Common variable immunodeficiency-associated granulomatous and interstitial lung disease.

Abstract:

PURPOSE OF REVIEW:Common variable immunodeficiency (CVID) is the most common primary immunodeficiency characterized by a deficiency of immunoglobulins. Approximately 30% of the patients develop autoimmune and granulomatous disease. Similar to sarcoidosis, granulomatous disease in CVID can potentially affect all organs, but the lung is the most common. Interstitial lung disease (ILD) manifests in 5-15% of CVID patients, and is present already at the initial diagnosis in the majority of patients. The number of published studies addressing ILD in CVID is limited. However, recently, several studies added substantial knowledge to the field and are discussed within this review in the context of the literature. RECENT FINDINGS:Histologically, ILD in CVID presents within the known patterns of sarcoid-like granuloma, organizing pneumonia, lymphocytic interstitial pneumonitis and nonspecific interstitial pneumonia. Often, these patterns are concomitantly found in the same patients. Three new articles were published which analyzed high-resolution computed tomography findings and response to treatment. SUMMARY:In a considerable number of patients, ILD is stable over years and patients may not need any immunosuppressive treatment. Prednisone treatment is often used as the first-line treatment and studies suggest response to treatment in 50-66% of cases. In progressive disease with lung function impairment, combined immunosuppressive treatment is recommended.

journal_name

Curr Opin Pulm Med

authors

Prasse A,Kayser G,Warnatz K

doi

10.1097/MCP.0b013e3283642c47

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

503-9

issue

5

eissn

1070-5287

issn

1531-6971

journal_volume

19

pub_type

杂志文章,评审
  • Pleural effusions in hematologic malignancies and their management with indwelling pleural catheters.

    abstract:PURPOSE OF REVIEW:Pleural effusions in patients with hematologic malignancy may represent malignant pleural effusion (MPE) or occur secondary to infection, treatment effects, and other common causes. The impact of MPE on prognosis in this cohort remains unclear. Indwelling pleural catheters (IPCs) are routinely placed ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000490

    authors: Vakil E,Jimenez CA,Faiz SA

    更新日期:2018-07-01 00:00:00

  • Spontaneous hemopneumothorax.

    abstract:PURPOSE OF REVIEW:Spontaneous hemopneumothorax can be life threatening, and is a cause of patients presenting with unexplained signs of significant hypovolemia. The debate relating to patient selection and timing of surgery in patients with spontaneous hemopneumothorax remains unresolved. RECENT FINDINGS:Our experienc...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcp.0000230631.11257.b9

    authors: Ng CSh,Yim AP

    更新日期:2006-07-01 00:00:00

  • Update on the diagnosis and classification of ILD.

    abstract:PURPOSE OF REVIEW:The purpose of this review is to provide an update on the diagnosis and classification of interstitial lung disease (ILD), with a specific focus on newly described ILD subtypes and phenotypes. In addition, the strengths and limitations of the current approach to ILD diagnosis and management are discus...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e328363f48d

    authors: Ryerson CJ,Collard HR

    更新日期:2013-09-01 00:00:00

  • Screening for lung cancer: a review.

    abstract:PURPOSE OF REVIEW:After the disappointing results of lung cancer screening trials conducted in the 1960s to the 1980s, a renewed interest in lung cancer screening emerged in the 1990s with the development of new technologies such as low-dose spiral CT. The literature regarding screening with biomarkers and CT continues...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcp.0000128432.79891.85

    authors: Manser R

    更新日期:2004-07-01 00:00:00

  • Outpatient talc administration via indwelling pleural catheters for malignant effusions.

    abstract:PURPOSE OF REVIEW:Malignant pleural effusion is a common cause of breathlessness and signifies advanced disease. Common options for definitive pleural intervention include insertion of an indwelling pleural catheter (IPC) or talc pleurodesis. RECENT FINDINGS:Administration of graded talc through an IPC offers an incre...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章

    doi:10.1097/MCP.0000000000000587

    authors: Dipper A,Bhatnagar R,Maskell N

    更新日期:2019-07-01 00:00:00

  • Experimental treatments for asthma.

    abstract::There has been increased recognition of the importance of inflammatory cells and their products in the pathogenesis of asthma. From this recognition has evolved a number of new approaches to treat the various components of the asthmatic inflammatory response. Nonselective anti-inflammatory agents such as cyclosporine ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-199701000-00006

    authors: Floreani AA,Rennard SI

    更新日期:1997-01-01 00:00:00

  • Novel methods for device and adherence monitoring in asthma.

    abstract:PURPOSE OF REVIEW:The article aims to provide an updated and evidence-based review of the innovative electronic health interventions to monitor and improve inhaler technique and adherence to recommended therapy in asthma. RECENT FINDINGS:Out of the 290 articles identified by the search strategy, 23 manuscripts fulfill...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000439

    authors: Bonini M,Usmani OS

    更新日期:2018-01-01 00:00:00

  • Upper airway reflexes.

    abstract::It is usually assumed that upper airway pressure receptors mediate the reflexes involved in sleep apneas, but many other receptors may be involved, including those responding to chemical stimuli. The reflexes to upper airway negative pressure have been further studied, and the timing of their inputs shown to be import...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-199811000-00013

    authors: Widdicombe J

    更新日期:1998-11-01 00:00:00

  • Neurotrophins and asthma.

    abstract::The neurotrophins are a family of peptides that promote survival, growth, and differentiation of neurons. Neurotrophins may also influence the function of nonneuronal cell types, including immune cells. The development and maintenance of asthma is thought to involve the nervous system and the immune system, but the ro...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200101000-00001

    authors: Carr MJ,Hunter DD,Undem BJ

    更新日期:2001-01-01 00:00:00

  • Diagnostic and therapeutic challenges of chronic obstructive pulmonary disease in the elderly.

    abstract:PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) imposes a large burden on the global population and even more so for the elderly who face significant obstacles in the diagnosis, management, and psychosocial effects of the disease. This review describes the current challenges and key points in the managem...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章

    doi:10.1097/MCP.0000000000000750

    authors: Allen B,Aboussouan LS

    更新日期:2021-03-01 00:00:00

  • Emerging concepts in pleural infection.

    abstract:PURPOSE OF REVIEW:Pleural infection remains an important pulmonary disease, causing significant morbidity and mortality. There is a resurgence of disease burden despite introduction of antibiotics and pneumococcal vaccines. A revisit of the pathogenesis and update on intervention may improve the care of pleural infecti...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000487

    authors: Chan KP,Fitzgerald DB,Lee YCG

    更新日期:2018-07-01 00:00:00

  • Advances in pleural diseases: what is the future for medical thoracoscopy?

    abstract:PURPOSE OF REVIEW:Medical thoracoscopy provides the physician a window into the pleural space. The procedure allows biopsy of the parietal pleura under direct visualization with good accuracy. In addition, it achieves therapeutic goals of fluid drainage, guided chest tube placement, and pleurodesis. RECENT FINDINGS:Co...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000265

    authors: Lee P,Mathur PN

    更新日期:2016-05-01 00:00:00

  • Is there a role for macrolides in severe asthma?

    abstract:PURPOSE OF REVIEW:Severe asthma is a heterogeneous syndrome, encompassing several distinct clinical phenotypes. Different molecular and cellular pathways or endotypes determine the type of underlying airway inflammation in patients with severe asthma, which can be categorized as eosinophilic asthma (allergic and nonall...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000017

    authors: Brusselle GG,Joos G

    更新日期:2014-01-01 00:00:00

  • Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a long-term benefit?

    abstract:PURPOSE OF REVIEW:The use of inhaled corticosteroids is one of the most controversial issues in COPD pharmacotherapy. Experts disagree about the benefits and harms of ICS for patients with COPD, yet a majority of patients with COPD are being treated with inhaled corticosteroids. This is a review of the most recent lite...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200403000-00005

    authors: Highland KB

    更新日期:2004-03-01 00:00:00

  • Precision medicine and treatable traits in chronic airway diseases - where do we stand?

    abstract:PURPOSE OF REVIEW:To provide an update on the implementation of precision medicine, based on treatable traits and mechanisms, in the daily clinical management of chronic airways diseases. RECENT FINDINGS:Recent insights into the complex and heterogeneous nature of chronic airway diseases including chronic obstructive ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000639

    authors: Ulrik CS,Vijverberg S,Hanania NA,Diamant Z

    更新日期:2020-01-01 00:00:00

  • Management of refractory hepatic hydrothorax.

    abstract:PURPOSE OF REVIEW:Treatment of hepatic hydrothorax is challenging because of its rapid symptomatic recurrence. This review will focus on potential therapeutic approaches to hepatic hydrothorax. RECENT FINDINGS:Hepatic hydrothorax is refractory to salt restriction and diuretics in approximately 25% of cases. Primary ma...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000058

    authors: Porcel JM

    更新日期:2014-07-01 00:00:00

  • The small airways in chronic obstructive pulmonary disease: pathology and effects on disease progression and survival.

    abstract:PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) is caused by a mixture of small airway disease (obstructive bronchitis) and parenchymal lung tissue destruction (emphysema). The relative contributions of these two pathologic states vary from person to person. Having the ability to phenotype patients into ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32835ceefc

    authors: Stewart JI,Criner GJ

    更新日期:2013-03-01 00:00:00

  • Improving adherence to asthma medications: current knowledge and future perspectives.

    abstract:PURPOSE OF REVIEW:Poor adherence to asthma controller medications, particularly inhaled corticosteroids, has been well known for decades and is a major cause of uncontrolled asthma and increased healthcare utilization. This review presents recent evidence on factors leading to nonadherence in specific age groups, paren...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000334

    authors: Blake KV

    更新日期:2017-01-01 00:00:00

  • Severity scoring systems for pneumonia: current understanding and next steps.

    abstract:PURPOSE OF REVIEW:To describe the current understanding and clinical applicability of severity scoring systems in pneumonia management. RECENT FINDINGS:Severity scores in community-acquired pneumonia are strong markers of mortality, but are not necessarily clinical decision-aid tools. The use of severity scores to sup...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000468

    authors: Ranzani OT,Taniguchi LU,Torres A

    更新日期:2018-05-01 00:00:00

  • Clinical relevance of distal deep vein thrombosis.

    abstract:PURPOSE OF REVIEW:To discuss pros and cons of anticoagulant treatment in the presence of symptomatic distal deep vein thrombosis. RECENT FINDINGS:Available data are responsible for a lack of consensus regarding treatment of distal deep vein thrombosis. SUMMARY:One standard diagnostic approach of suspected deep vein t...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32830460ea

    authors: Righini M,Bounameaux H

    更新日期:2008-09-01 00:00:00

  • Pharmacogenetics of asthma: toward precision medicine.

    abstract:PURPOSE OF REVIEW:Although currently available drugs to treat asthma are effective in most patients, a proportion of patients do not respond or experience side-effects; which is partly genetically determined. Pharmacogenetics is the study of how genetic variations influence drug response. In this review, we summarize p...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000335

    authors: Kersten ET,Koppelman GH

    更新日期:2017-01-01 00:00:00

  • Comorbidities of chronic facial pain and obstructive sleep apnea.

    abstract:PURPOSE OF REVIEW:This article explains the high comorbidity of craniofacial pain (chronic face pain, temporomandibular disorders, and primary headaches) with obstructive sleep breathing disorders and obstructive sleep apnea (OSA). It is recommended that physicians treating OSA should be aware of the concurrent chronic...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0000000000000325

    authors: Olmos SR

    更新日期:2016-11-01 00:00:00

  • Obstructive sleep apnea in pulmonary fibrosis.

    abstract:PURPOSE OF REVIEW:In previous years, there was limited research related to the role of sleep in interstitial lung diseases (ILDs). Physicians treating ILD patients tended to focus mainly on the daily disabling symptoms overlooking the possible significant role of coexisting sleep disorders, such as obstructive sleep ap...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章

    doi:10.1097/MCP.0000000000000697

    authors: Schiza SE,Bouloukaki I,Bolaki M,Antoniou KM

    更新日期:2020-09-01 00:00:00

  • Animal models of malignant pleural effusion.

    abstract:PURPOSE OF REVIEW:Malignant pleural effusion (MPE) poses a common and significant clinical problem. Its pathogenesis is poorly understood and therapeutic options are limited. Herein are summarized animal models of MPE and their contributions in unveiling new aspects of the pathobiology of the condition. RECENT FINDING...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32832af07c

    authors: Stathopoulos GT,Kalomenidis I

    更新日期:2009-07-01 00:00:00

  • New regimens in the management of posttraumatic respiratory failure.

    abstract::Many individuals are now surviving their injuries to face the consequences of an activated immunoinflammatory system and the complications of supportive therapy. The pulmonary system bears the force of this insult. An understanding of the epidemiology of acute respiratory failure, as well as a greater knowledge of the...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-199705000-00008

    authors: O'Keefe GE,Maier RV

    更新日期:1997-05-01 00:00:00

  • Pneumonia due to methicillin-resistant Staphylococcus aureus: clinical features, diagnosis and management.

    abstract:PURPOSE OF REVIEW:The review highlights the clinical findings and the management of community-acquired, health-care associated and nosocomial pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA). RECENT FINDINGS:Although previously considered as a purely nosocomial event, community-acquired MRSA pneumon...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e3283292666

    authors: Tacconelli E,De Angelis G

    更新日期:2009-05-01 00:00:00

  • Bronchiolitis with airflow obstruction.

    abstract::Bronchiolar lesions are becoming increasingly recognized as an important cause of airflow obstruction. For this reason, it is helpful to have an update of the current clinical, radiographic, and immunologic perspective. Among the bronchiolar airflow disorders, diffuse panbronchiolitis is related to HLA antigen Bw54, a...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Epler GR

    更新日期:1995-03-01 00:00:00

  • Thirty-day mortality rate in women with cancer and venous thromboembolism. Findings from the Registro Informatizado de la Enfermedad Trombo Embólica Registry.

    abstract:PURPOSE OF REVIEW:Cancer patients with venous thromboembolism (VTE) are at increased risk of mortality. Estimating the risks for specific causes of death may help to weigh the risks and benefits of different therapeutic strategies in an individual patient. RECENT FINDINGS:In the Registro Informatizado de la Enfermedad...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MCP.0b013e32835463a4

    authors: Trujillo-Santos J,Monreal M

    更新日期:2012-09-01 00:00:00

  • Cancer in interstitial pulmonary fibrosis and sarcoidosis.

    abstract::The occurrence of lung cancer in patients with diffuse interstitial pulmonary disease is well-known. The incidence, however, varies and ranges from 9.8 to 38%. The pathogenesis of lung cancer in pulmonary fibrosis is unclear, but genetic as well as environmental factors seem to be involved. ...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200309000-00010

    authors: Sharma OP,Lamb C

    更新日期:2003-09-01 00:00:00

  • Duration of anticoagulants in acute or recurrent venous thromboembolism.

    abstract::While the most recent trend in secondary prophylaxis after venous thromboembolism has been toward a prolonged duration, it has become obvious that individualization according to risk factors is crucial. Subgroup analyses in a long-term follow-up of a previous trial, as well as new trials on patients with idiopathic th...

    journal_title:Current opinion in pulmonary medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00063198-200007000-00012

    authors: Schulman S

    更新日期:2000-07-01 00:00:00