Abstract:
:Complexity generation in naturally occurring peptide scaffolds can occur either by posttranslational modifications of nascent ribosomal proteins or through post assembly line tailoring of nonribosomal peptides. Short enzymatic pathways utilizing bimodular and trimodular nonribosomal peptide synthetase (NRPS) assembly lines, followed by tailoring oxygenases and/or prenyltransferases, efficiently construct complex fungal peptidyl alkaloid scaffolds in Aspergilli, Neosartorya, and Penicillium species. Use of the nonproteinogenic amino acid anthranilate as chain-initiating building block and chain-terminating intramolecular nucleophile leads efficiently to peptidyl alkaloid scaffolds with two to seven fused rings.
journal_name
ACS Chem Bioljournal_title
ACS chemical biologyauthors
Walsh CT,Haynes SW,Ames BD,Gao X,Tang Ydoi
10.1021/cb4001684subject
Has Abstractpub_date
2013-07-19 00:00:00pages
1366-82issue
7eissn
1554-8929issn
1554-8937journal_volume
8pub_type
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