Synchronous and metachronous malignancy in endometrial cancer patients treated in a tertiary care center of Thailand.

Abstract:

OBJECTIVE:To evaluate the prevalence and features of non-endometrial cancers in Thai endometrial cancer (EC) patients. METHODS:EC patients treated in our institution were identified and the following data were collected: age, EC stage, histopathology, adjuvant therapy, other cancers, living status, and cause of death. RESULTS:The mean age of the 344 patients was 56.8 ± 10.8 years. Fifty (14.5%) had other synchronous and metachronous cancers. Mean ages of the patients with or without other cancers were not significantly different, 55.7 ± 10.04 years versus 57.1 ± 11.0 years, respectively (p=0.358). History of any cancer in the family and tumor in the lower uterine segment were more frequent among the patients with other cancers (6.0% vs. 1.7%, p=0.095; 12.0% vs. 1.0%, p<0.001; respectively). Six patients had ≥ 2 other cancers. Ovarian, breast, and colon were the three most common other cancers. After a median follow-up of 57.1 months, 18.3% of patients had died: 30.0% of patients with other cancers and 16.3% of those without other cancers. The corresponding EC deaths were 14.0% and 11.2%. The 5-year overall survival was significantly lower in patients who had other cancers: 79.3% (95% confidence interval [CI], 68.3 to 90.3) vs. 86.0% (95% CI, 81.7 to 90.3) than in those without (p=0.023). However, the corresponding disease-specific survival was not significantly different: 85.1% (95% CI, 75.5 to 94.7) compared with 89.0% (95% CI, 85.1 to 92.9), respectively (p=0.514). CONCLUSION:Thai EC patients had a high incidence of other cancers. Overall survival of EC patients who had other cancers was worse than those without, while disease-specific survival was not significantly different.

journal_name

J Gynecol Oncol

authors

Tangjitgamol S,Khunnarong J,Srijaipracharoen S

doi

10.3802/jgo.2015.26.4.293

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

293-302

issue

4

eissn

2005-0380

issn

2005-0399

pii

26.e12

journal_volume

26

pub_type

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