Mycolyl glycolipids stimulate macrophages to release a chemotactic factor.

Abstract:

:We have previously reported that mycolyl glycolipids from Nocardia rubra such as glucose or trehalose mycolates induced granuloma formation in mice. The structure of the carbohydrate moiety of the mycolyl glycolipids influenced the granuloma forming activity profoundly. Here, we have examined the macrophage-chemotactic activity in the culture supernatants stimulated with various glycolipids differing in carbohydrate moiety (trehalose 6,6'-dimycolate, or TDM; glucose monomycolate, or GM; mannose monomycolate, or MM; and fructose monomycolate, or FM). A distinctive chemotactic activity was detected with TDM or GM, but, little or none with MM or FM.

journal_name

FEMS Microbiol Lett

authors

Matsunaga I,Oka S,Inoue T,Yano I

doi

10.1016/0378-1097(90)90166-n

subject

Has Abstract

pub_date

1990-01-15 00:00:00

pages

49-53

issue

1-2

eissn

0378-1097

issn

1574-6968

journal_volume

55

pub_type

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