Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer.

Abstract:

OBJECTIVE:To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. METHODS:Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 specimens from patients presenting with ovarian tumors, which include 156 benign cysts, 172 epithelial ovarian cancers (stage I/II, n=72; stage III/IV, n=100), 36 germ cell tumors and 11 borderline tumors, were included in the study analysis. Receiver operating characteristic analysis were performed to determine the cutoffs for age, CA-125, hK6, and hK10. Sensitivity, specificity, negative, and positive predictive values were determined for various combinations of the biomarkers. RESULTS:The levels of hK6 and hK10 were significantly elevated in ovarian cancer cases compared to benign cysts. Combination of 3 markers, age/CA-125/hk6 or CA-125/hk6/hk10, showed improved specificity (100%) and positive predictive value (100%) for prediction of ovarian cancer, when compared to the performance of single markers having 80-92% specificity and 74-87% positive predictive value. Four-marker combination, age/CA-125/hK6/hK10 also showed 100% specificity and 100% positive predictive value, although it demonstrated low sensitivity (11.9%) and negative predictive value (52.8%). CONCLUSION:The combination of human tissue kallikreins and CA-125 showed potential for improving prediction of epithelial ovarian cancer in patients presenting with ovarian tumors.

journal_name

J Gynecol Oncol

authors

Koh SC,Huak CY,Lutan D,Marpuang J,Ketut S,Budiana NG,Saleh AZ,Aziz MF,Winarto H,Pradjatmo H,Hoan NK,Thanh PV,Choolani M

doi

10.3802/jgo.2012.23.3.175

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

175-81

issue

3

eissn

2005-0380

issn

2005-0399

journal_volume

23

pub_type

杂志文章
  • Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology.

    abstract:OBJECTIVE:This study was conducted to examine the effects of front-line chemotherapy on overall survival (OS) and postrecurrence survival (PRS) of patients with recurrent ovarian cancer, when stratifying the histologic type. METHODS:Five hundred and seventy-four patients with recurrent ovarian cancer with sufficient c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.1.43

    authors: Kajiyama H,Shibata K,Mizuno M,Umezu T,Suzuki S,Sekiya R,Niimi K,Mitsui H,Yamamoto E,Kawai M,Nagasaka T,Kikkawa F

    更新日期:2014-01-01 00:00:00

  • Early stage (IA-IB) primary carcinoma of the fallopian tube: case-control comparison to adenocarcinoma of the ovary.

    abstract:OBJECTIVE:Early stage primary carcinoma of the fallopian tube (PCFT) is an uncommon condition when strict criteria are applied. The aim of this study was to compare the outcome stage IA-IB PCFT to a matched group of ovarian cancer (OC). METHODS:Between 1990 and 2008, 32 patients with stage IA-IB of PCFT were recorded ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.1.9

    authors: Vaysse C,Touboul C,Filleron T,Mery E,Jouve E,Leguevaque P,Morice P,Leblanc E,Querleu D

    更新日期:2011-03-31 00:00:00

  • The risk of lymphedema after postoperative radiation therapy in endometrial cancer.

    abstract:OBJECTIVE:Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk of infection. The goal of this study is to investigate factors that influence the likelihood of lymphedema in patients with endometrial cancer who undergo adjuvant radiation with or without...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2016.27.e4

    authors: Mitra D,Catalano PJ,Cimbak N,Damato AL,Muto MG,Viswanathan AN

    更新日期:2016-01-01 00:00:00

  • Neoadjuvant chemotherapy followed by surgery has no therapeutic advantages over concurrent chemoradiotherapy in International Federation of Gynecology and Obstetrics stage IB-IIB cervical cancer.

    abstract:OBJECTIVE:We aimed to assess the efficacy of neoadjuvant chemotherapy followed by surgery (NACT+S), and compared the clinical outcome with that of concurrent chemoradiotherapy (CCRT) in patients with International Federation of Gynecology and Obstetrics (FIGO) IB-IIB cervical cancer. METHODS:We reviewed 85 patients wi...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2016.27.e52

    authors: Lee J,Kim TH,Kim GE,Keum KC,Kim YB

    更新日期:2016-09-01 00:00:00

  • The effectiveness of levonorgestrel releasing intrauterine system in the treatment of endometrial hyperplasia in Korean women.

    abstract:OBJECTIVE:Levonorgestrel releasing intrauterine system (LNG-IUS) has been shown to treat patients with non-atypical & atypical endometrial hyperplasia (EH) successfully in many western studies. Our purpose was to examine the effectiveness of LNG-IUS in the treatment of Korean women with EH. METHODS:We conducted a pros...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.2.102

    authors: Lee SY,Kim MK,Park H,Yoon BS,Seong SJ,Kang JH,Jun HS,Park CT

    更新日期:2010-06-01 00:00:00

  • SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.

    abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e46

    authors: Yue Y,Xia L,Xu S,Wang C,Wang X,Lu W,Xie X

    更新日期:2020-07-01 00:00:00

  • Prognostic models for locally advanced cervical cancer: external validation of the published models.

    abstract:OBJECTIVE:To externally validate the prognostic models for predicting the time-dependent outcome in patients with locally advanced cervical cancer (LACC) who were treated with concurrent chemoradiotherapy in an independent cohort. METHODS:A historical cohort of 297 women with LACC who were treated with radical concurr...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.3802/jgo.2017.28.e58

    authors: Lora D,Gómez de la Cámara A,Fernández SP,Enríquez de Salamanca R,Gómez JFPR

    更新日期:2017-09-01 00:00:00

  • Gynecologic oncology group trials in uterine corpus malignancies: recent progress.

    abstract::The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced e...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2008.19.4.218

    authors: Miller DS,King LP

    更新日期:2008-12-01 00:00:00

  • Programmed death-1 (PD-1) expression in cervical intraepithelial neoplasia and its relationship with recurrence after conization.

    abstract:OBJECTIVE:Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e27

    authors: Chang H,Hong JH,Lee JK,Cho HW,Ouh YT,Min KJ,So KA

    更新日期:2018-05-01 00:00:00

  • Impact of lymph node ratio on survival in stage III ovarian high-grade serous cancer: a Turkish Gynecologic Oncology Group study.

    abstract:OBJECTIVE:The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in patients with stage III ovarian high-grade serous carcinoma (HGSC). METHODS:A multicenter, retrospective department database review was performed to identify patients with ovarian HGSC at 6 gynecologic oncology cen...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e12

    authors: Ayhan A,Ozkan NT,Sarı ME,Celik H,Dede M,Akbayır Ö,Güngördük K,Şahin H,Haberal A,Güngör T,Arvas M,Meydanlı MM

    更新日期:2018-01-01 00:00:00

  • Comparing and evaluating the efficacy of methotrexate and actinomycin D as first-line single chemotherapy agents in low risk gestational trophoblastic disease.

    abstract:OBJECTIVE:The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS:We conducted a retrospective study o...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e8

    authors: Lee YJ,Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

    更新日期:2017-03-01 00:00:00

  • Early diagnosis of malignant-transformed ovarian mature cystic teratoma: fat-suppressed MRI findings.

    abstract::The most common form of malignant transformation developing from a mature cystic teratoma is squamous cell carcinoma, representing 80% of malignant transformations, while adenocarcinoma accounts for approximately 5%. Because of this rarity, few reports exist of preoperative diagnosis of this tumor by magnetic resonanc...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.2.125

    authors: Takagi H,Ichigo S,Murase T,Ikeda T,Imai A

    更新日期:2012-04-01 00:00:00

  • Synergistic growth inhibition by combination of adenovirus mediated p53 transfer and cisplatin in ovarian cancer cell lines.

    abstract:OBJECTIVE:This study was to investigate the synergistic growth inhibitory effect by combination of adenovirus mediated p53 gene transfer and cisplatin in ovarian cancer cell lines with different p53 gene mutation patterns. METHODS:Three ovarian cancer cell lines, p53 deleted SKOV3, p53 mutated OVCAR-3, and PA-1 with w...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.1.48

    authors: Ryu SY,Kim K,Lee WS,Kwon HC,Lee KH,Kim CM,Kang SB

    更新日期:2009-03-01 00:00:00

  • Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study.

    abstract:OBJECTIVE:Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. METHODS:This is a retrospective c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.4.239

    authors: Lim YK,Padma R,Foo L,Chia YN,Yam P,Chia J,Khoo-Tan H,Yap SP,Yeo R

    更新日期:2011-12-01 00:00:00

  • Insulin resistance and overweight prolonged fertility-sparing treatment duration in endometrial atypical hyperplasia patients.

    abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e35

    authors: Yang B,Xie L,Zhang H,Zhu Q,Du Y,Luo X,Chen X

    更新日期:2018-05-01 00:00:00

  • Robotic single site radical hysterectomy plus pelvic lymphadenectomy in gynecological cancers.

    abstract:OBJECTIVE:To evaluate the feasibility and the safety of robotic single-site radical hysterectomy (RSSRH) plus pelvic lymphadenectomy (PL) in endometrial or cervical cancer. METHODS:Patients with endometrial cancer (EC) International Federation of Gynecology and Obstetrics (FIGO) stage II, early cervical cancer (ECC) F...

    journal_title:Journal of gynecologic oncology

    pub_type: 临床试验,杂志文章

    doi:10.3802/jgo.2018.29.e2

    authors: Vizza E,Chiofalo B,Cutillo G,Mancini E,Baiocco E,Zampa A,Bufalo A,Corrado G

    更新日期:2018-01-01 00:00:00

  • The Korean guideline for cervical cancer screening.

    abstract::The incidence rate of cervical cancer in Korea is still higher than in other developed countries, notwithstanding the national mass-screening program. Furthermore, a new method has been introduced in cervical cancer screening. Therefore, the committee for cervical cancer screening in Korea updated the recommendation s...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,实务指引

    doi:10.3802/jgo.2015.26.3.232

    authors: Min KJ,Lee YJ,Suh M,Yoo CW,Lim MC,Choi J,Ki M,Kim YM,Kim JW,Kim JH,Park EW,Lee HY,Lim SC,Cho CH,Hong SR,Dang JY,Kim SY,Kim Y,Lee WC,Lee JK

    更新日期:2015-07-01 00:00:00

  • Treatment of the patients with abnormal cervical cytology: a "see-and-treat" versus three-step strategy.

    abstract:OBJECTIVE:To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. METHODS:A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.3.164

    authors: Cho H,Kim JH

    更新日期:2009-09-01 00:00:00

  • Late presentation of metastatic smooth muscle neoplasm of the uterus with low malignant potential.

    abstract::A 48-year-old woman underwent total abdominal hysterectomy with conservation of the ovaries and tubes. Histology showed a well-circumscribed smooth muscle tumor with foci of degeneration (including infarct-type necrosis) but no coagulative tumor cell necrosis and only mild focal cytological atypia. She presented, 24 y...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.1.69

    authors: Canciani GN,Burbos N,Duncan TJ,Lonsdale R,Nieto JJ

    更新日期:2012-01-01 00:00:00

  • Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS:Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.4.265

    authors: Raungkaewmanee S,Tangjitgamol S,Manusirivithaya S,Srijaipracharoen S,Thavaramara T

    更新日期:2012-10-01 00:00:00

  • Comparison of rivaroxaban and dalteparin for the long-term treatment of venous thromboembolism in patients with gynecologic cancers.

    abstract:OBJECTIVES:Two randomized, controlled studies comparing outcomes in patients treated with direct oral anticoagulants or low-molecular weight heparin for cancer-associated venous thromboembolism (VTE) have previously been performed. However, gynecologic cancers accounted for approximately 10% of the study populations. W...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e10

    authors: Lee JH,Lee JH,Jo KW,Huh JW,Oh YM,Lee JS

    更新日期:2020-01-01 00:00:00

  • Reproductive factors for ovarian cancer in southern Chinese women.

    abstract:OBJECTIVE:To investigate the association between reproductive factors and the risk of ovarian cancer among southern Chinese women. METHODS:A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, between 2006 and 2008. A structured questionnaire was used to obtain information on parity, ora...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2013.24.2.135

    authors: Pasalich M,Su D,Binns CW,Lee AH

    更新日期:2013-04-01 00:00:00

  • Universal tolerance of nab-paclitaxel for gynecologic malignancies in patients with prior taxane hypersensitivity reactions.

    abstract:OBJECTIVE:To report on the incidence of nab-paclitaxel hypersensitivity reactions (HSRs) in patients with prior taxane HSR. METHODS:From 2005 to 2015, all patients who received nab-paclitaxel for a gynecologic malignancy were identified. Chart abstraction included pathology, prior therapy, indication for nab-paclitaxe...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e38

    authors: Maurer K,Michener C,Mahdi H,Rose PG

    更新日期:2017-07-01 00:00:00

  • Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer.

    abstract:OBJECTIVE:The use of robotic radical hysterectomy has greatly increased in the treatment of early stage cervical cancer. We sought to compare surgical and oncologic outcomes of women undergoing robotic radical hysterectomy compared to open radical hysterectomy. METHODS:The clinic-pathologic, treatment, and recurrence ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e82

    authors: Shah CA,Beck T,Liao JB,Giannakopoulos NV,Veljovich D,Paley P

    更新日期:2017-11-01 00:00:00

  • Survival impact of low anterior resection in patients with epithelial ovarian cancer grossly confined to the pelvic cavity: a Korean multicenter study.

    abstract:OBJECTIVE:To evaluate survival impact of low anterior resection (LAR) in patients with epithelial ovarian cancer (EOC) grossly confined to the pelvis. METHODS:We retrospectively reviewed 397 patients who underwent primary staging surgery for treatment of 2014 International Federation of Gynecology and Obstetrics (FIGO...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e60

    authors: Kim M,Suh DH,Park JY,Paik ES,Lee S,Eoh KJ,Nam JH,Lee YY,Kim JW,Kim S

    更新日期:2018-07-01 00:00:00

  • Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases.

    abstract::Ovarian metastases from a primary urinary tract carcinoma are extremely rare. This can be difficult to distinguish from transitional cell carcinomas (TCC) of ovarian origin because of histologic similarity. A 65-year-old woman who was diagnosed with renal pelvis TCC 4 months prior was referred for evaluation of a left...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.1.59

    authors: Lee M,Jung YW,Kim SW,Kim SH,Kim YT

    更新日期:2010-03-01 00:00:00

  • Primary sarcoma of the cervix: an analysis of patient and tumor characteristics, treatment patterns, and outcomes.

    abstract:OBJECTIVE:Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS:The NCDB was queried for patients w...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e25

    authors: Albert A,Lee A,Allbright R,Vijayakumar S

    更新日期:2020-05-01 00:00:00

  • Comparison of four malignancy risk indices in the detection of malignant ovarian masses.

    abstract:OBJECTIVE:The aim of this study was to evaluate the ability of four risk of malignancy indices (RMI) to detect malignant ovarian tumors. METHODS:This is a prospective study of 100 women admitted to the Department of Obstetrics and Gynecology of Gulhane Military Medicine Academy for surgical exploration of pelvic masse...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.3.177

    authors: Aktürk E,Karaca RE,Alanbay I,Dede M,Karaşahin E,Yenen MC,Başer I

    更新日期:2011-09-01 00:00:00

  • Performance of a low cost magnifying device, Magnivisualizer, versus colposcope for detection of pre-cancer and cancerous lesions of uterine cervix.

    abstract:OBJECTIVE:To assess the performance of a low cost magnifying device (Magnivisualizer) compared to a standard optical colposcope for detection of precancerous and cancerous lesions of the uterine cervix. METHODS:A total of 659 consecutive symptomatic women attending a gynecologic outpatient clinic underwent unaided vis...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.4.282

    authors: Singh V,Parashari A,Gupta S,Sodhani P,Sehgal A

    更新日期:2014-10-01 00:00:00

  • Condom and oral contraceptive use and risk of cervical intraepithelial neoplasia in Australian women.

    abstract:OBJECTIVE:To assess the association between condom use and oral contraceptive consumption and the risk of cervical intraepithelial neoplasia (CIN). METHODS:A cross-sectional study was conducted in Perth clinics. A total of 348 women responded to the structured questionnaire. Information sought included demographic and...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,多中心研究

    doi:10.3802/jgo.2014.25.3.183

    authors: Chih HJ,Lee AH,Colville L,Xu D,Binns CW

    更新日期:2014-07-01 00:00:00