Abstract:
PURPOSE:To investigate a possible increased risk of esophageal obstruction among users of loratadine and pseudoephedrine (Claritin-D 24-Hour [C-D 24], the original, round, extended-release formulation) compared to two other tablet formulations of loratadine. METHODS:Pharmacy data of 12 managed care plans were screened to identify users in the three groups from 1 September 1996 to 31 December 1998. Users with a medical claim following their first loratadine prescription (Index prescription) indicating an esophageal obstruction or endoscopic procedure were considered claims-identified cases. Medical records were reviewed to validate case status. RESULTS:There were 233,901 users (61% female) and 245 claims-identified cases occurring within 30 days after the first prescription. The incidence rate per 10,000 users of claims-identified cases occurring on the Index prescription date was higher among C-D 24 users (IR = 1.4) than Claritin Regular (C-R) users (IR = 0.07; p < 0.002) or Claritin-D 12-Hour (C-D 12) users (IR = 0.3; p > 0.05). Medical record review of 15 claims-identified cases confirmed two cases of acute esophageal obstruction, both among C-D 24 users. CONCLUSIONS:Claims-based analysis suggested an increased risk of endoscopic procedures on the Index date among C-D 24 users compared to C-R users. However, after medical record review, the study did not provide conclusive evidence of an association between C-D 24 use and esophageal obstruction. This study highlights the importance of validating findings from claims data using medical records.
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
Manda B,Drinkard CR,Shatin D,Graham DJdoi
10.1002/pds.816keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
29-34issue
1eissn
1053-8569issn
1099-1557journal_volume
13pub_type
杂志文章abstract:OBJECTIVE:To identify the relevant prescribing quality domains of type 2 diabetes mellitus care as a basis for the selection of a minimal set of prescribing quality indicators from a set of previously validated indicators. METHODS:We used the principal factor analysis to identify the underlying dimensions or domains o...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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更新日期:2020-12-01 00:00:00
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更新日期:2002-04-01 00:00:00
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更新日期:2010-06-01 00:00:00
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更新日期:2020-03-01 00:00:00
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更新日期:2016-03-01 00:00:00
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更新日期:2009-04-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2019-08-01 00:00:00
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更新日期:2012-01-01 00:00:00
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