Abstract:
OBJECTIVE:The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS:We conducted a retrospective study of 126 patients with GTD who were treated between 2000 and 2013. A total of 71 patients with LR GTD were treated with MTX (8-day regimen or weekly regimen, n=53) or ACT-D (bi-weekly pulsed regimen or 5-day regimen, n=18). The successful treatment group and the failed treatment group were compared and analyzed to identify prognostic factors. RESULTS:The complete response rates were 83.3% for ACT-D and 62.2% for MTX, with no statistically significant difference. There was no severe adverse effect reported for either group. Longer interval durations from the index pregnancy (>2 months, p=0.040) and larger tumor size (>3 cm, p=0.020) were more common in non-responders than in responders; these results were statistically significant. CONCLUSION:Based on our results, ACT-D may be a better option than MTX as a first-line single chemotherapy agent for LR GTD. The bi-weekly pulsed ACT-D regimen had minimal, or at least the same, toxicities compared with MTX. However, due to the lack of strong supporting evidence, it cannot be conclusively stated that this is the best single agent for first-line chemotherapy in LR GTD patients. Further larger controlled trials will be necessary to establish the best guidelines for GTD treatment.
journal_name
J Gynecol Oncoljournal_title
Journal of gynecologic oncologyauthors
Lee YJ,Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JHdoi
10.3802/jgo.2017.28.e8subject
Has Abstractpub_date
2017-03-01 00:00:00pages
e8issue
2eissn
2005-0380issn
2005-0399pii
28.e8journal_volume
28pub_type
杂志文章abstract:OBJECTIVE:To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients. METHODS:EC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death....
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2015.26.4.293
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Levonorgestrel releasing intrauterine system (LNG-IUS) has been shown to treat patients with non-atypical & atypical endometrial hyperplasia (EH) successfully in many western studies. Our purpose was to examine the effectiveness of LNG-IUS in the treatment of Korean women with EH. METHODS:We conducted a pros...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.2.102
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology. METHODS:We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, di...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e17
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of re...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e6
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Uterine leiomyomas are the most common tumor of the uterus. But the molecular causes of uterine leiomyoma remain unclear. We conducted the current investigation in order to elucidate the molecular mechanisms in the development of uterine leiomyoma. METHODS:We employed a new and accurate reverse transcription...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.2.139
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:A prospective, randomized controlled trial was conducted to evaluate the efficacy of nerve-sparing radical hysterectomy (NSRH) in preserving bladder function and its oncologic safety in the treatment of cervical cancer. METHODS:From March 2003 to November 2005, 92 patients with cervical cancer stage IA2 to I...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,随机对照试验
doi:10.3802/jgo.2015.26.2.90
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:The use of robotic radical hysterectomy has greatly increased in the treatment of early stage cervical cancer. We sought to compare surgical and oncologic outcomes of women undergoing robotic radical hysterectomy compared to open radical hysterectomy. METHODS:The clinic-pathologic, treatment, and recurrence ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e82
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Neoadjuvant chemotherapy (NACT) for the treatment of epithelial ovarian cancer (EOC) has remained controversial. This meta-analysis was performed to systematically assess the efficacy and safety of NACT versus primary debulking surgery (PDS) in patients with EOC. METHODS:PubMed, Embase, ClinicalTrials.gov, a...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e12
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the prognostic value of lymph node ratio (LNR) in patients with stage III ovarian high-grade serous carcinoma (HGSC). METHODS:A multicenter, retrospective department database review was performed to identify patients with ovarian HGSC at 6 gynecologic oncology cen...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e12
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. METHODS:We included 113 women (mean age, 53 years; range, 29 to 72 years) with histopathology-confirmed ULMS from 2000 to 2012. Distribution of metastases was noted from imaging by ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.4.306
更新日期:2014-10-01 00:00:00
abstract::Ovarian metastases from a primary urinary tract carcinoma are extremely rare. This can be difficult to distinguish from transitional cell carcinomas (TCC) of ovarian origin because of histologic similarity. A 65-year-old woman who was diagnosed with renal pelvis TCC 4 months prior was referred for evaluation of a left...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.1.59
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To compare plasma protein expression between patients with squamous cell carcinoma (SCC) of the cervix and normal controls. METHODS:Plasma samples from patients with benign gynecological disease (normal cervix, n=6) and cervical cancer (SCC, n=6) were subjected to plasma proteomic analysis using two dimensio...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.3.173
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To show noninferiority of a limited-excision (resection of the dysplastic lesion only) vs. classical Large Loop Excision of the Transformation Zone (LLETZ). METHODS:In this prospective, randomized, multicenter trial, women with human papillomavirus (HPV) positive cervical intraepithelial neoplasia grade 3 we...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3802/jgo.2019.30.e42
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e35
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. METHODS:A retrospective chart review was carried out for...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e42
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). METHODS:A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.4.232
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:Two randomized, controlled studies comparing outcomes in patients treated with direct oral anticoagulants or low-molecular weight heparin for cancer-associated venous thromboembolism (VTE) have previously been performed. However, gynecologic cancers accounted for approximately 10% of the study populations. W...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e10
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. METHODS:A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical c...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.3.164
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To validate the efficacy of Seeplex HPV4A ACE for the detection of high-risk (HR) human papillomavirus (HPV) and HPV 16 and/or HPV 18 genotypes as compared to the PCR method and the Cervista HPV assays in cervical swab samples. METHODS:Besides liquid-based cytology, additional 97 cervical swab samples were c...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2012.23.1.5
更新日期:2012-01-01 00:00:00
abstract::Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma,...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.4.269
更新日期:2010-12-30 00:00:00
abstract:OBJECTIVE:To evaluate the feasibility and the safety of robotic single-site radical hysterectomy (RSSRH) plus pelvic lymphadenectomy (PL) in endometrial or cervical cancer. METHODS:Patients with endometrial cancer (EC) International Federation of Gynecology and Obstetrics (FIGO) stage II, early cervical cancer (ECC) F...
journal_title:Journal of gynecologic oncology
pub_type: 临床试验,杂志文章
doi:10.3802/jgo.2018.29.e2
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to develop and validate a questionnaire used to assess the level of general knowledge about cervical cancer, its primary and secondary prevention, and to identify sources of information about the disease among schoolgirls and female students. METHODS:THE QUESTIONNAIRE DEVELOPMENT PR...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.2.81
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:In cervical intraepithelial neoplasia (CIN), p16(INK4a) immunohistochemistry has been reported to be a useful diagnostic biomarker. However, limited information is available about the association between the p16(INK4a) immunohistochemistry and the outcomes of CIN. Here, we report p16(INK4a) immunohistochemist...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.3.215
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Accumulating evidence support that complete cytoreduction (CC) at the time of secondary cytoreductive surgery (SCS) improves survival in patients affected by recurrent ovarian cancer (ROC). Here, we aimed to determine whether artificial intelligence (AI) might be useful in weighting the importance of clinical...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e66
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To assess the association between condom use and oral contraceptive consumption and the risk of cervical intraepithelial neoplasia (CIN). METHODS:A cross-sectional study was conducted in Perth clinics. A total of 348 women responded to the structured questionnaire. Information sought included demographic and...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,多中心研究
doi:10.3802/jgo.2014.25.3.183
更新日期:2014-07-01 00:00:00
abstract::A 48-year-old woman underwent total abdominal hysterectomy with conservation of the ovaries and tubes. Histology showed a well-circumscribed smooth muscle tumor with foci of degeneration (including infarct-type necrosis) but no coagulative tumor cell necrosis and only mild focal cytological atypia. She presented, 24 y...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2012.23.1.69
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Hypermethylation of CpG island is a common mechanism for the inactivation of tumor suppressor genes. Hypermethylation of the E-cadherin promoter region has been rarely studied in endometrial carcinoma of Korean women. The purpose of this study is to investigate methylation status of E-cadherin promoter region...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.4.241
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:This study was conducted to examine the effects of front-line chemotherapy on overall survival (OS) and postrecurrence survival (PRS) of patients with recurrent ovarian cancer, when stratifying the histologic type. METHODS:Five hundred and seventy-four patients with recurrent ovarian cancer with sufficient c...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.1.43
更新日期:2014-01-01 00:00:00
abstract::The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced e...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.4.218
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy. METHODS:We prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during ben...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e96
更新日期:2019-11-01 00:00:00