delNAS(m)) from the GNAS locus in humans causes autosomal dominant pseudohypoparathyroidism type Ib (AD-PHP-Ib(delNASm)), a disorder of proximal tubular parathyroid hormone (PTH) resistance associated with loss of maternal G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández-Rebollo E,Maeda A,Reyes M,Turan S,Fröhlich LF,Plagge A,Kelsey G,Jüppner H,Bastepe M

更新日期：2012-04-24 00:00:00

abstract：:Primitive cells capable of generating small resistance arterioles and capillary structures in the injured myocardium have been identified repeatedly. However, these cells do not form large conductive coronary arteries that would have important implications in the management of the ischemic heart. In the current study,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bearzi C,Leri A,Lo Monaco F,Rota M,Gonzalez A,Hosoda T,Pepe M,Qanud K,Ojaimi C,Bardelli S,D'Amario D,D'Alessandro DA,Michler RE,Dimmeler S,Zeiher AM,Urbanek K,Hintze TH,Kajstura J,Anversa P

更新日期：2009-09-15 00:00:00

abstract：:Pith parenchyma cells store water in various plant organs. These cells are especially important for producing sugar and ethanol from the sugar juice of grass stems. In many plants, the death of pith parenchyma cells reduces their stem water content. Previous studies proposed that a hypothetical D gene might be respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujimoto M,Sazuka T,Oda Y,Kawahigashi H,Wu J,Takanashi H,Ohnishi T,Yoneda JI,Ishimori M,Kajiya-Kanegae H,Hibara KI,Ishizuna F,Ebine K,Ueda T,Tokunaga T,Iwata H,Matsumoto T,Kasuga S,Yonemaru JI,Tsutsumi N

更新日期：2018-09-11 00:00:00

abstract：:Adverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehl MR,Raison CL,Pace TWW,Arevalo JMG,Cole SW

更新日期：2017-11-21 00:00:00

abstract：:Noncanonical DNA structures that stall DNA replication can cause errors in genomic DNA. Here, we investigated how the noncanonical structures formed by sequences in genes associated with a number of diseases impacted DNA polymerization by the Klenow fragment of DNA polymerase. Replication of a DNA sequence forming an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi S,Brazier JA,Sugimoto N

更新日期：2017-09-05 00:00:00

abstract：:Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Long X,Creemers EE,Wang DZ,Olson EN,Miano JM

更新日期：2007-10-16 00:00:00

abstract：:Regulated changes in gene expression underlie many biological processes, but globally profiling cell-to-cell variations in transcriptional regulation is problematic when measuring single cells. Transcriptome-wide identification of regulatory heterogeneities can be robustly achieved by randomly collecting small numbers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bajikar SS,Fuchs C,Roller A,Theis FJ,Janes KA

更新日期：2014-02-04 00:00:00

abstract：:Mutations in BRCA1 are present in 45% of families that segregate with susceptibility for breast cancer and in 80-90% of families with both breast and ovarian cancer. Here we report that BRCA1 stimulates artificial and genomic promoter constructs containing p53-responsive elements. This activity of BRCA1 depends on the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Monteiro AN,August A,Aaronson SA,Hanafusa H

更新日期：1998-03-03 00:00:00

abstract：:The utility of adenovirus (Ad) vectors for gene transduction can be limited by receptor specificity. We developed a gene-delivery vehicle in which the potent Ad5 vector was genetically reengineered to display the mucosal-targeting sigma1 protein of reovirus type 3 Dearing (T3D). A sigma1 construct containing all but a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercier GT,Campbell JA,Chappell JD,Stehle T,Dermody TS,Barry MA

更新日期：2004-04-20 00:00:00

abstract：:SoxR is a transcription factor that governs a global defense against the oxidative stress caused by nitric oxide or excess superoxide in Escherichia coli. SoxR is a homodimer containing a pair of [2Fe-2S] clusters essential for its transcriptional activity, and changes in the stability of these metal centers could con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding H,Demple B

更新日期：1996-09-03 00:00:00

abstract：:A fundamental problem in cell biology is to understand how spatial information is recognized and integrated into morphogenetic responses. Budding yeast undergoes differentiation to filamentous growth, which involves changes in cell polarity through mechanisms that remain obscure. Here we define a regulatory input wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu S,Vadaie N,Prabhakar A,Li B,Adhikari H,Pitoniak A,Chow J,Chavel CA,Cullen PJ

更新日期：2016-04-05 00:00:00

abstract：:The eukaryotic DNA sliding clamp that keeps DNA polymerase engaged at a replication fork, called proliferating cell nuclear antigen (PCNA), is loaded onto the 3' ends of primer DNA through its interaction with a heteropentameric protein complex called replication factor C (RFC). The ATPase activity of RFC is necessary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiomi Y,Usukura J,Masamura Y,Takeyasu K,Nakayama Y,Obuse C,Yoshikawa H,Tsurimoto T

更新日期：2000-12-19 00:00:00

abstract：:The c-myc protooncogene has been implicated in control of growth and differentiation of mammalian cells. For instance, growth arrest is often preceded by reduction in c-myc mRNA and gene transcription. To elucidate the mechanisms of control of c-myc gene transcription, we have begun to characterize the interaction of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duyao MP,Buckler AJ,Sonenshein GE

更新日期：1990-06-01 00:00:00

abstract：:Ribosome crystal structures have revealed that two small subunit proteins, S9 and S13, have C-terminal tails, which, together with several features of 16S rRNA, contact the anticodon stem-loop of P-site tRNA. To test the functional importance of these protein tails, we created genomic deletions of the C-terminal regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoang L,Fredrick K,Noller HF

更新日期：2004-08-24 00:00:00

abstract：:A modification of the polymerase chain reaction has been used to establish the fact that a collection of Staphylococcus aureus toxins are "superantigens," each of which interacts with the T-cell alpha beta receptor of human T cells by means of a specific set of V beta elements. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi YW,Kotzin B,Herron L,Callahan J,Marrack P,Kappler J

更新日期：1989-11-01 00:00:00

abstract：:An antigen histochemically localized in the nuclei and cytoplasmic granules of normal and leukemic human myeloid cells has been identified as myeloperoxidase (MPO; EC 1.11.1.7). The localization and amount of the enzyme was determined by using a murine monoclonal antibody designated H-43-5 raised against nuclear prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murao S,Stevens FJ,Ito A,Huberman E

更新日期：1988-02-01 00:00:00

abstract：:In a well networked community, there is intense social interaction, and information disseminates briskly and broadly. This is important if the environment is volatile (i.e., keeps changing) and individuals never stop searching for fresh opportunities. Here, we present a simple model that attributes the rise of a dynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsili M,Vega-Redondo F,Slanina F

更新日期：2004-02-10 00:00:00

abstract：:A key idea in Lashley's formulation of the problem of serial order in behavior is the postulated neural representation of all serial elements before the action begins. We studied this question by recording the activity of individual neurons simultaneously in small ensembles in prefrontal cortex while monkeys copied ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averbeck BB,Chafee MV,Crowe DA,Georgopoulos AP

更新日期：2002-10-01 00:00:00

abstract：:We sequenced the genome of Saccharomyces cerevisiae strain YJM789, which was derived from a yeast isolated from the lung of an AIDS patient with pneumonia. The strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei W,McCusker JH,Hyman RW,Jones T,Ning Y,Cao Z,Gu Z,Bruno D,Miranda M,Nguyen M,Wilhelmy J,Komp C,Tamse R,Wang X,Jia P,Luedi P,Oefner PJ,David L,Dietrich FS,Li Y,Davis RW,Steinmetz LM

更新日期：2007-07-31 00:00:00