Abstract:
PURPOSE:We discuss the practical advantages and challenges of sharing controls among two or more concurrently conducted case-control studies. METHODS:We conducted two case-control studies, one of breast cancer and the other of endometrial cancer, with overlapping, shared control groups. The studies had overlapping geographic areas, identical telephone questionnaires and biosample collection, and identical age and race eligibility. RESULTS:Sharing controls reduced the number of potential controls that had to be identified by random-digit dialing by 25% and the number of eligible controls that had to be interviewed by 32%. The cost savings were approximately 2,96,000 dollars, or 7% of the program project that funded the studies. CONCLUSIONS:The disadvantage of sharing controls was the complexity of the design and the additional investigator time required to plan, monitor, and adjust the design. In the situation presented here, the complexities would have been reduced greatly if we had not attempted to frequency match on age in both studies. Generally, sharing controls is likely to work well when strict frequency matching is not required and there is a large overlap of interview questions, other data to be collected, and eligibility criteria among the studies.
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
Bunin GR,Baumgarten M,Norman SA,Strom BL,Berlin JAdoi
10.1002/pds.1130keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
523-30issue
8eissn
1053-8569issn
1099-1557journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Current guidelines for the empiric treatment of uncomplicated urinary tract infection in women recommend that first-line trimethoprim-sulfamethoxazole (TMP-SMX) or ofloxacin be given for 3 days and nitrofurantoin for 5 days. Increasing the duration of treatment raises costs, and perhaps, the incidence of adv...
journal_title:Pharmacoepidemiology and drug safety
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2021-02-01 00:00:00
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