Mechanism of HIV-1 virion entrapment by tetherin.

abstract：:Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found commonly associated w...

journal_title：PLoS pathogens

authors： Williams RA,Smith TK,Cull B,Mottram JC,Coombs GH

更新日期：2012-01-01 00:00:00

abstract：:Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known, no data about the quater...

journal_title：PLoS pathogens

authors： Klema VJ,Ye M,Hindupur A,Teramoto T,Gottipati K,Padmanabhan R,Choi KH

更新日期：2016-02-19 00:00:00

abstract：:Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have identified MV-infected keratinocytes and mononuclear cells in the ...

journal_title：PLoS pathogens

authors： Laksono BM,Fortugno P,Nijmeijer BM,de Vries RD,Cordisco S,Kuiken T,Geijtenbeek TBH,Duprex WP,Brancati F,de Swart RL

更新日期：2020-10-08 00:00:00

abstract：:Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and th...

journal_title：PLoS pathogens

authors： Denic M,Turlin E,Michel V,Fischer F,Khorasani-Motlagh M,Zamble D,Vinella D,de Reuse H

更新日期：2021-01-14 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease...

journal_title：PLoS pathogens

authors： Cui Y,Yu H,Zheng X,Peng R,Wang Q,Zhou Y,Wang R,Wang J,Qu B,Shen N,Guo Q,Liu X,Wang C

更新日期：2017-01-17 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an attenuated double-stranded DNA poxvirus currently developed as a vaccine vector against HIV/AIDS. Profiling of the innate immune responses induced by MVA is essential for the design of vaccine vectors and for anticipating potential adverse interactions between naturally acqui...

journal_title：PLoS pathogens

authors： Delaloye J,Roger T,Steiner-Tardivel QG,Le Roy D,Knaup Reymond M,Akira S,Petrilli V,Gomez CE,Perdiguero B,Tschopp J,Pantaleo G,Esteban M,Calandra T

更新日期：2009-06-01 00:00:00

abstract：:Abilities of bacterial pathogens to adapt to the iron limitation present in hosts is critical to their virulence. Bacterial pathogens have evolved diverse strategies to coordinately regulate iron metabolism and virulence associated functions to maintain iron homeostasis in response to changing iron availability in the...

journal_title：PLoS pathogens

authors： Pandey SS,Patnana PK,Lomada SK,Tomar A,Chatterjee S

更新日期：2016-11-30 00:00:00

abstract：:The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. The latter stage has been linked to chronic diseases. To analyze Cpn C...

journal_title：PLoS pathogens

authors： Mäurer AP,Mehlitz A,Mollenkopf HJ,Meyer TF

更新日期：2007-06-01 00:00:00

abstract：:HIV-1 infection of macrophages plays a key role in viral pathogenesis and progression to AIDS. Polyinosine-polycytidylic acid (poly(I:C); a synthetic analog of dsRNA) and bacterial lipopolysaccharide (LPS), the ligands for Toll-like receptors (TLR) TLR3 and TLR4, respectively, are known to decrease HIV-1 infection in ...

journal_title：PLoS pathogens

authors： Swaminathan G,Rossi F,Sierra LJ,Gupta A,Navas-Martín S,Martín-García J

更新日期：2012-09-01 00:00:00

abstract：:The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after import have not been studied. To elucidate these essential HIV-1 post-entry events, we labeled viral complexes with two fluorescently tagged virion-incorporated proteins (APOBEC3F or integrase), and analyzed the HIV-1 dynamics of ...

journal_title：PLoS pathogens

authors： Burdick RC,Delviks-Frankenberry KA,Chen J,Janaka SK,Sastri J,Hu WS,Pathak VK

更新日期：2017-08-21 00:00:00

abstract：:Interspecific and intervarietal hybridization may contribute to the biological diversity of fungal populations. Cryptococcus neoformans is a pathogenic yeast and the most common fungal cause of meningitis in patients with AIDS. Most patients are infected with either of the two varieties of C. neoformans, designated as...

journal_title：PLoS pathogens

authors： Litvintseva AP,Lin X,Templeton I,Heitman J,Mitchell TG

更新日期：2007-08-17 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1002924.]. ...

journal_title：PLoS pathogens

authors： Grard G,Fair JN,Lee D,Slikas E,Steffen I,Muyembe JJ,Sittler T,Veeraraghavan N,Ruby JG,Wang C,Makuwa M,Mulembakani P,Tesh RB,Mazet J,Rimoin AW,Taylor T,Schneider BS,Simmons G,Delwart E,Wolfe ND,Chiu CY,Leroy EM

更新日期：2017-09-07 00:00:00

abstract：:RNA polyadenylation (pA) is one of the major steps in regulation of gene expression at the posttranscriptional level. In this report, a genome landscape of pA sites of viral transcripts in B lymphocytes with Kaposi sarcoma-associated herpesvirus (KSHV) infection was constructed using a modified PA-seq strategy. We ide...

journal_title：PLoS pathogens

authors： Majerciak V,Ni T,Yang W,Meng B,Zhu J,Zheng ZM

更新日期：2013-01-01 00:00:00

abstract：:Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within th...

journal_title：PLoS pathogens

authors： Gunn BM,Morrison TE,Whitmore AC,Blevins LK,Hueston L,Fraser RJ,Herrero LJ,Ramirez R,Smith PN,Mahalingam S,Heise MT

更新日期：2012-01-01 00:00:00

abstract：:Neisseria gonorrhoeae causes the sexually-transmitted infection gonorrhea, a global disease that is difficult to treat and for which there is no vaccine. This pathogen employs an arsenal of conserved outer membrane proteins called TonB-dependent transporters (TdTs) that allow the gonococcus to overcome nutritional imm...

journal_title：PLoS pathogens

authors： Maurakis S,Keller K,Maxwell CN,Pereira K,Chazin WJ,Criss AK,Cornelissen CN

更新日期：2019-08-01 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:From 1992 onwards, outbreaks of a previously unknown illness have been reported in Asian seabass (Lates calcarifer) kept in maricultures in Southeast Asia. The most striking symptom of this emerging disease is the loss of scales. It was referred to as scale drop syndrome, but the etiology remained enigmatic. By using ...

journal_title：PLoS pathogens

authors： de Groof A,Guelen L,Deijs M,van der Wal Y,Miyata M,Ng KS,van Grinsven L,Simmelink B,Biermann Y,Grisez L,van Lent J,de Ronde A,Chang SF,Schrier C,van der Hoek L

更新日期：2015-08-07 00:00:00

abstract：:Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of ...

journal_title：PLoS pathogens

authors： Luo H,Li G,Wang B,Tian B,Gao J,Zou J,Shi S,Zhu S,Peng BH,Adam A,Martinez A,Hein K,Winkelmann ER,Mahmoud Y,Zhou X,Shan C,Rossi S,Weaver S,Barrett ADT,Sun SC,Zhang W,Shi PY,Wu P,Wang T

更新日期：2020-06-16 00:00:00

abstract：:The sedentary plant-parasitic nematodes are considered among the most economically damaging pathogens of plants. Following infection and the establishment of a feeding site, sedentary nematodes become immobile. Loss of mobility is reversed in adult males while females never regain mobility. The structural basis for th...

journal_title：PLoS pathogens

authors： Han Z,Thapa S,Reuter-Carlson U,Reed H,Gates M,Lambert KN,Schroeder NE

更新日期：2018-08-16 00:00:00

abstract：:Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-bo...

journal_title：PLoS pathogens

authors： Schmidt ME,Knudson CJ,Hartwig SM,Pewe LL,Meyerholz DK,Langlois RA,Harty JT,Varga SM

更新日期：2018-01-02 00:00:00

abstract：:Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human herpesviruses. Human N-myc interactor (Nmi) protein, which has been shown to interact with signal transducer and activator of transcription (STAT) proteins including ...

journal_title：PLoS pathogens

authors： Feng L,Sheng J,Vu GP,Liu Y,Foo C,Wu S,Trang P,Paliza-Carre M,Ran Y,Yang X,Sun X,Deng Z,Zhou T,Lu S,Li H,Liu F

更新日期：2018-01-29 00:00:00

abstract：:Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

journal_title：PLoS pathogens

authors： Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

更新日期：2018-12-19 00:00:00

abstract：:Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we...

journal_title：PLoS pathogens

authors： Wang X,Xu F,Liu J,Gao B,Liu Y,Zhai Y,Ma J,Zhang K,Baker TS,Schulten K,Zheng D,Pang H,Sun F

更新日期：2013-01-01 00:00:00

abstract：:EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). The EBV latency protein, EBNA2, transcriptionally activates the promoters of all latent viral protein-coding genes expressed in type III EBV lat...

journal_title：PLoS pathogens

authors： Li C,Romero-Masters JC,Huebner S,Ohashi M,Hayes M,Bristol JA,Nelson SE,Eichelberg MR,Van Sciver N,Ranheim EA,Scott RS,Johannsen EC,Kenney SC

更新日期：2020-06-15 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions between two critical modi...

journal_title：PLoS pathogens

authors： Sakane N,Kwon HS,Pagans S,Kaehlcke K,Mizusawa Y,Kamada M,Lassen KG,Chan J,Greene WC,Schnoelzer M,Ott M

更新日期：2011-08-01 00:00:00

abstract：:Isolated influenza A virus nucleoprotein exists in an equilibrium between monomers and trimers. Samples containing only monomers or only trimers can be stabilized by respectively low and high salt. The trimers bind RNA with high affinity but remain trimmers, whereas the monomers polymerise onto RNA forming nucleoprote...

journal_title：PLoS pathogens

authors： Chenavas S,Estrozi LF,Slama-Schwok A,Delmas B,Di Primo C,Baudin F,Li X,Crépin T,Ruigrok RW

更新日期：2013-03-01 00:00:00

abstract：:Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode...

journal_title：PLoS pathogens

authors： Luallen RJ,Reinke AW,Tong L,Botts MR,Félix MA,Troemel ER

更新日期：2016-06-30 00:00:00