Abstract:
:Severe hand, foot, and mouth disease (HFMD) is likely to develop critical complications such as brainstem encephalitis, acute pulmonary edema, and circulatory failure, which cause child mortality during outbreaks. This study aims to investigate factors that predict the severity of HFMD. One hundred sixteen in-patient children with severe HFMD and 202 with mild HFMD were retrospectively enrolled. Potential factors were collected for each child including sex, age, residence, modes of delivery, birth weight, virus types causing HFMD, and virus exposure history. Univariate and multivariable logistic regression were used to determine which factors were associated with HFMD severity. In the univariate analysis, breastfeeding (OR 0.514, 95 % CI 0.309-0.856), rural residence (OR 1.971, 95 % CI 1.239-3.137), current Enterovirus 71 (EV71) infection (OR 2.539, 95 % CI 1.504-4.287), and previous Epstein-Barr virus (EBV) exposure (OR 3.136, 95 % CI 1.863-5.278) were each associated with the severity of HFMD. In the multivariate model, breastfeeding (OR 0.570, 95 % CI 0.332-0.980), rural residence (OR 1.973, 95 % CI 1.202-3.237), current EV71 infection (OR 2.290, 95 % CI 1.315-3.987), and previous EBV exposure (OR 2.550, 95 % CI 1.470-4.422) remained independently associated with the severity of HFMD. In conclusion, previous EBV exposure, EV71 infection, and rural residence are risk factors for severe HFMD; breastfeeding is a protective factor.
journal_name
Eur J Pediatrjournal_title
European journal of pediatricsauthors
Li Y,Dang S,Deng H,Wang W,Jia X,Gao N,Li M,Wang Jdoi
10.1007/s00431-013-1939-1subject
Has Abstractpub_date
2013-05-01 00:00:00pages
661-6issue
5eissn
0340-6199issn
1432-1076journal_volume
172pub_type
杂志文章abstract::Forty-five children (25 girls; 20 boys) with meningomyelocele (MMC) were assessed for growth, skeletal maturation and pubertal development. The spinal defects were operated on shortly after birth and all children required cerebral drainage for hydrocephalus. Standard deviation scores for height, sitting height, sub-is...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00451900
更新日期:1985-07-01 00:00:00
abstract:UNLABELLED:We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. The deficiency was secondary to prolonged exclusive breastfeeding with inadequate nutritional amounts of vitamin B12 from the mother. There were no clinical or biological signs of ma...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1577-4
更新日期:2012-01-01 00:00:00
abstract::Adolescence obesity and depression are increasingly prevalent and are associated with various health complications. The aim of this study was to examine the association between weight status (normal weight, overweight, and obese) and depressive symptoms in adolescents and to explore the probable mediators, including o...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-012-1753-1
更新日期:2012-08-01 00:00:00
abstract::Omalizumab is currently used in severe asthma and has been tried in other allergic disorders. The authors report two patients with multiple food allergies and eosinophilic esophagitis on a very restrictive diet who have been treated with omalizumab, in order to improve food intolerance--the major distressing factor in...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1540-4
更新日期:2011-11-01 00:00:00
abstract:UNLABELLED:The true burden of influenza in children is difficult to assess and is probably underestimated as clinical signs are usually nonspecific, and formal viral identification is rarely searched. In this study, we compare the clinical features of infections related to the new H1N1/09 influenza virus with infection...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-011-1513-7
更新日期:2012-01-01 00:00:00
abstract::Resting metabolic rate (RMR) and the thermic effect of a meal (TEM) were measured in a group of 26 prepubertal children divided into three groups: (1) children with both parents obese (n = 8, group OB2); (2) children with no obese parents and without familial history of obesity (n = 8, OB0); and (3) normal body weight...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02072489
更新日期:1993-02-01 00:00:00
abstract::In fourteen infants, aged 9--60 days, with generalized oedema seen during a one year period the common denominator was the administration of dipyrone one to two days prior to the development of oedema. None of the other causes of oedema in early life could be incriminated in any of these babies. Pediatricians should b...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00477053
更新日期:1977-11-04 00:00:00
abstract::A girl, now three years old, is reported, in whom at the age of 5 months the diagnosis of 3-HMG-CoA lyase deficiency was established. The characteristic excretion pattern consisted of 3-HMG, 3-CH3-glutaconic acid, 3-CH3-glutaric acid and 3-HIVA. Activity of 3-HMG-CoA lyase in leucocytes was very low. She had compensat...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00442334
更新日期:1982-02-01 00:00:00
abstract:UNLABELLED:Growth hormone (GH) secretion was determined by evaluating circadian GH profiles for 24 h and GH responses to clonidine stimulation test and insulin-stimulated hypoglycaemia (ITT), in nine prepubertal children with beta-thalassaemia major (TM) and 17 with non-GH deficient short stature (NGHDSS). The TM child...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02029352
更新日期:1995-06-01 00:00:00
abstract:UNLABELLED:Tracheal bronchus (TB) associated with VACTERL has not been reported previously. A 5-month-old girl with VACTERL association was ventilator-dependent following surgical closure of a patent ductus arteriosus (PDA). Chest radiographs showed persistent hyperinflation of the right upper lobe. Bronchoscopy showed...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-002-1109-3
更新日期:2003-03-01 00:00:00
abstract::A mother carrying a fetus affected with 21-hydroxylase deficiency received prenatal treatment with dexamethasone (0.5 mg, tid, p.o.) started from the very beginning of the 8th week of gestation. Prenatal diagnosis had to rely on amniocentesis with karyotyping and steroid hormone determination, because HLA and DNA data...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02190657
更新日期:1994-08-01 00:00:00
abstract:UNLABELLED:Alleviation of suffering is considered to be one of the important goals of medical interventions. Understanding of what constitutes suffering in children admitted to a pediatric intensive care unit (PICU) is lacking. This study aims to assess perceptions by parents, doctors, and nurses of suffering in critic...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-014-2440-1
更新日期:2015-05-01 00:00:00
abstract::When boys affected with steroid sulfatase deficiency are delivered, the lack of the enzyme in the placenta may cause birth complications. In postnatal life this gene defect gives rise to X-linked recessive ichthyosis. In a series of 25 patients birth complications were reported in 9 cases. Of these boys, 4 displayed b...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00661898
更新日期:1983-03-01 00:00:00
abstract::Recombinant interleukin 2 (rIL2) was administered to a patient with Wiskott-Aldrich syndrome for the treatment of an intractable facial herpetiform lesion. This treatment appeared to be effective in suppressing the virus activity. At the same time, a transient improvement of the chronic eczematoid dermatitis was obser...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01957224
更新日期:1993-12-01 00:00:00
abstract::A 2-month-old infant was admitted to hospital because of recurrent vomiting for 1 week, progressive apathy, and focal seizures. The cranial MRI showed a noticeable result. ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-012-1681-0
更新日期:2012-06-01 00:00:00
abstract::The heuristic concept of "inborn errors of metabolism" was introduced more then 70 years ago and by analogy has prompted the more recent introduction of the term "inborn errors of immunity". It is now well recognized that many inborn errors of immunity can be considered inborn errors of metabolism. Typically, many for...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00491916
更新日期:1985-05-01 00:00:00
abstract:UNLABELLED:Successful therapy of vasodilatory shock in adults and children with arginine-vasopressin (AVP) has been reported previously. Data on the use of vasopressin in neonates is limited. This retrospective study reports the effects of AVP-treatment in neonates with catecholamine-resistant systemic vasodilatation a...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-006-0400-0
更新日期:2007-12-01 00:00:00
abstract::Of 496 neonates and infants less than 1 year of age admitted to the paediatric surgical intensive care unit (PSICU) over a 5 year period (1983-1987), 94 required total parenteral nutrition (TPN) for more than 14 consecutive days, generally due to congenital anomalies of the digestive tract. Cholestasis occurred in 15 ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF02171565
更新日期:1990-02-01 00:00:00
abstract:UNLABELLED:Nemaline myopathy, one of the most benign myopathies in older children and adults, may be rarely associated with early death in the neonate. The authors report two cases, describing the ante- and postnatal clinical courses. Family history may help in establishing the diagnosis, but this was not the case in t...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01955190
更新日期:1996-06-01 00:00:00
abstract::Understanding which children are at increased risk for poor outcome with COVID-19 is critical. In this study, we link pediatric population-based data from the US Center for Disease Control and Prevention to COVID-19 hospitalization and in-hospital death. In 27,045 US children with confirmed COVID-19, we demonstrate th...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-021-03955-x
更新日期:2021-01-20 00:00:00
abstract::Monocytes play an essential role in cellular host defense as circulating phagocytes, as well as precursors of macrophages. We investigated the principal phagocytic activities in monocytes from cord blood of term infants by analysing adherence, random migration, chemotaxis, bactericidal activity, phagocytosis-associate...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00439252
更新日期:1986-10-01 00:00:00
abstract:UNLABELLED:Increased plasma tumour necrosis factor alpha (TNF) concentration correlates with mortality in sepsis. We suggested that pentoxifylline (PTXF), which is known to inhibit TNF production, may improve survival and attenuate clinical symptoms of sepsis in neonates. Plasma TNF levels were evaluated in 29 newborn ...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01955273
更新日期:1996-05-01 00:00:00
abstract::Although tobacco use has decreased in the general population in recent years, smoking remains high among subpopulations. This study examined whether sexual identity is associated with cigarette smoking and e-cigarette use among high school students. Data were drawn from the US Youth Risk Behavior Surveillance System (...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-019-03420-w
更新日期:2019-09-01 00:00:00
abstract::Renal tubular dysgenesis is a critical disorder characterized by the Potter phenotype and severe hypotension in the early neonatal period. We herein report a 3-year-old female with renal tubular dysgenesis. Endocrinological studies showed a high plasma renin activity (over 49.2 ng/ml/h; normal range 2.0-15.2), high ac...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-008-0743-9
更新日期:2009-02-01 00:00:00
abstract::Screening for coeliac disease (CD) with serum antigliadin antibodies (AGA) was performed in 1032 diabetic children and adolescents. In 8 children CD had been diagnosed before study entry. Of the remaining 1024 children, 33 had an elevated AGA titre in the first serum sample. On follow-up an elevated AGA titre was conf...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/BF00445915
更新日期:1988-11-01 00:00:00
abstract::The triad of adrenocortical insufficiency with alacrima and achalasia is an unusual disease entity in paediatrics. The association of autonomic and peripheral neuropathies has more commonly been reported in older individuals. We describe four children (two siblings) with this disorder, aged between 3 and 6 years at di...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF01972967
更新日期:1995-01-01 00:00:00
abstract::Twelve preterm infants, median gestational age 31.5 weeks, were entered into a randomised, placebo-controlled trial of bronchodilator therapy. Their postnatal age was a median of 17.5 months and all suffered from recurrent respiratory symptoms. The infants received either inhaled placebo or 40 micrograms of ipratropiu...
journal_title:European journal of pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01955008
更新日期:1991-10-01 00:00:00
abstract::A 4.5-year-old male patient is described with chorioretinopathy, minor facial anomalies, delayed closure of the fontanel, mental retardation, moderate hypotonia, epilepsy and hepatic fibrosis. Postural control, intentional vocalising and manual dexterity were superior to the performance of patients with classical Zell...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00441774
更新日期:1985-11-01 00:00:00
abstract::A male infant with transient citrullinemia is described. Initially, he was found to have hypertyrosinemia and hypermethioninemia upon routine neonatal screening for inborn errors of metabolism performed at 4 days of age and was revealed to have citrullinemia upon detailed examination of plasma amino acids. At 30 days ...
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/BF00445674
更新日期:1983-10-01 00:00:00
abstract::Complex regional pain syndrome (CRPS) is a condition of unknown etiology characterized by autonomic, sensory, and motor disturbance. CRPS usually follows an injury in the affected limb, which is often trivial in nature. CRPS involving the facial region is rare, and there have been no previous descriptions in children....
journal_title:European journal of pediatrics
pub_type: 杂志文章
doi:10.1007/s00431-013-2159-4
更新日期:2014-03-01 00:00:00