Abstract:
OBJECTIVE:Although radiation therapy (RT) and concurrent chemoradiotherapy (CCRT) are the global standards for adjuvant therapy treatment in cervical cancer, many Japanese institutions choose chemotherapy (CT) because of the low frequency of irreversible adverse events. In this study, we aimed to clarify the trends of adjuvant therapy for intermediate/high-risk cervical cancer after radical surgery in Japan. METHODS:A questionnaire survey was conducted by the Japanese Gynecologic Oncology Group to 186 authorized institutions active in the treatment of gynecologic cancer. RESULTS:Responses were obtained from 129 facilities. Adjuvant RT/CCRT and intensity-modulated RT were performed in 98 (76%) and 23 (18%) institutions, respectively. On the other hand, CT was chosen as an alternative in 93 institutions (72%). The most common regimen of CT, which was used in 66 institutions (51%), was a combination of cisplatin/carboplatin with paclitaxel. CT was considered an appropriate alternative option to RT/CCRT in patients with risk factors such as bulky tumors, lymph node metastasis, lymphovascular invasion, parametrial invasion, and stromal invasion. The risk of severe adverse events was considered to be lower for CT than for RT/CCRT in 109 institutions (84%). CONCLUSION:This survey revealed a variety of policies regarding adjuvant therapy among institutions. A clinical study to assess the efficacy or non-inferiority of adjuvant CT is warranted.
journal_name
J Gynecol Oncoljournal_title
Journal of gynecologic oncologyauthors
Ikeda Y,Furusawa A,Kitagawa R,Tokinaga A,Ito F,Ukita M,Nomura H,Yamagami W,Tanabe H,Mikami M,Takeshima N,Yaegashi Ndoi
10.3802/jgo.2016.27.e29subject
Has Abstractpub_date
2016-05-01 00:00:00pages
e29issue
3eissn
2005-0380issn
2005-0399pii
27.e29journal_volume
27pub_type
杂志文章abstract:OBJECTIVE:Hypermethylation of CpG island is a common mechanism for the inactivation of tumor suppressor genes. Hypermethylation of the E-cadherin promoter region has been rarely studied in endometrial carcinoma of Korean women. The purpose of this study is to investigate methylation status of E-cadherin promoter region...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.4.241
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:This study was conducted to examine the effects of front-line chemotherapy on overall survival (OS) and postrecurrence survival (PRS) of patients with recurrent ovarian cancer, when stratifying the histologic type. METHODS:Five hundred and seventy-four patients with recurrent ovarian cancer with sufficient c...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.1.43
更新日期:2014-01-01 00:00:00
abstract::Toremifene is an anti-estrogen which has been shown to be effective in the treatment of breast cancer, and is thought to be a less uterotrophic agent than tamoxifen. The risk assessment concerning endometrial cancer has been inconclusive because of its rare use up to the mid-1990s. We report a case of an adenosarcoma,...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.4.269
更新日期:2010-12-30 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare responses to single-agent chemotherapies and evaluate the predictive factors of resistance in low risk (LR) gestational trophoblastic disease (GTD). The chemotherapy agents included methotrexate (MTX) and actinomycin D (ACT-D). METHODS:We conducted a retrospective study o...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e8
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To report on the incidence of nab-paclitaxel hypersensitivity reactions (HSRs) in patients with prior taxane HSR. METHODS:From 2005 to 2015, all patients who received nab-paclitaxel for a gynecologic malignancy were identified. Chart abstraction included pathology, prior therapy, indication for nab-paclitaxe...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e38
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:We aimed to assess the efficacy of neoadjuvant chemotherapy followed by surgery (NACT+S), and compared the clinical outcome with that of concurrent chemoradiotherapy (CCRT) in patients with International Federation of Gynecology and Obstetrics (FIGO) IB-IIB cervical cancer. METHODS:We reviewed 85 patients wi...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e52
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:In cervical intraepithelial neoplasia (CIN), p16(INK4a) immunohistochemistry has been reported to be a useful diagnostic biomarker. However, limited information is available about the association between the p16(INK4a) immunohistochemistry and the outcomes of CIN. Here, we report p16(INK4a) immunohistochemist...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.3.215
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The use of robotic radical hysterectomy has greatly increased in the treatment of early stage cervical cancer. We sought to compare surgical and oncologic outcomes of women undergoing robotic radical hysterectomy compared to open radical hysterectomy. METHODS:The clinic-pathologic, treatment, and recurrence ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e82
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To compare plasma protein expression between patients with squamous cell carcinoma (SCC) of the cervix and normal controls. METHODS:Plasma samples from patients with benign gynecological disease (normal cervix, n=6) and cervical cancer (SCC, n=6) were subjected to plasma proteomic analysis using two dimensio...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2008.19.3.173
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Our previous study showed that insulin resistance (IR) was related to endometrial hyperplasia as well as endometrial cancer. But the exact impact of IR on fertility-sparing treatment in endometrial hyperplasic disease is unclear. This study investigated how IR affects fertility-sparing treatment in endometria...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e35
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk of infection. The goal of this study is to investigate factors that influence the likelihood of lymphedema in patients with endometrial cancer who undergo adjuvant radiation with or without...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e4
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To determine whether preoperative platelets to lymphocyte ratio (PLR) could predict disease stage, surgical outcome, and survival in patients with epithelial ovarian cancer (EOC). METHODS:Medical records of EOC patients who had surgery between January 2004 and December 2010 were reviewed. Clinicopathological...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2012.23.4.265
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:Primary sarcoma of the cervix is rare and is associated with worse outcomes as compared to other histologies. The purpose of this study was to identify national treatment patterns and outcomes based on histological subtype using the National Cancer Database (NCDB). METHODS:The NCDB was queried for patients w...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e25
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:The standard dose for pegylated liposomal doxorubicin (PLD) is 50 mg/m² every 4 weeks. While 40 mg/m² has recently been used in clinical practice, evidence supporting this use remains lacking. METHODS:This phase III randomized, non-inferiority study compared progression-free survival (PFS) for patients with ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2021.32.e9
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of the pulmonary recruitment maneuver (PRM) at the end of the operation to decrease laparoscopy-induced abdominal or shoulder pain after gynecological oncologic surgery. METHODS:In total, 113 women undergoing laparoscopic surgery for malignant or premalignant gynecological lesio...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,随机对照试验
doi:10.3802/jgo.2018.29.e92
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to investigate the relationship between plasma levels of insulin-like growth factors-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and the risk for cervical intraepithelial neoplasia (CIN) and cervical cancer. METHODS:Plasma levels of IGF-1 and IGFBP-3 of 44 cervical cancer patient...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2010.21.3.174
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Locally advanced endometrioid adenocarcinoma (LA-EAC) accounts for the majority of deaths for this cancer, yet there is no consensus on adjuvant treatment after surgery. Past studies suggest that combined modality treatment (CMT) may improve outcomes over treatment with chemotherapy (CT) or radiation therapy ...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2018.29.e49
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic accuracy of dilatation and curettage (D&C) versus endometrial aspiration biopsy in follow-up evaluation of patients treated with progestin for endometrial hyperplasia (EH). METHODS:A prospective multicenter study was conducted from 2015 to 2018. Patients with EH were treated with pr...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e51
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). METHODS:A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2009.20.4.232
更新日期:2009-12-01 00:00:00
abstract::The Surgery Treatment Modality Committee of the Korean Gynecologic Oncology Group has determined to develop a surgical manual to facilitate clinical trials and to improve communication between investigators by standardizing and precisely describing operating procedures. The literature on anatomic terminology, identifi...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2017.28.e6
更新日期:2017-01-01 00:00:00
abstract::The most common form of malignant transformation developing from a mature cystic teratoma is squamous cell carcinoma, representing 80% of malignant transformations, while adenocarcinoma accounts for approximately 5%. Because of this rarity, few reports exist of preoperative diagnosis of this tumor by magnetic resonanc...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2012.23.2.125
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of age-adjusted Charlson comorbidity index (ACCI) in predicting disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS) among surgically treated patients with vulvar carcinoma. The secondary aim is to evaluate its impact as a predictor of the pattern of re...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e6
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects of pregnancy. METHODS:We prospectively examined consecutive cases in which the bilateral fallopian tubes were removed during ben...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2019.30.e96
更新日期:2019-11-01 00:00:00
abstract::This corrects the article on e25 in vol. 30, PMID: 30740956. ...
journal_title:Journal of gynecologic oncology
pub_type: 已发布勘误
doi:10.3802/jgo.2019.30.e101
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study was to elucidate the incidence of CINDEIN metastasis in cervical cancer. METHODS:A retrospective chart review was carried out for...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2016.27.e42
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To assess the performance of a low cost magnifying device (Magnivisualizer) compared to a standard optical colposcope for detection of precancerous and cancerous lesions of the uterine cervix. METHODS:A total of 659 consecutive symptomatic women attending a gynecologic outpatient clinic underwent unaided vis...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.4.282
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to develop and validate a questionnaire used to assess the level of general knowledge about cervical cancer, its primary and secondary prevention, and to identify sources of information about the disease among schoolgirls and female students. METHODS:THE QUESTIONNAIRE DEVELOPMENT PR...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2014.25.2.81
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:A prospective, randomized controlled trial was conducted to evaluate the efficacy of nerve-sparing radical hysterectomy (NSRH) in preserving bladder function and its oncologic safety in the treatment of cervical cancer. METHODS:From March 2003 to November 2005, 92 patients with cervical cancer stage IA2 to I...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章,随机对照试验
doi:10.3802/jgo.2015.26.2.90
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:To compare peri- and postoperative outcomes and complications of laparoscopic vs. robotic-assisted surgical staging for women with endometrial cancer at two established academic institutions. METHODS:Retrospective chart review of all women that underwent total hysterectomy with pelvic and para-aortic lymphad...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2013.24.1.21
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:As cancer stem cells (CSCs) are considered as the origin of tumor development, recurrence, and drug resistance, we aimed to explore the mechanism related to modulating stemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. METHODS:In this study, ovarian cancer stem cel...
journal_title:Journal of gynecologic oncology
pub_type: 杂志文章
doi:10.3802/jgo.2020.31.e46
更新日期:2020-07-01 00:00:00