Building a framework for the evaluation of knowledge translation for the Canadian Network for Observational Drug Effect Studies.

Abstract:

PURPOSE:The Canadian Network for Observational Drug Effect Studies (CNODES), a network of pharmacoepidemiologists and other researchers from seven provincial sites, provides evidence on the benefits and risks of drugs used by Canadians. The Knowledge Translation Team, one of CNODES' four main teams, evaluates the impact of its efforts using an iterative and emergent approach. This article shares key lessons from early evaluation phases, including identifying stakeholders and their evaluation needs, choosing evaluation theories and approaches, and developing evaluation questions, designs, and methods appropriate for the CNODES context. METHODS:Stakeholder analysis was conducted using documentary analysis to determine key contextual factors and research evidence needs of decision maker partners and other stakeholders. Selected theories and frameworks from the evaluation and knowledge translation literature informed decisions about evaluation design and implementation. A developmental approach to evaluation was deemed appropriate due to the innovative, complex, and ever-changing context. RESULTS:A theory of change, logic model, and potential evaluation questions were developed, informed by the stakeholder analysis. Early indicators of program impact (citation metrics, alternative metrics) have been documented; efforts to collect data on additional indicators are ongoing. CONCLUSION:A flexible, iterative, and emergent evaluation approach allows the Knowledge Translation Team to apply lessons learned from completed projects to ongoing research projects, adapt its approaches based on stakeholder needs, document successes, and be accountable to funders/stakeholders. This evaluation approach may be useful for other international pharmacoepidemiology research networks planning and implementing evaluations of similarly complex, multistakeholder initiatives that are subject to constant change.

authors

Sketris IS,Carter N,Traynor RL,Watts D,Kelly K,following contributing members of the CNODES Knowledge Translation Team: Pierre Ernst, JM Gamble, Brenda Hemmelgarn, Colleen Metge, Michael Paterson, Robert Platt W. and Gary Teare.

doi

10.1002/pds.4738

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

8-25

eissn

1053-8569

issn

1099-1557

journal_volume

29 Suppl 1

pub_type

杂志文章
  • Practical aspects of sharing controls between case-control studies.

    abstract:PURPOSE:We discuss the practical advantages and challenges of sharing controls among two or more concurrently conducted case-control studies. METHODS:We conducted two case-control studies, one of breast cancer and the other of endometrial cancer, with overlapping, shared control groups. The studies had overlapping geo...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1130

    authors: Bunin GR,Baumgarten M,Norman SA,Strom BL,Berlin JA

    更新日期:2005-08-01 00:00:00

  • Data sources on drug safety evaluation: a review of recent published meta-analyses.

    abstract:PURPOSE:Meta-analysis is a quantitative approach to summarize the findings from several studies and has been applied with increasing frequency to clinical trials. Because of their sample size and duration limitations, experimental studies (ESs) could not be able to detect late or rare adverse events (AEs), which may be...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.2260

    authors: Alves C,Batel-Marques F,Macedo AF

    更新日期:2012-01-01 00:00:00

  • National trends in long-term use of prescription opioids.

    abstract:PURPOSE:This study examined recent trends and correlates of prescription opioid use and long-term use in the United States. METHODS:Data were from 47 356 adult participants of National Health and Nutrition Survey from 1999-2000 to 2013-2014. Participants were asked about prescription medications used in the past 30 da...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4278

    authors: Mojtabai R

    更新日期:2018-05-01 00:00:00

  • Herbal products use during pregnancy: prevalence and predictors.

    abstract:PURPOSES:(1) Measure the prevalence of herbal product (HP) use, alone, and concomitantly with prescribed medications during pregnancy, (2) identify the most frequently consumed HP during gestation and (3) determine predictors of HP use at the beginning of pregnancy, and during the third trimester. METHODS:A questionna...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.1731

    authors: Moussally K,Oraichi D,Bérard A

    更新日期:2009-06-01 00:00:00

  • Trends in antidepressant prescriptions for children and adolescents in Germany from 2005 to 2012.

    abstract:PURPOSE:Longitudinal data on prescriptions of antidepressants (AD) in children and adolescents depression are scarce. This study aimed to examine AD prescription trends in children and adolescents in Germany. METHODS:Data of a large statutory health insurance company were analyzed for the period 2005-2012, and outpati...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 历史文章,杂志文章

    doi:10.1002/pds.3649

    authors: Hoffmann F,Glaeske G,Bachmann CJ

    更新日期:2014-12-01 00:00:00

  • Trends in the long-term use of benzodiazepine anxiolytics and hypnotics: A national register study for 2006 to 2014.

    abstract:PURPOSE:Long-term benzodiazepine (BZD) treatment continues to be a debated topic. Because individual BZDs have different clinical profiles, we assessed the nationwide trends of long-term BZD use at active substance level during years 2006 to 2014. METHODS:This study covered all reimbursed BZD purchases (n = 408 572-52...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4551

    authors: Kurko T,Saastamoinen LK,Tuulio-Henriksson A,Taiminen T,Tiihonen J,Airaksinen M,Hietala J

    更新日期:2018-06-01 00:00:00

  • Exposure to reactive intermediate-inducing drugs during pregnancy and the incident use of psychotropic medications among children.

    abstract:PURPOSE:Our study aimed to investigate the association between prenatal exposure to reactive intermediate (RI)-inducing drugs and the initiation of psychotropic medications among children. METHODS:We designed a cohort study using a pharmacy prescription database. Pregnant women were considered exposed when they receiv...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4161

    authors: Tran YH,Groen H,Bergman JE,Hak E,Wilffert B

    更新日期:2017-03-01 00:00:00

  • Disproportionality analysis for signal detection of implantable cardioverter-defibrillator-related adverse events in the Food and Drug Administration Medical Device Reporting System.

    abstract:BACKGROUND:The Food and Drug Administration (FDA) became aware of lead fracture and inappropriate shock events related to Sprint Fidelis leads in January 2007. The manufacturer announced a voluntary market withdrawal in October 2007. AIM:Our aim was to retrospectively evaluate this safety signal using disproportionali...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2261

    authors: Duggirala HJ,Herz ND,Caños DA,Sullivan RA,Schaaf R,Pinnow E,Marinac-Dabic D

    更新日期:2012-01-01 00:00:00

  • Adverse drug events among children presenting to a hospital emergency department in Newfoundland and Labrador, Canada.

    abstract:OBJECTIVES:The aim of this study was to examine epidemiologic characteristics of Adverse Drug Events (ADEs) among children and adolescents presenting to an Emergency Department (ED) in Newfoundland and Labrador (NL), Canada. MATERIALS AND METHODS:This study was conducted in three phases and included an ED chart review...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1900

    authors: Sikdar KC,Alaghehbandan R,Macdonald D,Barrett B,Collins KD,Gadag V

    更新日期:2010-02-01 00:00:00

  • The prescribed duration algorithm: utilising 'free text' from multiple primary care electronic systems.

    abstract:PURPOSE:To develop and test an algorithm that translates total dose and daily regimen, inputted as 'free text' on a prescription, into numerical values to calculate the prescribed treatment duration. METHOD:The algorithm was developed using antibiotic prescriptions (n = 711,714) from multiple primary care computer sys...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2012

    authors: Brooks CJ,Lyons RA,Jones KH,Hutton AJ,Walker R,Evans KA,Lloyd K,Ford DV

    更新日期:2010-09-01 00:00:00

  • Moderate alcohol consumption and adverse drug reactions among older adults.

    abstract:PURPOSE:To assess the effect of moderate alcohol consumption on Adverse Drug Reactions (ADRs) among older adults admitted to acute care hospitals and to examine the consistency of this effect across gender and age groups. METHODS:We used the GIFA (Italian Group of Pharmacoepidemiology in the Elderly) database, which i...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.721

    authors: Onder G,Landi F,Della Vedova C,Atkinson H,Pedone C,Cesari M,Bernabei R,Gambassi G,GIFA Study.

    更新日期:2002-07-01 00:00:00

  • An algorithm to identify preterm infants in administrative claims data.

    abstract:PURPOSE:To develop and validate an algorithm to identify preterm infants in the absence of birth certificates within Medicaid data. METHODS:Medicaid fee-for-service claims data from Florida (FL) and Texas (TX) were linked to vital statistics data for infants who were continuously eligible during the first 3 months fol...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3264

    authors: Eworuke E,Hampp C,Saidi A,Winterstein AG

    更新日期:2012-06-01 00:00:00

  • Trends in the use of maintenance immunosuppressive drugs among liver transplant recipients in Taiwan: a nationwide population-based study.

    abstract:PURPOSE:During the past two decades, many novel immunosuppressive drugs have been approved for transplant recipients. Trends in the use of maintenance immunosuppressants after liver transplantation in Asia are unclear. Thus, we aimed to analyze the prescription trends in maintenance immunosuppressive drugs among liver ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3964

    authors: Huang YY,Hsu CC,Chou CL,Loong CC,Wu MS,Chou YC

    更新日期:2016-06-01 00:00:00

  • Does antidepressant medication use affect persistence with diabetes medicines?

    abstract:PURPOSE:This study aimed to examine the effect of antidepressant use on persistence with newly initiated oral antidiabetic medicines in older people. METHODS:A retrospective study of administrative claims data from the Australian Government Department of Veterans' Affairs, from 1 July 2000 to 30 June 2008 of new users...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3424

    authors: Caughey GE,Preiss AK,Vitry AI,Gilbert AL,Ryan P,Shakib S,Esterman A,McDermott RA,Roughead EE

    更新日期:2013-06-01 00:00:00

  • Evidence generation from healthcare databases: recommendations for managing change.

    abstract::There is an increasing reliance on databases of healthcare records for pharmacoepidemiology and other medical research, and such resources are often accessed over a long period of time so it is vital to consider the impact of changes in data, access methodology and the environment. The authors discuss change in commun...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.4004

    authors: Bourke A,Bate A,Sauer BC,Brown JS,Hall GC

    更新日期:2016-07-01 00:00:00

  • Measurement of changes in antihypertensive drug utilisation following primary care educational interventions.

    abstract:PURPOSE:To measure changes in drug utilisation following a national general practice education program aimed at improving prescribing for hypertension. METHODS:A series of nationally implemented, multifaceted educational interventions using social marketing principles focusing on prescribing for hypertension, was comm...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1243

    authors: Horn FE,Mandryk JA,Mackson JM,Wutzke SE,Weekes LM,Hyndman RJ

    更新日期:2007-03-01 00:00:00

  • Validation of The Health Improvement Network (THIN) database for epidemiologic studies of chronic kidney disease.

    abstract:PURPOSE:Chronic kidney disease (CKD) is a prevalent and important outcome and covariate in pharmacoepidemiology. The Health Improvement Network (THIN) in the UK represents a unique resource for population-based studies of CKD. We compiled a valid list of Read codes to identify subjects with moderate to advanced CKD. M...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2203

    authors: Denburg MR,Haynes K,Shults J,Lewis JD,Leonard MB

    更新日期:2011-11-01 00:00:00

  • Statistical visualization for assessing performance of methods for safety surveillance using electronic databases.

    abstract:PURPOSE:The success of an epidemiological study for drug safety surveillance or comparative effectiveness depends largely on design and analysis strategies besides data quality. The Observational Medical Outcomes Partnership (OMOP) methods community implemented a collection of statistical methods with extensive paramet...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3419

    authors: Li X,Hui S,Ryan P,Rosenman M,Overhage M

    更新日期:2013-05-01 00:00:00

  • Addressing unmeasured confounding in comparative observational research.

    abstract:PURPOSE:Observational pharmacoepidemiological studies can provide valuable information on the effectiveness or safety of interventions in the real world, but one major challenge is the existence of unmeasured confounder(s). While many analytical methods have been developed for dealing with this challenge, they appear u...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.4394

    authors: Zhang X,Faries DE,Li H,Stamey JD,Imbens GW

    更新日期:2018-04-01 00:00:00

  • The potential of the European network of congenital anomaly registers (EUROCAT) for drug safety surveillance: a descriptive study.

    abstract:BACKGROUND:European Surveillance of Congenital Anomalies (EUROCAT) is a network of population-based congenital anomaly registries in Europe surveying more than 1 million births per year, or 25% of the births in the European Union. This paper describes the potential of the EUROCAT collaboration for pharmacoepidemiology ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1265

    authors: Meijer WM,Cornel MC,Dolk H,de Walle HE,Armstrong NC,de Jong-van den Berg LT,EUROCAT Working Group.

    更新日期:2006-09-01 00:00:00

  • Psychotropic drugs and risk of burn injury in individuals with mental illness: a 10-year population-based case-control study.

    abstract:PURPOSE:We aimed to investigate the association between psychotropic treatment and risk of burn injury in individuals with mental illness. METHODS:A nested case-control study was conducted by using the National Health Insurance Research Database in Taiwan. A total of 3187 cases with burn injury under International Cla...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3995

    authors: Chang CM,Wu KY,Chiu YW,Wu HT,Tsai YT,Chau YL,Tsai HJ

    更新日期:2016-08-01 00:00:00

  • Concomitant use of anti-dementia drugs with psychotropic drugs in Norway--a population-based study.

    abstract:PURPOSE:Concomitant use of anti-dementia drugs with psychotropic drugs is potentially problematic in patients with dementia. The aim of this study was to investigate how frequently patients in Norway use anti-dementia drugs concomitantly with psychotropic drugs. METHODS:Analyses are based on data from the Norwegian Pr...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.2211

    authors: Langballe EM,Engdahl B,Selbaek G,Nordeng H

    更新日期:2011-12-01 00:00:00

  • Assessing the impact of unmeasured confounders for credible and reliable real-world evidence.

    abstract:PURPOSE:We review statistical methods for assessing the possible impact of bias due to unmeasured confounding in real world data analysis and provide detailed recommendations for choosing among the methods. METHODS:By updating an earlier systematic review, we summarize modern statistical best practices for evaluating ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章,评审

    doi:10.1002/pds.5117

    authors: Zhang X,Stamey JD,Mathur MB

    更新日期:2020-10-01 00:00:00

  • Doctor hopping and doctor shopping for prescription opioids associated with increased odds of high-risk use.

    abstract:PURPOSE:Early detection of risky behaviors involving prescription opioids can assist prescribers in implementing safer prescribing. Patient-to-prescriber travel patterns may indicate potential opioid misuse. We introduce doctor hopping, patients bypassing nearby prescribers in favor of more distant ones, as a new spati...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4838

    authors: Young SG,Hayes CJ,Aram J,Tait MA

    更新日期:2019-08-01 00:00:00

  • The recording of human papillomavirus (HPV) vaccination in BIFAP primary care database: A validation study.

    abstract:PURPOSE:In Spain, a human papillomavirus (HPV) vaccine was firstly marketed in 2006 and mainly administered in primary care (PC) practices for girls/women or schools. As for all vaccines, a valid data source is required for research on observational effectiveness or safety. The objective of this study is to identify an...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.4674

    authors: Martín-Merino E,Llorente-García A,Montero-Corominas D,Huerta C

    更新日期:2019-02-01 00:00:00

  • Tramadol dependence: a survey of spontaneously reported cases in Sweden.

    abstract:BACKGROUND:Tramadol is a weak opioid analgesic, which is generally considered to be safe. However, conflicting data exist on the dependence potential of tramadol. OBJECTIVE:The aim of this study was to investigate occurrence of tramadol dependence and associated risk factors using spontaneously reported adverse drug r...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1838

    authors: Tjäderborn M,Jönsson AK,Ahlner J,Hägg S

    更新日期:2009-12-01 00:00:00

  • Retraction. "Epidemiological evaluation of intraoperative antibiosis as a protective agent against endophthalmitis after cataract surgery" by F. Krummenauer, S. Kurz and H.B. Dick.

    abstract::The following article from Pharmacoepidemiology and Drug Safety, “Epidemiological evaluation of intraoperative antibiosis as a protective agent against endophthalmitis after cataract surgery” by F. Krummenauer, S. Kurz and H.B. Dick, published online on July 11 2006 inWiley Online Library (wileyonlinelibrary.com), has...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 撤回出版物

    doi:

    authors:

    更新日期:2013-02-01 00:00:00

  • Evaluation of an ICD-10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients.

    abstract:PURPOSE:This study aimed to validate a predefined algorithm for osteonecrosis of the jaw (ONJ) among cancer patients in the Danish National Registry of Patients and to assess the nature of clinical information recorded in medical charts of ONJ patients. METHODS:We identified potential ONJ cases recorded in 2005-2010 a...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.3786

    authors: Ehrenstein V,Gammelager H,Schiødt M,Nørholt SE,Neumann-Jensen B,Folkmar TB,Pedersen L,Svaerke C,Sørensen HT,Ma H,Acquavella J

    更新日期:2015-07-01 00:00:00

  • An algorithm to derive a numerical daily dose from unstructured text dosage instructions.

    abstract:PURPOSE:The General Practice Research Database (GPRD) is a database of longitudinal patient records from general practices in the United Kingdom. It is an important data source for pharmacoepidemiology studies, but until now it has been tedious to calculate the daily dose and duration of exposure to drugs prescribed. T...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.1151

    authors: Shah AD,Martinez C

    更新日期:2006-03-01 00:00:00

  • Impact of a drug safety communication on the severity of benzonatate exposures reported to poison centers.

    abstract:PURPOSE:Identify if publication of the 2010 drug safety communication (DSC) regarding benzonatate was associated with a decrease in the incidence of severe benzonatate poisonings reported to United States poison centers. METHODS:This retrospective database study utilized the National Poison Data System to compare the ...

    journal_title:Pharmacoepidemiology and drug safety

    pub_type: 杂志文章

    doi:10.1002/pds.5136

    authors: Leonard JB,Seung H,Klein-Schwartz W

    更新日期:2021-01-01 00:00:00