Abstract:
:Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environments.
journal_name
ACS Chem Bioljournal_title
ACS chemical biologyauthors
Stupp GS,von Reuss SH,Izrayelit Y,Ajredini R,Schroeder FC,Edison ASdoi
10.1021/cb300520usubject
Has Abstractpub_date
2013-02-15 00:00:00pages
309-13issue
2eissn
1554-8929issn
1554-8937journal_volume
8pub_type
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