Abstract：
:The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. We conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking. 24 smokers were randomised to receive an inhaler of CBD (n=12) or placebo (n=12) for one week, they were instructed to use the inhaler when they felt the urge to smoke. Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly reduced the number of cigarettes smoked by ~40% during treatment. Results also indicated some maintenance of this effect at follow-up. These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Morgan CJ,Das RK,Joye A,Curran HV,Kamboj SKdoi
10.1016/j.addbeh.2013.03.011subject
Has Abstractpub_date
2013-09-01 00:00:00pages
2433-6issue
9eissn
0306-4603issn
1873-6327pii
S0306-4603(13)00083-Xjournal_volume
38pub_type
杂志文章,随机对照试验abstract：:The efficacy of the Alcohol Skills Training Program (ASTP; Miller, et al., 2000) was evaluated in 204 heavy-drinking college students randomly assigned to either ASTP (n=119) or an assessment-only control (n=85) condition. The volunteer ASTP sample (n=119) was also compared to a sample of students mandated to ASTP fol...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2010.08.009
更新日期：2010-12-01 00:00:00
abstract：:Using the National Longitudinal Study of Adolescent Health (Add Health), the current study applies a general biosocial theoretical model to polydrug use and associated substance-related problems. Along with measures of molecular genetic polymorphisms, neurocognitive skills, self-control, and environmental pathogens a ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.08.011
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:Non-abstinent goals can improve quality of life (QOL) among individuals with alcohol use disorders (AUDs). However, prior studies have defined "recovery" based on DSM criteria, and thus may have excluded individuals using non-abstinent techniques that do not involve reduced drinking. Furthermore, no prior stu...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.07.010
更新日期：2014-12-01 00:00:00
abstract：:The present study examined the role of action orientation in health behavior change. Eighty-six binge drinking college students completed measures of alcohol use, alcohol-related consequences (e.g., driving drunk), motivation to change drinking, and action orientation. Alcohol use and consequences were reassessed 1 mo...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(01)00186-1
更新日期：2002-03-01 00:00:00
abstract：:The Forbidden Food Survey is an instrument that was designed for use with eating disordered individuals. The first experiment in this study includes a description of the Forbidden Food Survey and the reliability and internal consistency of its scales. The second investigation examined the discriminant validity of the ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(88)90053-6
更新日期：1988-01-01 00:00:00
abstract：:Marriage has been cited as a protective factor against drug use, but the relationship between marriage and drug use has not been explored longitudinally during addiction treatment. The current study assessed individual trajectories of substance use during treatment as a function of marital status and perceived closene...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.10.020
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Substance use disorders (SUD) represent one of the most important public health problems which has an onset in adolescence. Although substantial data exist on adolescent substance use, studies examining the role of parental psychopathological profiles on adolescent offspring SUD are lacking. Thus, this study...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106611
更新日期：2021-01-01 00:00:00
abstract：:The current research examined whether alcohol consumption exacerbates suicidal ideations among gamblers in the general population. While prior research suggests problem gambling severity and excessive alcohol consumption are unique predictors of suicidal behaviors, the extant literature as almost exclusively focused o...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.12.017
更新日期：2016-04-01 00:00:00
abstract：:The purpose of this study was to examine the relationship of treatment outcomes in opioid detoxification to levels of counselor and peer alliance. Forty-one subjects were recruited from a larger, 180-day study of psychosocial treatment. Beginning at day 90, subjects completed monthly measures of alliance. Outcome meas...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(94)00080-i
更新日期：1995-05-01 00:00:00
abstract：:This study was conducted to identify the psychosocial factors associated with successful smoking cessation among ever-smokers aged 60 and older in the United States. Descriptive and multivariate analyses of the 2000 National Health Interview Survey (NHIS) were conducted. Controlling for sociodemographics and medical h...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2004.05.009
更新日期：2005-02-01 00:00:00
abstract：INTRODUCTION:Although it has been suggested that persons with psychopathological disorders experience greater difficulty in quitting smoking, the few studies that have analyzed personality disorders in smokers have failed to produce conclusive results. The aim of this study was to examine whether the presence of probab...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2013.03.017
更新日期：2013-08-01 00:00:00
abstract：:Psychosocial differences between criminal-justice-referred and voluntary clients, using a sample of 996 men and women in residential drug treatment in northern New Jersey, were explored. Results suggest differences in demographic characteristics between the two groups as well as differences in attitudes and behaviors ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(95)00102-6
更新日期：1997-03-01 00:00:00
abstract：:Using a cover story of the effects of alcohol on perceptual and motor abilities, two levels of alcohol consumed (moderate and none), two levels of alcohol expectancy (moderate and none), and two levels of sensation seeking (high and low) were combined to determine their effect on risk taking in a driving simulator. Ni...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(89)90037-3
更新日期：1989-01-01 00:00:00
abstract：:Emotional and role functioning difficulties are associated with chronic alcohol use and liver disease. Little is known about prospective changes in psychological and psychosocial functioning following orthotopic liver transplantation (OLT) amongst patients with alcoholic liver disease (ALD). We aimed to assess the fun...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2015.01.021
更新日期：2015-06-01 00:00:00
abstract：:In two experiments, nonsmoking females whose urine was acidified were more willing after smoking one cigarette to volunteer to smoke additional cigarettes than were females whose urine was made alkaline. Males did not exhibit this effect. The results indicate that physiological factors that influence nicotine intake d...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(82)90030-2
更新日期：1982-01-01 00:00:00
abstract：:College students experience myriad negative consequences from alcohol misuse. The strength of the association between level of alcohol use and consequences may change across the initial years of college, as students develop tolerance or learn to avoid negative effects of drinking. Time varying effect models (TVEM) all...
journal_title：Addictive behaviors
pub_type： 杂志文章,多中心研究
doi：10.1016/j.addbeh.2017.04.022
更新日期：2017-10-01 00:00:00
abstract：:Research shows that there has been a substantial increase in substance use and abuse during the COVID-19 pandemic, and that substance use/abuse is a commonly reported way of coping with anxiety concerning COVID-19. Anxiety about COVID-19 is more than simply worry about infection. Research provides evidence of a COVID ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106754
更新日期：2021-03-01 00:00:00
abstract：:This study examined prevalence of alcohol dependence symptoms and diagnosis among a nationally representative sample of recent onset adolescent drinkers aged 12-21 years (mean 17 years) across different levels of drinking drawn from National Survey of Drug Use and Health (N=9490). We assessed whether the relationship ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2011.07.014
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:In recent literature, abnormalities in the metacognitive domain have been pointed out as psychological variables that may account for a wide range of psychopathologies, including gambling disorder (GD). Considering the growing but scattered nature of the research concerning the relationship between metacog...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2020.106600
更新日期：2021-01-01 00:00:00
abstract：:The following questions, pertaining to cue reactivity in alcoholics, are discussed: (a) What cues are relevant to alcoholics' drinking? Previous research has been concerned with the obvious: bottles, glasses, pub/bar environments, and other visual cues. Presumably more potent cues, that is, smell, taste and internal e...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,评审
doi：10.1016/0306-4603(90)90046-z
更新日期：1990-01-01 00:00:00
abstract：:Ambulatory assessment (AA) methodologies have the potential to increase understanding and treatment of addictive behavior in seemingly unprecedented ways, due in part, to their emphasis on intensive repeated assessments of an individual's addictive behavior in context. But, many analytic techniques traditionally appli...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2017.12.018
更新日期：2018-08-01 00:00:00
abstract：:The goal of the present research was to test the value of evaluative conditioning (EC) to unobtrusively change alcohol-related attitudes and drinking behavior. In the EC paradigm, participants had to spot an irrelevant target picture in a series of trials in which many different stimuli were presented. In the experime...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2010.08.012
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:Chronic use of heroin typically leads to numerous negative life consequences and serious clinical impairment. Increased negative consequences can result in poor treatment outcomes as well as adverse health effects and impaired social functioning. Certain risk factors, including early substance use initiation...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.07.027
更新日期：2018-02-01 00:00:00
abstract：:Cigarette smoking is a clear problem among methadone-maintained persons, yet little is known about factors that may be associated with their motivation to quit smoking. A sample of 255 smokers, enrolled in a smoking cessation research protocol, completed measures of their smoking motivation, smoking habit, quitting hi...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2004.05.018
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVES:This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence. METHODS:This biphasic clinical trial consisted of a randomized, double-blind, placebo-controlled Detoxification Pha...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2009.03.014
更新日期：2009-06-01 00:00:00
abstract：:Sixty male subjects with self-reported high, moderate, and low aggressive dispositions were given the opportunity to aggress, by administering electric shocks, against an increasingly provocative fictitious opponent within the context of a competitive reaction time task. Subjects were randomly assigned to one of two c...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0306-4603(00)00175-1
更新日期：2002-03-01 00:00:00
abstract：:The relationship between heroin-related attentional bias (AB) and a proxy for dependence severity (monthly frequency of heroin use-injecting or inhaling) was measured in individuals attending a heroin harm reduction service. A flicker change blindness paradigm was employed in which change detection latencies were meas...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.06.019
更新日期：2007-04-01 00:00:00
abstract：OBJECTS:Understanding the neural basis underlying Internet gaming disorder (IGD) is essential for the diagnosis and treatment of this type of behavioural addiction. Aberrant resting-state functional connectivity (rsFC) of the default mode network (DMN) has been reported in individuals with IGD. Since rsFC is not a dire...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.10.019
更新日期：2019-03-01 00:00:00
abstract：:Greek-affiliated college students have been found to drink more heavily and frequently than other students. With female student drinking on the rise over the past decade, sorority women may be at particular risk for heavy consumption patterns. The current study is the first to apply the Theory of Planned Behavior (TPB...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2007.11.002
更新日期：2008-04-01 00:00:00
abstract：:Cigarette smoking-related symptomatology (e.g., craving; SRS) is linked to relapse after a quit attempt. SRS varies by menstrual phase, possibly due to variations in sex hormones (e.g., progesterone), though much of the research to-date has relied on observations from the menstrual cycle acting as a proxy for hormone ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2019.106148
更新日期：2020-03-01 00:00:00
