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Construction of a rhythm transfer system that mimics the cellular clock.

Abstract：

:Creation of an artificial oscillating gene expression system is one of the most challenging issues in synthetic biology. Here, we constructed a simple system to manipulate gene expression patterns to be circadian, reflecting the intrinsic cellular clock, by fusing a core clock protein, BMAL1 or CLOCK, with a zinc finger-type DNA binding domain. Circadian rhythmic gene expression was induced only when the target gene contained zinc finger-binding sequences. To our knowledge, this simple approach is the first to manipulate gene expression patterns into circadian rhythms and would be applicable to various endogenous genes.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Imanishi M,Yamamoto K,Yamada H,Hirose Y,Okamura H,Futaki S

doi

10.1021/cb300432s

subject

Has Abstract

pub_date

2012-11-16 00:00:00

pages

1817-21

issue

11

eissn

1554-8929

issn

1554-8937

journal_volume

7

pub_type

杂志文章

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