Long-term use of antihypertensive drugs and risk of cancer.

Abstract:

PURPOSE:Determine the relative risk of cancer users of commonly prescribed antihypertensive drugs with a focus on documenting risk in long-term users (>7.5 years). METHODS:We conducted a nested case-control study using the Saskatchewan Health databases. Cancer risks in users of beta-blockers, calcium channel blockers (CCBs), and rennin-angiotensin system inhibitors (RASIs), respectively, were compared to risks in users of thiazide diuretics. RESULTS:A total of 11,697 first cases of cancer and the subset of 6918 subjects who died from cancer were each matched to 10 controls. The mean total duration of use of the four classes of antihypertensive drugs (estimated by dispensation of prescriptions) ranged from 3.6 to 5.7 years. A subgroup of cases was exposed long term (mean total duration of use: 9.7-11.4 years, range: 7.5-23.1 years). Modest differences in risk between users of the four classes were detected for colon, head & neck, lung, and hematological cancers but none of these associations demonstrated a clear dose response relationship for both first cancer and fatal cancer. Otherwise, for cancer at all sites combined and for the four most common cancers, we were able to rule out, with reasonable confidence, small to modest differences in the risk of cancer among users of any duration (upper 95% confidence intervals (CIs): 1.45) and modest to large differences in risk among long-term users (upper 95%CI: 3.06). CONCLUSIONS:The long-term use of commonly prescribed classes of antihypertensive drugs does not appear to promote or initiate cancer.

authors

Assimes TL,Elstein E,Langleben A,Suissa S

doi

10.1002/pds.1656

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1039-49

issue

11

eissn

1053-8569

issn

1099-1557

journal_volume

17

pub_type

杂志文章
  • The positive predictive value of a hyperkalemia diagnosis in automated health care data.

    abstract:PURPOSE:Our objectives were to determine performance of coded hyperkalemia diagnosis at identifying (1) clinically evident hyperkalemia and (2) serum potassium>6 mmol/L. METHODS:This retrospective observational study included 8722 patients with diabetes within an integrated healthcare system who newly initiated an ang...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2030

    authors: Raebel MA,Smith ML,Saylor G,Wright LA,Cheetham C,Blanchette CM,Xu S

    更新日期:2010-11-01 00:00:00

  • Hospital usage of antibacterial agents in relation to size and type of hospital and geographical situation.

    abstract:PURPOSE:The objective of this study was to evaluate the level of use and therapy profile of antibacterial agents in hospitals. Further to explore whether type, size or geographical situation influenced antibacterial agents used. METHODS:Antibacterial use during 1998-1999, in 13 hospitals, including emergency, referral...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1080

    authors: Blix HS,Hartug S

    更新日期:2005-09-01 00:00:00

  • Assessment of colistimethate sodium (COLOBREATHE) risk minimization measures implemented in the European Union: A cross-sectional study.

    abstract:PURPOSE:To assess the effectiveness of additional risk minimization measures (aRMMs) implemented in Europe for colistimethate sodium (CMS) among healthcare professionals (HCPs) and patients/caregivers following safety concerns regarding incorrect use of CMS delivered via Turbospin inhaler. METHODS:A cross-sectional st...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4940

    authors: Kaplan S,Patino O,Rainville C,Madison T

    更新日期:2020-02-01 00:00:00

  • Evaluation of the representativeness of a Dutch non-malformed control group for the general pregnant population: are these controls useful for EUROCAT?

    abstract:PURPOSE:A case-control study is the most powerful design to test the risk of specific congenital malformations associated with a specific drug. However, malformation registries often lack non-malformed controls. For the Dutch EUROCAT, we collected a non-malformed control group: the 'Healthy Pregnant'. The aim of this s...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2254

    authors: Jentink J,Zetstra-van der Woude AP,Bos J,de Jong-van den Berg LT

    更新日期:2011-11-01 00:00:00

  • A systematic review of validated methods for identifying atrial fibrillation using administrative data.

    abstract:PURPOSE:The objectives of this study were to characterize the validity of algorithms to identify AF from electronic health data through a systematic review of the literature and to identify gaps needing further research. METHODS:Two reviewers examined publications during 1997-2008 that identified patients with atrial ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.2317

    authors: Jensen PN,Johnson K,Floyd J,Heckbert SR,Carnahan R,Dublin S

    更新日期:2012-01-01 00:00:00

  • Development and validation of a 5-year mortality prediction model using regularized regression and Medicare data.

    abstract:PURPOSE:De-implementation of low-value services among patients with limited life expectancy is challenging. Robust mortality prediction models using routinely collected health care data can enhance health care stakeholders' ability to identify populations with limited life expectancy. We developed and validated a claim...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4769

    authors: Lund JL,Kuo TM,Brookhart MA,Meyer AM,Dalton AF,Kistler CE,Wheeler SB,Lewis CL

    更新日期:2019-05-01 00:00:00

  • A computerized system for signal detection in spontaneous reporting system of Shanghai China.

    abstract:PURPOSE:We developed a computerized system for signal detection in spontaneous reporting system (SRS) of Shanghai. Data acquisition, data mining could be carried out automatically and the process of data preprocessing and cleaning could be facilitated. This system was expected to detect signals from SRS after drug lice...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1695

    authors: Ye X,Fu Z,Wang H,Du W,Wang R,Sun Y,Gao Q,He J

    更新日期:2009-02-01 00:00:00

  • Bayesian hierarchical methods in the detection of potentially teratogenic first-trimester medications.

    abstract:PURPOSE:Bayesian hierarchical models (BHMs) have been used to identify adverse drug reactions, allowing information sharing amongst adverse reactions and drugs expected to have similar properties. This study evaluated the use of BHMs in the routine signal detection analyses of potential first-trimester teratogens, wher...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4948

    authors: Cavadino A,Prieto-Merino D,Morris JK

    更新日期:2020-03-01 00:00:00

  • The choice of pharmacoeconomic study design during drug development--part 2.

    abstract::Pharmaceutical manufacturers are faced with the challenge of when and how to conduct pharmacoeconomic (PE) evaluations to satisfy formulary decision-makers. To illustrate the usefulness of decision analysis for strategic planning in drug development, a model was created to compare the cost-benefit of three PE design o...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-1557(199711/12)6:6<399::AID-PDS

    authors: Ungar W

    更新日期:1997-11-01 00:00:00

  • Drug safety data mining with a tree-based scan statistic.

    abstract:PURPOSE:In post-marketing drug safety surveillance, data mining can potentially detect rare but serious adverse events. Assessing an entire collection of drug-event pairs is traditionally performed on a predefined level of granularity. It is unknown a priori whether a drug causes a very specific or a set of related adv...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3423

    authors: Kulldorff M,Dashevsky I,Avery TR,Chan AK,Davis RL,Graham D,Platt R,Andrade SE,Boudreau D,Gunter MJ,Herrinton LJ,Pawloski PA,Raebel MA,Roblin D,Brown JS

    更新日期:2013-05-01 00:00:00

  • Cluster randomized trials to study the comparative effectiveness of therapeutics: stakeholders' concerns and recommendations.

    abstract:PURPOSE:To describe the concerns raised by health plan members, providers and purchasers related to studying the comparative effectiveness of therapeutics using cluster randomized trials (CRTs) within health plans. An additional goal was to develop recommendations for increasing acceptability. METHODS:Eighty-four qual...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1754

    authors: Mazor KM,Sabin JE,Goff SL,Smith DH,Rolnick S,Roblin D,Raebel MA,Herrinton LJ,Gurwitz JH,Boudreau D,Meterko V,Dodd KS,Platt R

    更新日期:2009-07-01 00:00:00

  • The state of dietary supplement adverse event reporting in the United States.

    abstract:PURPOSE:The Dietary Supplements Information Expert Committee (DSI-EC; the Committee) of the United States Pharmacopeial Convention (USP) reviews safety profiles of dietary supplements before development of USP-National Formulary (USP-NF) quality monographs. Because the veracity of dietary supplement adverse event repor...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.1627

    authors: Gardiner P,Sarma DN,Low Dog T,Barrett ML,Chavez ML,Ko R,Mahady GB,Marles RJ,Pellicore LS,Giancaspro GI

    更新日期:2008-10-01 00:00:00

  • A critical review of methods to evaluate the impact of FDA regulatory actions.

    abstract:PURPOSE:To conduct a synthesis of the literature on methods to evaluate the impacts of FDA regulatory actions and identify best practices for future evaluations. METHODS:We searched MEDLINE for manuscripts published between January 1948 and August 2011 that included terms related to FDA, regulatory actions, and empiri...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.3480

    authors: Briesacher BA,Soumerai SB,Zhang F,Toh S,Andrade SE,Wagner JL,Shoaibi A,Gurwitz JH

    更新日期:2013-09-01 00:00:00

  • Prevalence of risk factors for suicide in patients prescribed venlafaxine, fluoxetine, and citalopram.

    abstract:PURPOSE:Three recent observational studies reported that the risk of fatal overdose is greater with venlafaxine than SSRI use. It is not clear whether patient factors could account for this finding. We evaluated whether risk factors for suicide are more prevalent among patients prescribed venlafaxine than patients pres...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1095

    authors: Mines D,Hill D,Yu H,Novelli L

    更新日期:2005-06-01 00:00:00

  • Association between drug-specific indicators of prescribing quality and quality of drug treatment: a validation study.

    abstract:PURPOSE:To evaluate the concurrent validity of three European sets of drug-specific indicators of prescribing quality METHODS:In 200 hip fracture patients (≥65 years), consecutively recruited to a randomized controlled study in Sahlgrenska University Hospital in 2009, quality of drug treatment at study entry was asses...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/pds.3827

    authors: Wallerstedt SM,Belfrage B,Fastbom J

    更新日期:2015-09-01 00:00:00

  • Potential bias in pharmacoepidemiological studies due to the length of the drug free period: a study on antidepressant drug use in adults in the Netherlands.

    abstract:PURPOSE:The aim of this study was to evaluate the effect of the length of the drug free period on incidence measurements as well as on cohort characteristics in users of antidepressants. METHODS:The study population consisted of patients aged 18 years or older who filled a prescription for an antidepressant drug in th...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1223

    authors: Gardarsdottir H,Heerdink ER,Egberts AC

    更新日期:2006-05-01 00:00:00

  • Long-term persistence and adherence to blood pressure lowering agents among older Australians.

    abstract:PURPOSE:Poor adherence and persistence to blood pressure lowering (BPL) agents leads to increased risk of morbidity and mortality. The aim of this study was to investigate the long-term adherence, persistence, and re-initiation of BPL agents among older Australians (aged ≥65 years). METHODS:We utilised the Pharmaceuti...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4742

    authors: Si S,Ofori-Asenso R,Briffa T,Sanfilippo FM,Ilomaki J,Qin X,Tacey M,Reid CM,Liew D

    更新日期:2019-06-01 00:00:00

  • Increase in the duration of antidepressant treatment from 1994 to 2003: a nationwide population-based study from Finland.

    abstract:OBJECTIVE:We examined the length and continuity of antidepressant treatment and factors associated with long-term of treatment among adults. METHODS:Nationwide data from all reimbursed antidepressant prescriptions in 1994-2003 were linked with patients' data retrieved from Statistics Finland and the Finnish Hospital D...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2017

    authors: Sihvo S,Wahlbeck K,McCallum A,Sevon T,Arffman M,Haukka J,Keskimäki I,Hemminki E

    更新日期:2010-11-01 00:00:00

  • vigiRank for statistical signal detection in pharmacovigilance: First results from prospective real-world use.

    abstract:PURPOSE:vigiRank is a data-driven predictive model for emerging safety signals. In addition to disproportionate reporting patterns, it also accounts for the completeness, recency, and geographic spread of individual case reporting, as well as the availability of case narratives. Previous retrospective analysis suggeste...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4247

    authors: Caster O,Sandberg L,Bergvall T,Watson S,Norén GN

    更新日期:2017-08-01 00:00:00

  • Comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in patients with type 2 diabetes: use of propensity-score and instrumental variable methods to adjust for treatment-selection bias.

    abstract:PURPOSE:Type 2 diabetes is associated with increased cardiovascular risk. The comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in reducing risk of cardiovascular disease in real-world settings is unknown. METHODS:A retrospective database analysis was performed using a large m...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3261

    authors: Suh HS,Hay JW,Johnson KA,Doctor JN

    更新日期:2012-05-01 00:00:00

  • Design considerations, architecture, and use of the Mini-Sentinel distributed data system.

    abstract:PURPOSE:We describe the design, implementation, and use of a large, multiorganizational distributed database developed to support the Mini-Sentinel Pilot Program of the US Food and Drug Administration (FDA). As envisioned by the US FDA, this implementation will inform and facilitate the development of an active surveil...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2336

    authors: Curtis LH,Weiner MG,Boudreau DM,Cooper WO,Daniel GW,Nair VP,Raebel MA,Beaulieu NU,Rosofsky R,Woodworth TS,Brown JS

    更新日期:2012-01-01 00:00:00

  • Proton pump inhibitors and traditional nonsteroidal anti-inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury.

    abstract:PURPOSE:This study aims to examine the associations between proton pump inhibitors (PPIs), traditional nonsteroidal anti-inflammatory drugs (tNSAIDs), PPI + tNSAID co-exposure, and the development of the following: (i) acute interstitial nephritis (AIN), a specific kidney injury often attributed to these drugs, and (ii...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3329

    authors: Leonard CE,Freeman CP,Newcomb CW,Reese PP,Herlim M,Bilker WB,Hennessy S,Strom BL

    更新日期:2012-11-01 00:00:00

  • In utero opioid exposure and risk of infections in childhood: A multinational Nordic cohort study.

    abstract:PURPOSE:There is an increasing number of children with in utero exposure to opioids. Knowledge about opioid safety in pregnancy, particularly for outcomes later in childhood is scarce. It has been suggested that opioids can modulate immune system and increase the risk of infections. Our goal was to study the impact of ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.5088

    authors: Mahic M,Hernandez-Diaz S,Wood M,Kieler H,Odsbu I,Nørgaard M,Öztürk B,Bateman BT,Hjellvik V,Skurtveit S,Handal M

    更新日期:2020-12-01 00:00:00

  • Do people regard cheaper medicines effective? Population survey on public opinion of generic substitution in Finland.

    abstract:PURPOSE:Generic substitution (GS) is an important way to decrease medical costs. We aimed to study the opinions and attitudes of Finnish people about GS five years after it was introduced, the reasons for substituting and what people think about generic medicines. METHODS:We sent a postal survey to a random stratified...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2084

    authors: Heikkilä R,Mäntyselkä P,Ahonen R

    更新日期:2011-02-01 00:00:00

  • Global benefit-risk analysis of adjunctive aripiprazole in the treatment of patients with major depressive disorder.

    abstract:OBJECTIVE:This study quantified the overall merit of adjunctive aripiprazole in major depressive disorder (MDD). METHODS:Global benefit-risk (GBR) analysis quantified the benefit and risk differences between adjunctive aripiprazole and antidepressant (ADT) monotherapy. Three hundred and fifty six patients receiving AD...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1805

    authors: Wisniewski SR,Chen CC,Kim E,Kan HJ,Guo Z,Carlson BX,Tran QV,Pikalov A

    更新日期:2009-10-01 00:00:00

  • Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients?

    abstract:PURPOSE:We conducted a nested case-control study to evaluate the association between risk of cancer and mirtazapine use in depression patients in Taiwan. METHODS:We obtained data from the Taiwan National Health Insurance Research Database to conduct a population-based nested case-control study. The study cohort includ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3523

    authors: Sun LM,Lin MC,Liang JA,Chang YJ,Chang SN,Sung FC,Muo CH,Kao CH

    更新日期:2013-12-01 00:00:00

  • Psychotropics use in the Spanish elderly: predictors and evolution between years 1993 and 2003.

    abstract:PURPOSE:This study mainly aimed at describing the prevalence of psychotropic medication consumption in the Spanish elderly population between the years 1993 and 2003. METHODS:Descriptive, cross-sectional study covering the Spanish population aged 65 years and over, using data drawn from the 1993 and 2003 Spanish Natio...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1344

    authors: Carrasco-Garrido P,Jiménez-García R,Astasio-Arbiza P,Ortega-Molina P,de Miguel AG

    更新日期:2007-04-01 00:00:00

  • Measures to quantify the abuse of prescription opioids: a review of data sources and metrics.

    abstract:PURPOSE:The abuse and nonmedical use of prescription opioids and its subsequent consequences are an important public health concern. This phenomenon has paralleled the increase in the therapeutic use of opioids for pain management. There is thus a need to measure prescription opioid abuse to understand trends over time...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.3711

    authors: Secora AM,Dormitzer CM,Staffa JA,Dal Pan GJ

    更新日期:2014-12-01 00:00:00

  • Establishment of a pharmacoepidemiological database in Germany: methodological potential, scientific value and practical limitations.

    abstract:PURPOSE:We present a new population-based pharmacoepidemiological (PE) database obtained from statutory health insurances (SHIs) that is able to generate signals, to monitor prescribed drugs and to describe drug utilisation. We discuss methodological features of the database and we assess to which degree this database ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1545

    authors: Pigeot I,Ahrens W

    更新日期:2008-03-01 00:00:00

  • Patterns of prescription of four major antipsychotics: a retrospective study based on medical records of psychiatric inpatients.

    abstract:PURPOSE:(1) To identify factors associated with the choice among the three atypical antipsychotics available in France (amisulpride, olanzapine, risperidone) and the typical antipsychotic of reference: (haloperidol), (2) to compare psychotropic co-prescription rates according to antipsychotic. METHODS:All antipsychoti...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1122

    authors: Gasquet I,Gury C,Tcherny-Lessenot S,Quesnot A,Gaudebout P

    更新日期:2005-11-01 00:00:00