Analysing duration of episodes of pharmacological care: an example of antidepressant use in Danish general practice.

abstract：:We review the concept of time-dependent confounding by using the example in paper "Comparative effectiveness of individual angiotensin receptor blockers on risk of mortality in patients with chronic heart failure" by Desai et al. and illustrate how to adjust for it by using inverse probability of treatment weighting t...

journal_title：Pharmacoepidemiology and drug safety

authors： Yang W,Joffe MM

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Prior event rate ratio (PERR) adjustment method has been proposed to control for unmeasured confounding. We aimed to assess the performance of the PERR method in realistic pharmacoepidemiological settings. METHODS:Simulation studies were performed with varying effects of prior events on the probability of subs...

journal_title：Pharmacoepidemiology and drug safety

authors： Uddin MJ,Groenwold RH,van Staa TP,de Boer A,Belitser SV,Hoes AW,Roes KC,Klungel OH

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Hydroxyzine is indicated for the management of anxiety, skin and sleep disorders. In 2015, the European Medicines Agency (EMA) concluded that hydroxyzine was pro-arrhythmogenic and changes to the product information were implemented in Europe. This study aimed to evaluate their impact in Denmark, Scotland, E...

journal_title：Pharmacoepidemiology and drug safety

authors： Morales DR,Macfarlane T,MacDonald TM,Hallas J,Ernst MT,Herings RMC,Smits E,Overbeek JA,Mitchell L,Morant S,Mackenzie I,Doney ASF,Robertson C,Bennie M,Wei L,Nicholson L,Morris C,Flynn RWF

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:This study evaluated the safety of oseltamivir during the 2009 influenza pandemic. METHODS:Case reports were obtained from the Roche safety database. The incidence of adverse events (AEs) during the pandemic (1 May 2009 to 31 December 2009) was compared with that beforehand (during previous influenza seasons) ...

journal_title：Pharmacoepidemiology and drug safety

authors： Donner B,Bader-Weder S,Schwarz R,Peng MM,Smith JR,Niranjan V

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:This study aimed to examine the effect of antidepressant use on persistence with newly initiated oral antidiabetic medicines in older people. METHODS:A retrospective study of administrative claims data from the Australian Government Department of Veterans' Affairs, from 1 July 2000 to 30 June 2008 of new users...

journal_title：Pharmacoepidemiology and drug safety

authors： Caughey GE,Preiss AK,Vitry AI,Gilbert AL,Ryan P,Shakib S,Esterman A,McDermott RA,Roughead EE

更新日期：2013-06-01 00:00:00

abstract：:Adverse drug reaction surveillance conducted by the US Federal Food and Drug Administration (FDA) is important for detecting new safety information about pharmaceuticals. FDA has sought to stimulate reporting of reactions by practitioners and manufacturers. Over the five years from 1989 to 1993, reporting more than do...

journal_title：Pharmacoepidemiology and drug safety

authors： Faich GA

更新日期：1996-11-01 00:00:00

abstract：PURPOSE:Following safety concerns regarding trimetazidine, the European Medicines Agency (EMA) recommended restrictions on its use. Our objective was to determine the impact of regulatory actions on trimetazidine utilization in Portugal. METHODS:Retrospective interrupted time-series analysis of monthly ambulatory phar...

journal_title：Pharmacoepidemiology and drug safety

authors： Pinto D,Silva A,Heleno B,Rodrigues DS,Santos I,Caetano PA

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:Postmarketing drug safety surveillance relies upon measures of disproportionate reporting in spontaneous reporting systems. It has been hypothesized that products or events reported frequently may "mask" signals. METHODS:We analyzed the masking effect of vaccines in pediatrics in the EudraVigilance database by...

journal_title：Pharmacoepidemiology and drug safety

authors： Dodd C,Pacurariu A,Osokogu OU,Weibel D,Ferrajolo C,Vo DH,Becker B,Kors JA,Sturkenboom M

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The thorough analysis of special drug characteristics requires information on the specific brand of a drug. This information is often not sought in pharmacoepidemiologic surveys although in many countries packages are labelled with an unequivocal code (in Germany called Pharmazentralnummer (PZN)). We aimed to a...

journal_title：Pharmacoepidemiology and drug safety

authors： Quinzler R,Schmitt SP,Szecsenyi J,Haefeli WE

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to examine trends in potentially inappropriate medication (PIM) prescribing in Norwegian nursing homes. METHODS:Patients aged ≥70 years were included from three cross-sectional studies conducted in 1997, 2005 and 2011. PIMs were analyzed according to the Norwegian General Practice-Nur...

journal_title：Pharmacoepidemiology and drug safety

authors： Halvorsen KH,Selbaek G,Ruths S

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record (EHR) databases for large-scale monitoring of drug safety. METHODS:Aggregated demographic, clinical, and prescription data from eight databases in four countri...

journal_title：Pharmacoepidemiology and drug safety

authors： Coloma PM,Schuemie MJ,Trifirò G,Gini R,Herings R,Hippisley-Cox J,Mazzaglia G,Giaquinto C,Corrao G,Pedersen L,van der Lei J,Sturkenboom M,EU-ADR Consortium.

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Clopidogrel is an antiplatelet drug that is prescribed after percutaneous coronary intervention (PCI) to prevent stent thrombosis. Previous studies have suggested that some statins may inhibit the antiplatelet effects of clopidogrel via competitive metabolism of its activating enzyme cytochrome P450 3A4 (CYP...

journal_title：Pharmacoepidemiology and drug safety

authors： Blagojevic A,Delaney JA,Lévesque LE,Dendukuri N,Boivin JF,Brophy JM

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Current guidelines for the empiric treatment of uncomplicated urinary tract infection in women recommend that first-line trimethoprim-sulfamethoxazole (TMP-SMX) or ofloxacin be given for 3 days and nitrofurantoin for 5 days. Increasing the duration of treatment raises costs, and perhaps, the incidence of adv...

journal_title：Pharmacoepidemiology and drug safety

authors： Kahan NR,Chinitz DP,Kahan E

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Days supply (prescription duration) values are commonly used to estimate drug exposure and quantify adherence to therapy, yet accuracy is not routinely assessed, and potential inaccurate reporting has been previously identified. We examined the impact of cleaning days supply values on the measurement of adheren...

journal_title：Pharmacoepidemiology and drug safety

authors： Burden AM,Paterson JM,Gruneir A,Cadarette SM

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the association between socioeconomic position and use of lipid-lowering drugs and ACE-inhibitors after an acute myocardial infarction (AMI) when simultaneously considering participation in the national quality register RIKS-HIA (Register of Information and Knowledge about Swedish Heart Intensive...

journal_title：Pharmacoepidemiology and drug safety

authors： Ohlsson H,Rosvall M,Hansen O,Chaix B,Merlo J

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Gut microbiota has been postulated to serve as a significant promoter of CRC formation, and colonic dysbiosis was previously reported in CRC tissue. Our aim was to evaluate the association between the type and cumulative duration of antibiotic exposure and CRC risk. METHODS:We conducted a nested case-control s...

journal_title：Pharmacoepidemiology and drug safety

authors： Boursi B,Haynes K,Mamtani R,Yang YX

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To determine patterns of United Arab Emirates (UAE) citizen herbal medicine taking. METHODS:Questionnaire survey of UAE citizens attending a primary healthcare clinic in Abu Dhabi. RESULTS:Three hundred and thirty surveys were analysed. Seventy-six per cent (250/330) had previously used herbal products, and o...

journal_title：Pharmacoepidemiology and drug safety

authors： AlBraik FA,Rutter PM,Brown D

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Type 2 diabetes is associated with increased cardiovascular risk. The comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in reducing risk of cardiovascular disease in real-world settings is unknown. METHODS:A retrospective database analysis was performed using a large m...

journal_title：Pharmacoepidemiology and drug safety

authors： Suh HS,Hay JW,Johnson KA,Doctor JN

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:The purpose of this study is to assess positive predictive value (PPV), relative to medical chart review, of International Classification of Diseases (ICD)-9/10 diagnostic codes for identifying opioid overdoses and poisonings. METHODS:Data were obtained from Kaiser Permanente Northwest and Northern California....

journal_title：Pharmacoepidemiology and drug safety

authors： Green CA,Perrin NA,Janoff SL,Campbell CI,Chilcoat HD,Coplan PM

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To assess the effectiveness of additional risk minimization measures (aRMMs) implemented in Europe for colistimethate sodium (CMS) among healthcare professionals (HCPs) and patients/caregivers following safety concerns regarding incorrect use of CMS delivered via Turbospin inhaler. METHODS:A cross-sectional st...

journal_title：Pharmacoepidemiology and drug safety

authors： Kaplan S,Patino O,Rainville C,Madison T

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:The aims of the present study were to evaluate the use of drugs with anticholinergic properties in elderly patients and to identify risk factors that increase the patient's chance of being given such medications. METHODS:The study was performed on a sample of 1636 patients aged ≥65 years hospitalised during th...

journal_title：Pharmacoepidemiology and drug safety

authors： Wawruch M,Macugova A,Kostkova L,Luha J,Dukat A,Murin J,Drobna V,Wilton L,Kuzelova M

更新日期：2012-02-01 00:00:00

abstract：:Sixteen pathologically confirmed and 14 suspected cases of a new disease entity, fibrosing colonopathy, have been described in the UK and the US in children with cystic fibrosis since 1991. The patterns of use of pancreatic enzyme supplements in cases were compared with use in controls and in the market, in the 2 year...

journal_title：Pharmacoepidemiology and drug safety

authors： Bakowski MT,Prescott P

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:This paper introduces an improved tool for designing matched-pairs randomized trials. The tool allows the incorporation of clinical and other knowledge regarding the relative importance of variables used in matching and allows for multiple types of missing data. The method is illustrated in the context of a clu...

journal_title：Pharmacoepidemiology and drug safety

authors： Greevy RA Jr,Grijalva CG,Roumie CL,Beck C,Hung AM,Murff HJ,Liu X,Griffin MR

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To study the human teratogenic potential of two acetylsalicylic acid (ASA) drugs ASA-100 mg and ASA-500 mg. DESIGN:Pair analysis of cases with congenital abnormalities and matched healthy controls. SETTINGS:The large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormali...

journal_title：Pharmacoepidemiology and drug safety

authors： Czeizel AE,Rockenbauer M,Mosonyi A

更新日期：2000-05-01 00:00:00

abstract：:When a biological hypothesis of causal effect can be inferred, the hypothesis can sometimes be tested in the selfsame database that gave rise to the study data from which the hypothesis grew. Valid testing happens when the inferred biological hypothesis has scientific implications that predict new relations between ob...

journal_title：Pharmacoepidemiology and drug safety

authors： Walker AM

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Concomitant use of anti-dementia drugs with psychotropic drugs is potentially problematic in patients with dementia. The aim of this study was to investigate how frequently patients in Norway use anti-dementia drugs concomitantly with psychotropic drugs. METHODS:Analyses are based on data from the Norwegian Pr...

journal_title：Pharmacoepidemiology and drug safety

authors： Langballe EM,Engdahl B,Selbaek G,Nordeng H

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Long-term benzodiazepine (BZD) treatment continues to be a debated topic. Because individual BZDs have different clinical profiles, we assessed the nationwide trends of long-term BZD use at active substance level during years 2006 to 2014. METHODS:This study covered all reimbursed BZD purchases (n = 408 572-52...

journal_title：Pharmacoepidemiology and drug safety

authors： Kurko T,Saastamoinen LK,Tuulio-Henriksson A,Taiminen T,Tiihonen J,Airaksinen M,Hietala J

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Stimulants and atomoxetine should generally not be used or used only with caution in adults with pre-existing cardiovascular conditions. The extent to which pre-existing cardiovascular conditions influence initiation of these ADHD medications in adults is not known. METHODS:We performed a retrospective coho...

journal_title：Pharmacoepidemiology and drug safety

authors： Gerhard T,Winterstein AG,Olfson M,Huang C,Saidi A,Crystal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Multimorbidity (MM) (presence of more than one chronic condition within a same patient) imposes a heavy burden on patients and health care systems. In contrast to high-income countries, the epidemiology of this phenomenon is unclear in low- and middle-income countries, particularly among Iranian population. ME...

journal_title：Pharmacoepidemiology and drug safety

authors： Ebrahimoghli R,Janati A,Sadeghi-Bazargani H,Hamishehkar H,Ghaffari S,Sanaat Z,Farahbakhsh M,Farhoudi M,Khalili-Azimi A

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Triptan medications are serotonin agonists used to treat migraine, a chronic pain condition highly prevalent in women of reproductive age. Data on the safety of triptans during pregnancy are scant. We sought to quantify the association of prenatal triptan exposure on neurodevelopment in 3-year-old children. ME...

journal_title：Pharmacoepidemiology and drug safety

authors： Wood ME,Frazier JA,Nordeng HM,Lapane KL

更新日期：2016-05-01 00:00:00