Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease.

Abstract:

PURPOSE:The objective of this study was to evaluate the validity and completeness of the General Practice Research Database (GPRD) as a tool for research into inflammatory bowel disease epidemiology. METHODS:Patients diagnosed with inflammatory bowel disease were identified from GPRD. Mailed surveys were sent to the general practitioner caring for a stratified random sample of 170 of these patients and collected information on the diagnosis of inflammatory bowel disease and the most recent surgery and hospitalization. RESULTS:Usable surveys were returned for 157 patients (92%). The inflammatory bowel disease diagnosis was highly probable or probable in 144 (92%, 95% CI 86 to 96%). Among the 53 patients with a potentially incident inflammatory bowel disease diagnosis, 33 (62%) had the first recorded diagnosis in GPRD within 30 days of the date reported in the survey (median difference -8 days; interquartile range 0 to -81 days). Of 12 surgeries and 25 hospitalizations reported in the survey, 11 (92%) and 19 (76%) were identified in GPRD, respectively. CONCLUSIONS:The diagnosis of inflammatory bowel disease in GPRD appears reliable for most patients. Important medical events such as hospitalizations and surgery are recorded at a high rate, although algorithms to identify these events are complex.

authors

Lewis JD,Brensinger C,Bilker WB,Strom BL

doi

10.1002/pds.698

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

211-8

issue

3

eissn

1053-8569

issn

1099-1557

journal_volume

11

pub_type

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