Programmed cell death and the pathogenesis of tissue injury induced by type A Francisella tularensis.

Abstract:

:Francisella tularensis is a highly virulent bacterial species that causes various forms of tularemia in humans. The urgency in understanding the pathogenesis of these diseases has stimulated unprecedented interest in this bacterial species over the past few years. Recent findings underscore a number of important distinctions between the Francisella ssp. and emphasize the importance of using type A F. tularensis strains when characterizing pathophysiological responses that are relevant to the lethal forms of human disease. This review focuses on the mediators of cell death induction in infected tissues and the implications of these processes on the pathophysiological changes observed in various host species.

journal_name

FEMS Microbiol Lett

authors

Parmely MJ,Fischer JL,Pinson DM

doi

10.1111/j.1574-6968.2009.01791.x

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

1-11

issue

1

eissn

0378-1097

issn

1574-6968

pii

FML1791

journal_volume

301

pub_type

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