Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice.

abstract：BACKGROUND:Metabolically versatile soil bacteria Burkholderia cepacia complex (Bcc) have emerged as opportunistic pathogens, especially of cystic fibrosis (CF). Previously, we initiated the characterization of the phenylacetic acid (PA) degradation pathway in B. cenocepacia, a member of the Bcc, and demonstrated the ne...

journal_title：BMC microbiology

authors： Hamlin JN,Bloodworth RA,Cardona ST

更新日期：2009-10-18 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical c...

journal_title：BMC microbiology

authors： Zhang D,Dong P,Zhang K,Deng L,Bach C,Chen W,Li F,Protzer U,Ding H,Zeng C

更新日期：2012-12-28 00:00:00

abstract：BACKGROUND:The aminoglycoside-resistance genes encoding aminoglycoside modifying enzymes and 16S rRNA methyltransferases are main factors contributing to increasing resistance to aminoglycosides. Characterization and distribution of antimicrobial resistance gene profiles provide important information on the potential d...

journal_title：BMC microbiology

authors： Hu X,Xu B,Yang Y,Liu D,Yang M,Wang J,Shen H,Zhou X,Ma X

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Compared with many protists, Giardia lamblia has a simple life cycle alternating between cyst and trophozoite. Most research on the molecular biology of Giardia parasites has focused on trophozoites and the processes of excystation and encystation, whereas cysts have attracted less interest. The striking mor...

journal_title：BMC microbiology

authors： Faghiri Z,Widmer G

更新日期：2011-05-04 00:00:00

abstract：BACKGROUND:The human gastrointestinal (GI) tract microbiota is characterised by an abundance of uncultured bacteria most often assigned in phyla Firmicutes and Bacteroidetes. Diversity of this microbiota, even though approached with culture independent techniques in several studies, still requires more elucidation. The...

journal_title：BMC microbiology

authors： Krogius-Kurikka L,Kassinen A,Paulin L,Corander J,Mäkivuokko H,Tuimala J,Palva A

更新日期：2009-04-08 00:00:00

abstract：BACKGROUND:Central nervous system disease is the most serious form of tuberculosis, and is associated with high mortality and severe neurological sequelae. Though recent clinical reports suggest an association of distinct Mycobacterium tuberculosis strains with central nervous system disease, the microbial virulence fa...

journal_title：BMC microbiology

authors： Be NA,Bishai WR,Jain SK

更新日期：2012-01-13 00:00:00

abstract：BACKGROUND:Diazotrophic (nitrogen-fixing) Gram-positive and endospore-formed Paenibacillus spp. have potential uses as a bacterial fertilizer in agriculture. The transcriptional analysis of nitrogen fixation in Paenibacillus is lacking, although regulation mechanisms of nitrogen fixation have been well studied in Gram-...

journal_title：BMC microbiology

authors： Shi HW,Wang LY,Li XX,Liu XM,Hao TY,He XJ,Chen SF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Bacillus sp. H2O-1, isolated from the connate water of a Brazilian reservoir, produces an antimicrobial substance (denoted as AMS H2O-1) that is active against sulfate reducing bacteria, which are the major bacterial group responsible for biogenic souring and biocorrosion in petroleum reservoirs. Thus, the u...

journal_title：BMC microbiology

authors： Korenblum E,de Araujo LV,Guimarães CR,de Souza LM,Sassaki G,Abreu F,Nitschke M,Lins U,Freire DM,Barreto-Bergter E,Seldin L

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Cryptosporidium spp. and Giardia duodenalis are important causes of diarrheal diseases in humans and animals worldwide, and there is an increased interest in the role of animals in the mechanical transmission of these protozoa. To examine the role of yaks in this process, we examined the occurrence and genot...

journal_title：BMC microbiology

authors： Qi M,Cai J,Wang R,Li J,Jian F,Huang J,Zhou H,Zhang L

更新日期：2015-05-21 00:00:00

abstract：BACKGROUND:Recent studies suggest that the reported protective effects of statins (HMG-CoA reductase inhibitors) against community-acquired pneumonia (CAP) and sepsis in humans may be due to confounders and a healthy user-effect. To directly test whether statins are protective against Streptococcus pneumoniae, the lead...

journal_title：BMC microbiology

authors： Boyd AR,Hinojosa CA,Rodriguez PJ,Orihuela CJ

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Pseudomonas syringae is pathogenic to a large number of plant species. For host colonization and disease progression, strains of this bacterium utilize an array of type III-secreted effectors and other virulence factors, including small secreted molecules such as syringolin A, a peptide derivative that inhib...

journal_title：BMC microbiology

authors： Dudnik A,Dudler R

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Nitrosomonas europaea is a widely studied chemolithoautotrophic ammonia oxidizing bacterium. While significant work exists on the ammonia oxidation pathway of N. europaea, its responses to factors such as dissolved oxygen limitation or sufficiency or exposure to high nitrite concentrations, particularly at t...

journal_title：BMC microbiology

authors： Yu R,Chandran K

更新日期：2010-03-04 00:00:00

abstract：BACKGROUND:Acinetobacter baumannii is a gram-negative bacterium which causes opportunistic infections in immunocompromised hosts. Genome plasticity has given rise to a wide range of strain variation with respect to antimicrobial resistance profiles and expression of virulence factors which lead to altered phenotypes as...

journal_title：BMC microbiology

authors： Boone RL,Whitehead B,Avery TM,Lu J,Francis JD,Guevara MA,Moore RE,Chambers SA,Doster RS,Manning SD,Townsend SD,Dent L,Marshall D,Gaddy JA,Damo SM

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:The role of Aspergillus fumigatus mycotoxins in the colonization of the respiratory tract by conidia has not been studied extensively, even though patients at risk from invasive aspergillosis frequently exhibit respiratory epithelium damage. In a previous study, we found that filtrates of A. fumigatus cultur...

journal_title：BMC microbiology

authors： Khoufache K,Puel O,Loiseau N,Delaforge M,Rivollet D,Coste A,Cordonnier C,Escudier E,Botterel F,Bretagne S

更新日期：2007-01-23 00:00:00

abstract：BACKGROUND:The Gram-negative bacterium Erwinia amylovora is the causal agent of the devastating disease fire blight in rosaceous plants such as apple, pear, quince, raspberry, and cotoneaster. In order to survive and multiply in a host, microbes must be able to circumvent the toxic effects of antimicrobial plant compou...

journal_title：BMC microbiology

authors： Pletzer D,Weingart H

更新日期：2014-07-11 00:00:00

abstract：BACKGROUND:The compatible solute trehalose is involved in the osmostress response of Rhizobium etli, the microsymbiont of Phaseolus vulgaris. In this work, we reconstructed trehalose metabolism in R. etli, and investigated its role in cellular adaptation and survival to heat and desiccation stress under free living con...

journal_title：BMC microbiology

authors： Reina-Bueno M,Argandoña M,Nieto JJ,Hidalgo-García A,Iglesias-Guerra F,Delgado MJ,Vargas C

更新日期：2012-09-17 00:00:00

abstract：BACKGROUND:Mob family proteins are conserved between animals, plants and fungi and are essential for the activation of NDR kinases that control crucial cellular processes like cytokinesis, proliferation and morphology. RESULTS:We identified a hypomorphic allele of ChMOB2 in a random insertional mutant (vir-88) of the ...

journal_title：BMC microbiology

authors： Schmidpeter J,Dahl M,Hofmann J,Koch C

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Many plants have been used in traditional medicine for their antibacterial, antifungal, antiprotozoal, antiviral, antidiarrhoeal, analgesic, antimalarial, antioxidant, anti-inflammatory and anticancer activities. In order to find novel antimicrobial and antiviral agents, the aim of the present study was the ...

journal_title：BMC microbiology

authors： Di Petrillo A,Fais A,Pintus F,Santos-Buelga C,González-Paramás AM,Piras V,Orrù G,Mameli A,Tramontano E,Frau A

更新日期：2017-07-14 00:00:00

abstract：BACKGROUND:Aspergillus fumigatus is a ubiquitous saprotrophic fungus and an opportunistic pathogen of humans and animals. Humans and animals can inhale hundreds of A. fumigatus spores daily. Normally this is harmless for humans, but in case of immunodeficiency, invasive pulmonary aspergillosis (IPA) can develop with a ...

journal_title：BMC microbiology

authors： Valdes ID,van den Berg J,Haagsman A,Escobar N,Meis JF,Hagen F,Haas PJ,Houbraken J,Wösten HAB,de Cock H

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Gene knockouts are a common tool used to study gene function in various organisms. However, designing gene knockouts is complicated in viruses, which frequently contain sequences that code for multiple overlapping genes. Designing mutants that can be traced by the creation of new or elimination of existing r...

journal_title：BMC microbiology

authors： Taylor LJ,Strebel K

更新日期：2017-01-07 00:00:00

abstract：BACKGROUND:Avian pathogenic Escherichia coli (APEC) and uropathogenic E. coli (UPEC) are the two main subsets of extraintestinal pathogenic E. coli (ExPEC). Both types have multiple iron acquisition systems, including heme and siderophores. Although iron transport systems involved in the pathogenesis of APEC or UPEC ha...

journal_title：BMC microbiology

authors： Gao Q,Wang X,Xu H,Xu Y,Ling J,Zhang D,Gao S,Liu X

更新日期：2012-07-20 00:00:00

abstract：BACKGROUND:The sequenced O45:K1:H7 Escherichia coli meningitis strain S88 harbors a large virulence plasmid. To identify possible genetic determinants of pS88 virulence, we examined the transcriptomes of 88 plasmidic ORFs corresponding to known and putative virulence genes, and 35 ORFs of unknown function. RESULTS:Qua...

journal_title：BMC microbiology

authors： Lemaître C,Bidet P,Bingen E,Bonacorsi S

更新日期：2012-06-21 00:00:00

abstract：BACKGROUND:Saudi Arabia is mostly barren except the southwestern highlands that are susceptible to environmental changes, a hotspot for biodiversity, but poorly studied for microbial diversity and composition. In this study, 454-pyrosequencing of 16S rRNA gene hypervariable region V6 was used to analyze soil bacterial ...

journal_title：BMC microbiology

authors： Yasir M,Azhar EI,Khan I,Bibi F,Baabdullah R,Al-Zahrani IA,Al-Ghamdi AK

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Ureaplasma urealyticum is a major pathogen associated with many diseases. The ability of U. urealyticum to protect itself from oxidative stress is likely to be important for its pathogenesis and survival, but its oxidative stress tolerance mechanisms remain unclear. This study investigates the antioxidant ac...

journal_title：BMC microbiology

authors： Dai G,Li R,Chen H,Jiang C,You X,Wu Y

更新日期：2015-07-26 00:00:00

abstract：BACKGROUND:Fecal microbiota transplantation (FMT) has been recently approved by FDA for the treatment of refractory recurrent clostridial colitis (rCDI). Success of FTM in treatment of rCDI led to a number of studies investigating the effectiveness of its application in the other gastrointestinal diseases. However, in ...

journal_title：BMC microbiology

authors： Goloshchapov OV,Olekhnovich EI,Sidorenko SV,Moiseev IS,Kucher MA,Fedorov DE,Pavlenko AV,Manolov AI,Gostev VV,Veselovsky VA,Klimina KM,Kostryukova ES,Bakin EA,Shvetcov AN,Gumbatova ED,Klementeva RV,Shcherbakov AA,Gorchak

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The infections caused by antibiotic multidrug-resistant bacteria seriously threaten human health. To prevent and cure the infections caused by multidrug-resistant bacteria, new antimicrobial agents are required. Antimicrobial peptides are ideal therapy candidates for antibiotic-resistant pathogens. However, ...

journal_title：BMC microbiology

authors： Mao R,Teng D,Wang X,Zhang Y,Jiao J,Cao X,Wang J

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:Non-ribosomal peptide synthetase (NRPS) enzymes govern the assembly of amino acids and related monomers into peptide-like natural products. A key goal of the field is to develop methods to effective recombine NRPS domains or modules, and thereby generate modified or entirely novel products. We previously sho...

journal_title：BMC microbiology

authors： Calcott MJ,Ackerley DF

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Globally, staphylococci have developed resistance to many antibiotics. New approaches to chemotherapy are needed and one such approach could be to use plant derived actives with conventional antibiotics in a synergestic way. The purpose of this study was to isolate α-mangostin from the mangosteen (Garcinia m...

journal_title：BMC microbiology

authors： Phitaktim S,Chomnawang M,Sirichaiwetchakoon K,Dunkhunthod B,Hobbs G,Eumkeb G

更新日期：2016-08-26 00:00:00

abstract：BACKGROUND:Antimicrobial resistance is currently a major global issue. As the rate of emergence of antimicrobial resistance has superseded the rate of discovery and introduction of new effective drugs, the medical arsenal now is experiencing shortage of effective drugs to combat diseases, particularly against diseases ...

journal_title：BMC microbiology

authors： Teh CH,Nazni WA,Nurulhusna AH,Norazah A,Lee HL

更新日期：2017-02-16 00:00:00

abstract：BACKGROUND:The balanced synthesis of membrane phospholipids, fatty acids and cell wall constituents is a vital facet of bacterial physiology, but there is little known about the biochemical control points that coordinate these activities in Gram-positive bacteria. In Escherichia coli, the glycerol-phosphate acyltransfe...

journal_title：BMC microbiology

authors： Parsons JB,Yao J,Jackson P,Frank M,Rock CO

更新日期：2013-11-16 00:00:00