Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients?

abstract：PURPOSE:Pentaerythrityl tetranitrate (PETN) was the most commonly prescribed long-acting nitrate in Germany. We aimed to assess whether the discontinuation of PETN reimbursability in 2011 resulted in alternative prescriptions of anti-anginal medications or in a discontinuation of anti-anginal therapy. METHODS:This is ...

journal_title：Pharmacoepidemiology and drug safety

authors： Grimmsmann T,Chenot JF,Angelow A

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To assess the pattern of in-hospital changes in drug use in older patients from 2010 to 2016. METHODS:People aged 65 years or more acutely hospitalized in those internal medicine and geriatric wards that did continuously participate to the REgistro POliterapie Società Italiana di Medicina Interna register from...

journal_title：Pharmacoepidemiology and drug safety

authors： Franchi C,Ardoino I,Nobili A,Pasina L,Mannucci PM,Marengoni A,Perticone F,REPOSI investigators.

更新日期：2017-12-01 00:00:00

abstract：:Pharmaceutical manufacturers are faced with the challenge of when and how to conduct pharmacoeconomic (PE) evaluations to satisfy formulary decision-makers. To illustrate the usefulness of decision analysis for strategic planning in drug development, a model was created to compare the cost-benefit of three PE design o...

journal_title：Pharmacoepidemiology and drug safety

authors： Ungar W

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:Postmarketing drug safety surveillance relies upon measures of disproportionate reporting in spontaneous reporting systems. It has been hypothesized that products or events reported frequently may "mask" signals. METHODS:We analyzed the masking effect of vaccines in pediatrics in the EudraVigilance database by...

journal_title：Pharmacoepidemiology and drug safety

authors： Dodd C,Pacurariu A,Osokogu OU,Weibel D,Ferrajolo C,Vo DH,Becker B,Kors JA,Sturkenboom M

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:To examine whether patient focused drug surveillance was associated with a higher quality of drug treatment at nursing homes. METHODS:An intervention study in four nursing homes in Sweden and four other nursing homes served as controls. At the intervention nursing homes physicians focused on patients' health s...

journal_title：Pharmacoepidemiology and drug safety

authors： Olsson IN,Curman B,Engfeldt P

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Few studies have reported an association between proton pump inhibitor (PPI) use and tuberculosis. Tuberculosis incidence is relatively high in Asian people, and an increase in PPI prescriptions has been reported in South Korea. Thus, we investigated the association between PPI use and tuberculosis development....

journal_title：Pharmacoepidemiology and drug safety

authors： Song HJ,Park H,Park S,Kwon JW

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:The aim of this work was to study the use of systemic antibacterials and its possible determinants in Hungarian intensive care units (ICUs). METHODS:Hospital pharmacy. departments provided package level dispensing data for their corresponding ICU (2006). Data were converted into defined daily doses (DDDs) and ...

journal_title：Pharmacoepidemiology and drug safety

authors： Benko R,Matuz M,Peto Z,Bogár L,Viola R,Doró P,Soós G,Hajdú E

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Estimating drug effectiveness and safety among older adults in population-based studies using administrative health care claims can be hampered by unmeasured confounding as a result of frailty. A claims-based algorithm that identifies patients likely to be dependent, a proxy for frailty, may improve confounding...

journal_title：Pharmacoepidemiology and drug safety

authors： Faurot KR,Jonsson Funk M,Pate V,Brookhart MA,Patrick A,Hanson LC,Castillo WC,Stürmer T

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Oral morphine is the first-choice opioid for moderate to severe cancer pain. Transdermal fentanyl is an alternative in patients with stable requirements of high-potency opioids (HPO) or if drugs cannot be taken orally. Drug regulatory authorities have issued several alerts to use transdermal fentanyl only for c...

journal_title：Pharmacoepidemiology and drug safety

authors： Garbe E,Jobski K,Schmid U

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Outcome misclassification may occur in observational studies using administrative databases. We evaluated a two-step multiple imputation approach based on complementary internal validation data obtained from two subsamples of study participants to reduce bias in hazard ratio (HR) estimates in Cox regressions....

journal_title：Pharmacoepidemiology and drug safety

authors： Ni J,Leong A,Dasgupta K,Rahme E

更新日期：2017-08-01 00:00:00

abstract：:Data regarding the total number of anti-asthma drugs dispensed via community pharmacies within Northern Ireland from 1980 to 1997 were collected and analysed. The use of anti-asthma drugs within this population increased markedly over the study period from 19.84 DDDs/1000/day to 84.07 DDDs/1000/day. With the exception...

journal_title：Pharmacoepidemiology and drug safety

authors： Bell HM,McElnay JC,Hughes CM

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that hydroxyzine was pro-arrhythmogenic and changes to the product information were implemented in Europe. This study aimed to evaluate their impact in Denmark, Scotland, E...

journal_title：Pharmacoepidemiology and drug safety

authors： Morales DR,Macfarlane T,MacDonald TM,Hallas J,Ernst MT,Herings RMC,Smits E,Overbeek JA,Mitchell L,Morant S,Mackenzie I,Doney ASF,Robertson C,Bennie M,Wei L,Nicholson L,Morris C,Flynn RWF

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Confounding, a concern in nonexperimental research using administrative claims, is nearly ubiquitous in claims-based pharmacoepidemiology studies. A fixed-length look-back window for assessing comorbidity from claims is common, but it may be advantageous to use all historical claims. We assessed how the strengt...

journal_title：Pharmacoepidemiology and drug safety

authors： Gilbertson DT,Bradbury BD,Wetmore JB,Weinhandl ED,Monda KL,Liu J,Brookhart MA,Gustafson SK,Roberts T,Collins AJ,Rothman KJ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The use of prescription opioid analgesics has been increasing over the last few decades in Australia. In particular, oxycodone and fentanyl have increased substantially. We examined the gender and age trends in the prescribing of subsidised opioid analgesics in the Australian population for non-palliative care ...

journal_title：Pharmacoepidemiology and drug safety

authors： Hollingworth SA,Gray PD,Hall WD,Najman JM

更新日期：2015-06-01 00:00:00

abstract：:The article is devoted to the establishment and development of the National Pharmacovigilance system in Ukraine. A drug safety centre of Ukraine started to form a pharmacovigilance system in 1996. It has been operating on a regular basis since 2000 and now provides the regulatory services that include data collection ...

journal_title：Pharmacoepidemiology and drug safety

authors： Stefanov O,Sharayeva M,Jajtchenja V

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:High-grade cervical dysplasia or cervical intraepithelial neoplasia grade 2 or worse has been widely used as a surrogate endpoint in cervical cancer screening or prevention trials. METHODS:To identify high-grade cervical dysplasia and cervical cancer, we developed claims-based algorithms that incorporated a...

journal_title：Pharmacoepidemiology and drug safety

authors： Kim SC,Gillet VG,Feldman S,Lii H,Toh S,Brown JS,Katz JN,Solomon DH,Schneeweiss S

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:The purposes of the study are to compare safety specifications between Japan and the European Union (EU) and to identify the factors affecting categorization of important identified or potential risks. METHODS:Safety specifications were collected from orphan and nonorphan drugs approved in Japan between 2014 a...

journal_title：Pharmacoepidemiology and drug safety

authors： Hirota S,Yamaguchi T

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Under EU regulations, patient information leaflets (PILs) are required to be clear and understandable. Negations (e.g., not, no) are a linguistic aspect that may impact PIL comprehension, yet go unmentioned in these regulations. We conducted two studies to determine (1) how negations are used in Dutch PILs (stu...

journal_title：Pharmacoepidemiology and drug safety

authors： Burgers C,Beukeboom CJ,Sparks L,Diepeveen V

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:To develop a method for identifying the beginning and ending records of pregnancies in the automated medical records of the General Practice Research Database (GPRD). METHODS:Women's records from 1991 to 1999 were searched for codes from 17 pregnancy marker and 7 pregnancy outcome categories. Using the retriev...

journal_title：Pharmacoepidemiology and drug safety

authors： Hardy JR,Holford TR,Hall GC,Bracken MB

更新日期：2004-11-01 00:00:00

abstract：:The General Practice Research Database (GPRD) is the world's largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool. Several issues have threatened the viability of the database in recent years; in April 1999 responsibility for its man...

journal_title：Pharmacoepidemiology and drug safety

authors： Wood L,Coulson R

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:In epidemiological studies, non-response may introduce bias and limit generalizability. In genetic pharmacoepidemiological research, collection of DNA might be a major reason for non-response. We determined reasons for non-response and compared characteristics of non-responders and responders in a pharmacogenet...

journal_title：Pharmacoepidemiology and drug safety

authors： van Wieren-de Wijer DB,Maitland-van der Zee AH,de Boer A,Kroon AA,de Leeuw PW,Schiffers P,Janssen RG,Psaty BM,van Duijn CM,Stricker BH,Klungel OH

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Our aim was to describe and assess the medicinal products and doses used for euthanasia in a series of cases, identified within an epidemiological death certificate study in Belgium, where euthanasia was until recently legally forbidden and where guidelines for euthanasia are not available. METHODS:In a random...

journal_title：Pharmacoepidemiology and drug safety

authors： Vander Stichele RH,Bilsen JJ,Bernheim JL,Mortier F,Deliens L

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:Little is known about the effects of drug-drug interactions between valacyclovir and non-steroidal anti-inflammatory drugs (NSAIDs). In this study, we analysed the adverse event 'acute kidney injury (AKI)' resulting from a possible interaction between loxoprofen (a non-selective NSAID) and valacyclovir in repor...

journal_title：Pharmacoepidemiology and drug safety

authors： Yue Z,Shi J,Jiang P,Sun H

更新日期：2014-11-01 00:00:00

abstract：PURPOSE:Some studies have reported reduced risks of advanced, but not early, prostate cancer among statin users, and one study found a reduced risk only among statin users who had also used non-steroidal anti-inflammatory drugs (NSAIDs). We have previously reported no association between statin use and prostate cancer ...

journal_title：Pharmacoepidemiology and drug safety

authors： Coogan PF,Kelly JP,Strom BL,Rosenberg L

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To assess the feasibility of using Clinical Practice Research Datalink (CPRD) data for identifying populations of patients with chronic obstructive pulmonary disease (COPD) eligible for a hypothetical pragmatic trial. METHODS:A retrospective multidatabase cohort study using CPRD primary care and linked seconda...

journal_title：Pharmacoepidemiology and drug safety

authors： Requena G,Wolf A,Williams R,Dedman D,Quint JK,Murray-Thomas T,Pimenta JM

更新日期：2020-12-27 00:00:00

abstract：PURPOSE:Administrative claim databases are increasingly being used to study the safety of medication exposures during pregnancy. These studies are restricted to live births due to a reliance on algorithms for estimating gestational age that are based on codes associated with live delivery. Conditioning on live birth ma...

journal_title：Pharmacoepidemiology and drug safety

authors： Suarez EA,Landi SN,Conover MM,Jonsson Funk M

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To estimate the prevalence of use of prescription drugs with a potential for fetal harm among pregnant women in the United States. METHODS:A retrospective study was conducted using the automated databases of eight health maintenance organizations involved in the HMO Research Network Center for Education and Re...

journal_title：Pharmacoepidemiology and drug safety

authors： Andrade SE,Raebel MA,Morse AN,Davis RL,Chan KA,Finkelstein JA,Fortman KK,McPhillips H,Roblin D,Smith DH,Yood MU,Platt R,H Gurwitz J

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:This study aimed to assess the trends in antipsychotic prescriptions for outpatients in Japan, where a community-based approach to mental healthcare is emphasized. METHODS:This descriptive epidemiological study used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and...

journal_title：Pharmacoepidemiology and drug safety

authors： Kochi K,Sato I,Nishiyama C,Tanaka-Mizuno S,Doi Y,Arai M,Fujii Y,Matsunaga T,Ogawa Y,Furukawa TA,Kawakami K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Antiepileptic drugs (AEDs) are also prescribed for therapeutic indications other than epilepsy (EPI), namely, psychiatric disorders (PSY). Our aim was to develop an algorithm able to distinguish between EPI and PSY among childbearing age women based on differences in AED exposure in these patient groups. ME...

journal_title：Pharmacoepidemiology and drug safety

authors： Naldi I,Piccinni C,Mostacci B,Renzini J,Accetta G,Bisulli F,Tappatà M,Piazza A,Pagano P,Bianchi S,D'Alessandro R,Tinuper P,Poluzzi E,ESPEA (Emilia-Romagna Study on Pregnancy and Exposure to Antiepileptic drugs) Group.

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Most epidemiologic studies have detected no association between prior use of antidepressant medications and breast cancer risk. Despite the uniform conclusion, there is a continuous rise in the proportion of women using antidepressants, lending support to further monitoring of disease effects. METHODS:We condu...

journal_title：Pharmacoepidemiology and drug safety

authors： Wernli KJ,Hampton JM,Trentham-Dietz A,Newcomb PA

更新日期：2009-04-01 00:00:00