Chemical detoxification of small molecules by Caenorhabditis elegans.

Abstract:

:Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides. The resulting glucosylated derivatives have significantly reduced toxicity to C. elegans, suggesting that these chemical modifications represent a general mechanism for worms to detoxify their environments.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Stupp GS,von Reuss SH,Izrayelit Y,Ajredini R,Schroeder FC,Edison AS

doi

10.1021/cb300520u

subject

Has Abstract

pub_date

2013-02-15 00:00:00

pages

309-13

issue

2

eissn

1554-8929

issn

1554-8937

journal_volume

8

pub_type

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