Abstract:
PURPOSE:This study aimed to assess the trends in antipsychotic prescriptions for outpatients in Japan, where a community-based approach to mental healthcare is emphasized. METHODS:This descriptive epidemiological study used claims data from 1038 community pharmacies across Japan. Outpatients who were ≥18 years old and receiving their initial antipsychotic prescription during 2006-2012 were evaluated. The annual trends were reported for monotherapies, polypharmacy, antipsychotic doses, and the concurrent prescription of psychotropic medications. RESULTS:The 152 592 outpatients included 101 133 (66%) adults (18-64 years old) and 51 459 (34%) older adults (≥65 years old). Among the adults, second-generation antipsychotic monotherapy prescriptions increased from 49% in 2006 to 71% in 2012, first-generation antipsychotic monotherapy prescriptions decreased from 29 to 14%, and antipsychotic polypharmacy decreased from 23 to 15%, respectively. Among the older adults, second-generation antipsychotic monotherapy prescriptions increased from 64 to 82%, first-generation antipsychotic monotherapy prescriptions decreased from 29 to 12%, and antipsychotic polypharmacy decreased from 7 to 6%, respectively. During the study period, >80% of the adults and >90% of the older adults received antipsychotics at risperidone-equivalent doses of <6 mg/day. Anxiolytics/hypnotics, antidepressants, antiparkinson agents, mood stabilizers, and anti-dementia agents were concurrently prescribed with antipsychotics for 70, 33, 20, 20, and 0.3% of the adults and for 43, 16, 19, 8, and 16% of the older adults, respectively. CONCLUSIONS:The present study evaluated large-scale claims-based datasets and found that high-dose prescriptions and antipsychotic polypharmacy among Japanese outpatients were not as prevalent as has been previously thought. Copyright © 2017 John Wiley & Sons, Ltd.
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
Kochi K,Sato I,Nishiyama C,Tanaka-Mizuno S,Doi Y,Arai M,Fujii Y,Matsunaga T,Ogawa Y,Furukawa TA,Kawakami Kdoi
10.1002/pds.4187subject
Has Abstractpub_date
2017-06-01 00:00:00pages
642-656issue
6eissn
1053-8569issn
1099-1557journal_volume
26pub_type
杂志文章abstract:PURPOSE:To evaluate the impact of 2 policy changes on quetiapine dispensing in Australia: removal of prior authorisation for prescribing (policy 1: July 2007) and removal of repeat prescriptions for 25-mg quetiapine (policy 2: January 2014). METHODS:We performed an interrupted time series analysis using Pharmaceutical...
journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.1071
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journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.5191
更新日期:2021-01-01 00:00:00
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更新日期:2017-02-01 00:00:00
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doi:10.1002/pds.2261
更新日期:2012-01-01 00:00:00
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更新日期:2015-09-01 00:00:00
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/pds.3603
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/pds.910
更新日期:2004-08-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章,评审
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更新日期:2019-02-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1616
更新日期:2008-09-01 00:00:00
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doi:10.1002/pds.3719
更新日期:2015-01-01 00:00:00
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/pds.1303
更新日期:2007-05-01 00:00:00
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doi:10.1002/pds.4111
更新日期:2017-02-01 00:00:00
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doi:10.1002/(SICI)1099-1557(200003/04)9:2<113::AID-PDS
更新日期:2000-03-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.2017
更新日期:2010-11-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.1688
更新日期:2009-01-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1557(199907)8:4<275::AID-PDS427
更新日期:1999-07-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.4166
更新日期:2017-05-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 杂志文章
doi:10.1002/pds.2012
更新日期:2010-09-01 00:00:00