Safety profile of oseltamivir during the 2009 influenza pandemic.

abstract：:Meloxicam (Mobic((R))) was introduced in the UK in 1996 as a nonsteroidal anti-inflammatory drug (NSAID). To help evaluate the postmarketing experience with meloxicam in the UK, we used the General Practitioners Research Database (GPRD) to characterize the baseline risk of an upper gastrointestinal (GI) event among ne...

journal_title：Pharmacoepidemiology and drug safety

authors： Lanes SF,Rodrígeuz LA,Hwangg E

更新日期：2000-03-01 00:00:00

abstract：PURPOSE:Bayesian hierarchical models (BHMs) have been used to identify adverse drug reactions, allowing information sharing amongst adverse reactions and drugs expected to have similar properties. This study evaluated the use of BHMs in the routine signal detection analyses of potential first-trimester teratogens, wher...

journal_title：Pharmacoepidemiology and drug safety

authors： Cavadino A,Prieto-Merino D,Morris JK

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:We developed an adverse events (AEs) reporting form for Korean folk medicine. METHODS:The first version of the form was developed and tested in the clinical setting for spontaneous reporting of AEs. Additional revisions to the reporting form were made based on collected data and expert input. RESULTS:We devel...

journal_title：Pharmacoepidemiology and drug safety

authors： Park JH,Choi SM,Moon S,Kim S,Kim B,Kim MK,Lee S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The role of administrative databases for research on drug safety during pregnancy can be limited by their inaccurate assessment of the timing of exposure, as the gestational age at birth is typically unavailable. Therefore, we sought to develop and validate algorithms to estimate the gestational age at birth us...

journal_title：Pharmacoepidemiology and drug safety

authors： Margulis AV,Setoguchi S,Mittleman MA,Glynn RJ,Dormuth CR,Hernández-Díaz S

更新日期：2013-01-01 00:00:00

abstract：AIM:To determine the appropriate size of risk windows in both exposed and unexposed sub-cohorts. METHOD:Data was taken from a previous study of upper gastrointestinal haemorrhage and perforation. The length of each prescription for NSAIDs was estimated. The risk was calculated for the duration of a prescription plus i...

journal_title：Pharmacoepidemiology and drug safety

authors： McMahon AD,Evans JM,McGilchrist MM,McDevitt DG,MacDonald TM

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:Ejection fraction (EF) is crucial information when studying the use and effectiveness of therapies in patients with heart failure (HF) and myocardial infarction (MI). We aimed to assess the validity of claims data-based definitions of systolic dysfunction (SD). METHODS:We identified 1072 patients with EF recor...

journal_title：Pharmacoepidemiology and drug safety

authors： Li Q,Glynn RJ,Dreyer NA,Liu J,Mogun H,Setoguchi S

更新日期：2011-07-01 00:00:00

abstract：:Not everything is known about a medicine when it receives its licence for marketing. The merits of a new drug, balancing its beneficial and its untoward effects, become only established after sufficient experience has been gained from its use in real practice. Part of the reason for this is that our extensive phase II...

journal_title：Pharmacoepidemiology and drug safety

authors： Amery WK,ISPE.

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:We sought to describe the epidemiology of viral respiratory-tract infections and patterns in prescriptions of cough and cold medications among young children who were suffering from viral respiratory tract infections (vRTIs). METHODS:We conducted a cross-sectional study to examine vRTI-episode occurrence and...

journal_title：Pharmacoepidemiology and drug safety

authors： Cheng CL,Kao Yang YH,Liu CC,Lee PI

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:We describe the design, implementation, and use of a large, multiorganizational distributed database developed to support the Mini-Sentinel Pilot Program of the US Food and Drug Administration (FDA). As envisioned by the US FDA, this implementation will inform and facilitate the development of an active surveil...

journal_title：Pharmacoepidemiology and drug safety

authors： Curtis LH,Weiner MG,Boudreau DM,Cooper WO,Daniel GW,Nair VP,Raebel MA,Beaulieu NU,Rosofsky R,Woodworth TS,Brown JS

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Determine the relative risk of cancer users of commonly prescribed antihypertensive drugs with a focus on documenting risk in long-term users (>7.5 years). METHODS:We conducted a nested case-control study using the Saskatchewan Health databases. Cancer risks in users of beta-blockers, calcium channel blockers ...

journal_title：Pharmacoepidemiology and drug safety

authors： Assimes TL,Elstein E,Langleben A,Suissa S

更新日期：2008-11-01 00:00:00

abstract：:The General Practice Research Database (GPRD) is the world's largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool. Several issues have threatened the viability of the database in recent years; in April 1999 responsibility for its man...

journal_title：Pharmacoepidemiology and drug safety

authors： Wood L,Coulson R

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Propensity scores are used in observational studies to adjust for confounding, although they do not provide control for confounders omitted from the propensity score model. We sought to determine if tests used to evaluate logistic model fit and discrimination would be helpful in detecting the omission of an imp...

journal_title：Pharmacoepidemiology and drug safety

authors： Weitzen S,Lapane KL,Toledano AY,Hume AL,Mor V

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:To conduct a synthesis of the literature on methods to evaluate the impacts of FDA regulatory actions and identify best practices for future evaluations. METHODS:We searched MEDLINE for manuscripts published between January 1948 and August 2011 that included terms related to FDA, regulatory actions, and empiri...

journal_title：Pharmacoepidemiology and drug safety

authors： Briesacher BA,Soumerai SB,Zhang F,Toh S,Andrade SE,Wagner JL,Shoaibi A,Gurwitz JH

更新日期：2013-09-01 00:00:00

abstract：:Analysing duration of treatment episodes has become a standard task in many pharmacoepidemiological studies. However, such analyses are often carried out in a rather simplistic manner and more subtle issues are often ignored. In this paper, methods of analysing duration treatment episodes beyond simple analyses allowi...

journal_title：Pharmacoepidemiology and drug safety

authors： Gichangi A,Andersen M,Kragstrup J,Vach W

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:We use simulations and an empirical example to evaluate the performance of disease risk score (DRS) matching compared with propensity score (PS) matching when controlling large numbers of covariates in settings involving newly introduced treatments. METHODS:We simulated a dichotomous treatment, a dichotomous o...

journal_title：Pharmacoepidemiology and drug safety

authors： Wyss R,Ellis AR,Brookhart MA,Jonsson Funk M,Girman CJ,Simpson RJ Jr,Stürmer T

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To review conceptual issues regarding confounding by indication in the context of studies of calcium channel blockers (CCBs). METHODS:Review of literature, with special attention to two articles in the current issue. RESULTS:Conflicting arguments about the presence of uncontrollable confounding by indication ...

journal_title：Pharmacoepidemiology and drug safety

authors： Joffe MM

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:The General Practice Research Database (GPRD) is a database of longitudinal patient records from general practices in the United Kingdom. It is an important data source for pharmacoepidemiology studies, but until now it has been tedious to calculate the daily dose and duration of exposure to drugs prescribed. T...

journal_title：Pharmacoepidemiology and drug safety

authors： Shah AD,Martinez C

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Clinical trials of olmesartan for prevention of progression of renal disease in patients with diabetes showed renal protection but an unexpected imbalance in cardiac deaths. The US Food and Drug Administration requested from the manufacturer a cohort study of olmesartan, other angiotensin-receptor blockers (ARB...

journal_title：Pharmacoepidemiology and drug safety

authors： Walker AM,Liang C,Clifford CR,Parker C,Feldman A

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:To determine healthcare claim patterns associated using nonsteroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis (RA). METHODS:The CADEUS study randomly identified NSAID users within the French health insurance database. One-year claims data were extracted, and NSAID indication was obtained from ...

journal_title：Pharmacoepidemiology and drug safety

authors： Bernard MA,Bénichou J,Blin P,Weill A,Bégaud B,Abouelfath A,Moore N,Fourrier-Réglat A,CADEUS Team.

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Clopidogrel is an antiplatelet drug that is prescribed after percutaneous coronary intervention (PCI) to prevent stent thrombosis. Previous studies have suggested that some statins may inhibit the antiplatelet effects of clopidogrel via competitive metabolism of its activating enzyme cytochrome P450 3A4 (CYP...

journal_title：Pharmacoepidemiology and drug safety

authors： Blagojevic A,Delaney JA,Lévesque LE,Dendukuri N,Boivin JF,Brophy JM

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with severe renal complications, including acute renal failure, reduced glomerular filtration rate and interstitial nephritis. Caution against NSAIDs is therefore recommended in advanced chronic kidney disease. In this study, we examined NSAID use,...

journal_title：Pharmacoepidemiology and drug safety

authors： Kristensen SL,Fosbøl EL,Kamper AL,Køber L,Hommel K,Lamberts M,Abildstrøm SZ,Blicher TM,Torp-Pedersen C,Gislason GH

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Pharmacoepidemiologic studies of acute effects of episodic exposures often must control for many time-dependent confounders. Marginal structural models permit this and provide unbiased estimates when confounders are on the causal pathway. However, if causal pathway confounding is minimal, analyses with time-dep...

journal_title：Pharmacoepidemiology and drug safety

authors： Ray WA,Liu Q,Shepherd BE

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Stimulants and atomoxetine should generally not be used or used only with caution in adults with pre-existing cardiovascular conditions. The extent to which pre-existing cardiovascular conditions influence initiation of these ADHD medications in adults is not known. METHODS:We performed a retrospective coho...

journal_title：Pharmacoepidemiology and drug safety

authors： Gerhard T,Winterstein AG,Olfson M,Huang C,Saidi A,Crystal S

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To evaluate the concurrent validity of three European sets of drug-specific indicators of prescribing quality METHODS:In 200 hip fracture patients (≥65 years), consecutively recruited to a randomized controlled study in Sahlgrenska University Hospital in 2009, quality of drug treatment at study entry was asses...

journal_title：Pharmacoepidemiology and drug safety

authors： Wallerstedt SM,Belfrage B,Fastbom J

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Adverse drug events (ADEs) are an important cause of preventable hospitalizations among elderly individuals taking high-risk medications. The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin. METHODS:We conducted a prospectiv...

journal_title：Pharmacoepidemiology and drug safety

authors： Haynes K,Hennessy S,Localio AR,Cohen A,Leonard CE,Kimmel SE,Feldman HI,Strom BL,Metlay JP

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Previous reports have suggested that new evidence of the comparative effectiveness of different medication classes from randomized controlled trials (RCTs) does not always alter treatment decisions for first-line anti-hypertensive therapy. OBJECTIVES:To evaluate the association of RCT evidence in December 2...

journal_title：Pharmacoepidemiology and drug safety

authors： Delaney JA,McClelland RL,Furberg CD,Cooper R,Shea S,Burke G,Psaty BM

更新日期：2009-09-01 00:00:00

abstract：AIMS:To evaluate the pattern of prescribing of angiotensin-converting enzyme (ACE) inhibitors in general practice, related to the primary clinical diagnosis and concomitant medication. DESIGN:A descriptive survey of general practitioners' prescribing habits, presumptive diagnosis and patient demography over a period o...

journal_title：Pharmacoepidemiology and drug safety

authors： Connolly JP,Silke B,McGavock H,Wilson-Davies K

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To examine the effects of analgesics on bone mineral density (BMD), which have not been examined in a longitudinal study with multiple measurements. METHODS:We investigated changes in BMD associated with new use of analgesics in a prospective longitudinal cohort of mid-life women. BMD and medication use were m...

journal_title：Pharmacoepidemiology and drug safety

authors： Yoshida K,Yu Z,Greendale GA,Ruppert K,Lian Y,Tedeschi SK,Lin TC,Haneuse S,Glynn RJ,Hernández-Díaz S,Solomon DH

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:In pharmacoepidemiology, one of the main concerns is analysis of drug exposure time. However, in real-life settings, patient's behavior is complex and characterized by drug exposure dynamics. Multi-state models allow assessing the probabilities of various patterns, instead of just continuous use and/or disconti...

journal_title：Pharmacoepidemiology and drug safety

authors： Boucherie Q,Pauly V,Frauger E,Thirion X,Pradel V,Micallef J

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Discontinuing low-dose acetylsalicylic acid (ASA) therapy after upper gastrointestinal bleeding (UGIB) may increase the risk of cardiovascular-related death. Our aim was to compare mortality in UK primary care patients who discontinue ASA after UGIB with that in patients who continue therapy. METHODS:ASA users...

journal_title：Pharmacoepidemiology and drug safety

authors： González-Pérez A,Sáez ME,Johansson S,Nagy P,García Rodríguez LA

更新日期：2017-02-01 00:00:00