Bioactive lipids in pathological retinopathy.

Abstract:

:Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions.

journal_name

Crit Rev Food Sci Nutr

authors

Ma Q,Shen JH,Shen SR,Das UN

doi

10.1080/10408398.2011.565523

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1-16

issue

1

eissn

1040-8398

issn

1549-7852

journal_volume

54

pub_type

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