The risk of lymphedema after postoperative radiation therapy in endometrial cancer.

Abstract:

OBJECTIVE:Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk of infection. The goal of this study is to investigate factors that influence the likelihood of lymphedema in patients with endometrial cancer who undergo adjuvant radiation with or without chemotherapy. METHODS:A retrospective chart review identified all stage I-III endometrial cancer patients who had a hysterectomy with or without complete staging lymphadenectomy and adjuvant radiation therapy between January 2006 and February 2013. Patients with new-onset lymphedema after treatment were identified. Logistic regression was used to find factors that influenced lymphedema risk. RESULTS:Of 212 patients who met inclusion criteria, 15 patients (7.1%) developed new-onset lymphedema. Lymphedema was associated with lymph-node dissection (odds ratio [OR], 5.6; 95% CI, 1.01 to 105.5; p=0.048) and with the presence of pathologically positive lymph nodes (OR, 4.1; 95% CI, 1.4 to 12.3; p=0.01). Multivariate logistic regression confirmed the association with lymph-node positivity (OR, 3.2; 95% CI, 1.0007 to 10.7; p=0.0499) when controlled for lymph-node dissection. Median time to lymphedema onset was 8 months (range, 1 to 58 months) with resolution or improvement in eight patients (53.3%) after a median of 10 months. CONCLUSION:Lymph-node positivity was associated with an increased risk of lymphedema in endometrial cancer patients who received adjuvant radiation. Future studies are needed to explore whether node-positive patients may benefit from early lymphedema-controlling interventions.

journal_name

J Gynecol Oncol

authors

Mitra D,Catalano PJ,Cimbak N,Damato AL,Muto MG,Viswanathan AN

doi

10.3802/jgo.2016.27.e4

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

e4

issue

1

eissn

2005-0380

issn

2005-0399

pii

26.e28

journal_volume

27

pub_type

杂志文章
  • The effectiveness of levonorgestrel releasing intrauterine system in the treatment of endometrial hyperplasia in Korean women.

    abstract:OBJECTIVE:Levonorgestrel releasing intrauterine system (LNG-IUS) has been shown to treat patients with non-atypical & atypical endometrial hyperplasia (EH) successfully in many western studies. Our purpose was to examine the effectiveness of LNG-IUS in the treatment of Korean women with EH. METHODS:We conducted a pros...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.2.102

    authors: Lee SY,Kim MK,Park H,Yoon BS,Seong SJ,Kang JH,Jun HS,Park CT

    更新日期:2010-06-01 00:00:00

  • Platelet to lymphocyte ratio as a prognostic factor for epithelial ovarian cancer.

    abstract:OBJECTIVE:To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS:Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.4.265

    authors: Raungkaewmanee S,Tangjitgamol S,Manusirivithaya S,Srijaipracharoen S,Thavaramara T

    更新日期:2012-10-01 00:00:00

  • Erratum: Bowel resection rate but not bowel related morbidity is decreased after interval debulking surgery compared to primary surgery in patents with stage IIIC-IV ovarian cancer.

    abstract::This corrects the article on e25 in vol. 30, PMID: 30740956. ...

    journal_title:Journal of gynecologic oncology

    pub_type: 已发布勘误

    doi:10.3802/jgo.2019.30.e101

    authors: Tozzi R,Casarin J,Baysal A,Valenti G,Kilic Y,Majd HS,Morotti M

    更新日期:2019-09-01 00:00:00

  • Robot assisted surgery during the COVID-19 pandemic, especially for gynecological cancer: a statement of the Society of European Robotic Gynaecological Surgery (SERGS).

    abstract::All surgery performed in an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, irrespective of the known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status of the patient, should be regarded as high risk and protection of the surgical team at the bedside should be at the highe...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章,评审

    doi:10.3802/jgo.2020.31.e59

    authors: Kimmig R,Verheijen RHM,Rudnicki M,for SERGS Council.

    更新日期:2020-05-01 00:00:00

  • Metastasis to the ovaries from transitional cell carcinoma of the bladder and renal pelvis: a report of two cases.

    abstract::Ovarian metastases from a primary urinary tract carcinoma are extremely rare. This can be difficult to distinguish from transitional cell carcinomas (TCC) of ovarian origin because of histologic similarity. A 65-year-old woman who was diagnosed with renal pelvis TCC 4 months prior was referred for evaluation of a left...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2010.21.1.59

    authors: Lee M,Jung YW,Kim SW,Kim SH,Kim YT

    更新日期:2010-03-01 00:00:00

  • Early stage (IA-IB) primary carcinoma of the fallopian tube: case-control comparison to adenocarcinoma of the ovary.

    abstract:OBJECTIVE:Early stage primary carcinoma of the fallopian tube (PCFT) is an uncommon condition when strict criteria are applied. The aim of this study was to compare the outcome stage IA-IB PCFT to a matched group of ovarian cancer (OC). METHODS:Between 1990 and 2008, 32 patients with stage IA-IB of PCFT were recorded ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.1.9

    authors: Vaysse C,Touboul C,Filleron T,Mery E,Jouve E,Leguevaque P,Morice P,Leblanc E,Querleu D

    更新日期:2011-03-31 00:00:00

  • Survival outcome of women with synchronous cancers of endometrium and ovary: a 10 year retrospective cohort study.

    abstract:OBJECTIVE:Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. METHODS:This is a retrospective c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2011.22.4.239

    authors: Lim YK,Padma R,Foo L,Chia YN,Yam P,Chia J,Khoo-Tan H,Yap SP,Yeo R

    更新日期:2011-12-01 00:00:00

  • The efficacy of modified Swede Colposcopic Index in prediction of high-grade lesion and cancer of cervix.

    abstract:OBJECTIVE:To evaluate the efficacy of modified Swede Colposcopic Index (MSCI) to predict high-grade lesion and cancer of cervix (CIN2+, cervical intraepithelial neoplasia grade 2 or worse) in women with abnormal cervical cytology who underwent a colposcopy. METHODS:We conducted a retrospective study and MSCI using 5 f...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e78

    authors: Rodpenpear N,Pataradool K

    更新日期:2019-09-01 00:00:00

  • p16(INK4a) immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping.

    abstract:OBJECTIVE:In cervical intraepithelial neoplasia (CIN), p16(INK4a) immunohistochemistry has been reported to be a useful diagnostic biomarker. However, limited information is available about the association between the p16(INK4a) immunohistochemistry and the outcomes of CIN. Here, we report p16(INK4a) immunohistochemist...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2013.24.3.215

    authors: Nishio S,Fujii T,Nishio H,Kameyama K,Saito M,Iwata T,Kubushiro K,Aoki D

    更新日期:2013-07-01 00:00:00

  • Randomized phase III trial comparing pegylated liposomal doxorubicin (PLD) at 50 mg/m² versus 40 mg/m² in patients with platinum-refractory and -resistant ovarian carcinoma: the JGOG 3018 Trial.

    abstract:OBJECTIVE:The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks. While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking. METHODS:This phase III randomized, non-inferiority study compared progression-free survival (PFS) for patients with ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2021.32.e9

    authors: Motohashi T,Yabuno A,Michimae H,Ohishi T,Nonaka M,Takano M,Nishio S,Fujiwara H,Fujiwara K,Kondo E,Sugiyama T,Tabata T

    更新日期:2021-01-01 00:00:00

  • Integration of robotics into two established programs of minimally invasive surgery for endometrial cancer appears to decrease surgical complications.

    abstract:OBJECTIVE:To compare peri- and postoperative outcomes and complications of laparoscopic vs. robotic-assisted surgical staging for women with endometrial cancer at two established academic institutions. METHODS:Retrospective chart review of all women that underwent total hysterectomy with pelvic and para-aortic lymphad...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2013.24.1.21

    authors: Cardenas-Goicoechea J,Soto E,Chuang L,Gretz H,Randall TC

    更新日期:2013-01-01 00:00:00

  • The age-adjusted Charlson comorbidity index as a predictor of survival in surgically treated vulvar cancer patients.

    abstract:OBJECTIVE:To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of re...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e6

    authors: Di Donato V,Page Z,Bracchi C,Tomao F,Musella A,Perniola G,Panici PB

    更新日期:2019-01-01 00:00:00

  • Fertility-sparing treatment for intramucous, moderately differentiated, endometrioid endometrial cancer: a Gynecologic Cancer Inter-Group (GCIG) study.

    abstract:OBJECTIVE:'The Endometrial Cancer Conservative Treatment (E.C.Co.). A multicentre archive' is a worldwide project endorsed by the Gynecologic Cancer Inter-Group, aimed at registering conservatively treated endometrial cancer (EC) patients. This paper reports the oncological and reproductive outcomes of intramucous, G2,...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e74

    authors: Falcone F,Leone Roberti Maggiore U,Di Donato V,Perrone AM,Frigerio L,Bifulco G,Polterauer S,Casadio P,Cormio G,Masciullo V,Malzoni M,Greggi S

    更新日期:2020-09-01 00:00:00

  • Survival impact of low anterior resection in patients with epithelial ovarian cancer grossly confined to the pelvic cavity: a Korean multicenter study.

    abstract:OBJECTIVE:To evaluate survival impact of low anterior resection (LAR) in patients with epithelial ovarian cancer (EOC) grossly confined to the pelvis. METHODS:We retrospectively reviewed 397 patients who underwent primary staging surgery for treatment of 2014 International Federation of Gynecology and Obstetrics (FIGO...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e60

    authors: Kim M,Suh DH,Park JY,Paik ES,Lee S,Eoh KJ,Nam JH,Lee YY,Kim JW,Kim S

    更新日期:2018-07-01 00:00:00

  • Survival benefit of taxane plus platinum in recurrent ovarian cancer with non-clear cell, non-mucinous histology.

    abstract:OBJECTIVE:This study was conducted to examine the effects of front-line chemotherapy on overall survival (OS) and postrecurrence survival (PRS) of patients with recurrent ovarian cancer, when stratifying the histologic type. METHODS:Five hundred and seventy-four patients with recurrent ovarian cancer with sufficient c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.1.43

    authors: Kajiyama H,Shibata K,Mizuno M,Umezu T,Suzuki S,Sekiya R,Niimi K,Mitsui H,Yamamoto E,Kawai M,Nagasaka T,Kikkawa F

    更新日期:2014-01-01 00:00:00

  • Comparison of the Seeplex HPV4A ACE and the Cervista HPV assays for the detection of HPV in hybrid capture 2 positive media.

    abstract:OBJECTIVE:To validate the efficacy of Seeplex HPV4A ACE for the detection of high-risk (HR) human papillomavirus (HPV) and HPV 16 and/or HPV 18 genotypes as compared to the PCR method and the Cervista HPV assays in cervical swab samples. METHODS:Besides liquid-based cytology, additional 97 cervical swab samples were c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.1.5

    authors: Min KJ,So KA,Lee J,Hong HR,Hong JH,Lee JK,Kim AR

    更新日期:2012-01-01 00:00:00

  • Creating and field-testing the questionnaire for the assessment of knowledge about cervical cancer and its prevention among schoolgirls and female students.

    abstract:OBJECTIVE:The aim of this study was to develop and validate a questionnaire used to assess the level of general knowledge about cervical cancer, its primary and secondary prevention, and to identify sources of information about the disease among schoolgirls and female students. METHODS:THE QUESTIONNAIRE DEVELOPMENT PR...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.2.81

    authors: Jaglarz K,Tomaszewski KA,Kamzol W,Puskulluoglu M,Krzemieniecki K

    更新日期:2014-04-01 00:00:00

  • Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand.

    abstract:OBJECTIVE:To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients. METHODS:EC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death....

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2015.26.4.293

    authors: Tangjitgamol S,Khunnarong J,Srijaipracharoen S

    更新日期:2015-10-01 00:00:00

  • Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology.

    abstract:OBJECTIVES:To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology. METHODS:We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, di...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e17

    authors: Termrungruanglert W,Khemapech N,Tantitamit T,Havanond P

    更新日期:2019-03-01 00:00:00

  • Performance of a low cost magnifying device, Magnivisualizer, versus colposcope for detection of pre-cancer and cancerous lesions of uterine cervix.

    abstract:OBJECTIVE:To assess the performance of a low cost magnifying device (Magnivisualizer) compared to a standard optical colposcope for detection of precancerous and cancerous lesions of the uterine cervix. METHODS:A total of 659 consecutive symptomatic women attending a gynecologic outpatient clinic underwent unaided vis...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2014.25.4.282

    authors: Singh V,Parashari A,Gupta S,Sodhani P,Sehgal A

    更新日期:2014-10-01 00:00:00

  • Gynecologic oncology group trials in uterine corpus malignancies: recent progress.

    abstract::The Gynecologic Oncology Group (GOG) has conducted multiple trials related to malignancies of the uterine corpus. Recently, several of these trials have been presented and/or published. Areas of focus included the feasibility of laparoscopic staging for endometrial cancer, the adjuvant management of locally advanced e...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2008.19.4.218

    authors: Miller DS,King LP

    更新日期:2008-12-01 00:00:00

  • Surgical manual of the Korean Gynecologic Oncology Group: ovarian, tubal, and peritoneal cancers.

    abstract::The Surgery Treatment Modality Committee of the Korean Gynecologic Oncology Group has determined to develop a surgical manual to facilitate clinical trials and to improve communication between investigators by standardizing and precisely describing operating procedures. The literature on anatomic terminology, identifi...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e6

    authors: Jeon S,Lee SJ,Lim MC,Song T,Bae J,Kim K,Lee JY,Kim SW,Chang SJ,Lee JM

    更新日期:2017-01-01 00:00:00

  • SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells.

    abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2020.31.e46

    authors: Yue Y,Xia L,Xu S,Wang C,Wang X,Lu W,Xie X

    更新日期:2020-07-01 00:00:00

  • Efficacy of taxane and platinum-based chemotherapy guided by extreme drug resistance assay in patients with epithelial ovarian cancer.

    abstract:OBJECTIVE:To evaluate the efficacy of taxane and platinum-based chemotherapy guided by extreme drug resistance assay (EDRA) in patients with epithelial ovarian cancer. METHODS:Thirty-nine patients were enrolled, who were diagnosed as epithelial ovarian cancer, tubal cancer or primary peritoneal carcinoma and received ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.2.96

    authors: Joo WD,Lee JY,Kim JH,Yoo HJ,Roh HJ,Park JY,Kim DY,Kim YM,Kim YT,Nam JH

    更新日期:2009-06-01 00:00:00

  • Relationship between the precursors of high grade serous ovarian cancer and patient characteristics: decreased incidence of the p53 signature in pregnant women.

    abstract:OBJECTIVE:To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy. METHODS:We prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during ben...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2019.30.e96

    authors: Ida T,Fujiwara H,Kiriu T,Taniguchi Y,Kohyama A

    更新日期:2019-11-01 00:00:00

  • Treatment of the patients with abnormal cervical cytology: a "see-and-treat" versus three-step strategy.

    abstract:OBJECTIVE:To examine the correlation between cervical cytology and final histological results in patients who have undergone loop electrosurgical excision procedure (LEEP) with or without colposcopy-directed biopsy. METHODS:A retrospective review was performed of 829 patients who underwent LEEP for abnormal cervical c...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2009.20.3.164

    authors: Cho H,Kim JH

    更新日期:2009-09-01 00:00:00

  • Early diagnosis of malignant-transformed ovarian mature cystic teratoma: fat-suppressed MRI findings.

    abstract::The most common form of malignant transformation developing from a mature cystic teratoma is squamous cell carcinoma, representing 80% of malignant transformations, while adenocarcinoma accounts for approximately 5%. Because of this rarity, few reports exist of preoperative diagnosis of this tumor by magnetic resonanc...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2012.23.2.125

    authors: Takagi H,Ichigo S,Murase T,Ikeda T,Imai A

    更新日期:2012-04-01 00:00:00

  • Value of combined adjuvant chemotherapy and radiation on survival for stage III uterine cancer: is less radiation equal to more?

    abstract:OBJECTIVE:Locally advanced endometrioid adenocarcinoma (LA-EAC) accounts for the majority of deaths for this cancer, yet there is no consensus on adjuvant treatment after surgery. Past studies suggest that combined modality treatment (CMT) may improve outcomes over treatment with chemotherapy (CT) or radiation therapy ...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2018.29.e49

    authors: Wang CJ,Christie A,Folkert MR,Xie XJ,Albuquerque K

    更新日期:2018-07-01 00:00:00

  • Incidence of metastasis in circumflex iliac nodes distal to the external iliac nodes in cervical cancer.

    abstract:OBJECTIVE:A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. METHODS:A retrospective chart review was carried out for...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2016.27.e42

    authors: Takeshita S,Todo Y,Okamoto K,Sudo S,Yamashiro K,Kato H

    更新日期:2016-07-01 00:00:00

  • Universal tolerance of nab-paclitaxel for gynecologic malignancies in patients with prior taxane hypersensitivity reactions.

    abstract:OBJECTIVE:To report on the incidence of nab-paclitaxel hypersensitivity reactions (HSRs) in patients with prior taxane HSR. METHODS:From 2005 to 2015, all patients who received nab-paclitaxel for a gynecologic malignancy were identified. Chart abstraction included pathology, prior therapy, indication for nab-paclitaxe...

    journal_title:Journal of gynecologic oncology

    pub_type: 杂志文章

    doi:10.3802/jgo.2017.28.e38

    authors: Maurer K,Michener C,Mahdi H,Rose PG

    更新日期:2017-07-01 00:00:00