Abstract:
BACKGROUND:Chlamydiae are obligate intracellular pathogens that possess a type III secretion system to deliver proteins into the host cell during infection. Small molecule inhibitors of type III secretion in Yersinia, termed INPs (Innate Pharmaceuticals AB) were reported to strongly inhibit Chlamydia growth in epithelial cells. In this study we have analyzed the effect of these drugs on bacterial invasiveness. RESULTS:We demonstrate that INPs affect Chlamydia growth in a dose dependent manner after bacterial invasion. The efficiency of C. trachomatis L2 and C. caviae GPIC entry into host cells was not altered in the presence of INPs. In C. caviae, entry appears to proceed normally with recruitment of actin and the small GTPases Rac, Cdc42 and Arf6 to the site of bacterial entry. CONCLUSION:INPs have a strong inhibitory effect on Chlamydia growth. However, bacterial invasion is not altered in the presence of these drugs. In the light of these results, we discuss several hypotheses regarding the mode of action of INPs on type III secretion during the Chlamydia infectious cycle.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Muschiol S,Normark S,Henriques-Normark B,Subtil Adoi
10.1186/1471-2180-9-75subject
Has Abstractpub_date
2009-04-21 00:00:00pages
75issn
1471-2180pii
1471-2180-9-75journal_volume
9pub_type
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