Nutraceuticals and functional foods in the management of hyperlipidemia.

Abstract:

:Hyperlipidemia is one of the major risk factor for the development of cardiovascular disease. Hypolipidemic nutraceuticals and functional foods help improve serum lipid profiles as reducing total cholesterol, triglyceride, and low-density lipoprotein cholesterol, while elevating high-density lipoprotein cholesterol. The effectiveness of omega-3 polyunsaturated fatty acid, phytosterols, dietary fiber, and tea catechin in management of hyperlipidemia has been clearly demonstrated in epidemiological and interventional trials. Studies on mechanism reveal that they act as inhibitor or activator of critical enzyme, agonist or inhibitor of transcription factor, competitor of transporter, and sequestrant of bile acid to modulate lipid homeostasis. Hypolipidemic effects are also claimed in dietary proteins, many polyphenols, other phytochemicals, raw extract, or even whole food. This review attempts to give an overview of lipid homeostasis and summarize recent findings of hypolipidemic nutraceuticals and functional foods according to their active ingredients, focusing on the efficacy and underlying mechanisms.

journal_name

Crit Rev Food Sci Nutr

authors

Chen G,Wang H,Zhang X,Yang ST

doi

10.1080/10408398.2011.629354

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

1180-201

issue

9

eissn

1040-8398

issn

1549-7852

journal_volume

54

pub_type

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