Comprehension of a simplified assent form in a vaccine trial for adolescents.

Abstract:

INTRODUCTION:Future HIV vaccine efficacy trials with adolescents will need to ensure that participants comprehend study concepts in order to confer true informed assent. A Hepatitis B vaccine trial with adolescents offers valuable opportunity to test youth understanding of vaccine trial requirements in general. METHODS:Youth reviewed a simplified assent form with study investigators and then completed a comprehension questionnaire. Once enrolled, all youth were tested for HIV and confirmed to be HIV-negative. RESULTS:123 youth completed the questionnaire (mean age=15 years; 63% male; 70% Hispanic). Overall, only 69 (56%) youth answered all six questions correctly. CONCLUSIONS:Youth enrolled in a Hepatitis B vaccine trial demonstrated variable comprehension of the study design and various methodological concepts, such as treatment group masking.

journal_name

J Med Ethics

authors

Lee S,Kapogiannis BG,Flynn PM,Rudy BJ,Bethel J,Ahmad S,Tucker D,Abdalian SE,Hoffman D,Wilson CM,Cunningham CK,Adolescent Medicine Trials Network for HIV\/AIDS Interventions.

doi

10.1136/medethics-2012-101286

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

410-2

issue

6

eissn

0306-6800

issn

1473-4257

pii

medethics-2012-101286

journal_volume

39

pub_type

杂志文章
  • Patients' rights--why the Australian courts have rejected 'Bolam'.

    abstract::This point of view compares the issue of informed patient consent primarily as it operates in Australia and the United Kingdom. It affords an overview, also, of the applicable law in the United States and Canada. It particularly focuses on the legal test to be applied to patient consent as established in the Bolam cas...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.21.1.5

    authors: Kirby M

    更新日期:1995-02-01 00:00:00

  • Misused honorary authorship is no excuse for quantifying the unquantifiable.

    abstract::Kovacs argues that honorary authorship and regarding each co-author of multi-authored papers as if they were sole authors when the performance of researchers is being evaluated by their publications mean that we should require authors to identify what proportion of each publication should be attributed to each co-auth...

    journal_title:Journal of medical ethics

    pub_type: 评论,杂志文章

    doi:10.1136/medethics-2012-100939

    authors: Dyck MJ

    更新日期:2013-08-01 00:00:00

  • Placebo: the lie that comes true?

    abstract::Over the decades of experimentation on the placebo effect, it has become clear that it is driven largely by expectation, and that strong expectations of efficacy are more likely to give rise to the experience of benefit. No wonder the placebo effect has come to resemble a self-fulfilling prophecy. However, this resemb...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2012-101057

    authors: Justman S

    更新日期:2013-04-01 00:00:00

  • Medical professionalism in the age of online social networking.

    abstract::The rapid emergence and exploding usage of online social networking forums, which are frequented by millions, present clinicians with new ethical and professional challenges. Particularly among a younger generation of physicians and patients, the use of online social networking forums has become widespread. In this ar...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2009.029231

    authors: Guseh JS 2nd,Brendel RW,Brendel DH

    更新日期:2009-09-01 00:00:00

  • Voices of moral authority: parents, doctors and what will actually help.

    abstract::The public often believes that parents have a right to make medical decisions about their child. The idea that, in respect of children, doctors should do what parents tell them to do is problematic on the face of it. The effect of such a claim would be that a doctor who acted deliberately to harm a child would be maki...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章,评审

    doi:10.1136/medethics-2017-104705

    authors: Hain RDW

    更新日期:2018-07-01 00:00:00

  • Resuscitation and senility: a study of patients' opinions.

    abstract::In the context of 'Do-not-resuscitate' (DNR) decisions, there is a lack of information in the UK on the opinions of patients and prospective patients. Written anonymous responses to questionnaires issued to 322 out-patient subjects showed that 97 per cent would opt for cardiopulmonary resuscitation (CPR) in their curr...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.19.2.104

    authors: Robertson GS

    更新日期:1993-06-01 00:00:00

  • High hopes and automatic escalators: a critique of some new arguments in bioethics.

    abstract::Two protechnology arguments, the "hopeful principle" and the "automatic escalator", often used in bioethics, are identified and critically analysed in this paper. It is shown that the hopeful principle is closely related to the problematic precautionary principle, and the automatic escalator argument has close affinit...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2006.016477

    authors: Holm S,Takala T

    更新日期:2007-01-01 00:00:00

  • FY1 doctors' ethicolegal challenges in their first year of clinical practice: an interview study.

    abstract:BACKGROUND:There is little evidence of junior trainee perspectives in the design and implementation of medical ethics and law (MEL) curriculum in UK medical schools. AIM:To determine the ethical issues the foundation year 1 (FY1) doctors (first year after graduation)  encountered during clinical practice and the skill...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章,多中心研究

    doi:10.1136/medethics-2011-100391

    authors: Vivekananda-Schmidt P,Vernon B

    更新日期:2014-04-01 00:00:00

  • Ethical issues in screening for hearing impairment in newborns in developing countries.

    abstract::Screening of newborns for permanent congenital or early-onset hearing impairment has emerged as an essential component of neonatal care in developed countries, following favourable outcomes from early intervention in the critical period for optimal speech and language development. Progress towards a similar programme ...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2005.014720

    authors: Olusanya BO,Luxon LM,Wirz SL

    更新日期:2006-10-01 00:00:00

  • Experiment on identical siblings separated at birth: ethical implications for researchers, universities, and archives today.

    abstract::Several films, including Three Identical Strangers, examined ethical problems in an experiment that involved identical siblings who were adopted as infants and separated into different families to examine the effects of nature versus nurture. The study was primarily designed and directed by Dr Peter Neubauer. The expe...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2019-105983

    authors: Klitzman RL,Kelmenson AM

    更新日期:2020-05-04 00:00:00

  • Post-recruitment confirmation of informed consent by SMS.

    abstract:BACKGROUND:To allow patients to reflect about a decision to participate in a clinical trial, guidelines suggest a 24-h delay from when they are informed about the trial to when they give consent. In certain clinical settings, this is likely to hamper recruitment. METHOD:After oral and written information about the tri...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2009.033456

    authors: Gulbrandsen P,Jensen BF

    更新日期:2010-02-01 00:00:00

  • Legitimate requests and indecent proposals: matters of justice in the ethical assessment of phase I trials involving competent patients.

    abstract::The death of Jesse Gelsinger in 1999 during a gene therapy trial raised many questions about the ethical review of medical research. Here, the author argues that the principle of justice is interpreted too narrowly and receives insufficient emphasis and that what we permit in terms of bodily invasion affects the value...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2003.006684

    authors: Kong WM

    更新日期:2005-04-01 00:00:00

  • Communication with the seriously ill: physicians' attitudes in Saudi Arabia.

    abstract:OBJECTIVES:To study some ethical problems created by accession of a previously nomadic and traditional society to modern invasive medicine, by assessment of physicians' attitudes towards sharing information and decision-making with patients in the setting of a serious illness. DESIGN:Self-completion questionnaire admi...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.22.5.282

    authors: Mobeireek AF,al-Kassimi FA,al-Majid SA,al-Shimemry A

    更新日期:1996-10-01 00:00:00

  • Patients' ethical obligation for their health.

    abstract::In contemporary medical ethics health is rarely acknowledged to be an ethical obligation. This oversight is due to the preoccupation of most bioethicists with a rationalist, contract model for ethics in which moral obligation is limited to truth-telling and promise-keeping. Such an ethics is poorly suited to medicine ...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.10.3.138

    authors: Sider RC,Clements CD

    更新日期:1984-09-01 00:00:00

  • Sturdy for common things: cultivating moral sensemaking on the front lines of practice.

    abstract::This essay argues that the field of bioethics should concern itself especially with the process of making moral sense that unfolds among clinicians, patients and family members during common but high-stakes conversations occurring on the front lines of practice. The essay outlines the parameters of a bioethics grounde...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2011-100084

    authors: Browning DM

    更新日期:2012-04-01 00:00:00

  • Fear of a female planet: how John Harris came to endorse eugenic social engineering.

    abstract::In this paper, I respond to criticisms by John Harris, contained in a commentary on my article "Harris, harmed states, and sexed bodies", which appeared in the Journal of Medical Ethics, volume 37, number 5. I argue that Harris's response to my criticisms exposes the strong eugenic tendencies in his own thought, when ...

    journal_title:Journal of medical ethics

    pub_type: 评论,杂志文章

    doi:10.1136/jme.2011.045021

    authors: Sparrow R

    更新日期:2012-01-01 00:00:00

  • Smoke and mirrors: unanswered questions and misleading statements obscure the truth about organ sources in China.

    abstract::This response refutes the claim made in a recent article that organs for transplantation in China will no longer be sourced from executed prisoners. We identify ongoing ethical problems due to the lack of transparent data on current numbers of transplants in China; implausible and conflicting claims about voluntary do...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2016-103533

    authors: Rogers WA,Trey T,Fiatarone Singh M,Bridgett M,Bramstedt KA,Lavee J

    更新日期:2016-08-01 00:00:00

  • The Nordic concept of 'faellesskab'.

    abstract::The complex of cultural, political and societal affiliations, both in a historic and a contemporary perspective, is expressed by a special term in the Nordic languages, 'faellesskab', often with the addition of 'folkelig', as 'folkeligt faellesskab', where 'folkelig' means of the people. No corresponding term exists i...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.17.1.41

    authors: Riis P

    更新日期:1991-03-01 00:00:00

  • Women's reproductive autonomy: medicalisation and beyond.

    abstract::Reproductive autonomy is central to women's welfare both because childbearing takes place in women's bodies and because they are generally expected to take primary responsibility for child rearing. In 2005, the factors that influence their autonomy most strongly are poverty and belief systems that devalue such autonom...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章,评审

    doi:10.1136/jme.2004.013193

    authors: Purdy L

    更新日期:2006-05-01 00:00:00

  • Should we clone human beings? Cloning as a source of tissue for transplantation.

    abstract::The most publicly justifiable application of human cloning, if there is one at all, is to provide self-compatible cells or tissues for medical use, especially transplantation. Some have argued that this raises no new ethical issues above those raised by any form of embryo experimentation. I argue that this research is...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.25.2.87

    authors: Savulescu J

    更新日期:1999-04-01 00:00:00

  • Parental procreative obligation and the categorisation of disease: the case of cystic fibrosis.

    abstract::The advent of prenatal genetic diagnosis has sparked debates among ethicists and philosophers regarding parental responsibility towards potential offspring. Some have attempted to place moral obligations on parents to not bring about children with certain diseases in order to prevent harm to such children. There has b...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2010.039230

    authors: Bosslet GT

    更新日期:2011-05-01 00:00:00

  • Embryonic life and human life.

    abstract::A new human life comes into being not when there is mere cellular life in a human embryo, but when the newly developing body organs and systems begin to function as a whole, the author argues. This is symmetrical with the dealth of an existing human life, which occurs when its organs and systems have permanently cease...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.11.4.205

    authors: Shea MC

    更新日期:1985-12-01 00:00:00

  • Cancer Research UK'S obesity campaign in 2018 and 2019: effective health promotion or perpetuating the stigmatisation of obesity?

    abstract::In 2018 and 2019 Cancer Research UK (CRUK) launched a controversial advertising campaign to inform the British public of obesity being a preventable cause of cancer. On each occasion the advertisements used were emotive and provoked frustration among the British public which was widely vocalised on social media. As we...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2020-106192

    authors: Varshney N

    更新日期:2020-11-25 00:00:00

  • How physician executives and clinicians perceive ethical issues in Saudi Arabian hospitals.

    abstract:OBJECTIVES:To compare the perceptions of physician executives and clinicians regarding ethical issues in Saudi Arabian hospitals and the attributes that might lead to the existence of these ethical issues. DESIGN:Self-completion questionnaire administered from February to July 1997. SETTING:Different health regions i...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.25.1.51

    authors: Saeed KS

    更新日期:1999-02-01 00:00:00

  • Blameworthy bumping? Investigating nudge's neglected cousin.

    abstract::The realm of non-rational influence, which includes nudging, is home to many other morally interesting phenomena. In this paper, I introduce the term bumping, to discuss the category of unintentional non-rational influence. Bumping happens constantly, wherever people make choices in environments where they are affecte...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2018-105179

    authors: Miyata-Sturm A

    更新日期:2019-04-01 00:00:00

  • Can the Catholic Church agree to condom use by HIV-discordant couples?

    abstract::Does the position of the Roman Catholic Church on contraception also imply that the usage of condoms by HIV-discordant couples is illicit? A standard argument is to appeal to the doctrine of double effect to condone such usage, but this meets with the objection that there exists an alternative action that brings about...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.2009.030767

    authors: Bovens L

    更新日期:2009-12-01 00:00:00

  • The role of the principle of double effect in ethics education at US medical schools and its potential impact on pain management at the end of life.

    abstract:BACKGROUND:Because opioids can suppress respiratory drive, the principle of double effect (PDE) has been used to justify their use for terminally ill patients. Recent studies, however, suggest that the risk of respiratory depression in typical end-of-life (EOL) situations may be overstated and that heightened concern f...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2011-100105

    authors: Macauley R

    更新日期:2012-03-01 00:00:00

  • The annual reports of Local Research Ethics Committees.

    abstract::Each Local Research Ethics Committee (LREC) is expected to produce an annual report for its establishing authority. Reports from 145 LRECs were examined with regard to (a) whether the committees were working within the terms of the most recent guidelines from the Department of Health and (b) observations on the role o...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.21.4.214

    authors: Foster CG,Marshall T,Moodie P

    更新日期:1995-08-01 00:00:00

  • The deadly business of an unregulated global stem cell industry.

    abstract::In 2016, the Office of the State Coroner of New South Wales released its report into the death of an Australian woman, Sheila Drysdale, who had died from complications of an autologous stem cell procedure at a Sydney clinic. In this report, we argue that Mrs Drysdale's death was avoidable, and it was the result of a p...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/medethics-2016-104046

    authors: Lysaght T,Lipworth W,Hendl T,Kerridge I,Lee TL,Munsie M,Waldby C,Stewart C

    更新日期:2017-11-01 00:00:00

  • Genetic privacy: orthodoxy or oxymoron?

    abstract::In this paper we question whether the concept of "genetic privacy" is a contradiction in terms. And, if so, whether the implications of such a conclusion, inevitably impact on how society comes to perceive privacy and responsibility generally. Current law and ethical discourse place a high value on self-determination ...

    journal_title:Journal of medical ethics

    pub_type: 杂志文章

    doi:10.1136/jme.25.2.144

    authors: Sommerville A,English V

    更新日期:1999-04-01 00:00:00