Abstract:
BACKGROUND:The evolution of mycoplasmas from a common ancestor with Firmicutes has been characterized not only by genome down-sizing but also by horizontal gene transfer between mycoplasma species sharing a common host. The mechanisms of these gene transfers remain unclear because our knowledge of the mycoplasma mobile genetic elements is limited. In particular, only a few plasmids have been described within the Mycoplasma genus. RESULTS:We have shown that several species of ruminant mycoplasmas carry plasmids that are members of a large family of elements and replicate via a rolling-circle mechanism. All plasmids were isolated from species that either belonged or were closely related to the Mycoplasma mycoides cluster; none was from the Mycoplasma bovis-Mycoplasma agalactiae group. Twenty one plasmids were completely sequenced, named and compared with each other and with the five mycoplasma plasmids previously reported. All plasmids share similar size and genetic organization, and present a mosaic structure. A peculiar case is that of the plasmid pMyBK1 from M. yeatsii; it is larger in size and is predicted to be mobilizable. Its origin of replication and replication protein were identified. In addition, pMyBK1 derivatives were shown to replicate in various species of the M. mycoides cluster, and therefore hold considerable promise for developing gene vectors. The phylogenetic analysis of these plasmids confirms the uniqueness of pMyBK1 and indicates that the other mycoplasma plasmids cluster together, apart from the related replicons found in phytoplasmas and in species of the clade Firmicutes. CONCLUSIONS:Our results unraveled a totally new picture of mycoplasma plasmids. Although they probably play a limited role in the gene exchanges that participate in mycoplasma evolution, they are abundant in some species. Evidence for the occurrence of frequent genetic recombination strongly suggests they are transmitted between species sharing a common host or niche.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Breton M,Tardy F,Dordet-Frisoni E,Sagne E,Mick V,Renaudin J,Sirand-Pugnet P,Citti C,Blanchard Adoi
10.1186/1471-2180-12-257subject
Has Abstractpub_date
2012-11-12 00:00:00pages
257issn
1471-2180pii
1471-2180-12-257journal_volume
12pub_type
杂志文章相关文献
BMC MICROBIOLOGY文献大全abstract:BACKGROUND:Polymicrobial infections are responsible for significant mortality and morbidity in adults and children. Staphylococcus epidermidis and Candida albicans are the most frequent combination of organisms isolated from polymicrobial infections. Vascular indwelling catheters are sites for mixed species biofilm for...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-257
更新日期:2013-11-14 00:00:00
abstract:BACKGROUND:In the present work, we describe a group of anomalous dose-response (DR) profiles and develop a dynamic model that is able to explain them. Responses were obtained from conventional assays of three antimicrobial agents (nisin, pediocin and phenol) against two microorganisms (Carnobacterium piscicola and Leuc...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-220
更新日期:2010-08-19 00:00:00
abstract:BACKGROUND:Mycoplasmas-contamination of Orientia tsutsugamushi, one of the obligated intracellular bacteria, is a very serious problem in in vitro studies using cell cultures because mycoplasmas have significant influence on the results of scientific studies. Only a recommended decontamination method is to passage the ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-32
更新日期:2013-02-08 00:00:00
abstract:BACKGROUND:The ColRS two-component system has been shown to contribute to the membrane functionality and stress tolerance of Pseudomonas putida as well as to the virulence of Pseudomonas aeruginosa and plant pathogenic Xanthomonas species. However, the conditions activating the ColRS pathway and the signal(s) sensed by...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-162
更新日期:2014-06-20 00:00:00
abstract:BACKGROUND:A disrupted cell cycle progression of hepatocytes was reported in chronic hepatitis C virus (HCV) infection, which can contribute significantly in the associated pathogenesis. The present study aimed to further elaborate these disruptions by evaluating the expression of key cell cycle and apoptotic proteins ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-133
更新日期:2008-08-05 00:00:00
abstract:BACKGROUND:Tetrahymena thermophila is one of the best characterized unicellular eukaryotes and its genome is sequenced in its entirety. However, the AT-richness of the genome and an unusual codon usage cause problems in cloning and expression of the ciliate DNA. To overcome these technical hiatuses we developed a Cre-d...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-7-12
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Nitrosomonas europaea is a widely studied chemolithoautotrophic ammonia oxidizing bacterium. While significant work exists on the ammonia oxidation pathway of N. europaea, its responses to factors such as dissolved oxygen limitation or sufficiency or exposure to high nitrite concentrations, particularly at t...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-70
更新日期:2010-03-04 00:00:00
abstract:BACKGROUND:Chlamydia trachomatis, an obligate intracellular human pathogen, is the most prevalent bacterial sexually transmitted infection worldwide and a leading cause of preventable blindness. HtrA is a virulence and stress response periplasmic serine protease and molecular chaperone found in many bacteria. Recombina...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-190
更新日期:2008-11-06 00:00:00
abstract:BACKGROUND:Moraxella catarrhalis is a human-specific gram-negative bacterium readily isolated from the respiratory tract of healthy individuals. The organism also causes significant health problems, including 15-20% of otitis media cases in children and ~10% of respiratory infections in adults with chronic obstructive ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-140
更新日期:2013-06-19 00:00:00
abstract:BACKGROUND:Wolbachia, one of the most abundant taxa of intracellular Alphaproteobacteria, is widespread among arthropods and filarial nematodes. The presence of these maternally inherited bacteria is associated with modifications of host fitness, including a variety of reproductive abnormalities, such as cytoplasmic in...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1652-y
更新日期:2019-12-24 00:00:00
abstract:BACKGROUND:Accurate identification of Aspergillus species is a very important subject. Mass spectral fingerprinting using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is generally employed for the rapid identification of fungal isolates. However, the results are based on s...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-017-1009-3
更新日期:2017-04-26 00:00:00
abstract:BACKGROUND:Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities for causing disseminated disease in the blood of C3H/HeJ mice during early infection. RESULTS:B...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-016-0644-4
更新日期:2016-03-08 00:00:00
abstract:BACKGROUND:Bovicin HC5 is an antimicrobial peptide that shows a broad spectrum of activity and potential for biotechnological and therapeutic applications. To gain insight about the safety of bovicin HC5 application, the histological and immunostimulatory effects of orally administrated bovicin HC5 to BALB/c mice were ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-69
更新日期:2013-03-27 00:00:00
abstract:BACKGROUND:We have previously shown that supernatant from Candida albicans (CA) culture contains a Secretory Interleukin (IL)-12 Inhibitory Factor (CA-SIIF), which inhibits IL-12 production by human monocytes. However, the effect of CA-SIIF on secretion of other cytokines by monocytes is unknown, and detailed character...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-31
更新日期:2008-02-19 00:00:00
abstract:BACKGROUND:Probiotics have been reported to reduce total cholesterol levels in vitro, but more evidence is needed to determine the clinical relevance of this activity. Chinese traditional fermented pickles are a good source of lactic acid bacteria. Therefore, pickle samples were collected for screening lactic acid bact...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01922-4
更新日期:2020-08-04 00:00:00
abstract:BACKGROUND:Poorly understood but highly diverse microbial communities exist within anoxic and oxygen-depleted marine sediments. These communities often harbour single-celled eukaryotes that form symbiotic associations with different prokaryotes. During low tides in South-western British Columbia, Canada, vast areas of ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-145
更新日期:2010-05-19 00:00:00
abstract:BACKGROUND:The human gastrointestinal (GI) tract microbiota has been a subject of intense research throughout the 3rd Millennium. Now that a general picture about microbiota composition in health and disease is emerging, questions about factors determining development of microbiotas with specific community structures w...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1538-z
更新日期:2019-07-18 00:00:00
abstract:BACKGROUND:Mycobacterium avium is an environmental mycobacterium that can be divided into the subspecies avium, hominissuis, paratuberculosis and silvaticum. Some M. avium subspecies are opportunistic pathogens for animals and humans. They are ubiquitous in nature and can be isolated from natural sources of water, soil...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-7-14
更新日期:2007-03-05 00:00:00
abstract:BACKGROUND:Brucellosis incidence in China is divided into three stages: high incidence (1950s-1960s), decline (1970s-1980s), and re-emergence (1990s-2010s). At the re-emergence stage, Brucellosis incidence grew exponentially and spread to all 32 provinces. We describe the magnitude and the etiological distribution chan...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1149-0
更新日期:2018-01-10 00:00:00
abstract:BACKGROUND:Plant endophytic bacteria play an important role benefiting plant growth or being pathogenic to plants or organisms that consume those plants. Multiple species of bacteria have been found co-inhabiting plants, both cultivated and wild, with viruses and fungi. For these reasons, a general understanding of pla...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-1
更新日期:2013-01-03 00:00:00
abstract:BACKGROUND:A biofilm is a complex community of microorganisms that develop on surfaces in diverse environments. The thickness of the biofilm plays a crucial role in the physiology of the immobilized bacteria. The most cariogenic bacteria, mutans streptococci, are common inhabitants of a dental biofilm community. In thi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-236
更新日期:2008-12-29 00:00:00
abstract:BACKGROUND:Chlamydiae are obligate intracellular pathogens that possess a type III secretion system to deliver proteins into the host cell during infection. Small molecule inhibitors of type III secretion in Yersinia, termed INPs (Innate Pharmaceuticals AB) were reported to strongly inhibit Chlamydia growth in epitheli...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-75
更新日期:2009-04-21 00:00:00
abstract:BACKGROUND:Glycopeptidolipids (GPLs) are among the major free glycolipid components of the outer membrane of several saprophytic and clinically-relevant Mycobacterium species. The architecture of GPLs is based on a constant tripeptide-amino alcohol core of nonribosomal peptide synthetase origin that is N-acylated with ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-118
更新日期:2012-06-22 00:00:00
abstract:BACKGROUND:Mycoplasma pneumoniae has previously been characterized as a micro-organism that is genetically highly stable. In spite of this genetic stability, homologous DNA recombination has been hypothesized to lie at the basis of antigenic variation of the major surface protein, P1, of M. pneumoniae. In order to iden...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-167
更新日期:2008-10-02 00:00:00
abstract:BACKGROUND:The microbiota of the mammalian gastrointestinal (GI) tract consists of diverse populations of commensal bacteria that interact with host physiological function. Dysregulating these populations, through exogenous means such as antibiotics or dietary changes, can have adverse consequences on the health of the...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-189
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:Salmonella enterica is a facultative intracellular pathogen that replicates within a membrane-bound compartment termed Salmonella containing vacuole (SCV). The biogenesis of SCV requires Salmonella type III protein secretion/translocation system and their effector proteins which are translocated into host ce...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-228
更新日期:2010-08-26 00:00:00
abstract:BACKGROUND:The mce operons play an important role in the entry of M. tuberculosis into macrophages and non-phagocytic cells. Their non-redundant function as well as complex regulation is implied by the phenotype of mce mutants. Recently, mce1 operon was found to extend over 13 genes, fadD5 (Rv0166) being the first gene...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-128
更新日期:2010-04-27 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) biofilm producers represent an important etiological agent of many chronic human infections. Antibiotics and host immune responses are largely ineffective against bacteria within biofilms. Alternative actions and novel antimicrobials should be considered. In...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1484-9
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:The Gifsy-I phage integrates into the Salmonella Typhimurium chromosome via an integrase mediated, site-specific recombination mechanism. Excision of the Gifsy-I phage requires three proteins, the Gifsy-I integrase (Int), the Gifsy-I excisionase (Xis) protein, and host encoded Integration Host Factor (IHF). ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-8-199
更新日期:2008-11-17 00:00:00
abstract:BACKGROUND:The lung of patients with cystic fibrosis (CF) is particularly sensitive to Pseudomonas aeruginosa. This bacterium plays an important role in the poor outcome of CF patients. During the disease progress, first acquisition of P. aeruginosa is the key-step in the management of CF patients. Quantitative PCR (qP...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-143
更新日期:2013-06-21 00:00:00