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Devic's neuromyelitis optica: long-term follow-up and serial CSF findings in two cases.

Abstract：

:Sixteen cerebrospinal fluid (CSF) specimens serially obtained during long-term follow-up of two patients with Devic's neuromyelitis optica (DNO) were compared with 65 CSF samples from patients with multiple sclerosis (MS). By statistical analysis, the CSF profile in DNO was found to differ from that observed in MS, mainly showing pleocytosis, blood-brain barrier damage, and absence of persistent immunoglobulin G synthesis within the central nervous system. Oligoclonal bands, detected with isoelectric focusing, were present in CSF of 92% of the patients with MS, and in three CSF specimens from one patient with DNO during the first 6 months after disease onset. The bands disappeared in two subsequent samples. This finding has never been described in MS. One patient with DNO had an apparent chronic-relapsing course probably due to steroid dependence. The clinical and CSF features of our cases favour the nosographic independence of DNO and MS.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Piccolo G,Franciotta DM,Camana C,Bergamaschi R,Banfi P,Sandrini G,Citterio A

doi

10.1007/BF00314631

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

262-4

issue

4

eissn

0340-5354

issn

1432-1459

journal_volume

237

pub_type

杂志文章

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