Effects of analgesics on bone mineral density: A longitudinal analysis of the prospective SWAN cohort with three-group matching weights.

Abstract:

PURPOSE:To examine the effects of analgesics on bone mineral density (BMD), which have not been examined in a longitudinal study with multiple measurements. METHODS:We investigated changes in BMD associated with new use of analgesics in a prospective longitudinal cohort of mid-life women. BMD and medication use were measured annually. We compared BMD among new users of acetaminophen, NSAIDs, and opioids. Adjustment for baseline covariates was conducted through propensity score matching weights. On-treatment analysis was conducted with inverse probability of censoring weights. Analysis based on the initial treatment group was also conducted to provide insights into selection bias. Repeated BMD measurements were examined with generalized estimating equations. RESULTS:We identified 71 acetaminophen new users, 659 NSAID new users, and 84 opioid new users among 2365 participants. In the on-treatment analysis, the opioid group in comparison to the acetaminophen group had an additional average BMD decline of -0.06% [-1.24, 1.11] per year in the spine and -0.45% [-1.51, 0.61] per year in the femoral neck. BMD mean trajectories over time suggested a fifth-year decline in the opioid persistent users compared with other 2 groups. In the initial treatment group analysis, all 3 groups showed similar trajectories. CONCLUSION:The BMD decline over time was similar among the 3 groups. However, 5 years of continuous opioid use may be associated with a greater BMD decline than 5 years on other analgesics. Further studies examining the relationship between very long-term persistent opioid use and BMD are warranted.

authors

Yoshida K,Yu Z,Greendale GA,Ruppert K,Lian Y,Tedeschi SK,Lin TC,Haneuse S,Glynn RJ,Hernández-Díaz S,Solomon DH

doi

10.1002/pds.4362

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

182-190

issue

2

eissn

1053-8569

issn

1099-1557

journal_volume

27

pub_type

杂志文章
  • Pharmacoepidemiologic implications of erroneous varicella vaccinations in pregnancy through confusion with Varicella zoster immune globulin.

    abstract::A series of case reports to the varicella vaccine Pregnancy Registry described inadvertent administrations during pregnancy of this live virus product instead of the intended Varicella zoster immune globulin. Cases continued to accrue despite an early publication about the pattern. The persistent problem warrants spec...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.749

    authors: Wise RP,Braun MM,Seward JF,Mootrey GT,Shields KE,Salive ME,Krause PR

    更新日期:2002-12-01 00:00:00

  • The role of 5α-reductase inhibitors in gastro-oesophageal cancer risk: A nested case-control study.

    abstract:PURPOSE:The strong male predominance of gastro-oesophageal cancer suggests that sex hormones play an important role. 5α-Reductase (5AR) inhibitors have antiandrogen effects and have been shown to decrease cancer cell proliferation and metastasis. We conducted the first epidemiologic investigation into the association b...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4909

    authors: Busby J,Karasneh R,Murchie P,McMenamin Ú,Gadalla SM,Camargo MC,Iversen L,Lee AJ,Spence AD,Cardwell CR

    更新日期:2020-01-01 00:00:00

  • QUALYOP project 2: monitoring the dismantling of Italian psychiatric hospitals. Psychotropic drug use in 1072 inpatients.

    abstract:OBJECTIVE:This study describes the use of psychotropic drugs in a sample of eight Italian psychiatric hospitals. METHODS:A cross-sectional approach was used to collect information about sociodemographic and clinical characteristics of the inpatient population, and about medications prescribed. Prescribing behaviour in...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-1557(199908/09)8:5<331::AID-PDS

    authors: Barbui C,D'Avanzo B,Frattura L,Saraceno B

    更新日期:1999-08-01 00:00:00

  • Does antidepressant medication use affect persistence with diabetes medicines?

    abstract:PURPOSE:This study aimed to examine the effect of antidepressant use on persistence with newly initiated oral antidiabetic medicines in older people. METHODS:A retrospective study of administrative claims data from the Australian Government Department of Veterans' Affairs, from 1 July 2000 to 30 June 2008 of new users...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3424

    authors: Caughey GE,Preiss AK,Vitry AI,Gilbert AL,Ryan P,Shakib S,Esterman A,McDermott RA,Roughead EE

    更新日期:2013-06-01 00:00:00

  • An algorithm to derive a numerical daily dose from unstructured text dosage instructions.

    abstract:PURPOSE:The General Practice Research Database (GPRD) is a database of longitudinal patient records from general practices in the United Kingdom. It is an important data source for pharmacoepidemiology studies, but until now it has been tedious to calculate the daily dose and duration of exposure to drugs prescribed. T...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1151

    authors: Shah AD,Martinez C

    更新日期:2006-03-01 00:00:00

  • A large simple clinical trial prototype for assessment of OTC drug effects using patient-reported data.

    abstract:PURPOSE:Innovative methods are needed to assess risks related to treatment for common medical conditions, where therapy is usually patient-directed or over-the-counter (OTC), and where tolerability, i.e. patient experienced events, may affect patterns of use. A large-scale, blinded, randomised trial was conducted to co...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/pds.1083

    authors: Van Ganse E,Jones JK,Moore N,Parc JM,Wall R,Schneid H

    更新日期:2005-04-01 00:00:00

  • Socioeconomic position and secondary preventive therapy after an AMI.

    abstract:PURPOSE:To investigate the association between socioeconomic position and use of lipid-lowering drugs and ACE-inhibitors after an acute myocardial infarction (AMI) when simultaneously considering participation in the national quality register RIKS-HIA (Register of Information and Knowledge about Swedish Heart Intensive...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1917

    authors: Ohlsson H,Rosvall M,Hansen O,Chaix B,Merlo J

    更新日期:2010-04-01 00:00:00

  • A population-based case-control teratologic study of acetylsalicylic acid treatments during pregnancy.

    abstract:OBJECTIVE:To study the human teratogenic potential of two acetylsalicylic acid (ASA) drugs ASA-100 mg and ASA-500 mg. DESIGN:Pair analysis of cases with congenital abnormalities and matched healthy controls. SETTINGS:The large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormali...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/1099-1557(200005/06)9:3<193::AID-PDS498>3.

    authors: Czeizel AE,Rockenbauer M,Mosonyi A

    更新日期:2000-05-01 00:00:00

  • Why there is a need for pharmacovigilance.

    abstract::Not everything is known about a medicine when it receives its licence for marketing. The merits of a new drug, balancing its beneficial and its untoward effects, become only established after sufficient experience has been gained from its use in real practice. Part of the reason for this is that our extensive phase II...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-1557(199901/02)8:1<61::AID-PDS3

    authors: Amery WK,ISPE.

    更新日期:1999-01-01 00:00:00

  • Trends in antipsychotic prescriptions for Japanese outpatients during 2006-2012: a descriptive epidemiological study.

    abstract:PURPOSE:This study aimed to assess the trends in antipsychotic prescriptions for outpatients in Japan, where a community-based approach to mental healthcare is emphasized. METHODS:This descriptive epidemiological study used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4187

    authors: Kochi K,Sato I,Nishiyama C,Tanaka-Mizuno S,Doi Y,Arai M,Fujii Y,Matsunaga T,Ogawa Y,Furukawa TA,Kawakami K

    更新日期:2017-06-01 00:00:00

  • Impact of varying outcomes and definitions of suicidality on the associations of antiepileptic drugs and suicidality: comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR).

    abstract:PURPOSE:The purpose of this study is to quantify the impact of the different outcomes and definitions of suicidality on the association between antiepileptic drugs (AEDs) and suicidality. METHODS:Retrospective cohort studies of selected AEDs (carbamazepine, gabapentin, lamotrigine, phenytoin, pregabalin, topiramate an...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3928

    authors: Schuerch M,Gasse C,Robinson NJ,Alvarez Y,Walls R,Mors O,Christensen J,Hesse U,de Groot M,Schlienger R,Reynolds R,Klungel O,de Vries F

    更新日期:2016-03-01 00:00:00

  • Adverse drug reaction-related hospitalisations: a population-based cohort study.

    abstract:PURPOSE:To evaluate the extent, characteristics and determinants of adverse drug reaction (ADR)-related hospitalisations on a population-based level in 2003. METHODS:We performed a cohort study in the Integrated Primary Care Information (IPCI) database, a general practitioners (GPs) research database with longitudinal...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1565

    authors: van der Hooft CS,Dieleman JP,Siemes C,Aarnoudse AJ,Verhamme KM,Stricker BH,Sturkenboom MC

    更新日期:2008-04-01 00:00:00

  • Using fractional polynomials to model the effect of cumulative duration of exposure on outcomes: applications to cohort and nested case-control designs.

    abstract:PURPOSE:Determining the nature of the relationship between cumulative duration of exposure to an agent and the hazard of an adverse outcome is an important issue in environmental and occupational epidemiology, public health and clinical medicine. The Cox proportional hazards regression model can incorporate time-depend...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3607

    authors: Austin PC,Park-Wyllie LY,Juurlink DN

    更新日期:2014-08-01 00:00:00

  • In utero opioid exposure and risk of infections in childhood: A multinational Nordic cohort study.

    abstract:PURPOSE:There is an increasing number of children with in utero exposure to opioids. Knowledge about opioid safety in pregnancy, particularly for outcomes later in childhood is scarce. It has been suggested that opioids can modulate immune system and increase the risk of infections. Our goal was to study the impact of ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.5088

    authors: Mahic M,Hernandez-Diaz S,Wood M,Kieler H,Odsbu I,Nørgaard M,Öztürk B,Bateman BT,Hjellvik V,Skurtveit S,Handal M

    更新日期:2020-12-01 00:00:00

  • Revitalizing the General Practice Research Database: plans, challenges, and opportunities.

    abstract::The General Practice Research Database (GPRD) is the world's largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool. Several issues have threatened the viability of the database in recent years; in April 1999 responsibility for its man...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.608

    authors: Wood L,Coulson R

    更新日期:2001-08-01 00:00:00

  • Using medical records to supplement a claims-based comparative effectiveness analysis of antidepressants.

    abstract:PURPOSE:Because health insurance claims lack clinical information, comparative effectiveness research studies that rely on these data may be challenging to interpret and may result in biased inference. We conducted an exploratory study to determine if medical information contained in patient charts could offer clinical...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1988

    authors: Croghan TW,Esposito D,Daniel G,Wahl P,Stoto MA

    更新日期:2010-08-01 00:00:00

  • Provider risk factors for medication administration error alerts: analyses of a large-scale closed-loop medication administration system using RFID and barcode.

    abstract:PURPOSE:To determine the risk factors and rate of medication administration error (MAE) alerts by analyzing large-scale medication administration data and related error logs automatically recorded in a closed-loop medication administration system using radio-frequency identification and barcodes. METHODS:The subject h...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4068

    authors: Hwang Y,Yoon D,Ahn EK,Hwang H,Park RW

    更新日期:2016-12-01 00:00:00

  • Safety of deferasirox: a retrospective cohort study on the risks of gastrointestinal, liver and renal events.

    abstract:BACKGROUND:Deferasirox (DFX) is an effective and well-tolerated oral iron chelator elevating the adherence to iron chelating therapy among patients with iron overload. However, the US Food and Drug Administration issued a warning about the potential adverse events associated with DFX in 2010. METHODS:To examine the ri...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3657

    authors: Huang WF,Chou HC,Tsai YW,Hsiao FY

    更新日期:2014-11-01 00:00:00

  • Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease.

    abstract:PURPOSE:The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology. METHODS:Patients diagnosed with inflammatory bowel disease were identified from GPRD. Mailed surveys were sent to the g...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.698

    authors: Lewis JD,Brensinger C,Bilker WB,Strom BL

    更新日期:2002-04-01 00:00:00

  • Use of albumin in three French university hospitals: is prescription monitoring still useful in 2004?

    abstract:PURPOSE:Use of albumin (indications and quantities involved) has not been assessed in France since major changes occurred after the publication of Cochrane group meta-analysis. The objectives of this study were to measure the repartition of albumin indications in three French university hospitals in 2004 and to assess ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1328

    authors: Pradel V,Tardieu S,Micallef J,Signoret A,Villano P,Gauthier L,Vanelle P,Blin O,Albumin Study Group.

    更新日期:2007-01-01 00:00:00

  • Impact of cancer-related fatigue on chemotherapy-induced nausea and vomiting in Asian cancer patients.

    abstract:INTRODUCTION:Cancer-related fatigue (CRF) has been suggested to be associated with the occurrence of chemotherapy-induced nausea and vomiting (CINV). This study aims to evaluate the potential of CRF in predicting the occurrence of CINV. METHOD:This is a prospective, observational study. Recruited patients received mod...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3516

    authors: Poon KS,Un MK,Low XH,Cheung YT,Yap KY,Chan A

    更新日期:2013-12-01 00:00:00

  • Phosphodiesterase type 5 inhibitor use among pregnant and reproductive-age women in the United States.

    abstract:PURPOSE:To assess the prevalence and potential indications of PDE5 inhibitor use among pregnant and reproductive-age women in the United States. METHODS:We identified women 15 to 50 years with a livebirth from January 2001 through March 2018 in Sentinel Database. We assessed the prevalence of PDE5 inhibitor use prior ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.5112

    authors: Liu W,Menzin TJ,Woods CM,Haug NR,Li J,Mathew JA,Nguyen CP,Chai GP,Moeny DG,Shinde M

    更新日期:2021-02-01 00:00:00

  • Comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in patients with type 2 diabetes: use of propensity-score and instrumental variable methods to adjust for treatment-selection bias.

    abstract:PURPOSE:Type 2 diabetes is associated with increased cardiovascular risk. The comparative effectiveness of statin plus fibrate combination therapy and statin monotherapy in reducing risk of cardiovascular disease in real-world settings is unknown. METHODS:A retrospective database analysis was performed using a large m...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3261

    authors: Suh HS,Hay JW,Johnson KA,Doctor JN

    更新日期:2012-05-01 00:00:00

  • Doctor hopping and doctor shopping for prescription opioids associated with increased odds of high-risk use.

    abstract:PURPOSE:Early detection of risky behaviors involving prescription opioids can assist prescribers in implementing safer prescribing. Patient-to-prescriber travel patterns may indicate potential opioid misuse. We introduce doctor hopping, patients bypassing nearby prescribers in favor of more distant ones, as a new spati...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4838

    authors: Young SG,Hayes CJ,Aram J,Tait MA

    更新日期:2019-08-01 00:00:00

  • Incidence, risk factors, and outcomes of warfarin-associated major bleeding in Thai population.

    abstract:PURPOSE:This study aimed to describe incidence, risk factors, and outcomes of warfarin-associated major bleeding (WAMB) in Thai patients. METHOD:A nested case-control study was conducted in a cohort of adult patients receiving ≥6 months of warfarin therapy who were prospectively followed up at a tertiary care hospital...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4781

    authors: Priksri W,Rattanavipanon W,Saejear W,Tanyasaensook K,Phrommintikul A,Chulavatnatol S,Nathisuwan S

    更新日期:2019-07-01 00:00:00

  • Effectiveness of rosuvastatin compared to other statins for the prevention of cardiovascular events-a cohort study in 395 039 patients from clinical practice.

    abstract:PURPOSE:This study compared the effectiveness of rosuvastatin (RSV) to other statins prescribed in clinical practice in prevention of cardiovascular (CV) events. METHODS:This longitudinal inception cohort study, using Thomson Healthcare's MarketScan databases, included patients aged > or = 18 starting statin therapy d...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1843

    authors: Motsko SP,Russmann S,Ming EE,Singh VP,Vendiola RM,Jones JK

    更新日期:2009-12-01 00:00:00

  • Long-term use of antihypertensive drugs and risk of cancer.

    abstract:PURPOSE:Determine the relative risk of cancer users of commonly prescribed antihypertensive drugs with a focus on documenting risk in long-term users (>7.5 years). METHODS:We conducted a nested case-control study using the Saskatchewan Health databases. Cancer risks in users of beta-blockers, calcium channel blockers ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1656

    authors: Assimes TL,Elstein E,Langleben A,Suissa S

    更新日期:2008-11-01 00:00:00

  • Adverse drug reactions in hospitalized children in Fortaleza, Brazil.

    abstract:PURPOSE:To investigate the occurrence of adverse drug reactions (ADRs) and associated risk factors in a pediatric hospital in northeast Brazil, from August to December 2001. SUBJECTS/SETTING:Two hundred seventy two patients hospitalized for more than 24 hours. METHODS:Prospective cohort study. Daily visits were perfo...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1187

    authors: dos Santos DB,Coelho HL

    更新日期:2006-09-01 00:00:00

  • Drug counselling in pregnancy: an opinion survey of French community pharmacists.

    abstract:PURPOSE:The aim of the present study was to determine whether community pharmacists recommend appropriate medications and give valid information to pregnant women. METHODS:A total of 163 community pharmacists randomly selected in the Midi-Pyrénées area were interviewed by means of an open questionnaire. Ten scenarios ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.954

    authors: Damase-Michel C,Vié C,Lacroix I,Lapeyre-Mestre M,Montastruc JL

    更新日期:2004-10-01 00:00:00

  • Impact of antibiotic exposure on the risk of colorectal cancer.

    abstract:PURPOSE:Gut microbiota has been postulated to serve as a significant promoter of CRC formation, and colonic dysbiosis was previously reported in CRC tissue. Our aim was to evaluate the association between the type and cumulative duration of antibiotic exposure and CRC risk. METHODS:We conducted a nested case-control s...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3765

    authors: Boursi B,Haynes K,Mamtani R,Yang YX

    更新日期:2015-05-01 00:00:00