Abstract:
OBJECTIVE:To show noninferiority of a limited-excision (resection of the dysplastic lesion only) vs. classical Large Loop Excision of the Transformation Zone (LLETZ). METHODS:In this prospective, randomized, multicenter trial, women with human papillomavirus (HPV) positive cervical intraepithelial neoplasia grade 3 were randomized into two groups (1:1). Primary outcome was the rate of negative HPV tests after 6 months, secondary outcomes included cone size, complete resection rates as well as cytological and histological results after 6 and 12 months. A sample size of 1,000 was calculated to show noninferiority of the limited-excision compared to the LLETZ group using a noninferiority margin of 5%. Enrollment was stopped after 100 patients due to slow accrual. RESULTS:Patients in the limited-excision group did not show a lower number of negative HPV tests (78% [LLETZ]-80% [limited-excision]=-2%; 90% confidence interval=-15%, 12%). The limited-excision resulted in a substantially lower cone size (LLETZ: 1.97 mL vs. limited-excision: 1.02 mL; p<0.001) but higher numbers of involved margins (LLETZ: 8% vs. limited-excision: 20%). Although postoperative cytological results slightly differed, histological results were similar in both groups. One limited-excision patient received immediate re-conisation, whereas one patient in each group was scheduled for re-conisation after 6 months. CONCLUSION:The limited-excision could represent a promising option to reduce the surgical extent of conisations while maintaining oncological safety. The trial was not sufficiently powered to reach statistical significance due to early termination. Nevertheless, the study provides important insights in the feasibility of a limited-excision and could serve as a pilot study for future trials. TRIAL REGISTRATION:German Clinical Trials Register Identifier: DRKS00006169.
journal_name
J Gynecol Oncoljournal_title
Journal of gynecologic oncologyauthors
Kolben TM,Etzel LT,Bergauer F,Hagemann I,Hillemanns P,Repper M,Kaufmann AM,Sotlar K,Kolben T,Helms HJ,Gallwas J,Mahner S,Dannecker Cdoi
10.3802/jgo.2019.30.e42subject
Has Abstractpub_date
2019-05-01 00:00:00pages
e42issue
3eissn
2005-0380issn
2005-0399pii
30.e42journal_volume
30pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:This study was to investigate the synergistic growth inhibitory effect by combination of adenovirus mediated p53 gene transfer and cisplatin in ovarian cancer cell lines with different p53 gene mutation patterns. METHODS:Three ovarian cancer cell lines, p53 deleted SKOV3, p53 mutated OVCAR-3, and PA-1 with w...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.1.48
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e46
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of the pulmonary recruitment maneuver (PRM) at the end of the operation to decrease laparoscopy-induced abdominal or shoulder pain after gynecological oncologic surgery. METHODS:In total, 113 women undergoing laparoscopic surgery for malignant or premalignant gynecological lesio...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,随机对照试验
doi:10.3802/jgo.2018.29.e92
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:Two randomized, controlled studies comparing outcomes in patients treated with direct oral anticoagulants or low-molecular weight heparin for cancer-associated venous thromboembolism (VTE) have previously been performed. However, gynecologic cancers accounted for approximately 10% of the study populations. W...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e10
更新日期:2020-01-01 00:00:00
abstract::This corrects the article on e25 in vol. 30, PMID: 30740956. ...
journal_title:Journal of gynecologic oncology
pub_type: 已发布勘误
doi:10.3802/jgo.2019.30.e101
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Synchronous occurrence of endometrial and ovarian tumors is uncommon, and they affect less than 10% of women with endometrial or ovarian cancers. The aim of this study is to describe the epidemiological and clinical factors; and survival outcomes of women with these cancers. METHODS:This is a retrospective c...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2011.22.4.239
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients. METHODS:EC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death....
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2015.26.4.293
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. METHODS:The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.4.342
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Levonorgestrel releasing intrauterine system (LNG-IUS) has been shown to treat patients with non-atypical & atypical endometrial hyperplasia (EH) successfully in many western studies. Our purpose was to examine the effectiveness of LNG-IUS in the treatment of Korean women with EH. METHODS:We conducted a pros...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.2.102
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To investigate the efficacy of levonorgestrel-releasing intra-uterine system (LNG-IUS) treatment in patients affected by atypical complex hyperplasia/endometrial cancer (ACH/EC) wishing to preserve their fertility and to present fertility outcomes of those patients who actively tried to conceive. METHODS:Dat...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e57
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:This prospective randomized controlled pilot study aimed to find whether gelatin-thrombin matrix used as a tissue sealant (FloSeal) can prevent the occurrence of pelvic lymphocele in patients with gynecologic cancer who has undergone pelvic lymphadenectomy. METHODS:Each patient, who undergo a laparotomic pel...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,随机对照试验
doi:10.3802/jgo.2017.28.e37
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To evaluate survival impact of low anterior resection (LAR) in patients with epithelial ovarian cancer (EOC) grossly confined to the pelvis. METHODS:We retrospectively reviewed 397 patients who underwent primary staging surgery for treatment of 2014 International Federation of Gynecology and Obstetrics (FIGO...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e60
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Accumulating evidence support that complete cytoreduction (CC) at the time of secondary cytoreductive surgery (SCS) improves survival in patients affected by recurrent ovarian cancer (ROC). Here, we aimed to determine whether artificial intelligence (AI) might be useful in weighting the importance of clinical...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e66
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e29
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk of infection. The goal of this study is to investigate factors that influence the likelihood of lymphedema in patients with endometrial cancer who undergo adjuvant radiation with or without...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e4
更新日期:2016-01-01 00:00:00
abstract::The Surgery Treatment Modality Committee of the Korean Gynecologic Oncology Group has determined to develop a surgical manual to facilitate clinical trials and to improve communication between investigators by standardizing and precisely describing operating procedures. The literature on anatomic terminology, identifi...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e6
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To assess the clinical and cost-effectiveness of human papillomavirus (HPV) primary screening triage with p16/Ki-67 dual stain cytology compared to cytology. METHODS:We conducted an Excel®-based budget impact model to estimate the preinvasive and invasive cervical cancer cases identified, mortality rate, di...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e17
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of taxane and platinum-based chemotherapy guided by extreme drug resistance assay (EDRA) in patients with epithelial ovarian cancer. METHODS:Thirty-nine patients were enrolled, who were diagnosed as epithelial ovarian cancer, tubal cancer or primary peritoneal carcinoma and received ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.2.96
更新日期:2009-06-01 00:00:00
abstract::All surgery performed in an epicenter of the coronavirus disease 2019 (COVID-19) pandemic, irrespective of the known or suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) status of the patient, should be regarded as high risk and protection of the surgical team at the bedside should be at the highe...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,评审
doi:10.3802/jgo.2020.31.e59
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of re...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e6
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:We aimed to assess the efficacy of neoadjuvant chemotherapy followed by surgery (NACT+S), and compared the clinical outcome with that of concurrent chemoradiotherapy (CCRT) in patients with International Federation of Gynecology and Obstetrics (FIGO) IB-IIB cervical cancer. METHODS:We reviewed 85 patients wi...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e52
更新日期:2016-09-01 00:00:00
abstract::Fertility-sparing surgery was optimal to patients with tumor diameter smaller than 2 cm. For patients with larger tumors, neoadjuvant chemotherapy can debulk the tumor and offer the chance of surgery. We report 2 cases of stage IB1 cervical cancer treated by neoadjuvant chemotherapy and fertility-sparing surgery. Rele...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.3.287
更新日期:2013-07-01 00:00:00
abstract::This corrects the article on p. e43 in vol. 29, PMID: 29770616. ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,已发布勘误
doi:10.3802/jgo.2018.29.e80
更新日期:2018-09-01 00:00:00
abstract::Ovarian metastases from a primary urinary tract carcinoma are extremely rare. This can be difficult to distinguish from transitional cell carcinomas (TCC) of ovarian origin because of histologic similarity. A 65-year-old woman who was diagnosed with renal pelvis TCC 4 months prior was referred for evaluation of a left...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.1.59
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS:The NCDB was queried for patients w...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e25
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare operative feasibility and surgical outcome of the modified Cherney incision and vertical midline incision in patients undergoing radical hysterectomy and pelvic lymphadenectomy. METHODS:Between March 2005 and December 2007, retrospective data of 78 patients (n=17; modifie...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.4.246
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:DNA methylation has been shown to be a potential biomarker for early cancer detection. The aim of this study was to evaluate DNA methylation profiles according to liquid-based Pap (LBP) test results and to assess their diagnostic value in a Korean population. METHODS:A total of 205 patients with various Papa...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e14
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e35
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To describe metastatic pattern of uterine leiomyosarcomas (ULMS) and correlate it with clinical and histopathologic parameters. METHODS:We included 113 women (mean age, 53 years; range, 29 to 72 years) with histopathology-confirmed ULMS from 2000 to 2012. Distribution of metastases was noted from imaging by ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.4.306
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:'The Endometrial Cancer Conservative Treatment (E.C.Co.). A multicentre archive' is a worldwide project endorsed by the Gynecologic Cancer Inter-Group, aimed at registering conservatively treated endometrial cancer (EC) patients. This paper reports the oncological and reproductive outcomes of intramucous, G2,...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e74
更新日期:2020-09-01 00:00:00