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A synthetic derivative of plant allylpolyalkoxybenzenes induces selective loss of motile cilia in sea urchin embryos.

Abstract：

:Polyalkoxybenzenes are plant components displaying a wide range of biological activities. In these studies, we synthesized apiol and dillapiol isoxazoline analogues of combretastatins and evaluated their effect on sea urchin embryos. We have shown that p-methoxyphenyl isoxazoline caused sea urchin embryo immobilization due to the selective excision of motile cilia, whereas long immotile sensory cilia of apical tuft remained intact. This effect was completely reversed by washing the embryos. The compound did not alter cell division, blastulae hatching, and larval morphogenesis. In our hands, the molecule would serve as a convenient tool for in vivo studying morphogenetic processes in the sea urchin embryo. We anticipate that both the assay and the described derivative could be used for studies in ciliary function in embryogenesis.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Semenova MN,Tsyganov DV,Yakubov AP,Kiselyov AS,Semenov VV

doi

10.1021/cb700163q

subject

Has Abstract

pub_date

2008-02-15 00:00:00

pages

95-100

issue

2

eissn

1554-8929

issn

1554-8937

journal_volume

3

pub_type

信件

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