Abstract:
:The neurotrophins are a family of peptides that promote survival, growth, and differentiation of neurons. Neurotrophins may also influence the function of nonneuronal cell types, including immune cells. The development and maintenance of asthma is thought to involve the nervous system and the immune system, but the role that neurotrophins play in asthma is unknown. The cellular sources of the neurotrophins include mast cells, lymphocytes, macrophages, epithelial cells, smooth muscle cells, and eosinophils. The activation of neurotrophin receptors in immune cells and neurons involves ligand-induced homodimerization, which leads to activation of intrinsic Trk receptor kinase. The exact consequences of activating these receptors on immune cells is unknown, but rather than having unique actions on immune cells, the neurotrophins appear to act in concert with known immune regulating factors to modulate the maturation, accumulation, proliferation, and activation of immune cells. Neurotrophins can modulate afferent nerve function by stimulating the production of neuropeptides within airway afferent neurons. These neuropeptides may be released from the central terminals of airway afferent neurons, which leads to heightened autonomic reflex activity, and increased reactivity in the airways.
journal_name
Curr Opin Pulm Medjournal_title
Current opinion in pulmonary medicineauthors
Carr MJ,Hunter DD,Undem BJdoi
10.1097/00063198-200101000-00001keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
1-7issue
1eissn
1070-5287issn
1531-6971journal_volume
7pub_type
杂志文章,评审abstract::The progressive breakdown of the cell-mediated immunity, which characterizes the natural history of HIV infection, invariably leads to the development of miscellaneous opportunistic infections or neoplasms involving a number of tissues, including the respiratory tract. In particular, given the extent and the severity ...
journal_title:Current opinion in pulmonary medicine
pub_type: 杂志文章,评审
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
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journal_title:Current opinion in pulmonary medicine
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