Impact of EMA regulatory label changes on hydroxyzine initiation, discontinuation and switching to other medicines in Denmark, Scotland, England and the Netherlands: An interrupted time series regression analysis.

abstract：PURPOSE:To evaluate the concurrent validity of three European sets of drug-specific indicators of prescribing quality METHODS:In 200 hip fracture patients (≥65 years), consecutively recruited to a randomized controlled study in Sahlgrenska University Hospital in 2009, quality of drug treatment at study entry was asses...

journal_title：Pharmacoepidemiology and drug safety

authors： Wallerstedt SM,Belfrage B,Fastbom J

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To develop a method for data-driven exploration in pharmacovigilance and illustrate its use by identifying the key features of individual case safety reports related to medication errors. METHODS:We propose vigiPoint, a method that contrasts the relative frequency of covariate values in a data subset of intere...

journal_title：Pharmacoepidemiology and drug safety

authors： Juhlin K,Star K,Norén GN

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to estimate the prevalence of first-generation antipsychotics (FGA) prescribed for treatment of psychiatric and neurological conditions and use of benztropine to reduce extrapyramidal side effects (EPS) by patient race/ethnicity in a nationally representative sample of adult outpatient...

journal_title：Pharmacoepidemiology and drug safety

authors： Cook TB,Reeves GM,Teufel J,Postolache TT

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To develop a method for identifying the beginning and ending records of pregnancies in the automated medical records of the General Practice Research Database (GPRD). METHODS:Women's records from 1991 to 1999 were searched for codes from 17 pregnancy marker and 7 pregnancy outcome categories. Using the retriev...

journal_title：Pharmacoepidemiology and drug safety

authors： Hardy JR,Holford TR,Hall GC,Bracken MB

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Community Pharmacists both have an important responsibility in monitoring the ongoing safety of medicines and are widely accessible to do it. This study aims to investigate the knowledge, perceptions and practice of Pharmacovigilance amongst community pharmacists in Lagos State, South West Nigeria METHODS:A cr...

journal_title：Pharmacoepidemiology and drug safety

authors： Oreagba IA,Ogunleye OJ,Olayemi SO

更新日期：2011-01-01 00:00:00

abstract：:Before a medicine can be recommended for a marketing authorization research must be provided to regulators that convincingly supports the benefit-risk of the product in the claimed indication. The established criteria for such research are usually expressed in terms of evidence from randomized controlled trials (RCT)....

journal_title：Pharmacoepidemiology and drug safety

authors： Slattery J,Kurz X

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:This study aims to examine the associations between proton pump inhibitors (PPIs), traditional nonsteroidal anti-inflammatory drugs (tNSAIDs), PPI + tNSAID co-exposure, and the development of the following: (i) acute interstitial nephritis (AIN), a specific kidney injury often attributed to these drugs, and (ii...

journal_title：Pharmacoepidemiology and drug safety

authors： Leonard CE,Freeman CP,Newcomb CW,Reese PP,Herlim M,Bilker WB,Hennessy S,Strom BL

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:We developed a computerized system for signal detection in spontaneous reporting system (SRS) of Shanghai. Data acquisition, data mining could be carried out automatically and the process of data preprocessing and cleaning could be facilitated. This system was expected to detect signals from SRS after drug lice...

journal_title：Pharmacoepidemiology and drug safety

authors： Ye X,Fu Z,Wang H,Du W,Wang R,Sun Y,Gao Q,He J

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:We discuss the practical advantages and challenges of sharing controls among two or more concurrently conducted case-control studies. METHODS:We conducted two case-control studies, one of breast cancer and the other of endometrial cancer, with overlapping, shared control groups. The studies had overlapping geo...

journal_title：Pharmacoepidemiology and drug safety

authors： Bunin GR,Baumgarten M,Norman SA,Strom BL,Berlin JA

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:Leukotriene receptor antagonists are used in asthma and rhinitis treatment. Pharmacovigilance data have suggested an association between montelukast and depression, but the association has not been established in controlled study designs. We described the association between initiation of montelukast and depres...

journal_title：Pharmacoepidemiology and drug safety

authors： Winkel JS,Damkier P,Hallas J,Henriksen DP

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Long-term benzodiazepine (BZD) treatment continues to be a debated topic. Because individual BZDs have different clinical profiles, we assessed the nationwide trends of long-term BZD use at active substance level during years 2006 to 2014. METHODS:This study covered all reimbursed BZD purchases (n = 408 572-52...

journal_title：Pharmacoepidemiology and drug safety

authors： Kurko T,Saastamoinen LK,Tuulio-Henriksson A,Taiminen T,Tiihonen J,Airaksinen M,Hietala J

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Direct oral anticoagulants (DOACs) have been promoted in patients with nonvalvular atrial fibrillation (nv-AF) as a more convenient alternative to vitamin K antagonists. We estimated 1-year dabigatran and rivaroxaban adherence rates in nv-AF patients and assessed associations between baseline patient characteri...

journal_title：Pharmacoepidemiology and drug safety

authors： Maura G,Pariente A,Alla F,Billionnet C

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To examine whether patient focused drug surveillance was associated with a higher quality of drug treatment at nursing homes. METHODS:An intervention study in four nursing homes in Sweden and four other nursing homes served as controls. At the intervention nursing homes physicians focused on patients' health s...

journal_title：Pharmacoepidemiology and drug safety

authors： Olsson IN,Curman B,Engfeldt P

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)-related hospitalisations on a population-based level in 2003. METHODS:We performed a cohort study in the Integrated Primary Care Information (IPCI) database, a general practitioners (GPs) research database with longitudinal...

journal_title：Pharmacoepidemiology and drug safety

authors： van der Hooft CS,Dieleman JP,Siemes C,Aarnoudse AJ,Verhamme KM,Stricker BH,Sturkenboom MC

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Stimulants and atomoxetine should generally not be used or used only with caution in adults with pre-existing cardiovascular conditions. The extent to which pre-existing cardiovascular conditions influence initiation of these ADHD medications in adults is not known. METHODS:We performed a retrospective coho...

journal_title：Pharmacoepidemiology and drug safety

authors： Gerhard T,Winterstein AG,Olfson M,Huang C,Saidi A,Crystal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To develop and validate an algorithm to identify preterm infants in the absence of birth certificates within Medicaid data. METHODS:Medicaid fee-for-service claims data from Florida (FL) and Texas (TX) were linked to vital statistics data for infants who were continuously eligible during the first 3 months fol...

journal_title：Pharmacoepidemiology and drug safety

authors： Eworuke E,Hampp C,Saidi A,Winterstein AG

更新日期：2012-06-01 00:00:00

abstract：:The article is devoted to the establishment and development of the National Pharmacovigilance system in Ukraine. A drug safety centre of Ukraine started to form a pharmacovigilance system in 1996. It has been operating on a regular basis since 2000 and now provides the regulatory services that include data collection ...

journal_title：Pharmacoepidemiology and drug safety

authors： Stefanov O,Sharayeva M,Jajtchenja V

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:The decision whether to continue antidepressant use for depression during pregnancy requires weighing maternal and child risks and benefits. Little is known about the effectiveness of antidepressant therapy during pregnancy. The goal of this study is to evaluate whether standard administrative claims data can b...

journal_title：Pharmacoepidemiology and drug safety

authors： Swanson SA,Hernandez-Diaz S,Palmsten K,Mogun H,Olfson M,Huybrechts KF

更新日期：2015-09-01 00:00:00

abstract：:Sixteen pathologically confirmed and 14 suspected cases of a new disease entity, fibrosing colonopathy, have been described in the UK and the US in children with cystic fibrosis since 1991. The patterns of use of pancreatic enzyme supplements in cases were compared with use in controls and in the market, in the 2 year...

journal_title：Pharmacoepidemiology and drug safety

authors： Bakowski MT,Prescott P

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children. METHODS:We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they receiv...

journal_title：Pharmacoepidemiology and drug safety

authors： Tran YH,Groen H,Bergman JE,Hak E,Wilffert B

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To determine prescribing patterns by general physicians working in primary care (GPs) in Iran for the elderly and the prevalence of inappropriate prescribing. METHODS:We collected information about prescribed medicines for 10% of patients in primary care aged 65 years or above in six cities in one province dur...

journal_title：Pharmacoepidemiology and drug safety

authors： Ghadimi H,Esmaily HM,Wahlstrom R

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The objective of this study was to evaluate the prevalence of potential drug-drug interactions (DDIs) in hospitalised patients in correlation with patient's age and number of drugs prescribed and to determine the prevalence of inappropriate drugs prescribed to elderly patients. METHODS:Drugs prescribed during ...

journal_title：Pharmacoepidemiology and drug safety

authors： Radosević N,Gantumur M,Vlahović-Palcevski V

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:In epidemiological studies, non-response may introduce bias and limit generalizability. In genetic pharmacoepidemiological research, collection of DNA might be a major reason for non-response. We determined reasons for non-response and compared characteristics of non-responders and responders in a pharmacogenet...

journal_title：Pharmacoepidemiology and drug safety

authors： van Wieren-de Wijer DB,Maitland-van der Zee AH,de Boer A,Kroon AA,de Leeuw PW,Schiffers P,Janssen RG,Psaty BM,van Duijn CM,Stricker BH,Klungel OH

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Complex medication management in older people with multiple chronic conditions can introduce practice variation in polypharmacy prevalence. This study aimed to determine the inter-practice variation in polypharmacy prevalence and examine how this variation was influenced by patient and practice characteristics....

journal_title：Pharmacoepidemiology and drug safety

authors： Sinnige J,Braspenning JC,Schellevis FG,Hek K,Stirbu I,Westert GP,Korevaar JC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:UK primary care databases are frequently used in observational studies with cancer outcomes. We aimed to systematically review methods used by such studies to identify and validate incident cancers of the breast, colorectum, and prostate. METHODS:Medline and Embase (1980-2013) were searched for UK primary care...

journal_title：Pharmacoepidemiology and drug safety

authors： Rañopa M,Douglas I,van Staa T,Smeeth L,Klungel O,Reynolds R,Bhaskaran K

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate a possible increased risk of esophageal obstruction among users of loratadine and pseudoephedrine (Claritin-D 24-Hour [C-D 24], the original, round, extended-release formulation) compared to two other tablet formulations of loratadine. METHODS:Pharmacy data of 12 managed care plans were screened...

journal_title：Pharmacoepidemiology and drug safety

authors： Manda B,Drinkard CR,Shatin D,Graham DJ

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To evaluate the internet way of feedback to prescribing physicians, providing data on antimicrobial use and to assess the applicability of the DU90% (i.e. Drug Utilisation 90%--the number of drugs accounting for 90% of the volume of usage in defined daily doses, (DDDs)) methodology in the hospital setting. MET...

journal_title：Pharmacoepidemiology and drug safety

authors： Bergman U,Risinggård H,Vlahović-Palcevski V,Ericsson O

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:A case-control study is the most powerful design to test the risk of specific congenital malformations associated with a specific drug. However, malformation registries often lack non-malformed controls. For the Dutch EUROCAT, we collected a non-malformed control group: the 'Healthy Pregnant'. The aim of this s...

journal_title：Pharmacoepidemiology and drug safety

authors： Jentink J,Zetstra-van der Woude AP,Bos J,de Jong-van den Berg LT

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Warfarin is commonly used among patients who receive influenza, pneumococcal, and tetanus and diphtheria toxoid vaccines, and persons on warfarin therapy may also receive Hepatitis A vaccine. There has been concern that vaccinations could potentially alter coagulation parameters in patients on warfarin therapy....

journal_title：Pharmacoepidemiology and drug safety

authors： Jackson ML,Nelson JC,Chen RT,Davis RL,Jackson LA,Vaccine Safety Datalink investigators.

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:We sought to determine the incidence and risks for severe thrombocytopenia (platelets < 50,000/μL) in United States Veteran patients treated with pegylated interferon (PEG-IFN) plus ribavirin for hepatitis C virus-positive (HCV) chronic liver disease (CLD). METHODS:Using a retrospective, observational cohort s...

journal_title：Pharmacoepidemiology and drug safety

authors： Hermos JA,Quach L,Gagnon DR,Weber HC,Altincatal A,Cho K,Lawler EV,Grotzinger KM

更新日期：2014-05-01 00:00:00