Abstract:
:Treatment with biological drugs is associated with increased susceptibility to viral infections. Reactivation of JC virus (JCV) and human cytomegalovirus (HCMV) in adults after therapy has been documented. The long-term effects of biological and conventional therapy on human herpesviruses and polyomaviruses infections in young patients were assessed. One hundred eighty-six samples [urine, serum, and blood cells (PBMCs)] from 62 patients (15.8 ± 6.2 years old) with Crohn's disease, ulcerative rectocolitis or juvenile rheumatoid arthritis treated with immunotherapy or conventional therapy for over 12 months were tested by real time PCR. One hundred twenty-four samples (urine and blood) from 62 matched healthy volunteers (13.8 ± 8.6 years old) were included as controls. Sequencing of the JCV viral protein 1 (VP1) and transcriptional control region (TCR) was performed. Herpes simplex virus 1/2 and varicella zoster virus genomes were not detected in any patients, whereas Epstein-Barr virus, HCMV, and human herpesvirus-6 genomes were detected in 4.8%, 3.2%, and 1.6% of the patients, respectively. JCV was detected in 22.6% (14/62) of urine samples from patients and in 8% (5/62) from controls, in 50% (7/14) of sera from patients shedding JCV, and in 71.4% (5/7) of matched PBMCs. There was a significant association between infliximab treatment and excretion of JCV genotype 2. Subclinical infection/reactivation of JCV genotype 2 in young patients during infliximab therapy was demonstrated. Conversely, increased susceptibility to herpesviruses infection was not shown. Future studies are warranted to investigate the effects of JCV reactivation on the health of young patients treated with infliximab.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Comar M,Delbue S,Lepore L,Martelossi S,Radillo O,Ronfani L,D'Agaro P,Ferrante Pdoi
10.1002/jmv.23525subject
Has Abstractpub_date
2013-04-01 00:00:00pages
716-22issue
4eissn
0146-6615issn
1096-9071journal_volume
85pub_type
杂志文章abstract::Human metapneumovirus (hMPV) has been described as circulating among the Uruguayan population at least since 1998 based on serologic evidence. However, no isolation attempts, molecular detection, or genetic studies have been carried out so far in the country. In the present study, molecular detection of circulating hM...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21752
更新日期:2010-05-01 00:00:00
abstract::The infectivity titer of a standard stock of the SAR-55 strain of hepatitis E virus (HEV) was determined in cynomolgus macaques (Macaca fascicularis) and the effect of dose on the course of the infection was examined by weekly monitoring of alanine aminotransferase (ALT) and anti-HEV levels. Antibody to HEV (anti-HEV)...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430207
更新日期:1994-06-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofov...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21165
更新日期:2008-05-01 00:00:00
abstract::The reliability of the polymerase chain reaction (PCR) for prenatal diagnosis of human cytomegalovirus (HCMV) infection was determined by retrospective testing of 35 amniotic fluids identified previously as positive or negative for HCMV by virus isolation. Amniocentesis was performed in 26 pregnant women with primary ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470428
更新日期:1995-12-01 00:00:00
abstract::A possible new subgroup of human rotavirus was found by crossed immunoelectrophoresis and enzyme-linked immunosorbent assay. The epidemiology of the established subgroups 1 and 2 and this new variant was studied in two different communities. Of 398 rotavirus isolates from Malmö, Sweden, 26.8% were of type 1, 71.7% of ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890120205
更新日期:1983-01-01 00:00:00
abstract::Chronic hepatitis C (HCV) infection is associated with cognitive impairments which might be mediated through a secondary inflammatory cascade. Egypt has an unusually high prevalence of HCV monoinfections and is an ideal site for the study of the isolated effects of HCV infection. Therefore, in a hospital-based cross-s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21879
更新日期:2011-02-01 00:00:00
abstract::Noroviruses (NoV) and sapoviruses (SaV) are recognized as important causes of acute gastroenteritis in children worldwide. In this study, the prevalence and genetic variability of NoV and SaV were determined in hospitalized children <5 years of age with acute gastroenteritis in Hanoi, Vietnam. A total of 501 fecal spe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23185
更新日期:2012-02-01 00:00:00
abstract::Human bocavirus (HBoV) is known to be associated with a variety of clinical manifestation including acute gastroenteritis (AGE). Despite their global prevalence, no data is available on the epidemiology of HBoV associated with AGE in South Africa (SA). Between April 2009 and April 2015, 3765 stool specimens were colle...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25634
更新日期:2020-08-01 00:00:00
abstract::The natural history of chronic hepatitis B virus (HBV) infection is highly variable, ranging from a benign course to one of shortened life expectancy. Liver histology represents an accurate tool for assessing progressive liver disease, and has been used in five recent Phase III clinical trials of the oral nucleoside a...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
abstract::Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high-risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Sh...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24718
更新日期:2017-05-01 00:00:00
abstract::A single rotavirus strain causing asymptomatic infections as well as severe gastrointestinal disease has been described in the neonatal nurseries of the Christian Medical College, Vellore. In this study, quantitative real-time RT-PCR was used to determine the association of viral load with the presence of gastrointest...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21872
更新日期:2010-10-01 00:00:00
abstract::Subviral particles of hepatitis B virus have been used to present foreign epitopes. We attempted to present the hydrophilic domains of E2 envelope protein of hepatitis C virus (HCV) as a fusion protein with hepatitis B virus surface antigen (HBsAg). The five hydrophilic domains of HCV E2 antigen were inserted into HBs...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199610)50:2<145::AID-JMV7>
更新日期:1996-10-01 00:00:00
abstract::The prevalence of HHV-8 infection varies widely in South American populations, displaying geographical variations in its distribution. The heterogeneous genetic contributions provided by the transatlantic parental populations that modified the Native American genomes may explain this epidemiological observation. Aimin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24656
更新日期:2017-03-01 00:00:00
abstract::A 31-year-old woman contracted acute varicella at 13 weeks of gestation. Severe hydrops fetalis, hepatomegaly, and intrauterine fetal death were detected at 16 weeks of gestation by ultrasound examinations. An examination at autopsy, histopathology, and polymerase chain reaction (PCR) provided evidence of varicella-zo...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23531
更新日期:2013-05-01 00:00:00
abstract::Influenza epidemic is an important cause of severe illness in the elderly. Age-dependent morbidity of influenza in the elderly is associated with weakened immunity. The baseline age-related memory T cell activity in Chinese persons who are exposed to influenza virus through natural infection, are associated with the p...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21544
更新日期:2009-08-01 00:00:00
abstract::Herpesviruses produce assembly proteins (AP) that act as scaffolding proteins for the assembly of the viral capsids. The products of the assemblin gene, which encodes both maturational protease and AP, have been established for herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (CMV). We cloned an inframe O...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::It is well documented that perinatal transmission is the major cause of chronic HBV infection in China. However, the mechanisms of HBV perinatal transmission are not defined clearly. It is not known whether hepatitis B e antigen can cross the human placenta, and the rate of HBeAg decay in babies with and without HBV b...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10493
更新日期:2003-11-01 00:00:00
abstract::A line of hepatitis C virus (HCV) transgenic mice was established previously that was mediated by Cre/loxP system using HCV cDNA, including core, E1, E2 and NS2 genes. Intravenous infection of a recombinant adenovirus that expresses Cre DNA recombinase (AxCANCre) induced HCV structural protein expression in the liver ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200011)62:3<308::aid-jmv2>3.0.co
更新日期:2000-11-01 00:00:00
abstract::Management of patients infected with high-risk HPV (hrHPV) despite normal colposcopy following abnormal cytology remains a clinical challenge. The aim of this study was to evaluate if, in that specific population, initial HPV 16 and HPV 18 viral loads are predictive of infection clearance over a 24-month follow-up. A ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23276
更新日期:2012-06-01 00:00:00
abstract::Potential risk factors for the development of hepatocellular carcinoma were analysed in 40 Caucasian patients with this malignancy. A higher proportion (14 of 40; 35%) had evidence of hepatitis C virus (HCV) infection than had evidence of either hepatitis B virus (HBV) carriage (17.5%) or alcohol abuse (30%). In all 1...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380215
更新日期:1992-10-01 00:00:00
abstract::The Gaza Strip borders the southern part of Israel and Egypt. There is a remarkable difference in the prevalence of antibodies to hepatitis C virus (HCV) between Israel (0.5%) and Egypt (10%). A few thousand inhabitants cross the borders daily from the Gaza Strip to both countries. The objectives of this study were to...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199811)56:3<230::aid-jmv9>
更新日期:1998-11-01 00:00:00
abstract::Present diagnostic criteria for occult hepatitis B virus (HBV) infection requires blood or liver samples to test positive for at least two HBV DNA targets in hepatitis B surface antigen (HBsAg) negative individuals. These criteria were derived from studies involving referred or selected patient populations. The object...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23813
更新日期:2014-01-01 00:00:00
abstract::A study was carried out to determine whether hepatitis A virus (HAV) can be detected in the stools of patients hospitalized for HAV infection. Acute phase samples of whole blood and stool, as well as completed questionnaires, were obtained from 31 patients hospitalized at any of 13 hospitals in the Phoenix metropolita...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890090207
更新日期:1982-01-01 00:00:00
abstract::The relationships between host immune factors and HIV-1 disease progression are still in dispute. The RANTES SNPs exhibit distinct ethnic distribution and are associated with different effects on the course of HIV infection. Therefore, impact of RANTES gene polymorphism on HIV-1 transmission and progression needs to b...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21201
更新日期:2008-07-01 00:00:00
abstract::GII.b norovirus is an obligatory recombinant with an open reading frame (ORF) 1 comprising the GII.b genotype and the ORF 2 region corresponding to one of a number of other norovirus genotypes. GII.b is the second most common genotype after GII.4 associated with gastroenteritis outbreaks in Victoria, Australia. The st...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23633
更新日期:2013-08-01 00:00:00
abstract::A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucle...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199608)49:4<283::AID-JMV5>
更新日期:1996-08-01 00:00:00
abstract::HPV infection is a "necessary cause" of cervical cancer and it is sexually transmitted. Due to upcoming mass vaccination investigation on risk factors for infection is the basis to implement prophylactic strategy even in older women. The aim of the study was to evaluate predictors of high-risk (HR) HPV infection in ad...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21887
更新日期:2010-11-01 00:00:00
abstract::Several viruses are associated with gastroenteritis in infants. This pilot study, nested within a larger community-based project of early childhood infections, collected daily symptom data and 511 weekly stool samples from five healthy, fully vaccinated, term infants from birth until their second birthday. Real-time P...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24716
更新日期:2017-05-01 00:00:00
abstract::One hundred fifty-five chronic hepatitis C patients were assigned at random to receive natural lymphoblastoid interferon (IFN)alpha-n1, s.c., for 13 months in one of three treatment regimens: initial daily induction with 10 million units (MU) followed (group 1, n = 50) or not (group 2, n = 52) by 1 month of rest and t...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/jmv.1072
更新日期:2001-08-01 00:00:00